{"id":34432,"date":"2024-12-06T12:56:21","date_gmt":"2024-12-06T04:56:21","guid":{"rendered":"https:\/\/17aitech.com\/?p=34432"},"modified":"2024-12-06T12:56:21","modified_gmt":"2024-12-06T04:56:21","slug":"%e4%b8%8a%e4%ba%a4%e5%a4%a7%e6%b4%aa%e4%ba%ae%e8%af%be%e9%a2%98%e7%bb%84%e4%b8%8a%e6%b5%b7ai%e5%ae%9e%e9%aa%8c%e5%ae%a4%e5%9b%a2%e9%98%9f%e5%8f%91%e5%b8%83fsfp%ef%bc%8c%e5%9f%ba%e4%ba%8e%e8%af%ad","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=34432","title":{"rendered":"\u4e0a\u4ea4\u5927\u6d2a\u4eae\u8bfe\u9898\u7ec4&amp;\u4e0a\u6d77AI\u5b9e\u9a8c\u5ba4\u56e2\u961f\u53d1\u5e03FSFP\uff0c\u57fa\u4e8e\u8bed\u8a00\u6a21\u578b\u7684\u86cb\u767d\u8d28\u529f\u80fd\u5c0f\u6837\u672c\u9884\u6d4b\u65b9\u6cd5\uff0c\u767bNature\u5b50\u520a"},"content":{"rendered":"<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:<a href=\"https:\/\/www.jiqizhixin.com\/articles\/2024-07-08-23\" target=\"_blank\">\u4e0a\u4ea4\u5927\u6d2a\u4eae\u8bfe\u9898\u7ec4&amp;\u4e0a\u6d77AI\u5b9e\u9a8c\u5ba4\u56e2\u961f\u53d1\u5e03FSFP\uff0c\u57fa\u4e8e\u8bed\u8a00\u6a21\u578b\u7684\u86cb\u767d\u8d28\u529f\u80fd\u5c0f\u6837\u672c\u9884\u6d4b\u65b9\u6cd5\uff0c\u767bNature\u5b50\u520a<\/a><\/p>\n<section>\n<section>\n<section>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-883d0881563118a9d681a7bac22101e3.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-883d0881563118a9d681a7bac22101e3.png\"><\/a><\/p>\n<p>\u7f16\u8f91 |\u00a0ScienceAI<\/p>\n<p>\u8fd1\u65e5\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u81ea\u7136\u79d1\u5b66\u7814\u7a76\u9662\/\u7269\u7406\u5929\u6587\u5b66\u9662\/\u5f20\u6c5f\u9ad8\u7814\u9662\/\u836f\u5b66\u9662\u6d2a\u4eae\u6559\u6388\u8bfe\u9898\u7ec4\uff0c\u8054\u5408\u4e0a\u6d77\u4eba\u5de5\u667a\u80fd\u5b9e\u9a8c\u5ba4\u9752\u5e74\u7814\u7a76\u5458\u8c08\u6500\uff0c\u5728\u86cb\u767d\u8d28\u7a81\u53d8-\u6027\u8d28\u9884\u6d4b\u4e0a\u53d6\u5f97\u91cd\u8981\u7a81\u7834\u3002<\/p>\n<p>\u8be5\u5de5\u4f5c\u91c7\u7528\u5168\u65b0\u7684\u8bad\u7ec3\u7b56\u7565\uff0c\u5728\u4f7f\u7528\u6781\u5c11\u6e7f\u5b9e\u9a8c\u6570\u636e\u7684\u60c5\u51b5\u4e0b\uff0c\u6781\u5927\u5730\u63d0\u9ad8\u4e86\u4f20\u7edf\u86cb\u767d\u8d28\u9884\u8bad\u7ec3\u5927\u6a21\u578b\u5728\u7a81\u53d8-\u6027\u8d28\u9884\u6d4b\u7684\u6548\u679c\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u6210\u679c\u4ee5\u300a<em>Enhancing the efficiency of protein language models with minimal wet-lab data through few-shot learning<\/em>\u300b\u4e3a\u9898\uff0c\u4e8e 2024 \u5e74 7 \u6708 2 \u65e5\u53d1\u8868\u5728\u300a<em>Nature Communications<\/em>\u300b\u4e0a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-ba9f9ed87d74f2eab292db1eac6eb172.