{"id":35664,"date":"2024-12-29T08:00:20","date_gmt":"2024-12-29T00:00:20","guid":{"rendered":"https:\/\/17aitech.com\/?p=35664"},"modified":"2024-12-29T08:00:20","modified_gmt":"2024-12-29T00:00:20","slug":"%e5%a4%a7%e8%af%ad%e8%a8%80%e6%a8%a1%e5%9e%8b%e5%a6%82%e4%bd%95%e5%8a%a9%e5%8a%9b%e8%8d%af%e7%89%a9%e5%bc%80%e5%8f%91-%e5%93%88%e4%bd%9b%e5%9b%a2%e9%98%9f%e6%9c%80%e6%96%b0%e7%bb%bc%e8%bf%b0","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=35664","title":{"rendered":"\u5927\u8bed\u8a00\u6a21\u578b\u5982\u4f55\u52a9\u529b\u836f\u7269\u5f00\u53d1? \u54c8\u4f5b\u56e2\u961f\u6700\u65b0\u7efc\u8ff0"},"content":{"rendered":"<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:<a href=\"https:\/\/www.jiqizhixin.com\/articles\/2024-09-18-4\" target=\"_blank\">\u5927\u8bed\u8a00\u6a21\u578b\u5982\u4f55\u52a9\u529b\u836f\u7269\u5f00\u53d1? \u54c8\u4f5b\u56e2\u961f\u6700\u65b0\u7efc\u8ff0<\/a><\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-16119c483e498643cd92af29ac090f2a.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-16119c483e498643cd92af29ac090f2a.png\"><\/a><\/p>\n<p>\u4f5c\u8005 |\u00a0\u83ab\u7eb3\u4ec0\u5927\u5b66\u90d1\u4f0a\u5733<\/p>\n<p>\u7f16\u8f91 | ScienceAI<\/p>\n<p>\u5927\u8bed\u8a00\u6a21\u578b\u56e0\u5176\u5c55\u73b0\u51fa\u7c7b\u4eba\u822c\u7684\u63a8\u7406\u3001\u5de5\u5177\u4f7f\u7528\u548c\u95ee\u9898\u89e3\u51b3\u80fd\u529b\u800c\u5907\u53d7\u77a9\u76ee\uff0c\u6b64\u5916\uff0c\u5b83\u5728\u5316\u5b66\u3001\u751f\u7269\u5b66\u7b49\u4e13\u4e1a\u9886\u57df\u4e5f\u5c55\u73b0\u51fa\u6df1\u539a\u7684\u7406\u89e3\u80fd\u529b\uff0c\u8fdb\u4e00\u6b65\u63d0\u5347\u4e86\u5176\u5e94\u7528\u4ef7\u503c\u3002<\/p>\n<p>\u8fd1\u65e5\uff0c\u54c8\u4f5b\u5927\u5b66\u3001\u83ab\u7eb3\u4ec0\u5927\u5b66\u548c\u683c\u91cc\u83f2\u65af\u5927\u5b66\uff08Griffith University\uff09\u7ec4\u6210\u7684\u7814\u7a76\u56e2\u961f\uff0c\u53d1\u8868\u6700\u65b0\u7efc\u8ff0\u300a<em>Large Language Models in Drug Discovery and Development: From Disease Mechanisms to Clinical Trials<\/em>\u300b\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-ce6ea02c214529cdd7d9d5539f89f99f.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-ce6ea02c214529cdd7d9d5539f89f99f.png\"><\/a><\/p>\n<p>\u8bba\u6587\u94fe\u63a5\uff1a<em>https:\/\/arxiv.org\/pdf\/2409.04481<\/em><\/p>\n<p>\u672c\u6587\u9610\u8ff0\u5927\u8bed\u8a00\u6a21\u578b\u53ef\u4ee5\u5728\u7406\u89e3\u75be\u75c5\u673a\u5236\u3001\u836f\u7269\u53d1\u73b0\u548c\u4e34\u5e8a\u8bd5\u9a8c\u4e09\u4e2a\u836f\u7269\u53d1\u73b0\u7684\u57fa\u672c\u9636\u6bb5\u5c55\u73b0\u51fa\u91cd\u8981\u6f5c\u529b\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-fd8fe3d8fb1b594e942ce43ef0fbd068.