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\u7f16\u8f91\u00a0| ScienceAI<\/p>\n

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\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41422-024-01034-y<\/em><\/section>\n

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GeneCompass\u91c7\u7528\u57fa\u4e8eTransformer\u7684\u6df1\u5ea6\u5b66\u4e60<\/mark>\u67b6\u6784\uff0c\u6269\u5c55\u4f20\u7edf\u7684\u63a9\u7801\u8bed\u8a00\u6a21\u578b<\/mark>Masked Auto Encoder\uff08MAE\uff09\u65b9\u5f0f\u8fdb\u884c\u9884\u8bad\u7ec3\uff0c\u6839\u636e\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u4e0a\u4e0b\u6587\u540c\u65f6\u9884\u6d4b\u63a9\u7801\u7684\u57fa\u56e0\u53ca\u5176\u57fa\u56e0\u8868\u8fbe\uff0c\u6355\u83b7\u4e0d\u540c\u57fa\u56e0\u4e4b\u95f4\u5728\u4e0d\u540c\u7ec6\u80de\u80cc\u666f\u4e0b\u7684\u957f\u7a0b\u52a8\u6001\u5173\u8054\uff0c\u901a\u8fc7\u591a\u4efb\u52a1\u8054\u5408\u9884\u8bad\u7ec3\u5f62\u6210\u66f4\u52a0\u7ec6\u7c92\u5ea6\u7684\u751f\u547d\u57fa\u7840\u5927\u6a21\u578b\u3002\u9884\u8bad\u7ec3\u5b8c\u6210\u540e\uff0cGeneCompass\u8fdb\u4e00\u6b65\u5e94\u7528\u4e8e\u591a\u79cd\u4e0b\u6e38\u4efb\u52a1\uff0c\u7528\u4e8e\u5bf9\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u8fdb\u884c\u7f16\u7801\uff0c\u652f\u6491\u7ec6\u80de\u7c7b\u578b\u6807\u6ce8\u3001\u57fa\u56e0\u6270\u52a8\u9884\u6d4b\u3001\u836f\u7269\u53cd\u5e94\u9884\u6d4b\u548c\u57fa\u56e0\u8c03\u63a7\u5173\u7cfb\u9884\u6d4b\u7b49\u4efb\u52a1\u3002<\/p>\n

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\u56fe\u793a\uff1aGeneCompass\u6a21\u578b\u67b6\u6784\u3002<\/section>\n

\u89c4\u6a21\u6548\u5e94\uff1a\u591a\u7269\u79cd\u8054\u5408\u8bad\u7ec3\u6355\u83b7\u751f\u7269\u8fdb\u5316\u4fdd\u5b88\u89c4\u5f8b<\/strong><\/p>\n

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\u7814\u7a76\u7ed3\u679c\uff1aGeneCompass\u5177\u6709\u8de8\u7269\u79cd\u8868\u5f81\u80fd\u529b<\/strong><\/p>\n

\u7814\u7a76\u4eba\u5458\u5bf9\u4eba\u7c7b\u548c\u5c0f\u9f20\u540c\u4e00\u7ec6\u80de\u7c7b\u578b\uff08\u5fc3\u808c\u7ec6\u80de\uff09\u4e2d\u540c\u6e90\u57fa\u56e0\u548c\u975e\u540c\u6e90\u57fa\u56e0\u7684GeneCompass\u7f16\u7801\u8fdb\u884c\u4e86\u76f8\u4f3c\u6027\u5206\u6790\uff0c\u53ef\u4ee5\u770b\u51fa\u76f8\u8f83\u4e8e\u975e\u540c\u6e90\u57fa\u56e0\uff0c\u4e0d\u540c\u7269\u79cd\u7684\u540c\u6e90\u57fa\u56e0\u5177\u6709\u66f4\u76f8\u4f3c\u7684\u7f16\u7801\uff0c\u540c\u6e90\u57fa\u56e0\u5728\u4eba\u7c7b\u548c\u5c0f\u9f20\u4e4b\u95f4\u4e5f\u5177\u6709\u76f8\u4f3c\u7684\u57fa\u56e0\u8c03\u63a7\u5173\u7cfb\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u4e0d\u540c\u7269\u79cd\u7684\u540c\u6e90\u57fa\u56e0\u5177\u6709\u66f4\u76f8\u4f3c\u7684GeneCompass\u7f16\u7801\u3002<\/section>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u4eba\u7c7b\u548c\u5c0f\u9f20\u5fc3\u808c\u7ec6\u80de\u4e2dGATA4\u57fa\u56e0\u5177\u6709\u76f8\u4f3c\u7684\u8c03\u63a7\u5173\u7cfb\u3002<\/section>\n

