{"id":34617,"date":"2024-12-10T03:56:53","date_gmt":"2024-12-09T19:56:53","guid":{"rendered":"https:\/\/17aitech.com\/?p=34617"},"modified":"2024-12-10T03:56:53","modified_gmt":"2024-12-09T19:56:53","slug":"%e6%95%88%e7%8e%87%e9%ab%98%ef%bc%8c%e6%97%a0%e9%9c%80%e6%a0%87%e7%ad%be%ef%bc%8c%e8%b0%b7%e6%ad%8c%e5%9b%a2%e9%98%9f%e7%94%a8ai%e6%8c%96%e6%8e%98%e4%b8%b4%e5%ba%8a%e6%95%b0%e6%8d%ae%ef%bc%8c%e6%94%b9","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=34617","title":{"rendered":"\u6548\u7387\u9ad8\uff0c\u65e0\u9700\u6807\u7b7e\uff0c\u8c37\u6b4c\u56e2\u961f\u7528AI\u6316\u6398\u4e34\u5e8a\u6570\u636e\uff0c\u6539\u5584\u57fa\u56e0\u53d1\u73b0\u548c\u75be\u75c5\u9884\u6d4b\uff0c\u767bNature\u5b50\u520a"},"content":{"rendered":"<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:<a href=\"https:\/\/www.jiqizhixin.com\/articles\/2024-07-19-8\" target=\"_blank\">\u6548\u7387\u9ad8\uff0c\u65e0\u9700\u6807\u7b7e\uff0c\u8c37\u6b4c\u56e2\u961f\u7528AI\u6316\u6398\u4e34\u5e8a\u6570\u636e\uff0c\u6539\u5584\u57fa\u56e0\u53d1\u73b0\u548c\u75be\u75c5\u9884\u6d4b\uff0c\u767bNature\u5b50\u520a<\/a><\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-90c866561b5f3639a4704a16aca59d89.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-90c866561b5f3639a4704a16aca59d89.png\"><\/a><\/p>\n<p>\u7f16\u8f91 |\u00a0ScienceAI<\/p>\n<p>\u73b0\u4ee3\u533b\u7597\u4fdd\u5065\u7cfb\u7edf\u4f1a\u4ea7\u751f\u5927\u91cf\u9ad8\u7ef4\u4e34\u5e8a\u6570\u636e (HDCD)\uff0c\u4f8b\u5982\u80ba\u529f\u80fd\u56fe\u3001\u5149\u4f53\u79ef\u53d8\u5316\u63cf\u8bb0\u56fe\u6cd5 (PPG)\u3001\u5fc3\u7535\u56fe (ECG) \u8bb0\u5f55\u3001CT \u626b\u63cf\u548c MRI \u6210\u50cf\uff0c\u8fd9\u4e9b\u6570\u636e\u65e0\u6cd5\u7528\u5355\u4e2a\u4e8c\u8fdb\u5236\u6216\u8fde\u7eed\u6570\u5b57\u6765\u6982\u62ec\u3002<\/p>\n<p>\u4e86\u89e3\u6211\u4eec\u7684\u57fa\u56e0\u7ec4\u4e0e HDCD \u4e4b\u95f4\u7684\u8054\u7cfb\u4e0d\u4ec5\u53ef\u4ee5\u63d0\u9ad8\u6211\u4eec\u5bf9\u75be\u75c5\u7684\u4e86\u89e3\uff0c\u800c\u4e14\u5bf9\u4e8e\u75be\u75c5\u6cbb\u7597\u7684\u53d1\u5c55\u4e5f\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<p>\u8fd1\u65e5\uff0cGoogle Research \u7684\u57fa\u56e0\u7ec4\u5b66\u56e2\u961f\u5728\u5229\u7528 HDCD \u8868\u5f81\u75be\u75c5\u548c\u751f\u7269\u5b66\u7279\u5f81\u65b9\u9762\u53d6\u5f97\u4e86\u8fdb\u5c55\u3002<\/p>\n<p>\u7814\u7a76\u56e2\u961f\u63d0\u51fa\u4e86\u4e00\u79cd\u65e0\u76d1\u7763\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff0c\u5373\u4f4e\u7ef4\u5d4c\u5165\u57fa\u56e0\u53d1\u73b0\u7684\u8868\u793a\u5b66\u4e60 (REGLE)\uff0c\u7528\u4e8e\u53d1\u73b0\u57fa\u56e0\u53d8\u5f02\u4e0e HDCD \u4e4b\u95f4\u7684\u5173\u8054\u3002<\/p>\n<p>REGLE \u4f5c\u4e3a\u4e00\u79cd\u65b0\u9896\u7684\u57fa\u56e0\u53d1\u73b0\u65b9\u6cd5\uff0c\u53ef\u4ee5\u5229\u7528\u9ad8\u7ef4\u4e34\u5e8a\u6570\u636e\u4e2d\u7684\u9690\u85cf\u4fe1\u606f\uff0c\u5176\u8ba1\u7b97\u6548\u7387\u9ad8\uff0c\u4e0d\u9700\u8981\u75be\u75c5\u6807\u7b7e\uff0c\u5e76\u4e14\u53ef\u4ee5\u6574\u5408\u6765\u81ea\u4e13\u5bb6\u5b9a\u4e49\u77e5\u8bc6\u7684\u4fe1\u606f\u3002<\/p>\n<p>\u603b\u4f53\u800c\u8a00\uff0cREGLE \u5305\u542b\u7684\u4e34\u5e8a\u76f8\u5173\u4fe1\u606f\u8d85\u51fa\u4e86\u73b0\u6709\u4e13\u5bb6\u5b9a\u4e49\u7684\u7279\u5f81\u6240\u6355\u83b7\u7684\u4fe1\u606f\uff0c\u4ece\u800c\u53ef\u4ee5\u6539\u5584\u57fa\u56e0\u53d1\u73b0\u548c\u75be\u75c5\u9884\u6d4b\u3002<\/p>\n<p>\u76f8\u5173\u7814\u7a76\u4ee5\u300c<em>Unsupervised representation learning on high-dimensional clinical data improves genomic discovery and prediction<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 7 \u6708 8 \u65e5\u53d1\u5e03\u5728\u300a<em>Nature Genetics<\/em>\u300b\u4e0a\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-ba68e7c76820f1e17410d26e4a91d88e.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-ba68e7c76820f1e17410d26e4a91d88e.png\"><\/a><\/p>\n<p>\u8bba\u6587\u8fde\u63a5\uff1a<em>https:\/\/www.nature.com\/articles\/s41588-024-01831-6<\/em><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_78 ez-toc-wrap-left-text counter-hierarchy ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u6587\u7ae0\u76ee\u5f55<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" 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href=\"https:\/\/17aitech.com\/?p=34617\/#%E9%83%A8%E5%88%86%E5%8F%AF%E8%A7%A3%E9%87%8A%E7%9A%84%E5%B5%8C%E5%85%A5\" >\u90e8\u5206\u53ef\u89e3\u91ca\u7684\u5d4c\u5165<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/17aitech.com\/?p=34617\/#%E9%98%90%E6%98%8E%E4%BA%BA%E7%B1%BB%E7%89%B9%E5%BE%81%E5%92%8C%E7%96%BE%E7%97%85%E7%9A%84%E9%81%97%E4%BC%A0%E5%9F%BA%E7%A1%80\" >\u9610\u660e\u4eba\u7c7b\u7279\u5f81\u548c\u75be\u75c5\u7684\u9057\u4f20\u57fa\u7840<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E6%8F%AD%E7%A4%BA_HDCD_%E4%B8%AD%E7%9A%84%E9%9A%90%E8%97%8F%E4%BF%A1%E6%81%AF\"><\/span><strong>\u63ed\u793a