{"id":35484,"date":"2024-12-25T20:01:04","date_gmt":"2024-12-25T12:01:04","guid":{"rendered":"https:\/\/17aitech.com\/?p=35484"},"modified":"2024-12-25T20:01:04","modified_gmt":"2024-12-25T12:01:04","slug":"deepmind%e8%9b%8b%e7%99%bd%e8%b4%a8%e8%ae%be%e8%ae%a1%e6%96%b0%e5%b7%a5%e5%85%b7alphaproteo%ef%bc%8c%e4%bb%8e%e5%a4%b4%e8%ae%be%e8%ae%a1%e9%ab%98%e4%ba%b2%e5%92%8c%e5%8a%9b%e8%9b%8b%e7%99%bd%e7%bb%93","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=35484","title":{"rendered":"DeepMind\u86cb\u767d\u8d28\u8bbe\u8ba1\u65b0\u5de5\u5177AlphaProteo\uff0c\u4ece\u5934\u8bbe\u8ba1\u9ad8\u4eb2\u548c\u529b\u86cb\u767d\u7ed3\u5408\u5242\uff0c\u6210\u529f\u7387\u6700\u9ad888\uff05"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:DeepMind\u86cb\u767d\u8d28\u8bbe\u8ba1\u65b0\u5de5\u5177AlphaProteo\uff0c\u4ece\u5934\u8bbe\u8ba1\u9ad8\u4eb2\u548c\u529b\u86cb\u767d\u7ed3\u5408\u5242\uff0c\u6210\u529f\u7387\u6700\u9ad888\uff05<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91 |\u00a0ScienceAI<\/p>\n

\u50cf\u00a0AlphaFold<\/mark>\u00a0\u8fd9\u6837\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u5de5\u5177\uff0c\u5df2\u7ecf\u5e2e\u52a9\u6211\u4eec\u6df1\u5165\u4e86\u89e3\u4e86\u86cb\u767d\u8d28\u5982\u4f55\u76f8\u4e92\u4f5c\u7528\u4ece\u800c\u53d1\u6325\u5176\u529f\u80fd\uff0c\u4f46\u8fd9\u4e9b\u5de5\u5177\u65e0\u6cd5\u521b\u5efa\u65b0\u7684\u86cb\u767d\u8d28\u6765\u76f4\u63a5\u63a7\u5236\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\u73b0\u5728\uff0cGoogle DeepMind<\/mark> \u56e2\u961f\u63a8\u51fa\u4e86\u4e00\u79cd\u7528\u4e8e\u8bbe\u8ba1\u300c\u4e0e\u76ee\u6807\u5206\u5b50\u7ed3\u5408\u66f4\u7d27\u5bc6\u300d\u7684\u65b0\u578b\u86cb\u767d\u8d28\u7684 AI \u7cfb\u7edf AlphaProteo\u3002<\/p>\n

\u5728\u6d4b\u8bd5\u7684 7 \u79cd\u9776\u86cb\u767d\u4e0a\uff0cAlphaProteo \u7684\u5b9e\u9a8c\u6210\u529f\u7387\u66f4\u9ad8\uff0c\u5728\u6e7f\u5b9e\u9a8c\u5ba4\u4e2d\u6d4b\u8bd5\u4e2d\uff0c9% \u5230 88% \u5019\u9009\u5206\u5b50\u6210\u529f\u7ed3\u5408\uff0c\u8fd9\u6bd4\u5176\u4ed6\u65b9\u6cd5\u9ad8\u51fa 5 \u5230 100 \u500d\u3002\u800c\u4e14\uff0c\u6bd4\u73b0\u6709\u6700\u4f73\u65b9\u6cd5\u7684\u7ed3\u5408\u4eb2\u548c\u529b\u9ad8\u51fa 3 \u5230 300 \u500d\u3002<\/p>\n

