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<\/a><\/p>\n

\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

\u7a7a\u95f4\u7ec4\u5b66\u6280\u672f\u4ee5\u7ec6\u80de\u548c\u4e9a\u7ec6\u80de\u5206\u8fa8\u7387\u89e3\u6790\u590d\u6742\u5668\u5b98\u7684\u529f\u80fd\u7ec4\u4ef6\u3002<\/p>\n

\u5c71\u4e1c\u5927\u5b66\u7684\u7814\u7a76\u56e2\u961f\u5f15\u5165\u4e86\u7a7a\u95f4\u56fe\u5085\u91cc\u53f6\u53d8\u6362 \u00a0(Spatial Graph Fourier Transform\uff0cSpaGFT)\uff0c\u5e76\u5c06\u56fe\u4fe1\u53f7\u5904\u7406\u5e94\u7528\u4e8e\u5404\u79cd\u7a7a\u95f4\u7ec4\u5b66\u5206\u6790\u5e73\u53f0\uff0c\u4ee5\u751f\u6210\u53ef\u89e3\u91ca\u7684\u8868\u793a\u3002<\/p>\n

\u8fd9\u79cd\u8868\u793a\u652f\u6301\u7a7a\u95f4\u53ef\u53d8\u57fa\u56e0\u8bc6\u522b\u5e76\u6539\u8fdb\u57fa\u56e0\u8868\u8fbe\u63a8\u65ad\uff0c\u5728\u5206\u6790\u4eba\u7c7b\u548c\u5c0f\u9f20\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u65b9\u9762\u4f18\u4e8e\u73b0\u6709\u5de5\u5177\uff0c\u6548\u7387\u662f\u73b0\u6709\u5de5\u5177\u7684\u767e\u500d\u3002<\/p>\n

SpaGFT \u53ef\u4ee5\u8bc6\u522b\u4eba\u7c7b\u6dcb\u5df4\u7ed3 Visium \u6570\u636e\u4e2d B \u7ec6\u80de\u6210\u719f\u7684\u514d\u75ab\u533a\u57df\uff0c\u5e76\u4f7f\u7528\u5185\u90e8\u4eba\u7c7b\u6241\u6843\u4f53 CODEX \u6570\u636e\u8868\u5f81\u6b21\u7ea7\u6ee4\u6ce1\u7684\u53d8\u5316\u3002<\/p>\n

\u6b64\u5916\uff0c\u5b83\u53ef\u4ee5\u65e0\u7f1d\u96c6\u6210\u5230\u5176\u4ed6\u673a\u5668\u5b66\u4e60\u6846\u67b6\u4e2d\uff0c\u5c06\u7a7a\u95f4\u57df\u8bc6\u522b\u3001\u7ec6\u80de\u7c7b\u578b\u6ce8\u91ca\u548c\u4e9a\u7ec6\u80de\u7279\u5f81\u63a8\u65ad\u7684\u51c6\u786e\u6027\u63d0\u9ad8\u591a\u8fbe 40%\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cSpaGFT \u5728\u9ad8\u5206\u8fa8\u7387\u7a7a\u95f4\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\u4e2d\u68c0\u6d4b\u7a00\u6709\u4e9a\u7ec6\u80de\u5668\u3002\u8fd9\u4e3a\u63a2\u7d22\u7ec4\u7ec7\u751f\u7269\u5b66\u548c\u529f\u80fd\u63d0\u4f9b\u4e86\u4e00\u79cd\u53ef\u89e3\u91ca\u7684\u56fe\u5f62\u8868\u793a\u65b9\u6cd5\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cGraph Fourier transform for spatial omics representation and analyses of complex organs<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2024 \u5e74 8 \u6708 29 \u65e5\u53d1\u5e03\u5728\u300aNature Communications<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

