{"id":35066,"date":"2024-12-17T21:59:59","date_gmt":"2024-12-17T13:59:59","guid":{"rendered":"https:\/\/17aitech.com\/?p=35066"},"modified":"2024-12-17T21:59:59","modified_gmt":"2024-12-17T13:59:59","slug":"sota%e6%80%a7%e8%83%bd%ef%bc%8c%e5%8d%8e%e7%9b%9b%e9%a1%bf%e5%a4%a7%e5%ad%a6%e5%bc%80%e5%8f%91transformer%e6%a8%a1%e5%9e%8b%e5%b0%86%e8%b4%a8%e8%b0%b1%e8%bd%ac%e5%8c%96%e4%b8%ba%e8%82%bd%e5%ba%8f","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=35066","title":{"rendered":"SOTA\u6027\u80fd\uff0c\u534e\u76db\u987f\u5927\u5b66\u5f00\u53d1Transformer\u6a21\u578b\u5c06\u8d28\u8c31\u8f6c\u5316\u4e3a\u80bd\u5e8f\u5217\uff0c\u767bNature\u5b50\u520a"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:SOTA\u6027\u80fd\uff0c\u534e\u76db\u987f\u5927\u5b66\u5f00\u53d1Transformer\u6a21\u578b\u5c06\u8d28\u8c31\u8f6c\u5316\u4e3a\u80bd\u5e8f\u5217\uff0c\u767bNature\u5b50\u520a<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

\u57fa\u4e8e\u8d28\u8c31\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u7684\u4e00\u4e2a\u57fa\u672c\u6311\u6218\u662f\u8bc6\u522b\u4ea7\u751f\u6bcf\u4e2a\u4e32\u8054\u8d28\u8c31\u7684\u80bd\u3002\u5229\u7528\u5df2\u77e5\u80bd\u5e8f\u5217\u6570\u636e\u5e93\u7684\u65b9\u6cd5\u65e0\u6cd5\u68c0\u6d4b\u610f\u5916\u80bd\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u53ef\u80fd\u4e0d\u5207\u5b9e\u9645\u6216\u65e0\u6cd5\u5e94\u7528\u3002<\/p>\n

\u56e0\u6b64\uff0c\u65e0\u9700\u5148\u9a8c\u4fe1\u606f\uff08\u5373\u4ece\u5934\u80bd\u6d4b\u5e8f\uff09\u5373\u53ef\u5c06\u80bd\u5e8f\u5217\u5206\u914d\u5230\u4e32\u8054\u8d28\u8c31\u4e2d\u7684\u80fd\u529b\u5bf9\u4e8e\u6297\u4f53\u6d4b\u5e8f\u3001\u514d\u75ab\u80bd\u7ec4\u5b66\u548c\u5143\u86cb\u767d\u8d28\u7ec4\u5b66\u7b49\u4efb\u52a1\u975e\u5e38\u6709\u4ef7\u503c\u3002<\/p>\n

\u5c3d\u7ba1\u5df2\u7ecf\u5f00\u53d1\u51fa\u8bb8\u591a\u65b9\u6cd5\u6765\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u4f46\u5b83\u4ecd\u7136\u662f\u4e00\u4e2a\u60ac\u800c\u672a\u51b3\u7684\u6311\u6218\uff0c\u90e8\u5206\u539f\u56e0\u662f\u96be\u4ee5\u5bf9\u4e32\u8054\u8d28\u8c31\u7684\u4e0d\u89c4\u5219\u6570\u636e\u7ed3\u6784\u8fdb\u884c\u5efa\u6a21\u3002<\/p>\n

\u5728\u8fd9\u91cc\uff0c\u534e\u76db\u987f\u5927\u5b66\uff08University of Washington\uff09\u7684\u7814\u7a76\u4eba\u5458\u63cf\u8ff0\u4e86 Casanovo\uff0c\u8fd9\u662f\u4e00\u79cd\u673a\u5668\u5b66\u4e60\u6a21\u578b\uff0c\u5b83\u4f7f\u7528 Transformer \u795e\u7ecf\u7f51\u7edc\u67b6\u6784\u5c06\u4e32\u8054\u8d28\u8c31\u4e2d\u7684\u5cf0\u5e8f\u5217\u8f6c\u6362\u4e3a\u6784\u6210\u751f\u6210\u80bd\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u3002<\/p>\n