\u4ec5\u9700\u4e00\u8f6e\u4e2d\u7b49\u901a\u91cf\u7b5b\u9009\u4e14\u65e0\u9700\u8fdb\u4e00\u6b65\u4f18\u5316\uff0cAlphaProteo \u4fbf\u53ef\u751f\u6210\u9002\u7528\u4e8e\u591a\u79cd\u5e94\u7528\u7684\u300c\u5373\u7528\u578b\u300d\u7ed3\u5408\u5242\u3002\u5b83\u53ef\u4ee5\u5e2e\u52a9\u79d1\u5b66\u5bb6\u66f4\u597d\u5730\u4e86\u89e3\u751f\u7269\u7cfb\u7edf\u5982\u4f55\u8fd0\u4f5c\uff0c\u8282\u7701\u7814\u7a76\u65f6\u95f4\uff0c\u63a8\u8fdb\u836f\u7269\u8bbe\u8ba1\u7b49\u7b49\u3002<\/p>\n

\u8be5\u56e2\u961f\u4e8e 2024 \u5e74 9 \u6708 5 \u65e5\u4e0a\u7ebf\u4e86\u6700\u65b0\u8bba\u6587\u300aDe novo design of high-affinity protein binders with AlphaProteo<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/storage.googleapis.com\/deepmind-media\/DeepMind<\/mark>.com\/Blog\/alphaproteo-generates-novel-proteins-for-biology-and-health-research\/Protein_Design_White_Paper_2024.pdf<\/em><\/p>\n

\u4ece\u7ec6\u80de\u751f\u957f\u5230\u514d\u75ab\u53cd\u5e94\uff0c\u8eab\u4f53\u4e2d\u7684\u6bcf\u4e2a\u751f\u7269\u8fc7\u7a0b\u90fd\u4f9d\u8d56\u4e8e\u79f0\u4e3a\u86cb\u767d\u8d28\u7684\u5206\u5b50\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u597d\u6bd4\u94a5\u5319\u5f00\u9501\u4e00\u6837\uff0c\u4e00\u79cd\u86cb\u767d\u8d28\u53ef\u4ee5\u4e0e\u53e6\u4e00\u79cd\u86cb\u767d\u8d28\u7ed3\u5408\uff0c\u5e2e\u52a9\u8c03\u8282\u5173\u952e\u7684\u7ec6\u80de\u8fc7\u7a0b\u3002<\/p>\n

\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u662f\u86cb\u767d\u8d28\u529f\u80fd\u7684\u4e00\u4e2a\u57fa\u672c\u65b9\u9762\uff0c\u86cb\u767d\u8d28\u7ed3\u5408\u86cb\u767d\u662f\u6cbb\u7597\u3001\u8bca\u65ad\u548c\u751f\u7269\u533b\u5b66\u7814\u7a76\u7684\u57fa\u672c\u7ec4\u6210\u90e8\u5206\u3002<\/p>\n

\u4f20\u7edf\u4e0a\uff0c\u6297\u4f53\u3001\u7eb3\u7c73\u6297\u4f53\u548c\u5176\u4ed6\u652f\u67b6\uff08\u5982 DARPins\uff09\u901a\u8fc7\u514d\u75ab\u6216\u5b9a\u5411\u8fdb\u5316\u5f00\u53d1\u6210\u9488\u5bf9\u5404\u79cd\u9776\u6807\u7684\u7ed3\u5408\u7269\u3002\u4e0d\u8fc7\uff0c\u5b9e\u9a8c\u9009\u62e9\u65e0\u6cd5\u63a7\u5236\u76ee\u6807\u8868\u4f4d\uff0c\u800c\u4e14\u5bf9\u4e8e\u5e38\u89c4\u7814\u7a76\u5e94\u7528\u6765\u8bf4\u5f80\u5f80\u8fc7\u4e8e\u8d39\u529b\u3002<\/p>\n

\u4e0d\u4f7f\u7528\u5929\u7136\u86cb\u767d\u8d28\u4f5c\u4e3a\u8d77\u70b9\uff0c\u4ece\u5934\u8ba1\u7b97\u8bbe\u8ba1\u7ed3\u5408\u7269\u53ef\u4ee5\u9776\u5411\u9884\u5148\u6307\u5b9a\u7684\u8868\u4f4d\uff0c\u5e76\u751f\u6210\u6bd4\u6297\u4f53\u66f4\u5c0f\u3001\u66f4\u70ed\u7a33\u5b9a\u4e14\u66f4\u6613\u4e8e\u8868\u8fbe\u7684\u7ed3\u5408\u7269\u3002<\/p>\n