\u7814\u7a76\u4eba\u5458\u5c06GeneCompass\u7f16\u7801\u540e\u7684\u57fa\u56e0\u5d4c\u5165\u4e0e\u8de8\u7269\u79cd\u7ec6\u80de\u7c7b\u578b\u6807\u6ce8\u7684SOTA\u65b9\u6cd5CAME\u8fdb\u884c\u7ed3\u5408\uff0c\u53d1\u73b0\u5728\u591a\u79cd\u7ec6\u80de\u5c24\u5176\u662f\u89c6\u7f51\u819c\u7ec6\u80de\u4e2d\uff0cGeneCompass\u80fd\u591f\u663e\u8457\u63d0\u5347\u8de8\u7269\u79cd\u7ec6\u80de\u7c7b\u578b\u6807\u6ce8\u7684\u7cbe\u5ea6\u3002\u8fd9\u4e9b\u7ed3\u679c\u90fd\u5c55\u793a\u4e86GeneCompass\u901a\u8fc7\u591a\u7269\u79cd\u8054\u5408\u9884\u8bad\u7ec3\u83b7\u5f97\u4e86\u751f\u547d\u5e95\u5c42\u7684\u5171\u6027\u89c4\u5f8b\uff0c\u589e\u5f3a\u4e86\u57fa\u56e0\u8868\u5f81\u7684\u80fd\u529b\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u8de8\u7269\u79cd\u7ec6\u80de\u7c7b\u578b\u6807\u6ce8\u3002<\/section>\n

\u4e0b\u6e38\u4efb\u52a1\uff1a\u57fa\u56e0\u6270\u52a8\u9884\u6d4b\u4efb\u52a1<\/strong><\/p>\n

\u7814\u7a76\u4eba\u5458\u5229\u7528GeneCompass\u7f16\u7801\u7684\u57fa\u56e0\u5d4c\u5165\u6765\u9884\u6d4b\u7531\u57fa\u56e0\u6270\u52a8\u6240\u5bfc\u81f4\u7684\u5168\u5c40\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\uff0c\u5c06\u5176\u4e0e\u73b0\u6709\u5de5\u4f5cGEARS\u7ed3\u5408\u8d77\u6765\uff0c\u66ff\u6362\u4e86\u539f\u59cb\u4ece\u5171\u8868\u8fbe\u77e5\u8bc6\u56fe\u8c31<\/mark>\u4e2d\u5b66\u4e60\u5230\u7684\u57fa\u56e0\u5d4c\u5165\u3002\u5728\u524d20\u4e2a\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0(DEG)\u7684\u5747\u65b9\u8bef\u5dee(MSE)\u5e73\u5747\u964d\u4f4e\u4e8615.4%\uff0c\u4f7f\u5355\u57fa\u56e0\u6270\u52a8\u7684\u504f\u5dee\u51cf\u5c11\u4e865.9%\uff0c\u53cc\u57fa\u56e0\u6270\u52a8\u7684\u504f\u5dee\u51cf\u5c11\u4e8612.5%\u3002\u4e0b\u56fe\u5c55\u793a\u4e86\u53cc\u57fa\u56e0\u6270\u52a8TGFBR2+PRTG\u524d20\u4e2a\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\uff0c GeneCompass \u768417\/20 DEG\u9884\u6d4b\u7ed3\u679c\u6bd4GEARS \u7684\u9884\u6d4b\u7ed3\u679c\u66f4\u51c6\u786e\u3002<\/p>\n

<\/a><\/p>\n

\u4e0b\u6e38\u4efb\u52a1\uff1a\u836f\u7269\u53cd\u5e94\u9884\u6d4b\u3001\u57fa\u56e0\u8c03\u63a7\u9884\u6d4b\u3001\u836f\u7269\u5242\u91cf\u53cd\u5e94\u9884\u6d4b\u3001\u57fa\u56e0\u8868\u8fbe\u8c31\u9884\u6d4b<\/strong><\/p>\n