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\u76f8\u6bd4\u7ecf\u5178\u7edf\u8ba1\u65b9\u6cd5\uff0c\u57fa\u4e8e\u56fe\u7684\u65b9\u6cd5\u53ef\u4ee5\u6574\u5408\u8fd9\u4e24\u79cd\u89c6\u89d2\uff0c\u7528\u8282\u70b9\u8868\u793a\u7ec6\u80de\uff0c\u8fb9\u8868\u793a\u7a7a\u95f4\u6216\u529f\u80fd\u8054\u7cfb\uff0c\u901a\u8fc7\u56fe\u4fe1\u53f7\u7f16\u7801\u5206\u5b50\u7279\u5f81\uff0c\u63d0\u5347\u5206\u6790\u7684\u53ef\u89e3\u91ca\u6027\u3002\u73b0\u6709\u57fa\u4e8e\u56fe\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u5b58\u5728\u300c\u9ed1\u7bb1\u300d\u95ee\u9898\uff0c\u9700\u8981\u66f4\u901a\u7528\u7684\u56fe\u4fe1\u53f7\u8868\u793a\u6846\u67b6\u6765\u63ed\u793a\u590d\u6742\u5173\u7cfb\u3002<\/p>\n

\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\uff0c\u5c71\u4e1c\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86\u7a7a\u95f4\u56fe\u5085\u91cc\u53f6\u53d8\u6362\uff08 Spatial Graph Fourier Transform\uff0cSpaGFT\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u5206\u6790\u7279\u5f81\u8868\u793a\u65b9\u6cd5\uff0c\u7528\u4e8e\u7f16\u7801\u5e73\u6ed1\u56fe\u4fe1\u53f7\u6765\u8868\u793a\u7ec4\u7ec7\u548c\u7ec6\u80de\u5185\u7684\u751f\u7269\u8fc7\u7a0b\u3002\u5b83\u5c06\u56fe\u5f62\u4fe1\u53f7\u5904\u7406\u6280\u672f\u548c\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u8fde\u63a5\u8d77\u6765\uff0c\u652f\u6301\u5404\u79cd\u4e0b\u6e38\u5206\u6790\u5e76\u4fc3\u8fdb\u6709\u6d1e\u5bdf\u529b\u7684\u751f\u7269\u5b66\u53d1\u73b0\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aSpaGFT \u7528\u4e8e\u7a7a\u95f4\u7ec4\u5b66\u8868\u793a\u7684\u67b6\u6784\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u529f\u80fd\u4e0e\u6027\u80fd<\/strong><\/p>\n

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\u5b83\u6d88\u9664\u4e86\u5bf9\u9884\u5b9a\u4e49\u8868\u8fbe\u6a21\u5f0f\u7684\u9700\u6c42\uff0c\u5e76\u663e\u8457\u63d0\u9ad8\u4e86\u8ba1\u7b97\u6548\u7387\uff0c\u8fd9\u5728 31 \u4e2a\u4eba\/\u5c0f\u9f20 Visium \u548c Slide-seq V2 \u6570\u636e\u96c6\u7684\u57fa\u51c6\u6d4b\u8bd5\u4e2d\u5f97\u5230\u4e86\u8bc1\u660e\u3002<\/p>\n

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<\/a><\/p>\n

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\u6b64\u5916\uff0c\u5b9e\u65bd\u4f4e\u901a\u6ee4\u6ce2\u5668\u548c\u9006\u00a0GFT\u00a0\u53ef\u4ee5\u6709\u6548\u5730\u63a8\u65ad\u4f4e\u8868\u8fbe\u57fa\u56e0\u8868\u8fbe\u5e76\u53bb\u9664\u9ad8\u566a\u58f0\u86cb\u767d\u8d28\u5f3a\u5ea6\uff0c\u4ece\u800c\u5b9e\u73b0\u66f4\u7cbe\u786e\u7684\u7a7a\u95f4\u57df\u9884\u6d4b\uff0c\u5982\u4eba\u7c7b\u80cc\u5916\u4fa7\u524d\u989d\u53f6\u76ae\u8d28\u6240\u5c55\u793a\u7684\u90a3\u6837\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cSpaGFT \u901a\u8fc7\u5b9e\u73b0\u66f4\u51c6\u786e\u7684\u673a\u5668\u5b66\u4e60\u9884\u6d4b\uff0c\u4fc3\u8fdb\u4e86\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u7684\u89e3\u91ca\u3002<\/p>\n