\u8be5\u56e2\u961f\u6839\u636e 3000 \u4e07\u4e2a\u6807\u8bb0\u5149\u8c31\u8bad\u7ec3\u4e86 Casanovo \u6a21\u578b\uff0c\u5e76\u8bc1\u660e\u8be5\u6a21\u578b\u5728\u8de8\u7269\u79cd\u57fa\u51c6\u6570\u636e\u96c6\u4e0a\u7684\u8868\u73b0\u4f18\u4e8e\u51e0\u79cd\u5148\u8fdb\u65b9\u6cd5\u3002<\/p>\n

\u8be5\u56e2\u961f\u8fd8\u5f00\u53d1\u4e86\u4e00\u4e2a\u9488\u5bf9\u975e\u9176\u80bd\u8fdb\u884c\u5fae\u8c03\u7684 Casanovo \u7248\u672c\u3002\u8be5\u5de5\u5177\u6539\u5584\u4e86\u514d\u75ab\u80bd\u7ec4\u5b66\u548c\u5b8f\u86cb\u767d\u8d28\u7ec4\u5b66\u5b9e\u9a8c\u7684\u5206\u6790\uff0c\u5e76\u4f7f\u79d1\u5b66\u5bb6\u80fd\u591f\u66f4\u6df1\u5165\u5730\u7814\u7a76\u6697\u86cb\u767d\u8d28\u7ec4\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cSequence-to-sequence translation from mass spectra to peptides with a transformer model<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2024 \u5e74 7 \u6708 31 \u65e5\u53d1\u5e03\u5728\u300aNature Communications<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

\u8d28\u8c31\u6cd5\u662f\u76ee\u524d\u6700\u4e3b\u6d41\u7684\u5206\u6790\u6280\u672f\uff0c\u7528\u4e8e\u9274\u5b9a\u86cb\u767d\u8d28\u7ec4\uff0c\u8bc6\u522b\u548c\u91cf\u5316\u590d\u6742\u751f\u7269\u7cfb\u7edf\u4e2d\u7684\u86cb\u767d\u8d28\u3002\u4f46\u662f\uff0c\u4e32\u8054\u8d28\u8c31 (MS\/MS) \u6280\u672f\u4ea7\u751f\u7684\u6570\u636e\u975e\u5e38\u590d\u6742\uff0c\u5c06\u8fd9\u4e9b\u5149\u8c31\u8f6c\u6362\u6210\u86cb\u767d\u8d28\u6c28\u57fa\u9178\u5e8f\u5217\u7684\u8fc7\u7a0b\u975e\u5e38\u5177\u6709\u6311\u6218\u6027\u3002<\/p>\n

\u4e0e\u8bb8\u591a\u5176\u4ed6\u9886\u57df\u4e00\u6837\uff0c\u6df1\u5ea6\u5b66\u4e60\u5df2\u6210\u4e3a\u4ece\u5934\u80bd\u6d4b\u5e8f\u7684\u9996\u9009\u89e3\u51b3\u65b9\u6848\u3002\u4e0d\u8fc7\uff0c\u5b83\u4eec\u4ecd\u7136\u5b58\u5728\u4e00\u4e9b\u5c40\u9650\u6027\u3002\u4e0e\u5e8f\u5217\u6570\u636e\u5e93\u641c\u7d22\u76f8\u6bd4\uff0c\u4ece\u5934\u6d4b\u5e8f\u5de5\u5177\u901a\u5e38\u53ea\u80fd\u6ce8\u91ca\u5c11\u6570 MS\/MS \u5149\u8c31\uff0c\u5b83\u4eec\u96be\u4ee5\u539f\u751f\u7f16\u7801\u9ad8\u5206\u8fa8\u7387 MS\/MS \u6570\u636e\uff0c\u5e76\u4e14\u5b83\u4eec\u91c7\u7528\u4e86\u590d\u6742\u7684\u795e\u7ecf\u7f51\u7edc\u67b6\u6784\u548c\u540e\u5904\u7406\u6b65\u9aa4\u3002<\/p>\n