GeneCompass\u4f5c\u4e3a\u751f\u547d\u57fa\u7840\u5927\u6a21\u578b\uff0c\u652f\u6301\u76f4\u63a5\u4f7f\u7528\uff08zero-shot\uff09\u548c\u5fae\u8c03\uff08fine-tune\uff09\u4e24\u79cd\u6a21\u5f0f\u3002\u57fa\u4e8e\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u5728\u836f\u7269\u53cd\u5e94\u9884\u6d4b\u3001\u57fa\u56e0\u8c03\u63a7\u9884\u6d4b\u3001\u836f\u7269\u5242\u91cf\u53cd\u5e94\u9884\u6d4b\u3001\u57fa\u56e0\u8868\u8fbe\u8c31\u9884\u6d4b\u7b49\u591a\u79cd\u4e0b\u6e38\u4efb\u52a1\u4e0a\u8fdb\u884c\u4e86\u5145\u5206\u5b9e\u9a8c\uff0c\u9a8c\u8bc1\u4e86GeneCompass\u5728\u4e0d\u540c\u4efb\u52a1\u4e2d\u7684\u9002\u914d\u6027\u3002\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0cGeneCompass \u5728\u4e0d\u540c\u4e0b\u6e38\u4efb\u52a1\u4e2d\u5747\u53ef\u8fbe\u5230SOTA\u6c34\u5e73\uff0c\u76f8\u6bd4\u4e8e\u4f20\u7edf\u751f\u7269\u5b66\u65b9\u6cd5\u5bf9\u751f\u547d\u5e95\u5c42\u89c4\u5f8b\u5177\u6709\u66f4\u6df1\u7684\u7406\u89e3\u3002<\/p>\n

<\/a><\/p>\n

\u4e0b\u6e38\u4efb\u52a1\uff1a\u7ec6\u80de\u547d\u8fd0\u9884\u6d4b\u548c\u5173\u952e\u57fa\u56e0\u7b5b\u9009<\/strong><\/p>\n

\u7531\u4e8e\u57fa\u56e0\u53ca\u5176\u8868\u8fbe\u503c\u5728\u81ea\u76d1\u7763\u9884\u8bad\u7ec3\u8fc7\u7a0b\u4e2d\u540c\u65f6\u88ab\u63a9\u7801\u548c\u91cd\u5efa\uff0cGeneCompass\u80fd\u591f\u6355\u6349\u590d\u6742\u7684\u8c03\u63a7\u673a\u5236\uff0c\u5b9e\u73b0\u5b9a\u91cf\u7684\u6a21\u62df\u57fa\u56e0\u6270\u52a8\u3002\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u79cd\u80fd\u529b\uff0c\u7814\u7a76\u4eba\u5458\u6784\u5efaiPSC\u6a21\u62df\u8bf1\u5bfc\u5b9e\u9a8c\uff0c\u5728\u4eba\u7c7b\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u6a21\u62df\u4e24\u4e2a\u6c34\u5e73\u7684OSKM \u57fa\u56e0\uff08Oct4\u3001Sox2\u3001Klf4 \u548c c-Myc\uff09\u8fc7\u8868\u8fbe\u3002\u901a\u8fc7\u5bf9\u6bd4\u7ec6\u80de\u72b6\u6001\u5d4c\u5165\u7684\u76f8\u4f3c\u6027\u53ef\u4ee5\u770b\u51fa\uff0c\u968f\u7740\u8fc7\u8868\u8fbe\u6c34\u5e73\u7684\u63d0\u9ad8\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\u9010\u6e10\u5411iPSC\u7ec6\u80de\u53d1\u80b2\u3002\u8fd9\u4e0e\u73b0\u6709\u7ed3\u8bba\u662f\u4e00\u81f4\u7684\uff0c\u8bf4\u660eGeneCompass\u5177\u6709\u7528\u4e8e\u7ec6\u80de\u547d\u8fd0\u9884\u6d4b\u7684\u6f5c\u529b\u3002<\/p>\n