HDCD \u4e2d\u7684\u9690\u85cf\u4fe1\u606f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>\u7814\u7a76\u57fa\u56e0\u4e0e HDCD \u4e4b\u95f4\u8054\u7cfb\u7684\u4e00\u79cd\u7b80\u5355\u65b9\u6cd5\u662f\u5bf9\u6bcf\u4e2a\u6570\u636e\u5750\u6807\u6267\u884c\u00a0GWAS\uff0c\u4f8b\u5982\uff0c\u53ef\u4ee5\u7814\u7a76\u533b\u5b66\u56fe\u50cf\u4e2d\u6bcf\u4e2a\u50cf\u7d20\u503c\u7684\u53d8\u5316\u3002\u8fd9\u79cd\u65b9\u6cd5\u8ba1\u7b97\u6210\u672c\u9ad8\uff0c\u5e76\u4e14\u7531\u4e8e\u90bb\u8fd1\u5750\u6807\u4e4b\u95f4\u7684\u9ad8\u76f8\u5173\u6027\u548c\u5927\u91cf\u7684\u591a\u91cd\u6d4b\u8bd5\u8d1f\u62c5\uff0c\u53d1\u73b0\u663e\u8457\u5173\u8054\u7684\u80fd\u529b\u8f83\u4f4e\u3002<\/p>\n<p>\u4e00\u79cd\u66f4\u5e38\u7528\u7684\u65b9\u6cd5\u662f\u4e13\u6ce8\u4e8e\u4ece HDCD \u4e2d\u63d0\u53d6\u7684\u5c11\u91cf\u4e13\u5bb6\u5b9a\u4e49\u7279\u5f81 (Expert-defined Features\uff0cEDF) \u4f5c\u4e3a GWAS \u7684\u76ee\u6807\u7279\u5f81\u6216\u8868\u578b\u3002EDF \u53ef\u4ee5\u5305\u62ec\u4e34\u5e8a\u5df2\u77e5\u7684\u7279\u5f81\uff0c\u4f8b\u5982\u80ba\u91cf\u56fe\u7684\u7528\u529b\u80ba\u6d3b\u91cf (FVC) \u6216 1 \u79d2\u7528\u529b\u547c\u6c14\u91cf (FEV1)\u3002<\/p>\n<p>\u867d\u7136\u8fd9\u4e9b EDF \u662f\u4e13\u5bb6\u53d1\u73b0\u7684\u91cd\u8981\u7279\u5f81\uff0c\u4f46\u5047\u8bbe\u5b83\u4eec\u53ef\u80fd\u65e0\u6cd5\u5168\u9762\u6355\u83b7 HDCD \u4e2d\u7f16\u7801\u7684\u4fe1\u53f7\uff0c\u56e0\u6b64\u5bf9\u8fd9\u4e9b\u4fe1\u53f7\u8fd0\u884c GWAS \u53ef\u80fd\u65e0\u6cd5\u5145\u5206\u5229\u7528 HDCD \u7684\u6f5c\u529b\u3002<\/p>\n<p>REGLE \u65e8\u5728\u4f7f\u7528\u53d8\u5206\u81ea\u52a8\u7f16\u7801\u5668 (VAE) \u6a21\u578b\u514b\u670d\u8fd9\u4e9b\u9650\u5236\u3002\u8be5\u65b9\u6cd5\u5305\u62ec\u4e09\u4e2a\u4e3b\u8981\u6b65\u9aa4\uff1a<\/p>\n<p>(1) \u901a\u8fc7 VAE \u5b66\u4e60 HDCD \u7684\u975e\u7ebf\u6027\u3001\u4f4e\u7ef4\u3001\u89e3\u7ea0\u7f20\u8868\u793a\uff08\u5373\u7f16\u7801\u6216\u5d4c\u5165\uff09\uff1b<\/p>\n<p>(2) \u5bf9\u6bcf\u4e2a\u7f16\u7801\u5750\u6807\u72ec\u7acb\u8fdb\u884c