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-fd8fe3d8fb1b594e942ce43ef0fbd068.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u5927\u578b\u8bed\u8a00\u6a21\u578b\u5728\u836f\u7269\u53d1\u73b0\u548c\u5f00\u53d1\u7684\u672a\u6765\u683c\u5c40\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p>\u9996\u5148\uff0c\u672c\u6587\u5c55\u793a\u4e86\u8fc7\u53bb\u3001\u73b0\u5728\u7684\u836f\u7269\u7814\u53d1\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u8fc7\u7a0b\u5e76\u5c55\u73b0\u4e86\u5927\u8bed\u8a00\u6a21\u578b\uff08LLMs\uff09\u672a\u6765\u5728\u8fd9\u4e9b\u9636\u6bb5\u7684\u6f5c\u5728\u5e94\u7528\u3002<\/p>\n<p><strong>\u7406\u89e3\u75be\u75c5\u673a\u5236\uff1a<\/strong><\/p>\n<ul>\n<li>\u8fc7\u53bb\uff1a\u4f9d\u8d56\u624b\u52a8\u6587\u732e\u548c\u4e13\u5229\u641c\u7d22\u3002<\/li>\n<li>\u73b0\u5728\uff1a\u9664\u4e86\u624b\u52a8\u6587\u732e\u641c\u7d22\uff0c\u8fd8\u52a0\u5165\u4e86\u529f\u80fd\u57fa\u56e0\u7ec4\u5b66\u5206\u6790\u3002<\/li>\n<li>\u672a\u6765\uff1aLLMs \u5c06\u81ea\u52a8\u8bc6\u522b\u9776\u57fa\u56e0\uff0c\u53d1\u73b0\u751f\u5316\u548c\u836f\u7406\u5b66\u539f\u7406\u3002<\/li>\n<\/ul>\n<p><strong>\u836f\u7269\u53d1\u73b0\uff1a<\/strong><\/p>\n<ul>\n<li>\u8fc7\u53bb\uff1a\u901a\u8fc7\u5929\u7136\u4ea7\u7269\u7684\u53d1\u73b0\u548c\u968f\u673a\u7b5b\u9009\u8fdb\u884c\u836f\u7269\u7814\u53d1\u3002<\/li>\n<li>\u73b0\u5728\uff1a\u4f7f\u7528\u865a\u62df\u7b5b\u9009\u548c\u57fa\u4e8e\u7ed3\u6784\u7684\u624b\u52a8\u836f\u7269\u8bbe\u8ba1\u3002<\/li>\n<li>\u672a\u6765\uff1aLLMs \u5c06\u8bbe\u8ba1\u65b0\u578b\u6cbb\u7597\u65b9\u6cd5\uff0c\u81ea\u52a8\u751f\u6210\u836f\u7269\u8bbe\u8ba1\uff0c\u5e76\u81ea\u52a8\u8fdb\u884c\u5b9e\u9a8c\u3002<\/li>\n<\/ul>\n<p><strong>\u4e34\u5e8a\u8bd5\u9a8c\uff1a<\/strong><\/p>\n<ul>\n<li>\u8fc7\u53bb\u548c\u73b0\u5728\uff1a\u624b\u52a8\u5339\u914d\u75c5\u4eba\u4e0e\u8bd5\u9a8c\u3001\u8bbe\u8ba1\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u53ca\u6536\u96c6\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u3002<\/li>\n<li>\u672a\u6765\uff1aLLMs \u5c06\u81ea\u52a8\u8fdb\u884c\u75c5\u4eba\u5339\u914d\u3001\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u5e76\u9884\u6d4b\u8bd5\u9a8c\u7ed3\u679c\u3002<\/li>\n<\/ul>\n<p><strong>\u5927\u8bed\u8a00\u6a21\u578b\u7684\u5206\u7c7b<\/strong><\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-0c80f2bc5ca81d49bb1d659f2c65309a.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-0c80f2bc5ca81d49bb1d659f2c65309a.