<\/a><\/p>\n

\u6b64\u5916\uff0cGeneCompass\u53ef\u901a\u8fc7\u6a21\u62df\u57fa\u56e0\u6270\u52a8\u5206\u6790\u9884\u6d4b\u7ec6\u80de\u547d\u8fd0\u8f6c\u53d8\u4e2d\u7684\u5173\u952e\u8c03\u63a7\u56e0\u5b50\uff0c\u6709\u671b\u63d0\u9ad8\u6e7f\u5b9e\u9a8c\u7684\u6548\u7387\u5e76\u63ed\u793a\u65b0\u673a\u5236\u3002\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u4eba\u7c7bESC\u7ec6\u80de\u5411\u6027\u817a\u7ec6\u80de\u5206\u5316\u7684\u5b9e\u9a8c\uff0c\u5229\u7528GeneCompass\u5728ESC\u7ec6\u80de\u4e0a\u5f00\u5c55\u5e7f\u6cdb\u7684\u5355\u57fa\u56e0\u6a21\u62df\u8fc7\u8868\u8fbe\u3002\u901a\u8fc7\u6bd4\u8f83\u521d\u59cb\u3001\u6a21\u62df\u548c\u76ee\u6807\u7ec6\u80de\u5d4c\u5165\u4e4b\u95f4\u7684\u4f59\u5f26\u76f8\u4f3c\u5ea6\uff0c\u7814\u7a76\u4eba\u5458\u786e\u5b9a\u4e86\u4e94\u4e2a\u6f5c\u5728\u57fa\u56e0\uff0c\u5373 NR2F1\u3001NR5A1\u3001WT1\u3001TCF21 \u548c GATA4\u3002\u5176\u4e2d\u4e09\u4e2a\uff08 WT1\u3001NR5A1 \u548c NR2F1\uff09\u5df2\u6709\u7814\u7a76\u6210\u679c\u9a8c\u8bc1\u5bf9\u5c0f\u9f20\u4f53\u5185\u6027\u817a\u53d1\u80b2\u81f3\u5173\u91cd\u8981\u3002\u8fdb\u800c\uff0c\u7814\u7a76\u4eba\u5458\u5728 ESC \u4e2d\u5206\u522b\u8fc7\u8868\u8fbeNR5A1\u548c GATA4\uff0c\u514d\u75ab\u8367\u5149\u7ed3\u679c\u8868\u660e\uff0c\u5728\u4eba\u7c7b ESC \u4e2d\u5355\u72ec\u8fc7\u8868\u8fbe\u4efb\u4e00\u57fa\u56e0\u5747\u53ef\u8bf1\u5bfc\u6027\u817a\u57fa\u56e0\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aGeneCompass\u53ef\u7528\u4e8e\u6a21\u62df\u57fa\u56e0\u6270\u52a8\u4ee5\u6316\u6398\u5173\u952e\u8c03\u63a7\u56e0\u5b50\u3002<\/section>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u514d\u75ab\u8367\u5149\u7ed3\u679c\u8868\u660e\uff0c\u5728\u4eba\u7c7b ESC \u4e2d\u5355\u72ec\u8fc7\u8868\u8fbe\u4efb\u4e00\u57fa\u56e0\u5747\u53ef\u8bf1\u5bfc\u6027\u817a\u57fa\u56e0\u3002<\/section>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u4e3a\u8fc4\u4eca\u4e3a\u6b62\u6700\u5927\u89c4\u6a21\u7684\u3001\u5177\u6709\u77e5\u8bc6\u5d4c\u5165\u7684\u8de8\u7269\u79cd\u9884\u8bad\u7ec3\u751f\u547d\u57fa\u7840\u5927\u6a21\u578b\uff0cGeneCompass\u53ef\u5b9e\u73b0\u591a\u4e2a\u8de8\u7269\u79cd\u4e0b\u6e38\u4efb\u52a1\u7684\u8fc1\u79fb\u5b66\u4e60<\/mark>\uff0c\u5e76\u5728\u7ec6\u80de\u7c7b\u578b\u6ce8\u91ca\u3001\u5b9a\u91cf\u57fa\u56e0\u6270\u52a8\u9884\u6d4b\u3001\u836f\u7269\u654f\u611f\u6027\u5206\u6790<\/mark>\u7b49\u65b9\u9762\uff0c\u76f8\u6bd4\u5df2\u6709\u65b9\u6cd5\u53d6\u5f97\u66f4\u4f18\u6027\u80fd\u3002\u8fd9\u5145\u5206\u5c55\u793a\u4e86\u57fa\u4e8e\u591a\u7269\u79cd\u65e0\u6807\u6ce8\u5927\u6570\u636e\u9884\u8bad\u7ec3\uff0c\u518d\u5229\u7528\u4e0d\u540c\u5b50\u4efb\u52a1\u6570\u636e\u8fdb\u884c\u6a21\u578b\u5fae\u8c03\u7684\u7b56\u7565\u4f18\u52bf\uff0c\u6709\u671b\u6210\u4e3a\u5b9e\u73b0\u57fa\u56e0-\u7ec6\u80de\u7279\u5f81\u76f8\u5173\u8054\u7684\u5404\u79cd\u751f\u7269\u95ee\u9898\u5206\u6790\u9884\u6d4b\u7684\u901a\u7528\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n

