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\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

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soScope \u53ef\u4ee5\u6c47\u603b\u6765\u81ea\u7ec4\u5b66\u3001\u7a7a\u95f4\u5173\u7cfb\u548c\u56fe\u50cf\u7684\u591a\u6a21\u6001\u7ec4\u7ec7\u4fe1\u606f\uff0c\u5e76\u901a\u8fc7\u5206\u5e03\u5148\u9a8c\u4e0e\u7ec4\u5b66\u7279\u5b9a\u5efa\u6a21\u8054\u5408\u63a8\u65ad\u51fa\u5177\u6709\u589e\u5f3a\u5206\u8fa8\u7387\u7684\u7ec4\u5b66\u8c31\u3002<\/p>\n

\u901a\u8fc7\u5bf9 Visium\u3001Xenium\u3001spatial-CUT&Tag\u3001slide-DNA\/RNA-seq \u7b49\u591a\u79cd\u7a7a\u95f4\u7ec4\u5b66\u5e73\u53f0\u7684\u7efc\u5408\u8bc4\u4f30\uff0csoScope \u63d0\u9ad8\u4e86\u8bc6\u522b\u5177\u6709\u751f\u7269\u5b66\u610f\u4e49\u7684\u80a0\u9053\u548c\u80be\u810f\u7ed3\u6784\u7684\u6027\u80fd\uff0c\u63ed\u793a\u4e86\u65e0\u6cd5\u4ee5\u539f\u59cb\u5206\u8fa8\u7387\u89e3\u51b3\u7684\u80da\u80ce\u5fc3\u810f\u7ed3\u6784\uff0c\u5e76\u7ea0\u6b63\u4e86\u6d4b\u5e8f\u548c\u6837\u672c\u5904\u7406\u4e2d\u51fa\u73b0\u7684\u6837\u672c\u548c\u6280\u672f\u504f\u5dee\u3002<\/p>\n

\u6b64\u5916\uff0csoScope \u6269\u5c55\u5230\u7a7a\u95f4\u591a\u7ec4\u5b66\u6280\u672f spatial-CITE-seq \u548c\u7a7a\u95f4 ATAC-RNA-seq\uff0c\u5229\u7528\u8de8\u7ec4\u5b66\u53c2\u8003\u540c\u65f6\u8fdb\u884c\u591a\u7ec4\u5b66\u589e\u5f3a\u3002soScope \u63d0\u4f9b\u4e86\u4e00\u79cd\u591a\u529f\u80fd\u5de5\u5177\u6765\u63d0\u9ad8\u4e0d\u65ad\u6269\u5c55\u7684\u7a7a\u95f4\u7ec4\u5b66\u6280\u672f\u548c\u8d44\u6e90\u7684\u5229\u7528\u7387\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cTissue characterization at an enhanced resolution across spatial omics platforms with deep generative model<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2024 \u5e74 8 \u6708 2 \u65e5\u53d1\u5e03\u5728\u300aNature Communications<\/em>\u300b\u3002<\/p>\n

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\u867d\u7136\u8ba1\u7b97\u6280\u672f\u80fd\u591f\u6539\u5584\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u7684\u5206\u8fa8\u7387\uff0c\u4f46\u76ee\u524d\u7684\u65b9\u6cd5\u5927\u591a\u4ec5\u9488\u5bf9\u5355\u4e00\u7ec4\u7ec7\u6a21\u6001\uff0c\u96be\u4ee5\u5145\u5206\u5229\u7528\u591a\u6a21\u6001\u4fe1\u606f\u3002<\/p>\n

\u5728\u8fd9\u91cc\uff0c\u5317\u822a\u548c\u6e05\u534e\u7684\u7814\u7a76\u56e2\u961f\u5f15\u5165\u4e86\u7a7a\u95f4\u7ec4\u5b66\u8303\u56f4\uff08soScope\uff09\uff0c\u8fd9\u662f\u4e00\u4e2a\u5b8c\u5168\u751f\u6210\u7684\u6846\u67b6\uff0c\u5b83\u6a21\u62df\u6765\u81ea\u4e0d\u540c\u7a7a\u95f4\u7ec4\u5b66\u6280\u672f\u7684\u70b9\u7ea7\u6982\u51b5\u7684\u751f\u6210\u8fc7\u7a0b\uff0c\u65e8\u5728\u63d0\u9ad8\u5b83\u4eec\u7684\u7a7a\u95f4\u5206\u8fa8\u7387\u548c\u6570\u636e\u8d28\u91cf\u3002<\/p>\n

\u4e3a\u4e86\u5b9e\u73b0\u8fd9\u4e00\u76ee\u6807\uff0csoScope \u5c06\u6bcf\u4e2a\u70b9\u89c6\u4e3a\u589e\u5f3a\u7a7a\u95f4\u5206\u8fa8\u7387\u7684\u201c\u5b50\u70b9\u201d\u7684\u96c6\u5408\uff0c\u5176\u7ec4\u5b66\u7279\u5f81\u4e0e\u7a7a\u95f4\u4f4d\u7f6e\u548c\u5f62\u6001\u6a21\u5f0f\u76f8\u5173\u3002<\/p>\n

