{"id":34249,"date":"2024-12-03T02:02:12","date_gmt":"2024-12-02T18:02:12","guid":{"rendered":"https:\/\/17aitech.com\/?p=34249"},"modified":"2024-12-03T02:02:12","modified_gmt":"2024-12-02T18:02:12","slug":"%e6%a8%a1%e6%8b%9f5%e4%ba%bf%e5%b9%b4%e7%9a%84%e8%bf%9b%e5%8c%96%e4%bf%a1%e6%81%af%ef%bc%8c%e9%a6%96%e4%b8%aa%e5%90%8c%e6%97%b6%e6%8e%a8%e7%90%86%e8%9b%8b%e7%99%bd%e8%b4%a8%e5%ba%8f%e5%88%97%e3%80%81","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=34249","title":{"rendered":"\u6a21\u62df5\u4ebf\u5e74\u7684\u8fdb\u5316\u4fe1\u606f\uff0c\u9996\u4e2a\u540c\u65f6\u63a8\u7406\u86cb\u767d\u8d28\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u7684\u751f\u7269\u5b66\u5927\u6a21\u578b"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u6a21\u62df5\u4ebf\u5e74\u7684\u8fdb\u5316\u4fe1\u606f\uff0c\u9996\u4e2a\u540c\u65f6\u63a8\u7406\u86cb\u767d\u8d28\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u7684\u751f\u7269\u5b66\u5927\u6a21\u578b<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

\u5728\u4e09\u5341\u4ebf\u5e74\u7684\u81ea\u7136\u8fdb\u5316\u5386\u7a0b\u4e2d\uff0c\u73b0\u5b58\u86cb\u767d\u8d28\u7684\u5f62\u6001\u5f97\u4ee5\u5f62\u6210\uff0c\u7ecf\u5386\u4e86\u6f2b\u957f\u7684\u81ea\u7136\u7b5b\u9009\u8fc7\u7a0b\u3002\u8fdb\u5316\u5982\u540c\u5728\u5730\u8d28\u65f6\u95f4\u5c3a\u5ea6\u4e0a\u8fdb\u884c\u7684\u5e73\u884c\u5b9e\u9a8c\uff0c\u901a\u8fc7\u968f\u673a\u7a81\u53d8\u548c\u9009\u62e9\u673a\u5236\uff0c\u4f9d\u636e\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u3001\u7ed3\u6784\u4e0e\u529f\u80fd\u8fdb\u884c\u7b5b\u9009\u3002<\/p>\n

\u5728\u8fd9\u91cc\uff0cEvolutionaryScale \u7684\u7814\u7a76\u4eba\u5458\u5c55\u793a\u4e86\u5728\u8fdb\u5316\u4ea7\u751f\u7684\u6807\u8bb0\u4e0a\u8bad\u7ec3\u7684\u8bed\u8a00\u6a21\u578b\u53ef\u4ee5\u5145\u5f53\u8fdb\u5316\u6a21\u62df\u5668\uff0c\u7528\u4e8e\u751f\u6210\u4e0d\u540c\u4e8e\u5df2\u77e5\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u529f\u80fd\u6027\u86cb\u767d\u8d28\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86 ESM3\uff0c\u8fd9\u662f\u4e00\u79cd\u524d\u6cbf\u7684\u591a\u6a21\u6001\u751f\u6210\u8bed\u8a00\u6a21\u578b\uff0c\u53ef\u63a8\u7406\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u3002ESM3 \u53ef\u4ee5\u7ed3\u5408\u5176\u6a21\u6001\u6765\u9075\u5faa\u590d\u6742\u7684\u63d0\u793a\uff0c\u5e76\u4e14\u5bf9\u751f\u7269\u5b66\u5bf9\u9f50\uff08biological alignment\uff09\u9ad8\u5ea6\u654f\u611f\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u4f7f\u7528 ESM3 \u751f\u6210\u8367\u5149\u86cb\u767d\u3002\u5176\u4e2d\u4e00\u79cd\u529f\u80fd\u4e0a\u660e\u4eae\u7684\u8367\u5149\u86cb\u767d\uff0c\u4e0e\u5df2\u77e5\u7684\u8367\u5149\u86cb\u767d\u7684\u5e8f\u5217\u5dee\u5f02\u5f88\u5927\uff0858% \u540c\u6e90\u6027\uff09\u3002<\/p>\n