GWAS\uff1b<\/p>\n<p>(3) \u4f7f\u7528\u6765\u81ea\u7f16\u7801\u5750\u6807\u7684\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u5206 (PRS) \u4f5c\u4e3a\u4e00\u822c\u751f\u7269\u529f\u80fd\u7684\u9057\u4f20\u8bc4\u5206\uff0c\u7136\u540e\u53ef\u80fd\u5c06\u8fd9\u4e9b\u8bc4\u5206\u7ec4\u5408\u8d77\u6765\u4e3a\u7279\u5b9a\u75be\u75c5\u6216\u7279\u5f81\u521b\u5efa PRS\uff08\u7ed9\u5b9a\u5c11\u91cf\u75be\u75c5\u6807\u7b7e\uff09\u3002<\/p>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cREGLE \u8fd8\u5141\u8bb8\u5728\u4fee\u6539\u540e\u7684 VAE \u67b6\u6784\u4e2d\u5c06\u76f8\u5173 EDF \u9009\u62e9\u6027\u5730\u5305\u542b\u5728\u89e3\u7801\u5668\u7684\u8f93\u5165\u4e2d\uff0c\u4ece\u800c\u9f13\u52b1\u7f16\u7801\u5668\u4ec5\u5b66\u4e60 EDF \u672a\u8868\u793a\u7684\u6b8b\u5dee\u4fe1\u53f7\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-89e5b5990b6c50cebdd42e206c6c12de.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-89e5b5990b6c50cebdd42e206c6c12de.png\"><\/a><\/p>\n<section>\u56fe\u793a\uff1aREGLE \u7684\u4e09\u4e2a\u6b65\u9aa4\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n<h1><span class=\"ez-toc-section\" id=\"%E6%A3%80%E6%B5%8B%E8%82%BA%E5%92%8C%E5%BE%AA%E7%8E%AF%E5%8A%9F%E8%83%BD%E7%9A%84%E6%96%B0%E5%9F%BA%E5%9B%A0%E4%BD%8D%E7%82%B9\"><\/span><strong>\u68c0\u6d4b\u80ba\u548c\u5faa\u73af\u529f\u80fd\u7684\u65b0\u57fa\u56e0\u4f4d\u70b9<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e24\u79cd\u9ad8\u7ef4\u4e34\u5e8a\u6570\u636e\u6a21\u5f0f\u5c55\u793a\u4e86 REGLE \u7684\u529f\u80fd\uff1a\u6d4b\u91cf\u80ba\u529f\u80fd\u7684\u80ba\u91cf\u56fe\u548c\u6d4b\u91cf\u5fc3\u8840\u7ba1\u529f\u80fd\u7684 PPG\u3002\u4e24\u8005\u90fd\u53ef\u4ee5\u5728\u8bca\u6240\u6216\u6d88\u8d39\u8005\u53ef\u7a7f\u6234\u8bbe\u5907\u4e2d\u4ee5\u975e\u4fb5\u5165\u6027\u3001\u76f8\u5bf9\u4fbf\u5b9c\u7684\u65b9\u5f0f\u6536\u96c6\uff0c\u5e76\u4e14\u8fd9\u4e24\u79cd\u6a21\u5f0f\u90fd\u6709\u4f17\u6240\u5468\u77e5\u7684\u7279\u5f81\uff09\u3002<\/p>\n<p>\u4e0e\u5177\u6709\u76f8\u540c\u7ef4\u5ea6\u7684\u80ba\u91cf\u56fe\u548c PPG \u7279\u5f81\u7684\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\u76f8\u6bd4\uff0cREGLE \u5bf9\u5b66\u4e60\u7f16\u7801\u7684\u7814\u7a76\u6062\u590d\u4e86\u4e0e\u80ba\u548c\u5faa\u73af\u529f\u80fd\u76f8\u5173\u7684\u5927\u591a\u6570\u5df2\u77e5\u57fa\u56e0\u4f4d\u70b9\uff08loci\uff09\uff0c\u540c\u65f6\u8fd8\u68c0\u6d4b\u5230\u4e86\u5176\u4ed6\u4f4d\u70b9\uff08\u4f8b\u5982\uff0cPPG \u7684\u91cd\u8981\u4f4d\u70b9\u589e\u52a0\u4e86 45%\uff09\u3002\u5982\u679c\u8fd9\u4e9b\u4f4d\u70b9\u5728\u8fdb\u4e00\u6b65\u7684\u5206\u6790\u548c\u6e7f\u5b9e\u9a8c\u5ba4\u5b9e\u9a8c\u4e2d\u5f97\u5230\u9a8c\u8bc1\uff0c\u5b83\u4eec\u6709\u53ef\u80fd\u6210\u4e3a\u65b0\u7684\u836f\u7269\u9776\u70b9\u3002<\/p>\n<h1><span class=\"ez-toc-section\" id=\"%E6%94%B9%E8%BF%9B%E7%9A%84%E9%81%97%E4%BC%A0%E9%A3%8E%E9%99%A9%E8%AF%84%E5%88%86\"><\/span>\u6539\u8fdb\u7684\u9057\u4f20\u98ce\u9669\u8bc4\u5206<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u5206 (PRS) \u662f\u8bb8\u591a\u9057\u4f20\u53d8\u5f02\u5bf9\u7279\u5b9a\u7279\u5f81\u7684\u4f30\u8ba1\u5f71\u54cd\u7684\u603b\u7ed3\uff0c\u4ee5\u5355\u4e2a\u6570\u5b57\u8868\u793a\u3002\u901a\u8fc7\u5bf9 REGLE \u5d4c\u5165\u8fdb\u884c\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\u521b\u5efa\u7684 PRS \u53ef\u4ee5\u4ec5\u4f7f\u7528\u5c11\u91cf\u75be\u75c5\u6807\u7b7e\u8fdb\u884c\u7ec4\u5408\uff0c\u4ee5\u751f\u6210\u9488\u5bf9\u8be5\u7279\u5b9a\u75be\u75c5\u7684 PRS\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u89c2\u5bdf\u5230\uff0c\u4e0e\u73b0\u6709\u65b9\u6cd5\uff08\u4f8b\u5982\u7531\u4e13\u5bb6\u5b9a\u4e49\u7684\u7279\u5f81\u3001PCA \u548c PRS\uff09\u76f8\u6bd4\uff0c\u7531\u80ba\u91cf\u56fe\u7f16\u7801\u521b\u5efa\u7684\u80ba\u529f\u80fd PRS \u6539\u5584\u4e86\u00a0COPD \u548c\u54ee\u5598\u9884\u6d4b\uff0c\u5e76\u4e14\u6bd4\u98ce\u9669\u8c31\u4e24\u7aef\u7684\u7279\u5f81 PRS \u66f4\u6709\u6548\u5730\u5bf9\u98ce\u9669\u7ec4\u8fdb\u884c\u5206\u5c42\u3002\u54ee\u5598\u548c COPD \u7684\u591a\u4e2a\u72ec\u7acb\u6570\u636e\u96c6\uff08COPDGene\u3001eMERGE III\u3001Indiana Biobank \u548c EPIC-Norfolk\uff09\u4e2d\u7684\u591a\u4e2a\u6307\u6807\uff08AUC-ROC\u3001AUC-PR \u548c Pearson \u76f8\u5173\u6027\uff09\u5728\u7edf\u8ba1\u5b66\u4e0a\u663e\u8457\u6539\u5584\uff0c\u5982\u4e0b\u6240\u793a\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-835fc4a0b587fa6b8499b4ca0c5e4dd5.