\u5b83\u5728\u7a7a\u95f4\u57df\u8bc6\u522b\u7684\u51c6\u786e\u6027\u3001\u4ece\u7ec6\u80de\u7c7b\u578b\u5230\u6591\u70b9\u7684\u6ce8\u91ca\u8f6c\u79fb\u7684\u8f83\u4f4e\u9519\u8bef\u3001\u7ec6\u80de\u5230\u6591\u70b9\u6bd4\u5bf9\u7684\u6b63\u786e\u6027\u4ee5\u53ca\u4e9a\u7ec6\u80de\u6807\u5fd7\u63a8\u65ad\u7684\u9a8c\u8bc1\u635f\u5931\u65b9\u9762\u663e\u8457\u63d0\u9ad8\u4e86\u73b0\u6709\u6846\u67b6\u7684\u6027\u80fd 8-40%\u3002<\/p>\n

\u4ef7\u503c\u4e0e\u610f\u4e49<\/strong><\/p>\n

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SpaGFT \u4f7f\u7528\u56fe\u5085\u91cc\u53f6\u53d8\u6362\u6765\u5bfb\u627e\u65b0\u7684\u6f5c\u5728\u7a7a\u95f4\u6765\u8868\u793a\u57fa\u56e0\u8868\u8fbe\u5e76\u5b9e\u73b0\u5404\u79cd\u4e0b\u6e38\u4efb\u52a1\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e SVG \u8bc6\u522b\u3001\u57fa\u56e0\u8868\u8fbe\u589e\u5f3a\u548c\u529f\u80fd\u7ec4\u7ec7\u5355\u5143\u63a8\u65ad\u3002<\/p>\n

\u6b64\u5916\uff0c\u5c06 SpaGFT \u5e94\u7528\u5230\u73b0\u6709\u7684\u53ef\u89e3\u91ca\u7a7a\u95f4\u591a\u6a21\u6001\u6846\u67b6\uff08\u5982 UnitedNet\u3001MUSE \u548c modalities-autoencoder\uff09\u4e2d\u4e5f\u5177\u6709\u5f88\u597d\u7684\u6f5c\u529b\u3002<\/p>\n

\u4ee5 UnitedNet \u4e3a\u4f8b\uff0c\u5b83\u91c7\u7528\u53ef\u89e3\u91ca\u7684\u673a\u5668\u5b66\u4e60\u6280\u672f\u6765\u5256\u6790\u8bad\u7ec3\u6709\u7d20\u7684\u7f51\u7edc\u5e76\u91cf\u5316\u4e0d\u540c\u6a21\u5f0f\u4e0b\u7279\u5f81\u7684\u76f8\u5173\u6027\uff0c\u7279\u522b\u662f\u7814\u7a76\u7279\u5b9a\u4e8e\u7ec6\u80de\u7c7b\u578b\u7684\u5173\u7cfb\u3002<\/p>\n

<\/a><\/p>\n

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\u7b2c\u4e09\uff0c\u70b9\u56fe\u548c FTU \u62d3\u6251\u7684\u6539\u53d8\u4ee3\u8868\u7740\u5728\u6765\u81ea\u4e0d\u540c\u7ec4\u7ec7\u6216\u5b9e\u9a8c\u7684\u7a7a\u95f4\u6837\u672c\u4e2d\u8bc6\u522b FTU \u7684\u6f5c\u5728\u6311\u6218\uff0c\u8fd9\u4f1a\u5bfc\u81f4 FM \u7a7a\u95f4\u4e0d\u540c\u5e76\u4f7f\u5f97 FC \u65e0\u6cd5\u6bd4\u8f83\u3002<\/p>\n

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<\/a><\/p>\n

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\u76f8\u5173\u62a5\u9053\uff1ahttps:\/\/www.nature.com\/articles\/s41467-024-51590-5<\/em><\/p>\n

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