\u8be5\u7814\u7a76\u7684\u9884\u5370\u7248\u6587\u7ae0\u300cSimulating 500 million years of evolution with a language model<\/em>\u300d\u8fd1\u671f\u5c06\u53d1\u5e03\u5728 bioRxiv<\/em> \u9884\u5370\u5e73\u53f0\u3002<\/p>\n

<\/a><\/p>\n

\u81ea\u7136\u8fdb\u5316\u662f\u5982\u4f55\u5728\u8d85\u8fc7\u4e09\u5341\u4ebf\u5e74\u7684\u65f6\u95f4\u91cc\uff0c\u96d5\u7422\u51fa\u5f53\u524d\u81ea\u7136\u754c\u4e2d\u86cb\u767d\u8d28\u7684\u591a\u6837\u6027\u7684\u5462\uff1f<\/p>\n

\u8fd9\u4e00\u8fc7\u7a0b\u6d89\u53ca\u65e0\u6570\u968f\u673a\u7a81\u53d8\u4e0e\u81ea\u7136\u9009\u62e9\u4e8b\u4ef6\uff0c\u6bcf\u4e00\u4e2a\u73af\u8282\u90fd\u4e25\u683c\u8003\u9a8c\u7740\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u3001\u7ed3\u6784\u53ca\u5176\u6267\u884c\u7684\u751f\u7269\u529f\u80fd\uff0c\u53ea\u6709\u6700\u9002\u5e94\u73af\u5883\u53d8\u5316\u7684\u86cb\u767d\u8d28\u624d\u80fd\u7559\u5b58\u4e0b\u6765\u3002<\/p>\n

\u56e0\u6b64\uff0c\u73b0\u5b58\u86cb\u767d\u8d28\u5e8f\u5217\u4fe1\u606f\u4e2d\u5b9e\u8d28\u4e0a\u662f\u8574\u542b\u7740\u751f\u7269\u5b66\u53d8\u91cf\u5bf9\u51e0\u5341\u4ebf\u5e74\u6f2b\u957f\u8fdb\u5316\u8def\u5f84\u7684\u5f71\u54cd\u3002<\/p>\n

EvolutionaryScale \u56e2\u961f\u4e2d\u63d0\u51fa\u4e86\u4e00\u79cd\u521b\u65b0\u65b9\u6cd5\uff0c\u5373\u5229\u7528\u540d\u4e3a ESM3 \u7684\u591a\u6a21\u6001\u751f\u6210\u8bed\u8a00\u6a21\u578b\uff0c\u53ef\u4ee5\u6a21\u62df\u8fd9\u4e00\u5b8f\u5927\u7684\u8fdb\u5316\u8fc7\u7a0b\u3002<\/p>\n

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<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

<\/span><\/section>\n

\u89c6\u9891\u94fe\u63a5\uff1ahttps:\/\/mp.weixin.qq.com\/s\/S_BRIJcFKuKk111Gomo7xQ<\/a><\/section>\n
\u89c6\u9891\uff1aESM3 \u6982\u8ff0\u3002\uff08\u6765\u6e90\uff1a\u516c\u53f8\u5b98\u7f51\uff09<\/section>\n