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u5927\u8bed\u8a00\u6a21\u578b\u7684\u4e24\u79cd\u4e3b\u8981\u8303\u5f0f\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p>\u672c\u6587\u5c06\u5927\u8bed\u8a00\u6a21\u578b\u5206\u4e3a\u4e24\u7c7b: \u79d1\u5b66\u5927\u8bed\u8a00\u6a21\u578b\uff08Scientific Language Model\uff09\u548c\u4e00\u822c\u5927\u8bed\u8a00\u6a21\u578b\uff08General Language Model\uff09\u3002\u4e24\u8005\u7684\u5bf9\u6bd4\u548c\u5dee\u5f02\u5982\u4e0b:<\/p>\n<p><strong>\u79d1\u5b66\u5927\u8bed\u8a00\u6a21\u578b\uff1a<\/strong><\/p>\n<ul>\n<li>\u9886\u57df\uff1a\u6d89\u53ca\u5316\u5b66\uff08\u5206\u5b50\uff09\u3001\u751f\u7269\u5b66\uff08\u86cb\u767d\u8d28\u3001\u57fa\u56e0\uff09\u7b49\u4e13\u95e8\u9886\u57df\u3002<\/li>\n<li>\u8bad\u7ec3\u6570\u636e\uff1a\u5305\u62ec\u5316\u5b66\u4e2d\u7684\u00a0SMILES\u3001IUPAC \u5e8f\u5217\uff0c\u86cb\u767d\u8d28\u7684 FASTA \u5e8f\u5217\uff0c\u57fa\u56e0\u7684 FASTA \u5e8f\u5217\u7b49\u3002<\/li>\n<li>\u4efb\u52a1\u89e3\u51b3\u80fd\u529b\uff1a\u80fd\u591f\u5904\u7406\u5206\u5b50\u3001\u86cb\u767d\u8d28\u3001\u57fa\u56e0\u76f8\u5173\u7684\u4efb\u52a1\uff0c\u5982\u9006\u5408\u6210\u89c4\u5212\u3001\u53cd\u5e94\u9884\u6d4b\u3001\u5206\u5b50\u8bbe\u8ba1\u3001\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u3001\u57fa\u56e0\u7f51\u7edc\u5206\u6790\u7b49\u3002<\/li>\n<li>\u5de5\u5177\u578b\u4f7f\u7528\uff1a\u4f5c\u4e3a\u5de5\u5177\uff0c\u901a\u8fc7\u83b7\u53d6\u4efb\u52a1\u6240\u9700\u4fe1\u606f\uff0c\u751f\u6210\u9884\u6d4b\u7ed3\u679c\uff08\u5982\u86cb\u767d\u8d28-\u914d\u4f53\u7ed3\u5408\u4eb2\u548c\u529b\u8bc4\u5206\uff09\u3002<\/li>\n<\/ul>\n<p><strong>\u901a\u7528\u8bed\u8a00\u6a21\u578b\uff1a<\/strong><\/p>\n<ul>\n<li>\u9886\u57df\uff1a\u57fa\u4e8e\u66f4\u5e7f\u6cdb\u7684\u6587\u672c\u6570\u636e\uff0c\u5982\u4e66\u7c4d\u3001\u4e92\u8054\u7f51\u3001\u793e\u4ea4\u5a92\u4f53\u7b49\u3002<\/li>\n<li>\u8bad\u7ec3\u6570\u636e\uff1a\u5305\u62ec\u4e66\u7c4d\u3001\u95ee\u7b54\u7f51\u7ad9\u3001\u793e\u4ea4\u5a92\u4f53\u3001\u767e\u79d1\u7b49\u6765\u6e90\u3002<\/li>\n<li>\u4eba\u7c7b\u5f0f\u80fd\u529b\uff1a\u5177\u5907\u7406\u89e3\u80cc\u666f\u77e5\u8bc6\u3001\u63a8\u7406\u3001\u89d2\u8272\u626e\u6f14\uff08\u5982\u5316\u5b66\u5bb6\uff09\u3001\u89c4\u5212\u3001\u4f7f\u7528\u5de5\u5177\u548c\u4fe1\u606f\u68c0\u7d22\u7b49\u80fd\u529b\u3002<\/li>\n<li>\u52a9\u624b\u578b\u4f7f\u7528\uff1a\u53ef\u4ee5\u50cf\u52a9\u624b\u4e00\u6837\u4e0e\u7528\u6237\u4e92\u52a8\uff0c\u56de\u7b54\u95ee\u9898\u3001\u89e3\u91ca\u590d\u6742\u6982\u5ff5\u5e76\u5e2e\u52a9\u7528\u6237\u5b8c\u6210\u4efb\u52a1\u3002<\/li>\n<\/ul>\n<p><strong>\u5927\u8bed\u8a00\u6a21\u578b\u5728\u7406\u89e3\u75be\u75c5\u673a\u5236\u4e2d\u7684\u4f5c\u7528<\/strong><\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-914e76c15e3e80564847a8673208799e.