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-ba9f9ed87d74f2eab292db1eac6eb172.png\"><\/a><\/p>\n<p>\u8bba\u6587\u94fe\u63a5\uff1a<em>https:\/\/www.nature.com\/articles\/s41467-024-49798-6<\/em><\/p>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<p>\u9176\u5de5\u7a0b\u6216\u8005\u86cb\u767d\u8d28\u5de5\u7a0b\u662f\u8981\u5bf9\u86cb\u767d\u8d28\u505a\u7a81\u53d8\u5e76\u7b5b\u9009\u5f97\u5230\u6027\u8d28\u66f4\u4f18\u7684\u86cb\u767d\u8d28\u4ea7\u54c1\u3002\u4f20\u7edf\u7684\u6e7f\u5b9e\u9a8c\u65b9\u6cd5\u662f\u7c7b\u4f3c\u4e8e\u8d2a\u5a6a\u7b97\u6cd5\u5f0f\u7684\u641c\u7d22\u65b9\u6cd5\uff0c\u9700\u8981\u8fdb\u884c\u591a\u8f6e\u5b9e\u9a8c\u8fed\u4ee3\u5e76\u53cd\u590d\u8fdb\u884c\u5b9e\u9a8c\u9a8c\u8bc1\u3002<\/p>\n<p>\u8fd9\u4e9b\u6e7f\u5b9e\u9a8c\u65b9\u6cd5\u9700\u8981\u8017\u8d39\u5927\u91cf\u7684\u4eba\u529b\u548c\u65f6\u95f4\uff0c\u505a\u51fa\u4e00\u4e2a\u6ee1\u8db3\u9700\u6c42\u7684\u86cb\u767d\u8d28\u4ea7\u54c1\u5f80\u5f80\u9700\u8981\u6570\u5e74\u7684\u65f6\u95f4\uff0c\u800c\u4e14\u6e7f\u5b9e\u9a8c\u65b9\u6cd5\u80fd\u591f\u7b5b\u9009\u904d\u5386\u7684\u86cb\u767d\u8d28\u7a81\u53d8\u5e8f\u5217\u5e93\u975e\u5e38\u6709\u9650\u3002<\/p>\n<p>\u76ee\u524d\u6709\u4e00\u4e9b\u6df1\u5ea6\u5b66\u4e60\u7684\u65b9\u6cd5\u6765\u52a0\u901f\u8fd9\u4e2a\u86cb\u767d\u8d28\u7a81\u53d8\u6539\u9020\u8fdb\u7a0b\uff0c\u4f46\u662f\u8fd9\u4e9b\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u60f3\u8981\u5f97\u5230\u5f88\u9ad8\u7684\u51c6\u786e\u7387\u7684\u8bdd\uff0c\u9700\u8981\u5229\u7528\u6210\u5343\u4e0a\u4e07\u7684\u86cb\u767d\u8d28\u7a81\u53d8\u6570\u636e\u6765\u8bad\u7ec3\u6a21\u578b\u3002\u800c\u8fd9\u4e2a\u5927\u89c4\u6a21\u9ad8\u8d28\u91cf\u7684\u7a81\u53d8\u6570\u636e\u7684\u83b7\u53d6\uff0c\u53cd\u8fc7\u6765\u4e5f\u662f\u4f20\u7edf\u6e7f\u5b9e\u9a8c\u7684\u5de8\u5927\u95e8\u69db\u3002<\/p>\n<p>\u56e0\u800c\uff0c\u884c\u4e1a\u5185\u6025\u9700\u4e00\u79cd\u5728\u4e0d\u9700\u8981\u5927\u91cf\u6e7f\u5b9e\u9a8c\u6570\u636e\u60c5\u51b5\u4e0b\uff0c\u4f9d\u7136\u80fd\u591f\u5bf9\u86cb\u767d\u8d28\u7a81\u53d8-\u529f\u80fd\u505a\u51fa\u51c6\u786e\u9884\u6d4b\u7684\u65b9\u6cd5\u3002<\/p>\n<p>\u76ee\u524d\u7684\u86cb\u767d\u8d28\u65e0\u76d1\u7763\u9884\u8bad\u7ec3\u6a21\u578b\u80fd\u5728\u5b8c\u5168\u6ca1\u6709\u6e7f\u5b9e\u9a8c\u7684\u60c5\u51b5\uff0c\u4ee5\u96f6\u6837\u672c(zero-shot)\u9884\u6d4b\u86cb\u767d\u8d28\u7a81\u53d8-\u6027\u8d28\u7684\u53d8\u5316\uff0c\u4f46\u662f\u8fd9\u79cd\u9884\u6d4b\u65b9\u6cd5\u5f80\u5f80\u7cbe\u5ea6\u8f83\u4f4e\uff0c\u4e14\u4e0a\u8ff0\u65e0\u76d1\u7763\u6a21\u578b\u65e0\u6cd5\u76f4\u63a5\u5229\u7528\u6709\u9650\u7684\u6e7f\u5b9e\u9a8c\u6570\u636e\u5bf9\u4e0a\u9762\u65e0\u76d1\u7763\u6a21\u578b\u8fdb\u884c\u5fae\u8c03\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