ESM3 \u4e0d\u4ec5\u80fd\u591f\u7406\u89e3\u548c\u751f\u6210\u86cb\u767d\u8d28\u5e8f\u5217\uff0c\u8fd8\u80fd\u7efc\u5408\u8003\u8651\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u4e0e\u529f\u80fd\uff0c\u6210\u4e3a\u4e00\u4e2a\u5f3a\u5927\u7684\u8fdb\u5316\u6a21\u62df\u5de5\u5177\u3002\u8be5\u6a21\u578b\u8bbe\u8ba1\u6709\u72ec\u7279\u7684\u51e0\u4f55\u6ce8\u610f\u529b\u673a\u5236\uff0c\u80fd\u9ad8\u6548\u5904\u7406\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\u4fe1\u606f\uff0c\u8fd9\u5bf9\u4e8e\u7406\u89e3\u53ca\u9884\u6d4b\u86cb\u767d\u8d28\u884c\u4e3a\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aESM3 \u53ef\u4ee5\u540c\u65f6\u63a8\u7406\u86cb\u767d\u8d28\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u8bed\u8a00\u6a21\u578b\u57fa\u4e8e\u79bb\u6563\u5355\u5143\u6216\u6807\u8bb0\u8fdb\u884c\u64cd\u4f5c\u3002\u4e3a\u4e86\u521b\u5efa\u4e00\u4e2a\u80fd\u591f\u63a8\u7406\u86cb\u767d\u8d28\u7684\u4e09\u4e2a\u57fa\u672c\u751f\u7269\u5b66\u7279\u6027\uff08\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\uff09\u7684\u6a21\u578b\uff0c\u7814\u7a76\u4eba\u5458\u5fc5\u987b\u5c06\u4e09\u7ef4\u7ed3\u6784\u548c\u529f\u80fd\u8f6c\u6362\u4e3a\u79bb\u6563\u5b57\u6bcd\u8868\uff0c\u5e76\u6784\u5efa\u4e00\u79cd\u5c06\u6bcf\u4e2a\u4e09\u7ef4\u7ed3\u6784\u5199\u6210\u5b57\u6bcd\u5e8f\u5217\u7684\u65b9\u6cd5\u3002<\/p>\n

\u8fd9\u4f7f\u5f97 ESM3 \u80fd\u591f\u8fdb\u884c\u5927\u89c4\u6a21\u8bad\u7ec3\uff0c\u4ece\u800c\u91ca\u653e\u65b0\u5174\u7684\u751f\u6210\u80fd\u529b\u3002ESM3 \u7684\u8bcd\u6c47\u8868\u5c06\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u90fd\u6574\u5408\u5728\u540c\u4e00\u4e2a\u8bed\u8a00\u6a21\u578b\u4e2d\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aESM3 \u901a\u8fc7\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u7684\u591a\u6a21\u6001\u63d0\u793a\u4e3a PETase \u6d3b\u6027\u4f4d\u70b9\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u652f\u67b6\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

ESM3 \u7684\u8bad\u7ec3\u76ee\u6807\u5f88\u7b80\u5355\u3002\u5bf9\u4e8e\u6bcf\u79cd\u86cb\u767d\u8d28\uff0c\u63d0\u53d6\u3001\u6807\u8bb0\u548c\u90e8\u5206\u5c4f\u853d\u5176\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u3002ESM3 \u7684\u4efb\u52a1\u662f\u4f7f\u7528\u53d7\u81ea\u7136\u8bed\u8a00\u5904\u7406\u6a21\u578b\u542f\u53d1\u7684\u5c4f\u853d\u8bed\u8a00\u5efa\u6a21\u76ee\u6807\u6765\u9884\u6d4b\u5c4f\u853d\u4f4d\u7f6e\u3002<\/p>\n

\u4e3a\u4e86\u5b8c\u6210\u8fd9\u9879\u4efb\u52a1\uff0cESM3 \u5fc5\u987b\u5b66\u4e60\u6df1\u5165\u4e86\u89e3\u8fdb\u5316\u89c4\u6a21\u6570\u636e\u4e2d\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u4e4b\u95f4\u7684\u8054\u7cfb\u3002\u5f53\u6269\u5c55\u5230\u6570\u5341\u4ebf\u79cd\u86cb\u767d\u8d28\u548c\u6570\u5341\u4ebf\u4e2a\u53c2\u6570\u65f6\uff0cESM3 \u5b66\u4f1a\u6a21\u62df\u8fdb\u5316\u3002<\/p>\n