AlphaProteo \u86cb\u767d\u8d28\u8bbe\u8ba1\u7cfb\u7edf<\/strong><\/p>\n

\u8fd1\u671f\uff0c\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60<\/mark>\u7684\u6a21\u578b\u5728\u751f\u7269\u5206\u5b50\u7ed3\u6784\u9884\u6d4b\u548c\u86cb\u767d\u8d28\u8bbe\u8ba1\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\u3002\u8fd9\u63a8\u52a8\u4e86\u5173\u952e\u79d1\u5b66\u548c\u793e\u4f1a\u6311\u6218\u7684\u8fdb\u5c55\uff0c\u5305\u62ec\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u9884\u6d4b\u548c\u8bbe\u8ba1\u3002<\/p>\n

\u73b0\u5728\u65e0\u9700\u9ad8\u901a\u91cf\u7b5b\u9009\u5373\u53ef\u83b7\u5f97\u9488\u5bf9\u67d0\u4e9b\u9776\u6807\u7684\u8ba1\u7b97\u8bbe\u8ba1\u7ed3\u5408\u7269\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u65e0\u9700\u8fdb\u884c\u5b9e\u9a8c\u4f18\u5316\u5373\u53ef\u5b9e\u73b0\u9ad8\u7ed3\u5408\u4eb2\u548c\u529b\uff0c\u4f8b\u5982\u5bf9\u4e8e\u5c0f\u80bd\u6216\u65e0\u5e8f\u9776\u6807\u3002<\/p>\n

\u7136\u800c\uff0c\u9488\u5bf9\u51f8\u8868\u4f4d\u6216\u6781\u6027\u8868\u4f4d\u7684\u6210\u529f\u7387\u4ecd\u7136\u5f88\u4f4e\uff0c\u521d\u59cb\u8bbe\u8ba1\u7684\u4eb2\u548c\u529b\u901a\u5e38\u5f88\u5dee\uff0c\u8bb8\u591a\u9776\u6807\u4ecd\u7136\u96be\u4ee5\u5904\u7406\u3002<\/p>\n

\u5728\u6700\u65b0\u7684\u8bba\u6587\u4e2d\uff0cDeepMind<\/mark> \u56e2\u961f\u4ecb\u7ecd\u4e86 AlphaProteo \u86cb\u767d\u8d28\u8bbe\u8ba1\u7cfb\u7edf\uff0c\u5e76\u8868\u660e\u5b83\u53ef\u4ee5\u8bbe\u8ba1\u4ece\u5934\u86cb\u767d\u8d28\u7ed3\u5408\u86cb\u767d\uff0c\u8be5\u7cfb\u7edf\u5177\u6709\u4ee5\u4e0b\u4f18\u52bf\uff1a<\/p>\n

1\u3001\u9ad8\u6210\u529f\u7387\uff1a\u901a\u8fc7\u7b5b\u9009\u6570\u5341\u79cd\u8bbe\u8ba1\u5019\u9009\u7269\u53ef\u4ee5\u83b7\u5f97\u7a33\u5b9a\u3001\u9ad8\u8868\u8fbe\u548c\u7279\u5f02\u6027\u7684\u7ed3\u5408\u7269\uff0c\u4ece\u800c\u65e0\u9700\u4f7f\u7528\u9ad8\u901a\u91cf\u65b9\u6cd5\u3002<\/p>\n

2\u3001\u9ad8\u4eb2\u548c\u529b\uff1a\u5bf9\u4e8e\u9664\u4e00\u4e2a\u76ee\u6807\u4e4b\u5916\u7684\u6bcf\u4e2a\u6d4b\u8bd5\u76ee\u6807\uff0c\u6700\u4f73\u7ed3\u5408\u5242\u5177\u6709\u4e9a\u7eb3\u6469\u5c14\u6216\u4f4e\u7eb3\u6469\u5c14\u7ed3\u5408\u4eb2\u548c\u529b\uff08KD<\/sub>\uff09\uff0c\u4ece\u800c\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e86\u4e0b\u6e38\u4eb2\u548c\u529b\u4f18\u5316\u6240\u9700\u7684\u52b3\u52a8\u529b\u3002<\/p>\n