\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\uff0c\u534e\u76db\u987f\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u4ecb\u7ecd\u4e86 Casanovo\uff0c\u5b83\u5c06\u4ece\u5934\u80bd\u6d4b\u5e8f\u4efb\u52a1\u91cd\u65b0\u5b9a\u4e49\u4e3a\u673a\u5668\u7ffb\u8bd1\u95ee\u9898\uff1a\u5c31\u50cf\u5c06\u53e5\u5b50\u4e2d\u7684\u5355\u8bcd\u5e8f\u5217\u4ece\u4e00\u79cd\u8bed\u8a00\u7ffb\u8bd1\u6210\u53e6\u4e00\u79cd\u8bed\u8a00\u4e00\u6837\uff0cCasanovo \u5c06 MS\/MS \u5149\u8c31\u4e2d\u7684\u5cf0\u5e8f\u5217\u7ffb\u8bd1\u6210\u751f\u6210\u80bd\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u3002<\/p>\n

\u4ed6\u4eec\u4f7f\u7528\u4e86 Transformer\u67b6\u6784\uff0c\u5141\u8bb8 Casanovo \u76f4\u63a5\u4f7f\u7528\u6784\u6210 MS\/MS \u5149\u8c31\u7684 m\/z \u548c\u5f3a\u5ea6\u503c\u5bf9\uff0c\u800c\u65e0\u9700\u5bf9 m\/z \u8f74\u8fdb\u884c\u79bb\u6563\u5316\uff0c\u5e76\u76f4\u63a5\u8f93\u51fa\u9884\u6d4b\u7684\u80bd\u5e8f\u5217\uff0c\u800c\u65e0\u9700\u590d\u6742\u7684\u52a8\u6001\u7f16\u7a0b\u6b65\u9aa4\u3002\u8be5\u56e2\u961f\u4e4b\u524d\u66fe\u4f7f\u7528\u591a\u7269\u79cd\u57fa\u51c6\u7684\u6709\u9650\u8d28\u8c31\u96c6\u8bad\u7ec3 Casanovo\u3002<\/p>\n

\u5728\u6700\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5bf9 Casanovo \u8fdb\u884c\u4e86\u91cd\u5927\u6539\u8fdb\uff0c\u5e76\u5c55\u793a\u4e86\u5176\u5728\u5e94\u5bf9\u4ece\u5934\u80bd\u6d4b\u5e8f\u5e38\u89c1\u6311\u6218\u65b9\u9762\u7684\u6709\u6548\u6027\u3002<\/p>\n

\u4ed6\u4eec\u6269\u5c55\u4e86\u8bad\u7ec3\u96c6\uff0c\u4f7f\u7528\u4e86\u4ece 6.69 \u4ebf\u4e2a\u5149\u8c31\u7684\u6d77\u91cf\u96c6\u5408\u4e2d\u5f97\u51fa\u7684 MassIVE-KB\u00a0\u5149\u8c31\u5e93\uff0c\u5e76\u7ed3\u5408\u4e86\u6781\u5176\u4e25\u683c\u7684 FDR \u63a7\u5236\u3002<\/p>\n

\u5177\u4f53\u6765\u8bf4\uff0c\u6570\u636e\u662f\u5728 1% FDR \u4e0b\u641c\u7d22\u7684\uff0c\u4e4b\u540e\u53ea\u4fdd\u7559\u6bcf\u4e2a\u72ec\u7279\u524d\u4f53\u7684\u524d 100 \u4e2a PSM\uff0c\u76f8\u5f53\u4e8e 3000 \u4e07\u4e2a\u9ad8\u8d28\u91cf PSM\uff08\u4e0e\u539f\u59cb\u641c\u7d22\u76f8\u6bd4\uff0cFDR \u5747\u4e3a 0%\uff09\u3002\u800c\u4e14\u6dfb\u52a0\u4e86\u6ce2\u675f\u641c\u7d22\u89e3\u7801\u7a0b\u5e8f\u6765\u9884\u6d4b\u6bcf\u4e2a MS\/MS \u5149\u8c31\u7684\u6700\u4f73\u80bd\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aCasanovo \u4f7f\u7528 Transformer \u67b6\u6784\u6267\u884c\u4ece\u5934\u80bd\u6d4b\u5e8f\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