ESM3 \u80fd\u591f\u751f\u6210\u4e0d\u540c\u4e8e\u73b0\u6709\u5df2\u77e5\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u529f\u80fd\u6027\u86cb\u767d\u8d28\u3002\u6b64\u6a21\u578b\u7684\u7279\u70b9\u5728\u4e8e\u5176\u80fd\u591f\u7406\u89e3\u548c\u54cd\u5e94\u590d\u6742\u7684\u591a\u6a21\u5f0f\u63d0\u793a\uff0c\u540c\u65f6\u5bf9\u751f\u7269\u5b66\u5bf9\u9f50\u6709\u5f88\u9ad8\u7684\u654f\u611f\u5ea6\u3002<\/p>\n

ESM3 \u5bf9\u751f\u7269\u5b66\u5bf9\u9f50\u7684\u9ad8\u5ea6\u654f\u611f\uff0c\u610f\u5473\u7740\u5b83\u80fd\u7cbe\u51c6\u5730\u8bc6\u522b\u5e76\u9075\u5faa\u751f\u7269\u8fdb\u5316\u548c\u529f\u80fd\u76f8\u5173\u7684\u6a21\u5f0f\u3002\u901a\u8fc7\u8fd9\u79cd\u5bf9\u9f50\uff0c\u6a21\u578b\u80fd\u591f\u66f4\u597d\u5730\u7406\u89e3\u86cb\u767d\u8d28\u5982\u4f55\u6839\u636e\u5176\u751f\u7269\u5b66\u89d2\u8272\u548c\u73af\u5883\u9700\u6c42\u8fdb\u5316\uff0c\u4ece\u800c\u5728\u8bbe\u8ba1\u65b0\u86cb\u767d\u8d28\u65f6\uff0c\u66f4\u51c6\u786e\u5730\u53cd\u6620\u81ea\u7136\u754c\u7684\u751f\u7269\u903b\u8f91\u548c\u8fdb\u5316\u7ea6\u675f\u3002<\/p>\n

\u5b83\u53ef\u4ee5\u6309\u7167\u63d0\u793a\u751f\u6210\u65b0\u7684\u86cb\u767d\u8d28\u3002ESM3 \u7684\u591a\u6a21\u6001\u63a8\u7406\u80fd\u529b\u4f7f\u79d1\u5b66\u5bb6\u80fd\u591f\u4ee5\u524d\u6240\u672a\u6709\u7684\u63a7\u5236\u7a0b\u5ea6\u751f\u6210\u65b0\u86cb\u767d\u8d28\u3002\u4f8b\u5982\uff0c\u53ef\u4ee5\u63d0\u793a\u6a21\u578b\u7ed3\u5408\u7ed3\u6784\u3001\u5e8f\u5217\u548c\u529f\u80fd\uff0c\u4e3a PETase \u7684\u6d3b\u6027\u4f4d\u70b9\u63d0\u51fa\u6f5c\u5728\u7684\u652f\u67b6\uff0cPETase \u662f\u4e00\u79cd\u964d\u89e3\u805a\u5bf9\u82ef\u4e8c\u7532\u9178\u4e59\u4e8c\u9187\u916f (PET) \u7684\u9176\uff0c\u8fd9\u662f\u86cb\u767d\u8d28\u5de5\u7a0b\u5e08\u5206\u89e3\u5851\u6599\u5e9f\u7269\u7684\u7814\u7a76\u76ee\u6807\u3002<\/p>\n

\u89e3\u51b3\u4e86\u66f4\u96be\u7684\u751f\u6210\u95ee\u9898<\/strong><\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aESM3 \u6a21\u578b\u5728\u751f\u6210\u6ee1\u8db3\u539f\u5b50\u914d\u4f4d\u63d0\u793a\u7684\u86cb\u767d\u8d28\u7684\u4efb\u52a1\u4e0a\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

ESM3 \u89e3\u51b3\u5177\u6709\u6311\u6218\u6027\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u4efb\u52a1\u7684\u80fd\u529b\uff0c\u4f1a\u968f\u7740\u86cb\u767d\u8d28\u89c4\u6a21\u7684\u6269\u5927\u800c\u663e\u73b0\u3002\u5176\u4e2d\u4e00\u9879\u4efb\u52a1\u662f\u539f\u5b50\u534f\u8c03\uff0c\u5373\u6839\u636e\u6307\u5b9a\u5e8f\u5217\u4e2d\u8ddd\u79bb\u8f83\u8fdc\u4f46\u7ed3\u6784\u4e2d\u8ddd\u79bb\u8f83\u8fd1\u7684\u6c28\u57fa\u9178\u539f\u5b50\u4f4d\u7f6e\u7684\u63d0\u793a\u6765\u8bbe\u8ba1\u86cb\u767d\u8d28\u3002<\/p>\n

