{"id":35905,"date":"2025-01-02T23:00:17","date_gmt":"2025-01-02T15:00:17","guid":{"rendered":"https:\/\/17aitech.com\/?p=35905"},"modified":"2025-01-02T23:00:17","modified_gmt":"2025-01-02T15:00:17","slug":"%e6%9b%b4%e7%ae%80%e5%8d%95%e3%80%81%e6%9b%b4%e6%b8%85%e6%99%b0%ef%bc%8c%e8%a7%a3%e6%9e%90%e6%a0%b8%e9%85%b8%e3%80%81%e8%9b%8b%e7%99%bd%e3%80%81%e7%bb%86%e8%83%9e%e7%ad%89%e7%bb%93%e6%9e%84%ef%bc%8cai","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=35905","title":{"rendered":"\u66f4\u7b80\u5355\u3001\u66f4\u6e05\u6670\uff0c\u89e3\u6790\u6838\u9178\u3001\u86cb\u767d\u3001\u7ec6\u80de\u7b49\u7ed3\u6784\uff0cAI\u5b9e\u73b0\u5feb\u901f\u5206\u5b50\u6a21\u5f0f\u6316\u6398"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u66f4\u7b80\u5355\u3001\u66f4\u6e05\u6670\uff0c\u89e3\u6790\u6838\u9178\u3001\u86cb\u767d\u3001\u7ec6\u80de\u7b49\u7ed3\u6784\uff0cAI\u5b9e\u73b0\u5feb\u901f\u5206\u5b50\u6a21\u5f0f\u6316\u6398<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91 | \u767d\u83dc\u53f6<\/p>\n

\u4f4e\u6e29\u7535\u5b50\u65ad\u5c42\u626b\u63cf\u6280\u672f\u53ef\u4ee5\u4ee5\u7eb3\u7c73\u7ea7\u5206\u8fa8\u7387\u5bf9\u7ec6\u80de\u4e09\u7ef4\u7ed3\u6784\u8fdb\u884c\u5e38\u89c4\u53ef\u89c6\u5316\u3002\u5f53\u4e0e\u5355\u7c92\u5b50\u65ad\u5c42\u626b\u63cf\u6280\u672f\u76f8\u7ed3\u5408\u65f6\uff0c\u53ef\u4ee5\u83b7\u5f97\u539f\u751f\u73af\u5883\u4e2d\u5e38\u89c1\u5927\u5206\u5b50\u7684\u8fd1\u539f\u5b50\u5206\u8fa8\u7387\u7ed3\u6784\u3002<\/p>\n

\u4f4e\u6e29\u7535\u5b50\u65ad\u5c42\u626b\u63cf\/\u5355\u7c92\u5b50\u65ad\u5c42\u626b\u63cf\uff08CET\/SPT\uff09\u9762\u4e34\u7684\u4e24\u4e2a\u7a81\u51fa\u6311\u6218\u662f\u86cb\u767d\u8d28\u7684\u81ea\u52a8\u8bc6\u522b\u548c\u5b9a\u4f4d\uff0c\u8fd9\u4e24\u9879\u4efb\u52a1\u53d7\u5230\u7ec6\u80de\u5185\u5206\u5b50\u62e5\u6324\u3001\u4f4e\u6e29\u7535\u5b50\u65ad\u5c42\u626b\u63cf\u65ad\u5c42\u56fe\u50cf\u7279\u6709\u7684\u6210\u50cf\u5931\u771f\u4ee5\u53ca\u65ad\u5c42\u626b\u63cf\u6570\u636e\u96c6\u7684\u5e9e\u5927\u89c4\u6a21\u7684\u963b\u788d\u3002<\/p>\n

\u76ee\u524d\u7684\u65b9\u6cd5\u5b58\u5728\u51c6\u786e\u5ea6\u4f4e\u3001\u9700\u8981\u5927\u91cf\u4e14\u8017\u65f6\u7684\u624b\u52a8\u6807\u8bb0\u6216\u4ec5\u9650\u4e8e\u68c0\u6d4b\u7279\u5b9a\u7c7b\u578b\u7684\u86cb\u767d\u8d28\u7684\u95ee\u9898\u3002<\/p>\n