3\u3001\u6574\u4f53\u4f18\u52bf\uff1a\u4f7f\u7528\u5355\u4e00\u8bbe\u8ba1\u65b9\u6cd5\uff0c\u65e0\u9700\u590d\u6742\u7684\u4eba\u5de5\u5e72\u9884\uff0c\u5373\u53ef\u6210\u529f\u83b7\u5f97\u9488\u5bf9\u4e00\u7cfb\u5217\u5177\u6709\u4e0d\u540c\u7ed3\u6784\u548c\u751f\u5316\u7279\u6027\u7684\u9776\u6807\u7684\u7ed3\u5408\u5242\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aAlphaProteo \u6982\u8ff0\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u4e86\u89e3\u86cb\u767d\u8d28\u76f8\u4e92\u7ed3\u5408\u7684\u590d\u6742\u65b9\u5f0f<\/strong><\/p>\n

\u80fd\u591f\u4e0e\u9776\u86cb\u767d\u7d27\u5bc6\u7ed3\u5408\u7684\u86cb\u767d\u8d28\u7ed3\u5408\u5242\u5f88\u96be\u8bbe\u8ba1\u3002\u4f20\u7edf\u65b9\u6cd5\u8017\u65f6\u5de8\u5927\uff0c\u9700\u8981\u591a\u8f6e\u5927\u91cf\u7684\u5b9e\u9a8c\u5ba4\u5de5\u4f5c\u3002\u5728\u521b\u5efa\u7ed3\u5408\u5242\u540e\uff0c\u5b83\u4eec\u8fd8\u9700\u8981\u8fdb\u884c\u5927\u91cf\u989d\u5916\u7684\u5b9e\u9a8c\u4ece\u800c\u4f18\u5316\u7ed3\u5408\u4eb2\u548c\u6027\u3002<\/p>\n

AlphaProteo \u7ecf\u8fc7\u86cb\u767d\u8d28\u6570\u636e\u5e93<\/mark> (PDB) \u4e2d\u7684\u5927\u91cf\u86cb\u767d\u8d28\u6570\u636e\u548c AlphaFold<\/mark> \u4e2d\u7684 1 \u4ebf\u591a\u6761\u9884\u6d4b\u7ed3\u6784\u7684\u8bad\u7ec3\uff0c\u5df2\u7ecf\u4e86\u89e3\u4e86\u5206\u5b50\u76f8\u4e92\u7ed3\u5408\u7684\u65e0\u6570\u65b9\u5f0f\u3002\u7ed9\u5b9a\u76ee\u6807\u5206\u5b50\u7684\u7ed3\u6784\u548c\u8be5\u5206\u5b50\u4e0a\u7684\u4e00\u7ec4\u9996\u9009\u7ed3\u5408\u4f4d\u7f6e\uff0cAlphaProteo \u4f1a\u751f\u6210\u4e00\u4e2a\u5019\u9009\u86cb\u767d\u8d28\uff0c\u8be5\u86cb\u767d\u8d28\u5728\u8fd9\u4e9b\u4f4d\u7f6e\u4e0e\u76ee\u6807\u7ed3\u5408\u3002<\/p>\n

<\/a><\/p>\n

\u89c6\u9891\u94fe\u63a5\uff1ahttps:\/\/mp.weixin.qq.com\/s\/tfoqGsXiqOVXFJgNVQLczg<\/a><\/p>\n

\u89c6\u98911\uff1a\u9884\u6d4b\u7684\u86cb\u767d\u8d28\u7ed3\u5408\u7269\u7ed3\u6784\u4e0e\u9776\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u7684\u56fe\u793a\u3002\u84dd\u8272\u90e8\u5206\u662f AlphaProteo \u751f\u6210\u7684\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u5408\u7269\u7ed3\u6784\uff0c\u65e8\u5728\u4e0e\u9776\u86cb\u767d\u7ed3\u5408\u3002\u9ec4\u8272\u90e8\u5206\u662f\u9776\u86cb\u767d\uff0c\u5177\u4f53\u6765\u8bf4\u662f SARS-CoV-2 \u523a\u7a81\u53d7\u4f53\u7ed3\u5408\u57df\u3002\uff08\u6765\u6e90\uff1aDeepMind<\/mark> \u5b98\u7f51\uff09<\/p>\n