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-914e76c15e3e80564847a8673208799e.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u4e86\u89e3\u75be\u75c5\u673a\u5236\u3002\u8fd9\u5f20\u56fe\u8868\u5206\u4e3a\u4e24\u90e8\u5206\uff0c\u5de6\u8fb9\u5c55\u793a\u4e86\u75be\u75c5\u7814\u7a76\u7684\u5173\u952e\u6d41\u7a0b\uff0c\u53f3\u8fb9\u5c55\u793a\u4e86\u5927\u8bed\u8a00\u6a21\u578b\uff08LLM\uff09\u5728\u8fd9\u4e9b\u6d41\u7a0b\u4e2d\u7684\u5177\u4f53\u5e94\u7528\u9886\u57df\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p><strong>\u75be\u75c5\u7814\u7a76\u6d41\u7a0b<\/strong><\/p>\n<p><strong>1.\u4e34\u5e8a\u5206\u578b\uff08Clinical Sub-typing\uff09\uff1a<\/strong><\/p>\n<p>\u901a\u8fc7\u591a\u7ec4\u5b66\u6570\u636e\u7684\u6536\u96c6\uff08\u5982\u57fa\u56e0\u3001\u86cb\u767d\u8d28\u3001\u4ee3\u8c22\u7ec4\u7b49\uff09\uff0c\u7ed3\u5408\u4e34\u5e8a\u5206\u6790\u548c\u4f26\u7406\u6cd5\u89c4\u8981\u6c42\uff0c\u5bf9\u75be\u75c5\u8fdb\u884c\u5206\u578b\u3002\u76ee\u7684\u662f\u66f4\u597d\u5730\u7406\u89e3\u75be\u75c5\u7684\u5f02\u8d28\u6027\uff0c\u4ece\u800c\u4e3a\u540e\u7eed\u7684\u9776\u70b9\u53d1\u73b0\u6253\u4e0b\u57fa\u7840\u3002<\/p>\n<p><strong>2.\u9776\u70b9-\u75be\u75c5\u5173\u8054\uff08Target-Disease Linkage\uff09\uff1a<\/strong><\/p>\n<p>\u901a\u8fc7\u57fa\u56e0\u8868\u8fbe\u8c31\u5206\u6790\u3001\u591a\u901a\u8def\u5206\u6790\u7b49\u65b9\u6cd5\uff0c\u7ed3\u5408\u5b9e\u9a8c\u5de5\u5177\uff08\u5982 CRISPR-Cas9\u3001RNA \u5e72\u6270\u7b49\uff09\uff0c\u5bfb\u627e\u5e76\u9a8c\u8bc1\u75be\u75c5\u4e0e\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u7684\u5173\u8054\u6027\u3002\u8fd9\u4e00\u6b65\u5bf9\u4e8e\u836f\u7269\u5f00\u53d1\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<p><strong>3.\u9776\u70b9\u9a8c\u8bc1\uff08Target Validation\uff09\uff1a<\/strong><\/p>\n<p>\u9a8c\u8bc1\u9776\u70b9\u7684\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027\uff0c\u8bc4\u4f30\u5176\u836f\u7269\u5f00\u53d1\u6f5c\u529b\u3002\u6d89\u53ca\u9776\u70b9\u5b89\u5168\u3001\u836f\u7269\u53ef\u53ca\u6027\uff08Drugability\uff09\u548c\u6d4b\u8bd5\u53ef\u884c\u6027\u3002\u9776\u70b9\u7684\u4f5c\u7528\u673a\u5236\uff08\u5982\u6fc0\u52a8\u5242\u3001\u62ee\u6297\u5242\u3001\u8c03\u8282\u5242\u7b49\uff09\u4e5f\u4f1a\u5728\u8fd9\u4e00\u9636\u6bb5\u8fdb\u884c\u786e\u8ba4\uff0c\u4ece\u800c\u9009\u62e9\u5408\u9002\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u5982\u86cb\u767d\u8d28\u3001\u5c0f\u5206\u5b50\u6216RNA\u6cbb\u7597\u3002<\/p>\n<p><strong>LLM \u7684\u5e94\u7528\u9886\u57df<\/strong><\/p>\n<p><strong>1.