{"id":35614,"date":"2024-12-28T08:00:13","date_gmt":"2024-12-28T00:00:13","guid":{"rendered":"https:\/\/17aitech.com\/?p=35614"},"modified":"2024-12-28T08:00:13","modified_gmt":"2024-12-28T00:00:13","slug":"%e5%8a%a0%e9%80%9f%e8%9b%8b%e7%99%bd%e8%b4%a8%e5%b7%a5%e7%a8%8b%ef%bc%8c%e5%be%ae%e8%bd%af%e5%bc%80%e5%8f%91%e8%9b%8b%e7%99%bd%e7%aa%81%e5%8f%98%e6%95%88%e5%ba%94%e9%a2%84%e6%b5%8bai%e6%a1%86%e6%9e%b6","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=35614","title":{"rendered":"\u52a0\u901f\u86cb\u767d\u8d28\u5de5\u7a0b\uff0c\u5fae\u8f6f\u5f00\u53d1\u86cb\u767d\u7a81\u53d8\u6548\u5e94\u9884\u6d4bAI\u6846\u67b6\u00b5Former"},"content":{"rendered":"<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:<a href=\"https:\/\/www.jiqizhixin.com\/articles\/2024-09-14-6\" target=\"_blank\">\u52a0\u901f\u86cb\u767d\u8d28\u5de5\u7a0b\uff0c\u5fae\u8f6f\u5f00\u53d1\u86cb\u767d\u7a81\u53d8\u6548\u5e94\u9884\u6d4bAI\u6846\u67b6\u00b5Former<\/a><\/p>\n<section><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-39bb53e59fca378ab17b14740a0a8359.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-39bb53e59fca378ab17b14740a0a8359.png\"><\/a><\/section>\n<p>\u7f16\u8f91 | KX<\/p>\n<p>\u86cb\u767d\u8d28\u5de5\u7a0b\u662f\u5408\u6210\u751f\u7269\u5b66\u9886\u57df\u7684\u91cd\u8981\u7814\u7a76\u65b9\u5411\u4e4b\u4e00\u3002\u8fd1\u5e74\u6765\uff0cAI \u8f85\u52a9\u7684\u86cb\u767d\u8d28\u5de5\u7a0b\u9010\u6e10\u53d1\u5c55\u6210\u4e3a\u4e00\u79cd\u9ad8\u6548\u7684\u86cb\u767d\u8d28\u5206\u5b50\u8bbe\u8ba1\u65b0\u7b56\u7565\u3002<\/p>\n<p>\u8fd1\u65e5\uff0c\u5fae\u8f6f\u7814\u7a76\u9662\u79d1\u5b66\u667a\u80fd\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86\u6df1\u5ea6\u5b66\u4e60\u6846\u67b6 \u00b5Former\uff0c\u5176\u5c06\u9884\u8bad\u7ec3\u7684\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u4e0e\u5b9a\u5236\u8bbe\u8ba1\u7684\u8bc4\u5206\u6a21\u5757\u76f8\u7ed3\u5408\uff0c\u4ece\u800c\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u7a81\u53d8\u6548\u5e94\u3002<\/p>\n<p>\u00b5Former \u5728\u9884\u6d4b\u9ad8\u9636\u7a81\u53d8\u4f53\u3001\u5efa\u6a21\u4e0a\u4f4d\uff08epistatic\uff09\u76f8\u4e92\u4f5c\u7528\u548c\u5904\u7406\u63d2\u5165\u65b9\u9762\uff0c\u5b9e\u73b0\u4e86\u6700\u5148\u8fdb\u7684\u6027\u80fd\u3002<\/p>\n<p>\u901a\u8fc7\u5c06 \u00b5Former \u4e0e\u5f3a\u5316\u5b66\u4e60\u6846\u67b6\u76f8\u7ed3\u5408\uff0c\u53ef\u4ee5\u9ad8\u6548\u63a2\u7d22\u5e7f\u9614\u7684\u7a81\u53d8\u7a7a\u95f4\uff0c\u6db5\u76d6\u6570\u4e07\u4ebf\u4e2a\u7a81\u53d8\u5019\u9009\u7269\uff0c\u6765\u8bbe\u8ba1\u6d3b\u6027\u589e\u5f3a\u7684\u86cb\u767d\u8d28\u53d8\u4f53\u3002\u8be5\u6a21\u578b\u6210\u529f\u9884\u6d4b\u4e86\u7531\u4e8e\u9176\u6d3b\u6027\u589e\u5f3a\u800c\u8868\u73b0\u51fa 2000 \u500d\u7ec6\u83cc\u751f\u957f\u7387\u589e\u52a0\u7684\u7a81\u53d8\u4f53\u3002<\/p>\n<p>\u76f8\u5173\u7814\u7a76\u4ee5\u300c<em>Accelerating protein engineering with fitness landscape modeling and reinforcement learning<\/em>\u300d\u4e3a\u9898\uff0c\u53d1\u8868\u5728\u9884\u5370\u5e73\u53f0 <em>bioRxiv<\/em> \u4e0a\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-e234df6dac2acec626042574f3e3ba6c.