Casanovo \u7684\u51fa\u8272\u8868\u73b0\u6e90\u4e8e\u4e24\u4e2a\u65b9\u9762\uff1a\u4e00\u65b9\u9762\u662f\u62e5\u6709\u5927\u91cf\u9ad8\u8d28\u91cf\u8bad\u7ec3\u6570\u636e\uff0c\u53e6\u4e00\u65b9\u9762\u5c31\u662f\u7528\u4e86 Transformer \u67b6\u6784\u3002<\/p>\n

Transformer \u67b6\u6784\u7279\u522b\u9002\u5408\u5c06\u53ef\u53d8\u957f\u5ea6\u5e8f\u5217\u7684\u5143\u7d20\u7f6e\u4e8e\u8bed\u5883\u4e2d\uff0c\u56e0\u6b64\u5728\u81ea\u7136\u8bed\u8a00\u5efa\u6a21\u65b9\u9762\u88ab\u8bc1\u660e\u975e\u5e38\u6210\u529f\u3002\u4e0e\u5faa\u73af\u795e\u7ecf\u7f51\u7edc\u76f8\u6bd4\uff0cTransformer \u67b6\u6784\u80fd\u591f\u5b66\u4e60\u5e8f\u5217\u5143\u7d20\u4e4b\u95f4\u7684\u957f\u8ddd\u79bb\u4f9d\u8d56\u5173\u7cfb\uff0c\u5e76\u4e14\u53ef\u4ee5\u5e76\u884c\u5316\u4ee5\u5b9e\u73b0\u9ad8\u6548\u8bad\u7ec3\u3002<\/p>\n

Casanovo \u5c06\u8d28\u8c31\u5cf0\u7f16\u7801\u4e3a\u5e8f\u5217\uff0c\u7c7b\u4f3c\u4e8e\u5c06\u53e5\u5b50\u4e2d\u7684\u5355\u8bcd\u6807\u8bb0\u5316\uff0c\u5229\u7528 Transformer \u67b6\u6784\u7684\u4f18\u52bf\u548c\u5927\u578b\u8bed\u8a00\u6a21\u578b\u7684\u5feb\u901f\u53d1\u5c55\u6765\u6539\u8fdb MS\/MS \u5149\u8c31\u7684\u4ece\u5934\u80bd\u6d4b\u5e8f\u3002<\/p>\n

\u6709\u4e00\u4e2a\u91cd\u8981\u7684\u672a\u51b3\u95ee\u9898\u662f\u6a21\u578b\u53c2\u6570\u7684\u6570\u91cf\u5982\u4f55\u5f71\u54cd\u4ece\u5934\u6d4b\u5e8f\u6027\u80fd\uff0c\u7814\u7a76\u4eba\u5458\u8868\u793a\u5c06\u6b64\u7559\u5f85\u672a\u6765\u7814\u7a76\u3002<\/p>\n

Casanovo \u7684\u5e94\u7528\u573a\u666f\u975e\u5e38\u591a\u3002\u6700\u660e\u663e\u7684\u662f\uff0c\u4efb\u4f55\u80bd\u6570\u636e\u5e93\u4e0d\u53ef\u7528\u3001\u4e0d\u5b8c\u6574\u6216\u975e\u5e38\u5927\u7684\u5e94\u7528\u90fd\u53ef\u80fd\u53d7\u76ca\u4e8e\u4ece\u5934\u6d4b\u5e8f\uff0c\u4f8b\u5982\u53e4\u86cb\u767d\u8d28\u7ec4\u5b66\u3001\u6cd5\u533b\u5b66\u6216\u5929\u4f53\u751f\u7269\u5b66\u3002<\/p>\n