\u57fa\u56e0\u7ec4\u5206\u6790\uff08Genomics Analysis\uff09\uff1a<\/strong><\/p>\n<p>LLM \u53ef\u4ee5\u5e2e\u52a9\u9884\u6d4b\u57fa\u56e0\u53d8\u5f02\u3001\u542f\u52a8\u5b50\u533a\u57df\u3001\u8f6c\u5f55\u56e0\u5b50\u7ed3\u5408\u4f4d\u70b9\u7b49\u4fe1\u606f\uff0c\u4ece\u800c\u5e2e\u52a9\u79d1\u7814\u4eba\u5458\u5728\u57fa\u56e0\u7ec4\u5c42\u9762\u7406\u89e3\u75be\u75c5\u673a\u5236\u3002<\/p>\n<p><strong>2.\u8f6c\u5f55\u7ec4\u5206\u6790\uff08Transcriptomics Analysis\uff09\uff1a<\/strong><\/p>\n<p>LLM \u53ef\u4ee5\u5904\u7406 mRNA \u8868\u8fbe\u5206\u6790\u3001\u57fa\u56e0\u7f51\u7edc\u5206\u6790\u7b49\u590d\u6742\u6570\u636e\uff0c\u8f85\u52a9\u7814\u7a76\u4eba\u5458\u6316\u6398\u91cd\u8981\u7684\u8f6c\u5f55\u7ec4\u4fe1\u606f\uff0c\u4e86\u89e3\u57fa\u56e0\u7684\u8c03\u63a7\u6a21\u5f0f\u548c\u8868\u8fbe\u5dee\u5f02\u3002<\/p>\n<p><strong>3.\u86cb\u767d\u8d28\u9776\u70b9\u5206\u6790\uff08Protein Target Analysis\uff09\uff1a<\/strong><\/p>\n<p>LLM \u80fd\u591f\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u3001\u529f\u80fd\u6ce8\u91ca\u3001\u86cb\u767d\u8d28\u95f4\u76f8\u4e92\u4f5c\u7528\u4ee5\u53ca\u914d\u4f53\u7ed3\u5408\u4f4d\u70b9\u7b49\u4fe1\u606f\uff0c\u5e2e\u52a9\u79d1\u7814\u4eba\u5458\u9009\u62e9\u6f5c\u5728\u7684\u836f\u7269\u9776\u70b9\u3002<\/p>\n<p><strong>4.\u75be\u75c5\u901a\u8def\u5206\u6790\uff08Disease Pathway Analysis\uff09\uff1a<\/strong><\/p>\n<p>LLM \u5728\u75be\u75c5\u901a\u8def\u5206\u6790\u4e2d\u80fd\u591f\u5206\u6790\u86cb\u767d\u8d28\u4e0e\u75be\u75c5\u4e4b\u95f4\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\uff0c\u8bc6\u522b\u6f5c\u5728\u7684\u6cbb\u7597\u9776\u70b9\u548c\u5e72\u9884\u9014\u5f84\uff0c\u4ece\u800c\u52a0\u901f\u836f\u7269\u5f00\u53d1\u8fc7\u7a0b\u3002<\/p>\n<p><strong>5.\u8f85\u52a9\u529f\u80fd\uff08Assistance\uff09\uff1a<\/strong><\/p>\n<p>LLM \u8fd8\u53ef\u4ee5\u63d0\u4f9b\u77e5\u8bc6\u53d1\u73b0\u3001\u4fe1\u606f\u68c0\u7d22\u7b49\u8f85\u52a9\u529f\u80fd\uff0c\u5e2e\u52a9\u79d1\u7814\u4eba\u5458\u5feb\u901f\u83b7\u53d6\u76f8\u5173\u4fe1\u606f\uff0c\u52a0\u5feb\u7814\u7a76\u8fdb\u7a0b\u3002<\/p>\n<p><strong>\u5927\u8bed\u8a00\u6a21\u578b\u5728\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u4f5c\u7528<\/strong><\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-fc4b2ef7c79dafbbe0fe0cffac2f98d0.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-fc4b2ef7c79dafbbe0fe0cffac2f98d0.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u836f\u7269\u53d1\u73b0\u3002\u8fd9\u5f20\u56fe\u5206\u4e3a\u4e24\u90e8\u5206\uff0c\u5de6\u8fb9\u5c55\u793a\u4e86\u836f\u7269\u53d1\u73b0\u7684\u8fc7\u7a0b\uff0c\u53f3\u8fb9\u5c55\u793a\u4e86\u5927\u8bed\u8a00\u6a21\u578b\uff08LLM\uff09\u5728\u836f\u7269\u53d1\u73b0\u5404\u9636\u6bb5\u7684\u5177\u4f53\u5e94\u7528\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p><strong>\u836f\u7269\u53d1\u73b0\u8fc7\u7a0b<\/strong><\/p>\n<p><strong>1.