\u675c\u514b\u5927\u5b66\uff08Duke University\uff09\u7684\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86 MiLoPYP\uff0c\u8fd9\u662f\u4e00\u4e2a\u4e24\u6b65\u5f0f\u6570\u636e\u96c6\u7279\u5b9a\u5bf9\u6bd4\u5b66\u4e60\u6846\u67b6\uff0c\u53ef\u5b9e\u73b0\u5feb\u901f\u5206\u5b50\u6a21\u5f0f\u6316\u6398\uff0c\u7136\u540e\u8fdb\u884c\u51c6\u786e\u7684\u86cb\u767d\u8d28\u5b9a\u4f4d\u3002<\/p>\n

MiLoPYP \u80fd\u591f\u6709\u6548\u68c0\u6d4b\u548c\u5b9a\u4f4d\u5404\u79cd\u76ee\u6807\uff0c\u5305\u62ec\u7403\u72b6\u548c\u7ba1\u72b6\u590d\u5408\u7269\u4ee5\u53ca\u5927\u578b\u819c\u86cb\u767d\uff0c\u8fd9\u5c06\u6709\u52a9\u4e8e\u7b80\u5316\u548c\u6269\u5927\u9ad8\u5206\u8fa8\u7387\u5de5\u4f5c\u6d41\u7a0b\u5728\u539f\u4f4d\u7ed3\u6784\u6d4b\u5b9a\u4e2d\u7684\u9002\u7528\u6027\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cMiLoPYP: self-supervised molecular pattern mining and particle localization in situ<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2024 \u5e74 9 \u6708 9 \u65e5\u53d1\u5e03\u5728\u300aNature Methods<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

\u7ec6\u80de\u6837\u672c\u5236\u5907\u3001\u65ad\u5c42\u626b\u63cf\u6570\u636e\u6536\u96c6\u548c\u56fe\u50cf\u5904\u7406\u65b9\u9762\u7684\u6700\u65b0\u8fdb\u5c55\u5df2\u4f7f CET\/SPT\u00a0\u6210\u4e3a\u9ad8\u5206\u8fa8\u7387\u786e\u5b9a\u5929\u7136\u72b6\u6001\u4e0b\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u9996\u9009\u6280\u672f\u3002\u7136\u800c\uff0c\u4e00\u4e2a\u5c1a\u5b58\u7684\u6280\u672f\u6311\u6218\u662f\u7f3a\u4e4f\u8ba1\u7b97\u5de5\u5177\u6765\u6709\u6548\u5730\u7b5b\u9009 CET \u6355\u83b7\u7684\u62e5\u6324\u7ec6\u80de\u73af\u5883\u7684\u5185\u5728\u590d\u6742\u6027\u3002<\/p>\n

\u4e3a\u4e86\u5e94\u5bf9\u8fd9\u4e9b\u6311\u6218\uff0c\u675c\u514b\u5927\u5b66\u7684\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86 MiLoPYP\uff0c\u4e00\u4e2a\u7528\u4e8e\u5206\u5b50\u6a21\u5f0f\u6316\u6398\u7684\u5f3a\u5927\u4e14\u7279\u5b9a\u4e8e\u6570\u636e\u96c6\u7684\u6846\u67b6\uff0c\u5b83\u6709\u52a9\u4e8e\u7ec6\u80de\u5185\u5bb9\u63a2\u7d22\uff0c\u5e76\u5141\u8bb8\u68c0\u6d4b\u5305\u62ec\u7403\u72b6\u3001\u819c\u9644\u7740\u548c\u7ea4\u7ef4\u72b6\u86cb\u767d\u8d28\u5728\u5185\u7684\u591a\u79cd\u76ee\u6807\u3002<\/p>\n