\u5728\u91cd\u8981\u7684\u86cb\u767d\u8d28\u7ed3\u5408\u9776\u70b9\u4e0a\u53d6\u5f97\u6210\u529f<\/strong><\/p>\n

\u4e3a\u4e86\u6d4b\u8bd5 AlphaProteo\uff0c\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u4e86\u9488\u5bf9\u5404\u79cd\u9776\u86cb\u767d\u7684\u7ed3\u5408\u5242\uff0c\u5305\u62ec\u4e24\u79cd\u4e0e\u611f\u67d3\u6709\u5173\u7684\u75c5\u6bd2\u86cb\u767d BHRF1 \u548c SARS-CoV-2 \u523a\u7a81\u86cb\u767d\u53d7\u4f53\u7ed3\u5408\u57df SC2RBD\uff0c\u4ee5\u53ca\u4e94\u79cd\u4e0e\u764c\u75c7\u3001\u708e\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6709\u5173\u7684\u86cb\u767d IL-7R\u0251\u3001PD-L1\u3001TrkA\u3001IL-17A \u548c VEGF-A\u3002<\/p>\n

AlphaProteo \u7cfb\u7edf\u5177\u6709\u6781\u5177\u7ade\u4e89\u529b\u7684\u7ed3\u5408\u6210\u529f\u7387\u548c\u4e00\u6d41\u7684\u7ed3\u5408\u5f3a\u5ea6\u3002\u5bf9\u4e8e\u4e03\u4e2a\u9776\u70b9\uff0cAlphaProteo \u5728\u8ba1\u7b97\u673a\u6a21\u62df\u4e2d\u751f\u6210\u5019\u9009\u86cb\u767d\uff0c\u8fd9\u4e9b\u86cb\u767d\u5728\u5b9e\u9a8c\u6d4b\u8bd5\u65f6\u4e0e\u76ee\u6807\u86cb\u767d\u7d27\u5bc6\u7ed3\u5408\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aAlphaProteo \u4e3a\u5176\u751f\u6210\u6210\u529f\u7ed3\u5408\u5242\u7684\u4e03\u79cd\u9776\u86cb\u767d\u7684\u9884\u6d4b\u7ed3\u6784\u56fe\u3002\u84dd\u8272\u8868\u793a\u5728\u6e7f\u5b9e\u9a8c\u5ba4\u4e2d\u6d4b\u8bd5\u7684\u7ed3\u5408\u5242\u793a\u4f8b\uff0c\u9ec4\u8272\u662f\u86cb\u767d\u8d28\u9776\u70b9\uff0c\u6df1\u9ec4\u8272\u7a81\u51fa\u663e\u793a\u7684\u662f\u9884\u671f\u7684\u7ed3\u5408\u533a\u57df\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u5bf9\u4e8e\u4e00\u4e2a\u7279\u5b9a\u9776\u6807\uff0c\u5373\u75c5\u6bd2\u86cb\u767d BHRF1\uff0c\u5728 Google DeepMind<\/mark> Wet Lab \u4e2d\u8fdb\u884c\u6d4b\u8bd5\u65f6\uff0c88% \u5019\u9009\u5206\u5b50\u6210\u529f\u7ed3\u5408\u3002\u6839\u636e\u6d4b\u8bd5\u7684\u9776\u6807\uff0cAlphaProteo \u7ed3\u5408\u5242\u7684\u7ed3\u5408\u529b\u5e73\u5747\u6bd4\u73b0\u6709\u6700\u4f73\u8bbe\u8ba1\u65b9\u6cd5\u5f3a 10 \u500d\u3002<\/p>\n