\u836f\u7269\u7c7b\u578b\u9009\u62e9\uff1a<\/strong><\/p>\n<p>\u79d1\u5b66\u5bb6\u53ef\u4ee5\u9009\u62e9\u4e0d\u540c\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u5305\u62ec\u86cb\u767d\u8d28\u3001\u5c0f\u5206\u5b50\u836f\u7269\u548c RNA\u3002\u8be5\u56fe\u4ee5\u5c0f\u5206\u5b50\u836f\u7269\u4e3a\u4f8b\uff0c\u5c55\u793a\u4e86\u5b83\u4eec\u5728\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<p><strong>2.\u836f\u7269\u53d1\u73b0\u6d41\u7a0b\uff1a<\/strong><\/p>\n<ul>\n<li>\u547d\u4e2d\u8bc6\u522b\uff08Hit Identification\uff09\uff1a\u901a\u8fc7\u7b5b\u9009\u5927\u91cf\u5316\u5408\u7269\uff0c\u627e\u5230\u4e0e\u9776\u70b9\u6709\u521d\u6b65\u53cd\u5e94\u7684\u5206\u5b50\u3002<\/li>\n<li>\u547d\u4e2d\u5230\u5148\u5bfc\uff08Hit to Lead\uff09\uff1a\u8fdb\u4e00\u6b65\u4f18\u5316\u8fd9\u4e9b\u521d\u6b65\u547d\u4e2d\u5206\u5b50\uff0c\u4ee5\u63d0\u9ad8\u5176\u4e0e\u9776\u70b9\u7684\u7ed3\u5408\u80fd\u529b\u3002<\/li>\n<li>\u5148\u5bfc\u4f18\u5316\uff08Lead Optimization\uff09\uff1a\u5bf9\u5148\u5bfc\u5316\u5408\u7269\u8fdb\u884c\u7ed3\u6784\u6539\u9020\uff0c\u589e\u5f3a\u5176\u7597\u6548\u548c\u836f\u7269\u7279\u6027\u3002<\/li>\n<li>\u4e34\u5e8a\u524d\u7814\u7a76\uff08Pre-clinical\uff09\uff1a\u5728\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u524d\uff0c\u8bc4\u4f30\u5019\u9009\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/li>\n<li>\u836f\u7269\u5019\u9009\u7269\uff08Drug Candidates\uff09\uff1a\u901a\u8fc7\u4e0a\u8ff0\u6d41\u7a0b\uff0c\u4ea7\u751f\u6700\u7ec8\u53ef\u4f9b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5019\u9009\u836f\u7269\u3002<\/li>\n<\/ul>\n<p><strong>LLM \u7684\u5e94\u7528\u9886\u57df<\/strong><\/p>\n<p><strong>1.\u5316\u5b66\u9886\u57df\uff08Chemistry\uff09\uff1a<\/strong><\/p>\n<p>LLM \u53ef\u4ee5\u7528\u4e8e\u5316\u5b66\u673a\u5668\u4eba\u81ea\u52a8\u5316\u5408\u6210\u3001\u9006\u5408\u6210\u89c4\u5212\u548c\u53cd\u5e94\u9884\u6d4b\u7b49\u4efb\u52a1\uff0c\u5e2e\u52a9\u5316\u5b66\u5bb6\u52a0\u901f\u5316\u5408\u7269\u7684\u53d1\u73b0\u3002<\/p>\n<p><strong>2.\u8ba1\u7b97\u673a\u6a21\u62df\uff08In Silico Simulation\uff09\uff1a<\/strong><\/p>\n<p>LLM \u80fd\u591f\u8fdb\u884c\u5206\u5b50\u751f\u6210\u3001\u86cb\u767d\u8d28\u751f\u6210\u548c\u86cb\u767d\u8d28-\u914d\u4f53\u76f8\u4e92\u4f5c\u7528\u9884\u6d4b\uff0c\u4ece\u800c\u52a0\u5feb\u865a\u62df\u836f\u7269\u7b5b\u9009\u8fc7\u7a0b\u3002<\/p>\n<p><strong>3.ADMET\u9884\u6d4b\uff1a<\/strong><\/p>\n<p>LLM \u80fd\u591f\u9884\u6d4b\u5019\u9009\u836f\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff08Pharmacokinetics\uff09\u3001\u6bd2\u6027\uff08Toxicity\uff09\u548c\u7406\u5316\u6027\u8d28\uff08Physicochemical Properties\uff09\uff0c\u5e2e\u52a9\u8bc4\u4f30\u836f\u7269\u5728\u4eba\u4f53\u4e2d\u7684\u884c\u4e3a\u3002<\/p>\n<p><strong>4.