\u7136\u800c\uff0c\u5373\u4f7f\u5728\u5206\u6790\u4eba\u7c7b\u6216\u6a21\u5f0f\u751f\u7269\u6570\u636e\u65f6\uff0cCasanovo \u4e5f\u53ef\u4ee5\u534f\u52a9\u68c0\u6d4b\u300c\u5916\u6765\u300d\u5149\u8c31\uff0c\u5373\u6570\u636e\u5e93\u4e2d\u4e0d\u5b58\u5728\u7684\u80bd\u4ea7\u751f\u7684\u5149\u8c31\u3002\u6b64\u7c7b\u5916\u6765\u5149\u8c31\u53ef\u80fd\u5bf9\u5e94\u4e8e\u5b9e\u9a8c\u8fc7\u7a0b\u4e2d\u5f15\u5165\u7684\u6c61\u67d3\u7269\uff0c\u4f46\u5b83\u4eec\u4e5f\u53ef\u80fd\u4ee3\u8868\u5fae\u751f\u7269\u7269\u79cd\u3001\u9057\u4f20\u53d8\u5f02\u6216\u8f6c\u63a5\u80bd\u3002<\/p>\n

\u603b\u7684\u6765\u8bf4\uff0c\u7814\u7a76\u4eba\u5458\u8bbe\u60f3\u5c06 Casanovo \u7528\u4f5c\u5728\u6807\u51c6\u6570\u636e\u5e93\u641c\u7d22\u8fc7\u7a0b\u4e2d\u672a\u80fd\u5206\u914d\u80bd\u7684\u5149\u8c31\u7684\u540e\u5904\u7406\u5668\uff0c\u7c7b\u4f3c\u4e8e\u7ea7\u8054\u641c\u7d22\u7684\u6700\u540e\u9636\u6bb5\u3002<\/p>\n

Casanovo \u56e2\u961f\u5c1a\u672a\u63a2\u7d22\u7684\u4ece\u5934\u6d4b\u5e8f\u7684\u4e00\u4e2a\u91cd\u8981\u5e94\u7528\u662f\u6297\u4f53\u6d4b\u5e8f\u3002\u4e0d\u8fc7\uff0c\u5fb7\u56fd BAM \u7684 Denis Beslic \u56e2\u961f\u7684\u4e00\u9879\u7814\u7a76\u5bf9\u5305\u62ec Casanovo \u5728\u5185\u7684\u516d\u79cd\u4ece\u5934\u6d4b\u5e8f\u5de5\u5177\u5728\u6297\u4f53\u6d4b\u5e8f\u95ee\u9898\u4e0a\u8fdb\u884c\u4e86\u7cfb\u7edf\u6bd4\u8f83\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aNovor\u3001pNovo 3\u3001DeepNovo\u3001SMSNet\u3001PointNovo \u548c Casanovo \u5bf9 IgG1-Human-HC \u4e0a\u4e0d\u540c\u9176\u7684\u603b\u4f53\u53ec\u56de\u7387\u548c\u7cbe\u786e\u5ea6\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u76f8\u5173\u94fe\u63a5\uff1ahttps:\/\/academic.oup.com\/bib\/article\/24\/1\/bbac542\/6955273?login=false<\/em><\/section>\n
\u7ed3\u679c\u663e\u793a\uff0cCasanovo \u5728\u8003\u8651\u7684\u6240\u6709\u6307\u6807\u4e0a\u90fd\u8fdc\u8fdc\u4f18\u4e8e\u7ade\u4e89\u65b9\u6cd5\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u6b21\u6bd4\u8f83\u91c7\u7528\u4e86\u8d2a\u5a6a\u89e3\u7801\u7684 Casanovo \u7248\u672c\uff0c\u5e76\u4e14\u4ec5\u5bf9 200 \u4e07\u5f20\u5149\u8c31\u8fdb\u884c\u4e86\u8bad\u7ec3\u3002<\/section>\n

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