>\u7814\u7a76\u65b9\u6cd5<\/strong><\/p>\n<section>\n<section>\n<section>\n<section>\n<p>\u5728\u672c\u7814\u7a76\u5de5\u4f5c\u4e2d\uff0c\u6211\u4eec\u63d0\u51fa\u4e86\u4e00\u79cd\u89e3\u51b3\u65b9\u6cd5(FSFP)\uff0c\u7efc\u5408\u5229\u7528\u5143\u5b66\u4e60\uff0c\u6392\u5e8f\u5b66\u4e60\u548c\u53c2\u6570\u9ad8\u6548\u7684\u5fae\u8c03\u65b9\u6cd5\uff0c\u5728\u53ea\u5229\u7528\u4efb\u610f\u51e0\u5341\u4e2a\u6e7f\u5b9e\u9a8c\u6570\u636e\u4e0b\u4fbf\u53ef\u4ee5\u8bad\u7ec3\u86cb\u767d\u8d28\u9884\u8bad\u7ec3\u6a21\u578b\uff0c\u5e76\u5927\u5e45\u63d0\u9ad8\u5bf9\u86cb\u767d\u8d28\u7a81\u53d8-\u6027\u8d28\u9884\u6d4b\u7684\u6548\u679c\u3002<\/p>\n<p>\u5728\u5305\u542b87\u4e2a\u9ad8\u901a\u91cf\u7a81\u53d8\u6570\u636e\u96c6\u00a0ProteinGym\u7684\u6d4b\u8bd5\u4e2d\uff0cFSFP\u65b9\u6cd5\u5148\u5229\u7528\u86cb\u767d\u8d28\u9884\u8bad\u7ec3\u6a21\u578b\u8bc4\u4f30\u76ee\u6807\u86cb\u767d\u8d28\u4e0eProteinGym\u4e2d\u7684\u86cb\u767d\u8d28\u7684\u76f8\u4f3c\u5ea6\uff0c\u5e76\u4eceProteinGym\u4e2d\u53d6\u51fa\u4e0e\u76ee\u6807\u86cb\u767d\u8d28\u6700\u76f8\u8fd1\u7684\u4e24\u4e2a\u86cb\u767d\u8d28\u6570\u636e\u96c6\u4f5c\u4e3a\u5143\u5b66\u4e60\u7684\u4e24\u4e2a\u8f85\u52a9\u4efb\u52a1\uff0c\u540c\u65f6\u5229\u7528GEMME\u5bf9\u76ee\u6807\u86cb\u767d\u8d28\u7684\u6253\u5206\u6570\u636e\u4f5c\u4e3a\u7b2c\u4e09\u4e2a\u8f85\u52a9\u4efb\u52a1\u3002<\/p>\n<p>\u6700\u540e\u5229\u7528\u6392\u5e8f\u5b66\u4e60\u635f\u5931\u51fd\u6570\u548cLora\u8bad\u7ec3\u65b9\u6cd5\uff0c\u5728\u6781\u5c11\u91cf\uff08\u51e0\u5341\u4e2a\uff09\u7684\u771f\u5b9e\u6e7f\u5b9e\u9a8c\u6570\u636e\u4e0a\u8bad\u7ec3\u86cb\u767d\u8d28\u9884\u8bad\u7ec3\u6a21\u578b\u3002<\/p>\n<p>\u6211\u4eec\u7684\u6d4b\u8bd5\u7ed3\u679c\u8868\u660e\uff0c\u5373\u4fbf\u662f\u5728\u539f\u59cb\u7684\u86cb\u767d\u8d28\u9884\u8bad\u7ec3\u6a21\u578b\u5bf9\u7a81\u53d8-\u6027\u8d28\u9884\u6d4b\u7684 spearman\u76f8\u5173\u6027\u4f4e\u4e8e0.1\u7684\u60c5\u51b5\u4e0b\uff0cFSFP\u65b9\u6cd5\u53ea\u5229\u7528\u4efb\u610f20\u4e2a\u6e7f\u5b9e\u9a8c\u6570\u636e\u8bad\u7ec3\u6a21\u578b\uff0c\u4e5f\u80fd\u5c06\u4e0a\u8ff0\u7684\u9884\u6d4b\u76f8\u5173\u6027\u5927\u5e45\u63d0\u9ad8\u52300.5\u4ee5\u4e0a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-8074721faf477ddcbd168c80f775a25f.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-8074721faf477ddcbd168c80f775a25f.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1aFSFP 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data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-57501647de231109734e7567103fba11.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u4f7f\u7528 FSFP \u5de5\u7a0b\u5316 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