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<\/a><\/p>\n

\u56fe\u793a\uff1a\u4e0e\u5176\u4ed6\u8bbe\u8ba1\u65b9\u6cd5\u76f8\u6bd4\uff0cAlphaProteo \u7684\u8bbe\u8ba1\u5728\u672a\u8fdb\u884c\u5b9e\u9a8c\u4f18\u5316\u7684\u60c5\u51b5\u4e0b\u5bf9\u4e03\u79cd\u76ee\u6807\u86cb\u767d\u7684\u6700\u4f73\u4eb2\u548c\u529b\u3002\u4eb2\u548c\u529b\u8d8a\u4f4e\uff0c\u610f\u5473\u7740\u7ed3\u5408\u86cb\u767d\u4e0e\u76ee\u6807\u86cb\u767d\u7684\u7ed3\u5408\u8d8a\u7d27\u5bc6\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u5bf9\u591a\u79cd\u86cb\u767d\u8d28\u7684\u9a8c\u8bc1\u7ed3\u679c<\/strong><\/p>\n

\u7814\u7a76\u4eba\u5458\u9664\u4e86\u5728\u5176\u6e7f\u5b9e\u9a8c\u5ba4\u4e2d\u8fdb\u884c\u8ba1\u7b97\u673a\u9a8c\u8bc1\u548c\u6d4b\u8bd5 AlphaProteo \u4e4b\u5916\uff0c\u8fd8\u8058\u8bf7\u4e86\u00a0Francis Crick\u00a0\u7814\u7a76\u6240\u7684 Peter Cherepanov\u3001Katie Bentley \u548c David LV Bauer \u7814\u7a76\u5c0f\u7ec4\u6765\u9a8c\u8bc1\u5176\u86cb\u767d\u8d28\u7ed3\u5408\u5242\u3002<\/p>\n

\u5728\u4e0d\u540c\u7684\u5b9e\u9a8c\u4e2d\uff0c\u4ed6\u4eec\u6df1\u5165\u7814\u7a76\u4e86\u4e00\u4e9b\u66f4\u5f3a\u7684 SC2RBD \u548c VEGF-A \u7ed3\u5408\u5242\u3002<\/p>\n

\u7814\u7a76\u5c0f\u7ec4\u8bc1\u5b9e\uff0c\u8fd9\u4e9b\u7ed3\u5408\u5242\u7684\u7ed3\u5408\u76f8\u4e92\u4f5c\u7528\u786e\u5b9e\u4e0e AlphaProteo \u6240\u9884\u6d4b\u7684\u76f8\u4f3c\u3002\u6b64\u5916\uff0c\u7814\u7a76\u5c0f\u7ec4\u8fd8\u8bc1\u5b9e\u4e86\u8fd9\u4e9b\u7ed3\u5408\u5242\u5177\u6709\u6709\u7528\u7684\u751f\u7269\u5b66\u529f\u80fd\u3002\u4f8b\u5982\uff0c\u4e00\u4e9b SC2RBD \u7ed3\u5408\u5242\u88ab\u8bc1\u660e\u53ef\u4ee5\u9632\u6b62 SARS-CoV-2 \u53ca\u5176\u67d0\u4e9b\u53d8\u4f53\u611f\u67d3\u7ec6\u80de\u3002<\/p>\n

AlphaProteo \u7684\u6027\u80fd\u8868\u660e\uff0c\u5b83\u53ef\u4ee5\u5927\u5927\u51cf\u5c11\u6d89\u53ca\u5e7f\u6cdb\u5e94\u7528\u7684\u86cb\u767d\u8d28\u7ed3\u5408\u5242\u7684\u521d\u59cb\u5b9e\u9a8c\u6240\u9700\u7684\u65f6\u95f4\u3002<\/p>\n

\u7136\u800c\uff0c\u8be5\u4eba\u5de5\u667a\u80fd<\/mark>\u7cfb\u7edf\u6709\u5c40\u9650\u6027\uff0c\u56e0\u4e3a\u5b83\u65e0\u6cd5\u9488\u5bf9\u7b2c 8 \u4e2a\u9776\u70b9 TNF\u0251\uff08\u4e00\u79cd\u4e0e\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7b49\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u76f8\u5173\u7684\u86cb\u767d\u8d28\uff09\u8bbe\u8ba1\u6210\u529f\u7684\u7ed3\u5408\u7269\u3002\u7814\u7a76\u4eba\u5458\u9009\u62e9 TNF\u0251 \u6765\u6311\u6218 AlphaProteo\uff0c\u56e0\u4e3a\u8ba1\u7b97\u5206\u6790\u8868\u660e\u8bbe\u8ba1\u7ed3\u5408\u7269\u975e\u5e38\u56f0\u96be\u3002<\/p>\n