\u5148\u5bfc\u4f18\u5316\uff08Lead Optimization\uff09\uff1a<\/strong><\/p>\n<p>LLM \u80fd\u591f\u901a\u8fc7\u4f18\u5316\u5206\u5b50\u7ed3\u6784\u548c\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff0c\u5e2e\u52a9\u6539\u8fdb\u5019\u9009\u5316\u5408\u7269\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p><strong>5.\u8f85\u52a9\u529f\u80fd\uff08Assistance\uff09\uff1a<\/strong><\/p>\n<p>LLM \u8fd8\u53ef\u4ee5\u63d0\u4f9b\u4fe1\u606f\u68c0\u7d22\u548c\u77e5\u8bc6\u89e3\u91ca\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u5feb\u901f\u83b7\u53d6\u6240\u9700\u4fe1\u606f\uff0c\u63d0\u5347\u836f\u7269\u5f00\u53d1\u7684\u6548\u7387\u3002<\/p>\n<p><strong>\u5927\u8bed\u8a00\u6a21\u578b\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u4f5c\u7528<\/strong><\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-55167c6648d8cdaab44c45a1470df80d.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-55167c6648d8cdaab44c45a1470df80d.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8fd9\u5f20\u56fe\u8868\u5de6\u4fa7\u5c55\u793a\u4e86\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e0d\u540c\u9636\u6bb5\uff0c\u53f3\u4fa7\u5c55\u793a\u4e86\u5927\u8bed\u8a00\u6a21\u578b\uff08LLM\uff09\u5728\u8fd9\u4e9b\u9636\u6bb5\u4e2d\u7684\u5e94\u7528\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p><strong>\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5<\/strong><\/p>\n<p><strong>1.\u7b2c\u4e00\u9636\u6bb5\uff08Phase 1\uff09\uff1a<\/strong><\/p>\n<p>\u4e3b\u8981\u6d4b\u8bd5\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6700\u4f73\u5242\u91cf\u6c34\u5e73\u3002\u901a\u5e38\u5728 15 \u5230 50 \u540d\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u8fdb\u884c\u3002<\/p>\n<p><strong>2.\u7b2c\u4e8c\u9636\u6bb5\uff08Phase 2\uff09\uff1a<\/strong><\/p>\n<p>\u63a2\u7d22\u836f\u7269\u7684\u6709\u6548\u6027\u4ee5\u53ca\u53ef\u80fd\u7684\u526f\u4f5c\u7528\uff0c\u53c2\u4e0e\u4eba\u6570\u901a\u5e38\u5c11\u4e8e 100 \u4eba\u3002<\/p>\n<p><strong>3.\u7b2c\u4e09\u9636\u6bb5\uff08Phase 3\uff09\uff1a<\/strong><\/p>\n<p>\u5c06\u65b0\u6cbb\u7597\u4e0e\u73b0\u6709\u6cbb\u7597\u8fdb\u884c\u6bd4\u8f83\uff0c\u9a8c\u8bc1\u65b0\u836f\u7269\u7684\u6548\u679c\uff0c\u901a\u5e38\u6709\u8d85\u8fc7 100 \u4eba\u53c2\u4e0e\u3002<\/p>\n<p><strong>4.