\u8fd9\u8861\u91cf\u4e86\u6a21\u578b\u5728\u7ed3\u6784\u751f\u6210\u4e2d\u5b9e\u73b0\u539f\u5b50\u7ea7\u7cbe\u5ea6\u7684\u80fd\u529b\uff0c\u8fd9\u5bf9\u4e8e\u8bbe\u8ba1\u529f\u80fd\u6027\u86cb\u767d\u8d28\u81f3\u5173\u91cd\u8981\u3002ESM3 \u89e3\u51b3\u8fd9\u4e9b\u4efb\u52a1\u7684\u80fd\u529b\u968f\u7740\u89c4\u6a21\u7684\u6269\u5927\u800c\u63d0\u9ad8\uff0c\u4e5f\u5c31\u662f\u8bf4\uff0cESM3 \u89e3\u51b3\u4e86\u66f4\u96be\u7684\u751f\u6210\u95ee\u9898\uff0c\u800c\u89c4\u6a21\u662f\u5176\u4e2d\u7684\u4e00\u4e2a\u51fd\u6570\u3002<\/p>\n

ESM3 \u901a\u8fc7\u4f7f\u7528\u7c7b\u4f3c\u4e8e LLM \u4e2d\u5e94\u7528\u7684\u4eba\u7c7b\u53cd\u9988\u5f3a\u5316\u5b66\u4e60 (RLHF) \u7684\u5bf9\u9f50\u65b9\u6cd5\uff0c\u901a\u8fc7\u53cd\u9988\u8fdb\u4e00\u6b65\u6539\u8fdb\u3002ESM3 \u65e0\u9700\u63a5\u6536\u4eba\u7c7b\u7684\u53cd\u9988\uff0c\u800c\u662f\u53ef\u4ee5\u81ea\u6211\u6539\u8fdb\uff0c\u63d0\u4f9b\u6709\u5173\u5176\u81ea\u8eab\u751f\u6210\u8d28\u91cf\u7684\u53cd\u9988\u3002\u6e7f\u5b9e\u9a8c\u5ba4\u5b9e\u9a8c\u6216\u73b0\u6709\u5b9e\u9a8c\u6570\u636e\u7684\u53cd\u9988\u4e5f\u53ef\u7528\u4e8e\u4f7f ESM3 \u7684\u751f\u6210\u4e0e\u751f\u7269\u5b66\u4fdd\u6301\u4e00\u81f4\u3002<\/p>\n

\u8de8\u8d8a 5 \u4ebf\u5e74\u7684\u81ea\u7136\u8fdb\u5316\u8ddd\u79bb<\/strong><\/p>\n

\u7814\u7a76\u4eba\u5458\u5229\u7528 ESM3 \u8bbe\u8ba1\u4e86\u4e00\u79cd\u540d\u4e3a esmGFP \u7684\u65b0\u8367\u5149\u86cb\u767d\uff0c\u5b83\u4e0e\u5df2\u77e5\u6700\u76f8\u4f3c\u7684\u8367\u5149\u86cb\u767d\u5e8f\u5217\u540c\u6e90\u6027\u4ec5\u4e3a 58%\uff0c\u8fd9\u5728\u4ee5\u5f80\u7684\u4eba\u5de5\u8bbe\u8ba1\u4e2d\u662f\u6781\u4e3a\u7f55\u89c1\u7684\u3002<\/p>\n