\u63a5\u4e0b\u6765\uff0c\u8be5\u56e2\u961f\u5c06\u7ee7\u7eed\u6539\u8fdb\u548c\u6269\u5c55 AlphaProteo \u7684\u529f\u80fd\uff0c\u6700\u7ec8\u76ee\u6807\u662f\u89e3\u51b3\u8fd9\u4e9b\u5177\u6709\u6311\u6218\u6027\u7684\u9776\u70b9\u3002\u5b9e\u73b0\u5f3a\u7ed3\u5408\u901a\u5e38\u53ea\u662f\u8bbe\u8ba1\u53ef\u80fd\u5bf9\u5b9e\u9645\u5e94\u7528\u6709\u7528\u7684\u86cb\u767d\u8d28\u7684\u7b2c\u4e00\u6b65\uff0c\u5728\u7814\u53d1\u8fc7\u7a0b\u4e2d\u8fd8\u6709\u66f4\u591a\u7684\u751f\u7269\u5de5\u7a0b\u969c\u788d\u9700\u8981\u514b\u670d\u3002<\/p>\n

\u5f00\u53d1\u66f4\u5168\u9762\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u4ea7\u54c1<\/strong><\/p>\n

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\u672a\u6765\uff0cDeepMind<\/mark> \u5c06\u4e0e\u79d1\u5b66\u754c\u5408\u4f5c\uff0c\u5229\u7528 AlphaProteo \u89e3\u51b3\u6709\u5f71\u54cd\u529b\u7684\u751f\u7269\u5b66\u95ee\u9898\u5e76\u4e86\u89e3\u5176\u5c40\u9650\u6027\u3002\u4ed6\u4eec\u8fd8\u4e00\u76f4\u5728 Isomorphic Labs \u63a2\u7d22\u5176\u836f\u7269\u8bbe\u8ba1\u5e94\u7528\uff0c\u5e76\u5bf9\u672a\u6765\u7684\u53d1\u5c55\u611f\u5230\u5174\u594b\u3002<\/p>\n

\u8be5\u56e2\u961f\u5c06\u4e0d\u65ad\u63d0\u9ad8 AlphaProteo \u7b97\u6cd5\u7684\u6210\u529f\u7387\u548c\u4eb2\u548c\u529b\uff0c\u6269\u5927\u5b83\u53ef\u4ee5\u89e3\u51b3\u7684\u8bbe\u8ba1\u95ee\u9898\u8303\u56f4\uff0c\u5e76\u4e0e\u673a\u5668\u5b66\u4e60<\/mark>\u3001\u7ed3\u6784\u751f\u7269\u5b66\u3001\u751f\u7269\u5316\u5b66\u548c\u5176\u4ed6\u5b66\u79d1\u7684\u7814\u7a76\u4eba\u5458\u5408\u4f5c\uff0c\u4e3a\u793e\u533a\u5f00\u53d1\u8d1f\u8d23\u4efb\u3001\u66f4\u5168\u9762\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u4ea7\u54c1\u3002<\/p>\n

\u76f8\u4fe1 AlphaProteo \u5c06\u4e3a\u8bb8\u591a\u751f\u7269\u5e94\u7528\u5f00\u8f9f\u65b0\u7684\u89e3\u51b3\u65b9\u6848\uff0c\u4f8b\u5982\u63a7\u5236\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\uff0c\u6210\u50cf\u86cb\u767d\u8d28\u3001\u7ec6\u80de\u548c\u7ec4\u7ec7\uff0c\u8d4b\u4e88\u5404\u79cd\u6548\u5e94\u7cfb\u7edf\u76ee\u6807\u7279\u5f02\u6027\u7b49\u7b49\u3002<\/p>\n

\u76f8\u5173\u5185\u5bb9\uff1a<\/p>\n

https:\/\/x.com\/GoogleDeepMind<\/mark>\/status\/1831710991475777823<\/em><\/p>\n

https:\/\/deepmind.google\/discover\/blog\/alphaproteo-generates-novel-proteins-for-biology-and-health-research\/?utm_source=x&utm_medium=&utm_campaign=gdm&utm_content=<\/em><\/p>\n

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