MiLoPYP \u662f\u4e00\u4e2a\u6df1\u5ea6\u5b66\u4e60\u6846\u67b6\uff0c\u7531\u7ec6\u80de\u5185\u5bb9\u6316\u6398\u548c\u63a2\u7d22\u6a21\u5757\u4ee5\u53ca\u86cb\u767d\u8d28\u7279\u5b9a\u7c92\u5b50\u5b9a\u4f4d\u6a21\u5757\u7ec4\u6210\u3002\u8fd9\u4e24\u4e2a\u6a21\u5757\u90fd\u53ea\u9700\u8981\u6781\u5c11\u7684\u76d1\u7763\uff0c\u4ece\u800c\u63d0\u9ad8\u4e86\u5b83\u4eec\u7684\u5b9e\u7528\u6027\u3002<\/p>\n

\u5728\u7ec6\u80de\u5185\u5bb9\u63a2\u7d22\u6a21\u5757\u4e2d\uff0cMiLoPYP \u4e0d\u4f7f\u7528\u4ee5\u6bcf\u4e2a\u4f53\u7d20\u4e3a\u4e2d\u5fc3\u7684\u7b80\u5355\u6ed1\u52a8\u7a97\u53e3\u65b9\u6cd5\uff0c\u800c\u662f\u5229\u7528\u9ad8\u65af\u5dee (DoG) \u91d1\u5b57\u5854\u6765\u8bc6\u522b\u611f\u5174\u8da3\u7684\u5173\u952e\u5750\u6807\uff0c\u4ece\u800c\u63d0\u9ad8\u4e86\u8ba1\u7b97\u6548\u7387\u3002<\/p>\n

\u7136\u540e\u4ece\u65ad\u5c42\u56fe\u50cf\u4e2d\u63d0\u53d6\u4ee5\u8fd9\u4e9b\u5750\u6807\u4e3a\u4e2d\u5fc3\u7684\u5b50\u4f53\u79ef\uff0c\u5e76\u5c06\u5176\u8f93\u5165\u7528\u4e8e\u8868\u5f81\u5b66\u4e60\u7684 Siamese \u7f51\u7edc\u3002\u901a\u8fc7\u5229\u7528\u6210\u5bf9\u7684\u589e\u5f3a\u5b50\u4f53\u79ef\u4f5c\u4e3a\u8f93\u5165\uff0c\u7f51\u7edc\u53ef\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u6bcf\u4e2a\u5b50\u4f53\u79ef\u4e0e\u5176\u589e\u5f3a\u5b50\u4f53\u79ef\u4e4b\u95f4\u7684\u76f8\u4f3c\u6027\uff0c\u4ece\u800c\u65e0\u9700\u4f7f\u7528\u771f\u5b9e\u6807\u7b7e\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aMiLoPYP \u6a21\u5757\u6982\u8ff0\uff0c\u7528\u4e8e\u81ea\u76d1\u7763\u7ec6\u80de\u5185\u5bb9\u63a2\u7d22\u548c\u534a\u76d1\u7763\u7c92\u5b50\u5b9a\u4f4d\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u7ecf\u8fc7\u8bad\u7ec3\u540e\uff0c\u7f51\u7edc\u53ef\u4ee5\u6709\u6548\u5730\u5b66\u4e60\u5c06\u5f62\u72b6\u76f8\u4f3c\u7684\u86cb\u767d\u8d28\u7ec4\u5408\u5728\u4e00\u8d77\uff0c\u540c\u65f6\u5c06\u5f62\u72b6\u4e0d\u540c\u7684\u86cb\u767d\u8d28\u5206\u914d\u7ed9\u8fdc\u8ddd\u79bb\u8868\u793a\u3002<\/p>\n

MiLoPYP \u63d0\u4f9b\u4e86\u4e09\u79cd\u65b9\u6cd5\u6765\u53ef\u89c6\u5316\u5b66\u4e60\u5230\u7684\u5d4c\u5165\uff1a2D \u7f51\u683c\u53ef\u89c6\u5316\u30013D \u65ad\u5c42\u626b\u63cf\u53ef\u89c6\u5316\u548c 3D \u5d4c\u5165\u4ea4\u4e92\u4f1a\u8bdd\u3002<\/p>\n