\u901a\u8fc7\u6307\u5bfc ESM3 \u5173\u6ce8\u8367\u5149\u86cb\u767d\u5f62\u6210\u548c\u50ac\u5316\u8272\u7d20\u4f53\u53cd\u5e94\u6240\u5fc5\u9700\u7684\u5e8f\u5217\u548c\u7ed3\u6784\u7279\u5f81\uff0c\u6a21\u578b\u7ecf\u8fc7\u4e00\u7cfb\u5217\u8fed\u4ee3\u8bbe\u8ba1\uff0c\u6700\u7ec8\u4ea7\u751f\u4e86\u5177\u6709\u660e\u4eae\u8367\u5149\u6548\u679c\u7684 esmGFP\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aesmGFP \u4e0e\u5df2\u77e5\u8367\u5149\u86cb\u767d\u6bd4\u8f83\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u8be5\u86cb\u767d\u4e0d\u4ec5\u5728\u5e8f\u5217\u4e0a\u4e0e\u5df2\u77e5\u86cb\u767d\u6709\u663e\u8457\u5dee\u5f02\uff0c\u800c\u4e14\u5728\u5b9e\u9a8c\u4e2d\u5c55\u73b0\u51fa\u4e0e\u5e38\u89c1\u8367\u5149\u86cb\u767d\u76f8\u4f3c\u7684\u8367\u5149\u5f3a\u5ea6\u3002\u8fd9\u76f8\u5f53\u4e8e\u8de8\u8d8a\u4e86\u8d85\u8fc7 5 \u4ebf\u5e74\u7684\u81ea\u7136\u8fdb\u5316\u8ddd\u79bb\u3002<\/p>\n

EvolutionaryScale \u662f\u4e00\u5bb6\u975e\u76c8\u5229\u516c\u53f8\u3002\u4ed6\u4eec\u7684\u4f7f\u547d\u662f\u901a\u8fc7\u4e0e\u79d1\u5b66\u754c\u5408\u4f5c\u4ee5\u53ca\u5f00\u653e\u3001\u5b89\u5168\u548c\u8d1f\u8d23\u4efb\u7684\u7814\u7a76\uff0c\u5f00\u53d1\u4eba\u5de5\u667a\u80fd\u6765\u7406\u89e3\u751f\u7269\u5b66\uff0c\u9020\u798f\u4eba\u7c7b\u5065\u5eb7\u548c\u793e\u4f1a\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0cESM \u9879\u76ee\u4e00\u76f4\u81f4\u529b\u4e8e\u901a\u8fc7\u4ee3\u7801\u548c\u6a21\u578b\u53d1\u5e03\u6765\u5f00\u653e\u79d1\u5b66\uff0c\u8be5\u56e2\u961f\u627f\u8bfa\u5c06\u7ee7\u7eed\u575a\u6301\u4e0b\u53bb\u3002<\/p>\n

\u8be5\u516c\u53f8\u6210\u7acb\u4e8e 2023 \u5e74 7 \u6708\u5df2\u7ecf\u5b8c\u6210 1.42 \u4ebf\u7f8e\u5143\u79cd\u5b50\u8f6e\u878d\u8d44\uff0c\u5e76\u5df2\u7ecf\u4e0e\u4e9a\u9a6c\u900a\uff08Amazon\uff09\u548c\u82f1\u4f1f\u8fbe\uff08NVIDIA\uff09\u516c\u53f8\u8fbe\u6210\u5408\u4f5c\u3002<\/p>\n

ESM\u76f8\u5173\u4ee3\u7801\uff1ahttps:\/\/github.com\/evolutionaryscale\/esm<\/em><\/section>\n
\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/evolutionaryscale-public.s3.us-east-2.amazonaws.com\/research\/esm3.pdf<\/em><\/section>\n
\u76f8\u5173\u62a5\u9053\uff1a<\/section>\n
https:\/\/www.evolutionaryscale.ai\/blog\/esm3-release<\/em><\/section>\n
https:\/\/twitter.com\/ylecun\/status\/1805634811773571496<\/em><\/section>\n
https:\/\/twitter.com\/ylecun\/status\/1805581310548697360<\/em><\/section>\n
https:\/\/x.com\/ebetica\/status\/1805599844246884677<\/em><\/section>\n
https:\/\/www.businesswire.com\/news\/home\/20240625717839\/en\/<\/em><\/section>\n

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