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-835fc4a0b587fa6b8499b4ca0c5e4dd5.png\"><\/a><\/p>\n<section>\u56fe\u793a\uff1a\u80ba\u91cf\u56fe\u7f16\u7801 (SPINC) \u548c\u6b8b\u5dee\u80ba\u91cf\u56fe\u7f16\u7801 (RSPINC) PRS \u4e0e\u4e13\u5bb6\u5b9a\u4e49\u7684\u7279\u5f81 PRS \u5bf9\u54ee\u5598\u60a3\u75c5\u7387\u7684\u6bd4\u8f83\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n<p>\u7c7b\u4f3c\u5730\uff0c\u4ece PPG \u7684 REGLE \u5d4c\u5165\u4e2d\u5f97\u5230\u7684 PRS \u53ef\u4ee5\u6539\u5584\u9ad8\u8840\u538b\u548c\u6536\u7f29\u538b (SBP) \u9884\u6d4b\u3002\u5728\u4e09\u4e2a\u72ec\u7acb\u6570\u636e\u96c6\uff08COPDGene\u3001eMERGE III \u548c EPIC-Norfolk\uff09\u4ee5\u53ca\u82f1\u56fd\u751f\u7269\u5e93\u7684\u4fdd\u7559\u6d4b\u8bd5\u96c6\u4e2d\u8bc4\u4f30\u4e86\u7531 PPG \u7f16\u7801\u548c PPG \u7279\u5f81\u751f\u6210\u7684\u9ad8\u8840\u538b\u548c SBP PRS\u3002<\/p>\n<p>\u89c2\u5bdf\u5230\uff0c\u5728\u591a\u4e2a\u6570\u636e\u96c6\u4e2d\uff0c\u4f7f\u7528\u6765\u81ea PPG \u7f16\u7801\u7684 PRS \u6bd4\u4f7f\u7528\u6765\u81ea\u4e13\u5bb6\u5b9a\u4e49\u7279\u5f81\u7684 PRS \u5177\u6709\u4e00\u81f4\u7684\u6539\u8fdb\u8d8b\u52bf\uff0c\u65e0\u8bba\u662f\u9ad8\u8840\u538b\u8fd8\u662f SBP\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-fc940000c4ebdc7704b8940bd90e3ef7.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-fc940000c4ebdc7704b8940bd90e3ef7.png\"><\/a><\/p>\n<section>\u56fe\u793a\uff1a\u9ad8\u8840\u538b (HTN) \u7684 PPG \u7f16\u7801 (PLENC) PRS \u6bd4\u8f83\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-6233cef78e2bb5a46b7a0cb4635ddd4f.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-6233cef78e2bb5a46b7a0cb4635ddd4f.png\"><\/a><\/p>\n<section>\u56fe\u793a\uff1a\u6536\u7f29\u538b (SBP) \u7684 PPG \u7f16\u7801 (PLENC) PRS \u6bd4\u8f83\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n<h1><span class=\"ez-toc-section\" id=\"%E9%83%A8%E5%88%86%E5%8F%AF%E8%A7%A3%E9%87%8A%E7%9A%84%E5%B5%8C%E5%85%A5\"><\/span><strong>\u90e8\u5206\u53ef\u89e3\u91ca\u7684\u5d4c\u5165<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>\u5229\u7528 REGLE \u7684\u751f\u6210\u7279\u6027\uff0c\u901a\u8fc7\u56fa\u5b9a\u4e13\u5bb6\u5b9a\u4e49\u7279\u5f81\u7684\u503c\u5e76\u6539\u53d8\u4e00\u4e2a\u7f16\u7801\u5750\u6807\u800c\u5c06\u5176\u4ed6\u7f16\u7801\u5750\u6807\u4fdd\u6301\u4e3a\u96f6\u6765\u7814\u7a76\u7f16\u7801\u5750\u6807\u5bf9\u80ba\u91cf\u56fe\u5f62\u72b6\u7684\u5f71\u54cd\u3002\u7136\u540e\uff0c\u4ec5\u4f7f\u7528\u8bad\u7ec3\u6a21\u578b\u7684\u89e3\u7801\u5668\u90e8\u5206\u751f\u6210\u76f8\u5e94\u7684\u80ba\u91cf\u56fe\u3002<\/p>\n<p>\u5178\u578b\u7684\u6d41\u91cf-\u4f53\u79ef\u80ba\u91cf\u56fe\u7531\u4e24\u4e2a\u4e0d\u540c\u7684\u90e8\u5206\u7ec4\u6210\uff1a\uff081\uff09\u76f8\u5bf9\u8f83\u77ed\u7684\u90e8\u5206\u4ee5\u8fbe\u5230\u5cf0\u503c\u6d41\u91cf\uff0c\u5176\u4e2d\u6d41\u91cf\u968f\u7740\u4f53\u79ef\u7684\u589e\u52a0\u800c\u5355\u8c03\u589e\u52a0\uff1b\uff082\uff09\u80ba\u91cf\u56fe\u7684\u4e3b\u8981\u90e8\u5206\uff0c\u5176\u4e2d\u6d41\u91cf\u5355\u8c03\u51cf\u5c11\u3002<\/p>\n<p>\u4e0b\u56fe\u663e\u793a\uff0c\u6539\u53d8\u7b2c\u4e00\u4e2a\u5750\u6807\u76f8\u5f53\u4e8e\u6269\u5927\u6216\u7f29\u5c0f\u7b2c\u4e8c\u90e8\u5206\uff08\u8d1f\u659c\u7387\uff09\uff0c\u540c\u65f6\u4fdd\u6301\u7b2c\u4e00\u90e8\u5206\u76f8\u5bf9\u56fa\u5b9a\u3002\u4e8b\u5b9e\u4e0a\uff0c\u66f2\u7ebf\u7b2c\u4e8c\u90e8\u5206\u7684\u51f9\u5ea6\u88ab\u80ba\u75c5\u5b66\u5bb6\u79f0\u4e3a\u51f9\u9677\uff0c\u8fd9\u662f\u6c14\u9053\u963b\u585e\u7684\u6307\u6807\uff0c\u6807\u51c6 EDF \u65e0\u6cd5\u5f88\u597d\u5730\u8868\u793a\u51fa\u6765\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-3faa7d14b21898da3a56e2b1f4822312.gif\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/07\/frc-3faa7d14b21898da3a56e2b1f4822312.gif\"><\/a><\/p>\n<section>\u56fe\u793a\uff1a\u6539\u53d8\u4e00\u4e2a\u547c\u5438\u56fe\u7f16\u7801\u5750\u6807\u7684\u6548\u679c\u3002\uff08\u6765\u6e90\uff1aGoogle Research\uff09<\/section>\n<h1><span class=\"ez-toc-section\" id=\"%E9%98%90%E6%98%8E%E4%BA%BA%E7%B1%BB%E7%89%B9%E5%BE%81%E5%92%8C%E7%96%BE%E7%97%85%E7%9A%84%E9%81%97%E4%BC%A0%E5%9F%BA%E7%A1%80\"><\/span><strong>\u9610\u660e\u4eba\u7c7b\u7279\u5f81\u548c\u75be\u75c5\u7684\u9057\u4f20\u57fa\u7840<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>REGLE \u662f\u4e00\u79cd\u65e0\u76d1\u7763\u5b66\u4e60\u65b9\u6cd5\uff0c\u53ef\u6267\u884c\u9057\u4f20\u5206\u6790\u3001\u6539\u8fdb\u7684\u65b0\u57fa\u56e0\u4f4d\u70b9\u53d1\u73b0\u548c\u98ce\u9669\u9884\u6d4b\u3002\u7531\u4e8e\u96be\u4ee5\u5927\u89c4\u6a21\u624b\u52a8\u53d1\u73b0 