1\u3001\u5bf9\u4e8e 2D \u7f51\u683c\u53ef\u89c6\u5316\uff0c2D \u7279\u5f81\u5411\u91cf\u88ab\u5206\u914d\u7ed9\u5b50\u65ad\u5c42\u56fe\u7684\u5404\u4e2a xy \u5207\u7247\uff0c\u5e76\u653e\u7f6e\u5728\u6839\u636e\u5f52\u4e00\u5316\u7279\u5f81\u5750\u6807\u503c\u7740\u8272\u7684 2D \u7f51\u683c\u4e0a\u3002<\/p>\n

2\u3001\u5bf9\u4e8e 3D \u65ad\u5c42\u56fe\u53ef\u89c6\u5316\uff0cMiLoPYP \u5141\u8bb8\u901a\u8fc7\u6839\u636e\u5176\u5f52\u4e00\u5316\u7684 2D \u8868\u793a\u4e3a\u65ad\u5c42\u56fe\u4e2d\u7684\u6bcf\u4e2a\u4f53\u7d20\u5206\u914d\u4e0d\u540c\u7684\u989c\u8272\u6765\u6620\u5c04\u6570\u636e\u96c6\u4e2d\u5b58\u5728\u7684\u7ed3\u6784\u591a\u6837\u6027\uff0c\u5176\u4e2d\u76f8\u4f3c\u989c\u8272\u7684\u4f53\u7d20\u8868\u793a\u7ed3\u6784\u540c\u8d28\u7684\u7279\u5f81\u3002<\/p>\n

3\u3001\u5bf9\u4e8e 3D \u5d4c\u5165\u4ea4\u4e92\u4f1a\u8bdd\uff0c\u9996\u5148\u4f7f\u7528\u8fc7\u5ea6\u805a\u7c7b\u7b97\u6cd5\u4e3a\u5d4c\u5165\u5206\u914d\u79bb\u6563\u6807\u7b7e\uff0c\u5e76\u6839\u636e\u5176\u5d4c\u5165\u5750\u6807\u8fdb\u884c\u7740\u8272\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u7ec6\u83cc\u7ec6\u80de\u5185\u5929\u7136\u6838\u7cd6\u4f53\u7684\u7ed3\u6784\u6620\u5c04\u548c\u7cbe\u786e\u8bc6\u522b\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u7528\u6237\u53ef\u4ee5\u4ea4\u4e92\u65b9\u5f0f\u9009\u62e9\u5d4c\u5165\u7a7a\u95f4\u7684\u7279\u5b9a\u533a\u57df\uff0c\u5e76\u901a\u8fc7\u5c06\u5757\u6620\u5c04\u5230\u5176\u539f\u59cb\u65ad\u5c42\u56fe\u50cf\u4f4d\u7f6e\u6765\u65b9\u4fbf\u5730\u53ef\u89c6\u5316\u5757\u3002<\/p>\n

MiLoPYP \u7684\u53ef\u89c6\u5316\u5de5\u5177\u5141\u8bb8\u7528\u6237\u65b9\u4fbf\u5730\u63a2\u7d22\u548c\u9009\u62e9\u5927\u91cf\u65ad\u5c42\u56fe\u50cf\u4e2d\u9891\u7e41\u51fa\u73b0\u7684\u7c92\u5b50\u5b50\u96c6\uff0c\u5e76\u5c06\u5176\u7528\u4f5c\u86cb\u767d\u8d28\u5b9a\u4f4d\u6a21\u5757\u7684\u8f93\u5165\u3002<\/p>\n

\u7531\u4e8e\u539f\u59cb\u7684\u57fa\u4e8e DoG \u7684\u5750\u6807\u901a\u5e38\u7cbe\u5ea6\u8f83\u4f4e\uff0c\u56e0\u6b64\u9700\u8981\u8fdb\u884c\u7ec6\u5316\u6b65\u9aa4\u6765\u63d0\u9ad8\u86cb\u767d\u8d28\u5b9a\u4f4d\u7684\u51c6\u786e\u6027\u3002<\/p>\n