\u7b2c\u56db\u9636\u6bb5\uff08Phase 4\uff09\uff1a<\/strong><\/p>\n<p>\u836f\u7269\u83b7\u6279\u540e\uff0c\u8bc4\u4f30\u5176\u957f\u671f\u6548\u679c\uff0c\u901a\u5e38\u6709\u8d85\u8fc7 1000 \u540d\u53c2\u4e0e\u8005\u3002<\/p>\n<p><strong>LLM \u7684\u5e94\u7528\u9886\u57df<\/strong><\/p>\n<p><strong>1.\u4e34\u5e8a\u5b9e\u8df5\uff08Clinical Practice\uff09\uff1a<\/strong><\/p>\n<ul>\n<li>ICD\u00a0\u7f16\u7801\uff1a\u5e2e\u52a9\u751f\u6210\u548c\u4f18\u5316\u75be\u75c5\u5206\u7c7b\u7f16\u7801\u3002<\/li>\n<li>\u75c5\u4eba-\u8bd5\u9a8c\u5339\u914d\uff1a\u901a\u8fc7\u5206\u6790\u60a3\u8005\u7279\u5f81\uff0c\u81ea\u52a8\u5339\u914d\u5408\u9002\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<li>\u4e34\u5e8a\u8bd5\u9a8c\u9884\u6d4b\uff1a\u9884\u6d4b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6210\u529f\u7387\u548c\u7ed3\u679c\u3002<\/li>\n<li>\u4e34\u5e8a\u8bd5\u9a8c\u89c4\u5212\uff1a\u534f\u52a9\u7814\u7a76\u4eba\u5458\u5236\u5b9a\u6709\u6548\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u3002<\/li>\n<\/ul>\n<p><strong>2.\u60a3\u8005\u7ed3\u679c\uff08Patient Results\uff09\uff1a<\/strong><\/p>\n<p>\u60a3\u8005\u7ed3\u679c\u9884\u6d4b\uff1a\u6839\u636e\u73b0\u6709\u6570\u636e\u9884\u6d4b\u60a3\u8005\u6cbb\u7597\u7684\u6548\u679c\u3002<\/p>\n<p><strong>3.\u8f85\u52a9\u529f\u80fd\uff08Assistance\uff09\uff1a<\/strong><\/p>\n<ul>\n<li>\u6587\u4ef6\u64b0\u5199\uff1a\u5e2e\u52a9\u751f\u6210\u4e34\u5e8a\u8bd5\u9a8c\u76f8\u5173\u6587\u4ef6\u548c\u62a5\u544a\u3002<\/li>\n<li>\u4fe1\u606f\u68c0\u7d22\uff1a\u5feb\u901f\u67e5\u627e\u548c\u6574\u7406\u4e0e\u8bd5\u9a8c\u76f8\u5173\u7684\u4fe1\u606f\u3002<\/li>\n<li>\u77e5\u8bc6\u89e3\u91ca\uff1a\u5bf9\u590d\u6742\u7684\u533b\u5b66\u6216\u836f\u7269\u4fe1\u606f\u8fdb\u884c\u89e3\u91ca\uff0c\u65b9\u4fbf\u7814\u7a76\u4eba\u5458\u548c\u533b\u751f\u7406\u89e3\u3002<\/li>\n<\/ul>\n<p><strong>\u6210\u719f\u5ea6\u8bc4\u4f30: \u5927\u8bed\u8a00\u6a21\u578b\u5728\u836f\u7269\u7814\u53d1\u7684\u5e94\u7528<\/strong><\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-c3fc1ab48f1c4c811b5b71573038a9d5.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/09\/frc-c3fc1ab48f1c4c811b5b71573038a9d5.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u4e0b\u6e38\u4efb\u52a1\u4e2d\u7684 LLM \u6210\u719f\u5ea6\u8bc4\u4f30\u3002\u8fd9\u5f20\u56fe\u8868\u5c55\u793a\u4e86\u4e24\u79cd\u7c7b\u578b\u7684\u5927\u8bed\u8a00\u6a21\u578b\u7684\u5e94\u7528\u6210\u719f\u5ea6\uff1a\u79d1\u5b66\u5927\u8bed\u8a00\u6a21\u578b\uff08Specialized LMs\uff09\u548c\u4e00\u822c\u5927\u8bed\u8a00\u6a21\u578b\uff08General 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