EDF\uff0c\u56e0\u6b64\u65e0\u76d1\u7763\u5b66\u4e60 HDCD \u8868\u793a\u5bf9\u57fa\u56e0\u7ec4\u53d1\u73b0\u5f88\u6709\u5438\u5f15\u529b\u3002<\/p>\n<p>REGLE \u6846\u67b6\u8fd8\u901a\u8fc7\u4fee\u6539\u4f20\u7edf\u7684 VAE \u67b6\u6784\u6765\u652f\u6301\u5728\u5efa\u6a21\u4e2d\u539f\u5219\u6027\u5730\u4f7f\u7528\u8fd9\u4e9b\u7279\u5f81\u3002\u5728\u4e24\u79cd\u4e34\u5e8a\u6570\u636e\u6a21\u5f0f\uff08\u80ba\u91cf\u56fe\u548c PPG\uff09\u4e2d\u5c55\u793a\u4e86 REGLE\uff0c\u5b83\u4eec\u53ef\u4ee5\u5728\u4e34\u5e8a\u73af\u5883\u4e2d\u8fdb\u884c\u5e38\u89c4\u6d4b\u91cf\uff0c\u4e5f\u53ef\u4ee5\u901a\u8fc7\u667a\u80fd\u624b\u673a\u6216\u53ef\u7a7f\u6234\u8bbe\u5907\u88ab\u52a8\u548c\u975e\u4fb5\u5165\u6027\u5730\u6d4b\u91cf\u3002<\/p>\n<p>REGLE \u63d0\u4f9b\u4e86\u4e00\u79cd\u5728\u6ca1\u6709\u6807\u8bb0\u6570\u636e\u7684\u60c5\u51b5\u4e0b\u8bc6\u522b\u9057\u4f20\u5bf9\u5668\u5b98\u529f\u80fd\u5f71\u54cd\u7684\u673a\u5236\uff0c\u5e76\u5141\u8bb8\u5c06\u4e13\u5bb6\u7279\u5f81\u7eb3\u5165\u6a21\u578b\u3002\u5b83\u8fd8\u63d0\u4f9b\u4e86\u4e00\u79cd\u4f7f\u7528\u5f88\u5c11\u7684\u6807\u7b7e\u521b\u5efa\u75be\u75c5\u548c\u7279\u5f81\u7279\u5f02\u6027 PRS \u7684\u65b9\u6cd5\u3002\u672a\u6765\uff0c\u8fd9\u79cd\u7c7b\u4f3c\u7684\u65b9\u6cd5\u5c06\u8d8a\u6765\u8d8a\u591a\u5730\u7528\u4e8e\u8fdb\u4e00\u6b65\u9610\u660e\u4eba\u7c7b\u7279\u5f81\u548c\u75be\u75c5\u7684\u9057\u4f20\u57fa\u7840\u3002<\/p>\n<p>\u53c2\u8003\u5185\u5bb9\uff1a<em>https:\/\/research.google\/blog\/harnessing-hidden-genetic-information-in-clinical-data-with-regle\/<\/em><\/p>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section data-autoskip=\"1\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:<a href=\"https:\/\/www.jiqizhixin.com\/articles\/2024-07-19-8\" target=\"_blank\">\u6548\u7387\u9ad8\uff0c\u65e0\u9700\u6807\u7b7e\uff0c\u8c37\u6b4c\u56e2\u961f\u7528AI\u6316\u6398\u4e34\u5e8a\u6570\u636e\uff0c\u6539\u5584\u57fa\u56e0\u53d1\u73b0\u548c\u75be\u75c5\u9884\u6d4b\uff0c\u767bNature\u5b50\u520a<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u6548\u7387\u9ad8\uff0c\u65e0\u9700\u6807\u7b7e\uff0c\u8c37\u6b4c [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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