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-e234df6dac2acec626042574f3e3ba6c.png\"><\/a><\/p>\n<section>\u8bba\u6587\u94fe\u63a5\uff1a<em>https:\/\/doi.org\/10.1101\/2023.11.16.565910<\/em><\/section>\n<p>\u86cb\u767d\u8d28\u5de5\u7a0b\u65e8\u5728\u8bbe\u8ba1\u5177\u6709\u6240\u9700\u529f\u80fd\u548c\u7279\u6027\u7684\u86cb\u767d\u8d28\u3002\u901a\u8fc7\u4f18\u5316\u86cb\u767d\u8d28\u5e8f\u5217\u5b9e\u73b0\u7684\u9ad8\u6548\u86cb\u767d\u8d28\u5de5\u7a0b\u53ef\u4ee5\u6781\u5927\u5730\u4fc3\u8fdb\u751f\u7269\u836f\u7269\u3001\u9176\u7b49\u7684\u8bbe\u8ba1\u3002\u5b9e\u73b0\u8fd9\u4e00\u76ee\u6807\u7684\u4e00\u79cd\u6709\u524d\u9014\u7684\u65b9\u6cd5\u662f\u5c06\u86cb\u767d\u8d28\u5e8f\u5217\u51c6\u786e\u5730\u6620\u5c04\u5230\u5176\u76f8\u5e94\u7684\u529f\u80fd\u4e0a\uff0c\u4ece\u800c\u80fd\u591f\u9ad8\u6548\u5730\u641c\u7d22\u5177\u6709\u6240\u9700\u529f\u80fd\u7684\u5e8f\u5217\u3002<\/p>\n<p>\u96f6\u6837\u672c\u65b9\u6cd5\u65e0\u9700\u4f9d\u8d56\u540c\u6e90\u7269\u6216\u591a\u5e8f\u5217\u6bd4\u5bf9 (MSA) \u5373\u53ef\u9884\u6d4b\u7a81\u53d8\u6548\u5e94\uff0c\u51cf\u5c11\u4e86\u4e00\u4e9b\u4f9d\u8d56\u6027\uff0c\u4f46\u5728\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u591a\u6837\u6027\u7279\u6027\u65b9\u9762\u5374\u5b58\u5728\u4e0d\u8db3\u3002<\/p>\n<p>\u57fa\u4e8e\u6df1\u5ea6\u7a81\u53d8\u626b\u63cf (DMS) \u6216 MAVE \u6570\u636e\u8bad\u7ec3\u7684\u57fa\u4e8e\u5b66\u4e60\u7684\u6a21\u578b\uff0c\u5df2\u88ab\u7528\u4e8e\u5355\u72ec\u6216\u4e0e MSA\u3001\u8bed\u8a00\u6a21\u578b\u4e00\u8d77\u9884\u6d4b\u9002\u5e94\u5ea6\u666f\u89c2\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5f53\u5b9e\u9a8c\u6570\u636e\u7a00\u758f\u65f6\uff0c\u8fd9\u4e9b\u6570\u636e\u9a71\u52a8\u7684\u6a21\u578b\u5f80\u5f80\u96be\u4ee5\u505a\u51fa\u5408\u7406\u7684\u9884\u6d4b\u3002<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_78 ez-toc-wrap-left-text counter-hierarchy ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u6587\u7ae0\u76ee\u5f55<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 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\u6982\u89c8\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n<p>\u00b5Former \u662f\u4e00\u79cd\u7528\u4e8e\u7a81\u53d8\u6548\u5e94\u9884\u6d4b\u7684\u4e24\u6b65\u89e3\u51b3\u65b9\u6848\uff0c\u5373\u9884\u6d4b\u7a81\u53d8\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u9002\u5e94\u5ea6\u5f97\u5206\u3002\u00b5Former \u7531\u4e00\u4e2a\u81ea\u76d1\u7763\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u548c\u4e00\u7ec4\u76d1\u7763\u8bc4\u5206\u6a21\u5757\u7ec4\u6210\u3002<\/p>\n<p>\u9996\u5148\uff0c\u901a\u8fc7\u5728\u5927\u91cf\u672a\u6807\u8bb0\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u96c6\u4e0a\u9884\u8bad\u7ec3\u63a9\u853d\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b (PLM)\u3002\u5728\u9884\u8bad\u7ec3\u9636\u6bb5\uff0c\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u4f7f\u7528\u4ece UniRef50 \u6536\u96c6\u7684\u8d85\u8fc7 3000 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href=\"https:\/\/www.jiqizhixin.com\/articles\/2024-09-14-6\" target=\"_blank\">\u52a0\u901f\u86cb\u767d\u8d28\u5de5\u7a0b\uff0c\u5fae\u8f6f\u5f00\u53d1\u86cb\u767d\u7a81\u53d8\u6548\u5e94\u9884\u6d4bAI\u6846\u67b6\u00b5Former<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u52a0\u901f\u86cb\u767d\u8d28\u5de5\u7a0b\uff0c\u5fae\u8f6f\u5f00 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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