MiLoPYP \u7684\u7ec6\u5316\u6b65\u9aa4\u4ee5\u534a\u76d1\u7763\u65b9\u5f0f\u8fdb\u884c\u8bad\u7ec3\uff0c\u5e76\u751f\u6210\u4e00\u4e2a\u6982\u7387\u70ed\u56fe\uff0c\u8be5\u56fe\u8868\u793a\u7ed9\u5b9a\u86cb\u767d\u8d28\u5728\u65ad\u5c42\u56fe\u50cf\u4e2d\u6bcf\u4e2a\u4f53\u7d20\u4e2d\u5b58\u5728\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

\u7136\u540e\u5bf9\u8be5\u6982\u7387\u70ed\u56fe\u5e94\u7528\u975e\u6700\u5927\u6291\u5236 (NMS)\uff0c\u7136\u540e\u4f7f\u7528\u7528\u6237\u5b9a\u4e49\u7684\u6982\u7387\u503c\u8fdb\u884c\u540e\u5904\u7406\u548c\u9608\u503c\u5904\u7406\u3002\u7ec6\u5316\u6b65\u9aa4\u4ea7\u751f\u7684\u4f4d\u7f6e\u6784\u6210\u6700\u7ec8\u7684 3D \u5750\u6807\u8f93\u51fa\uff0c\u7528\u4e8e\u540e\u7eed\u7684 SPT \u7ec6\u5316\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u4ece\u539f\u4f4d\u7247\u5c42\u4e2d\u540c\u65f6\u8bc6\u522b\u548c\u786e\u5b9a\u591a\u79cd\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

MiLoPYP \u63d0\u4f9b\u4e86\u4e00\u79cd\u4fbf\u6377\u7684\u5de5\u5177\u6765\u7ed8\u5236\u7ec6\u80de\u5185\u90e8\u56fe\u8c31\u5e76\u627e\u5230\u591a\u79cd\u86cb\u767d\u8d28\u5728\u5176\u539f\u751f\u73af\u5883\u4e2d\u7684\u4f4d\u7f6e\uff0c\u8fd9\u662f SPT \u8fdb\u884c\u9ad8\u5206\u8fa8\u7387\u5206\u6790\u6240\u5fc5\u9700\u7684\u3002MiLoPYP \u65e0\u9700\u8d39\u529b\u7684\u624b\u52a8\u6807\u8bb0\uff0c\u5373\u53ef\u6709\u6548\u5730\u7ed8\u5236\u6574\u5957\u65ad\u5c42\u56fe\u8c31\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u89e3\u91ca\u3001\u53d1\u73b0\u548c\u9009\u62e9\u76ee\u6807\u5927\u5206\u5b50\u3002<\/p>\n

\u9664\u4e86\u7cbe\u786e\u8bc6\u522b\u7403\u72b6\u5927\u5206\u5b50\u5916\uff0cMiLoPYP \u8fd8\u53ef\u4ee5\u51c6\u786e\u68c0\u6d4b\u819c\u7ed3\u5408\u548c\u7ba1\u72b6\u590d\u5408\u7269\uff0c\u4f7f\u5176\u6210\u4e3a\u539f\u4f4d\u5206\u5b50\u6a21\u5f0f\u6316\u6398\u7684\u591a\u529f\u80fd\u5de5\u5177\u3002\u91cd\u8981\u7684\u662f\uff0c\u8be5\u6846\u67b6\u5177\u6709\u8ba1\u7b97\u6548\u7387\uff0c\u80fd\u591f\u5904\u7406\u6570\u767e\u5f20\u65ad\u5c42\u56fe\uff0c\u8fd9\u662f\u9ad8\u5206\u8fa8\u7387 SPT \u5206\u6790\u6240\u9700\u7684\u3002<\/p>\n

\u5f00\u6e90\u5730\u5740\uff1ahttps:\/\/github.com\/nextpyp\/cet_pick<\/em><\/p>\n

\u7528\u6237\u6307\u5357\uff1ahttps:\/\/nextpyp.app\/milopyp\/<\/em><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41592-024-02403-6<\/em><\/p>\n

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