\u7136\u540e\uff0csoScope \u4f7f\u7528\u591a\u6a21\u6001\u6df1\u5ea6\u5b66\u4e60<\/mark>\u6846\u67b6\u6574\u5408\u6591\u70b9\u7ec4\u5b66\u6982\u51b5\u3001\u7a7a\u95f4\u5173\u7cfb\u548c\u9ad8\u5206\u8fa8\u7387\u5f62\u6001\u5b66\u56fe\u50cf\uff0c\u5e76\u8054\u5408\u63a8\u65ad\u5b50\u6591\u70b9\u5206\u8fa8\u7387\u4e0b\u7684\u7ec4\u5b66\u6982\u51b5\u3002\u901a\u8fc7\u9009\u62e9\u7ec4\u5b66\u7279\u5b9a\u5206\u5e03\uff0csoScope \u53ef\u4ee5\u5bf9\u4e0d\u540c\u7684\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u8fdb\u884c\u7cbe\u786e\u5efa\u6a21\u548c\u51cf\u5c11\u53d8\u5f02\u3002<\/p>\n

<\/a><\/p>\n

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soScope \u63d0\u4f9b\u4e86\u4e00\u79cd\u7edf\u4e00\u7684\u5de5\u5177\uff0c\u8be5\u5de5\u5177\u7ed3\u5408\u4e86\u591a\u6a21\u6001\u7ec4\u7ec7\u56fe\u8c31\uff0c\u4ee5\u589e\u5f3a\u5177\u6709\u4e0d\u540c\u5206\u5b50\u7c7b\u522b\u7684\u7ec4\u5b66\u56fe\u8c31\u3002soScope \u53ef\u4ee5\u6709\u6548\u63d0\u9ad8\u7a7a\u95f4\u5206\u8fa8\u7387\uff0c\u51cf\u5c11\u4e0d\u5fc5\u8981\u7684\u53d8\u5316\uff0c\u5e76\u80fd\u591f\u8868\u5f81\u65e0\u6cd5\u5728\u539f\u59cb\u5206\u8fa8\u7387\u4e0b\u68c0\u6d4b\u5230\u7684\u590d\u6742\u7ec4\u7ec7\u7ed3\u6784\u3002<\/p>\n

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\u56fe\u793a\uff1a\u5bf9\u6765\u81ea\u591a\u79cd\u7ec4\u7ec7\u548c\u5e73\u53f0\u7684\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u6570\u636e\u96c6\u4e0a\u7684 soScope \u8fdb\u884c\u8bc4\u4f30\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u8be5\u56e2\u961f\u5e7f\u6cdb\u8bc4\u4f30\u4e86 soScope \u5bf9\u901a\u8fc7\u591a\u79cd\u7a7a\u95f4\u6280\u672f\u5206\u6790\u7684\u591a\u79cd\u5206\u5b50\u7c7b\u578b\u7684\u6709\u6548\u6027\u548c\u666e\u904d\u6027\uff0c\u5305\u62ec Visium\u3001Xenium\u3001spatial-CUT&Tag\u3001slide-DNA-seq\u3001slide-RNA-seq\u3001spatial-CITE-seq \u548c spatial ATAC-RNA-seq\u3002<\/p>\n

\u5728\u5065\u5eb7\u548c\u60a3\u75c5\u7ec4\u7ec7\u4e2d\uff0csoScope \u6539\u8fdb\u4e86\u7ec4\u7ec7\u57df\u8bc6\u522b\uff0c\u63d0\u9ad8\u4e86\u5df2\u77e5\u6807\u8bb0\u7684\u53ef\u533a\u5206\u6027\uff0c\u5e76\u7ea0\u6b63\u4e86\u6570\u636e\u548c\u6280\u672f\u504f\u5dee\u3002\u8be5\u65b9\u6cd5\u80fd\u591f\u63ed\u793a\u6bd4\u539f\u59cb\u5206\u8fa8\u7387\u9ad8\u51fa 36 \u500d\u7684\u66f4\u7cbe\u7ec6\u7684\u7ec4\u7ec7\u7ed3\u6784\u3002\u5b83\u53ef\u4ee5\u6709\u6548\u5730\u9002\u5e94\u7a7a\u95f4\u591a\u7ec4\u5b66\u6570\u636e\uff0c\u4ee5\u540c\u65f6\u589e\u5f3a\u591a\u7ec4\u5b66\u6982\u51b5\u3002<\/p>\n

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<\/a><\/p>\n

\u56fe\u793a\uff1a\u4f7f\u7528\u7a7a\u95f4 CITE-seq \u5c06\u591a\u7ec4\u5b66 soScope \u5e94\u7528\u4e8e\u6765\u81ea\u4eba\u4f53\u76ae\u80a4\u7ec4\u7ec7\u7684\u7a7a\u95f4\u86cb\u767d\u8d28 + \u8f6c\u5f55\u6570\u636e\u96c6\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

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