\u4e0a\u8ff0\u7814\u7a76\u7531\u300c\u6307\u5357\u9488\u8054\u76df\u300d\u56e2\u961f\u5b8c\u6210\uff0c\u300c\u6307\u5357\u9488\u8054\u76df\u300d\u56e2\u961f\u76ee\u524d\u7531\u5317\u4eac\u5e72\u7ec6\u80de\u4e0e\u518d\u751f\u533b\u5b66\u7814\u7a76\u9662\/\u4e2d\u56fd\u79d1\u5b66\u9662\u52a8\u7269\u7814\u7a76\u6240\u674e\u946b\u56e2\u961f\u8054\u5408\u8ba1\u7b97\u673a\u7f51\u7edc\u4fe1\u606f\u4e2d\u5fc3\uff0c\u81ea\u52a8\u5316\u7814\u7a76\u6240\uff0c\u8ba1\u7b97\u6280\u672f\u7814\u7a76\u6240\uff0c\u6570\u5b66\u4e0e\u7cfb\u7edf\u79d1\u5b66\u7814\u7a76\u9662\u7b49\u7ec4\u6210\uff0c\u8054\u76df\u7684\u76ee\u6807\u662f\u5efa\u7acb\u6570\u667a\u9a71\u52a8\u7684\u751f\u547d\u79d1\u5b66\u7814\u7a76\u65b0\u8303\u5f0f\uff0c\u89e3\u6790\u751f\u547d\u7684\u672c\u8d28\u89c4\u5f8b\u3002<\/p>\n

\u52a0\u5165\u6211\u4eec\uff1a<\/strong><\/p>\n

\u4e2d\u56fd\u79d1\u5b66\u9662\u52a8\u7269\u7814\u7a76\u6240\/\u4e2d\u56fd\u79d1\u5b66\u9662\u5e72\u7ec6\u80de\u4e0e\u518d\u751f\u533b\u5b66\u521b\u65b0\u7814\u7a76\u9662\u5e72\u7ec6\u80de\u5fae\u73af\u5883\u4e0e\u7ec6\u80de\u547d\u8fd0\u51b3\u5b9a\u7814\u7a76\u7ec4\uff08\u674e\u946b\u7814\u7a76\u7ec4\uff09\u957f\u671f\u62db\u8058\u535a\u58eb\u540e\u82e5\u5e72\u540d\uff0c\u52a9\u7406\u7814\u7a76\u54581\u540d\uff0c\u79d1\u7814\u52a9\u7406\uff08\u884c\u653f\u5c97\uff091\u540d\u3002\u5b9e\u9a8c\u5ba4\u5c06\u4e3a\u7533\u8bf7\u4eba\u63d0\u4f9b\u6d53\u539a\u7684\u5b66\u672f\u6c1b\u56f4\u3001\u4e13\u6ce8\u7684\u79d1\u7814\u73af\u5883\u548c\u826f\u597d\u7684\u5408\u4f5c\u5e73\u53f0\uff0c\u5e76\u6709\u673a\u4f1a\u53c2\u4e0e\u56fd\u5185\u5916\u8457\u540d\u5b9e\u9a8c\u5ba4\u7684\u5408\u4f5c\u9879\u76ee\uff0c\u62d3\u5c55\u5b66\u672f\u89c6\u91ce\uff0c\u5728\u5b66\u672f\u754c\u53ca\u5de5\u4e1a\u754c\u7b51\u9020\u826f\u597d\u7684\u804c\u4e1a\u524d\u666f\u57fa\u7840\u3002<\/p>\n

\u6709\u610f\u8005\u8bf7\u5c06\u76f8\u5173\u6750\u6599\u4ee5\u9644\u4ef6\u5f62\u5f0f\u53d1\u9001\u5230E-mail\uff1axinli@ioz.ac.cn\uff0c\u6284\u9001zhang_jie0115@163.com\u3002\u90ae\u4ef6\u53ca\u9644\u4ef6\u540d\u79f0\u4e3a\uff1a\u5e94\u8058\u5c97\u4f4d+\u4e2a\u4eba\u59d3\u540d+\u6700\u540e\u5b66\u5386\u4e13\u4e1a\u3002<\/p>\n

\u8054\u7cfb\u4eba\u53ca\u8054\u7cfb\u7535\u8bdd\uff1a\u674e\u8001\u5e08\uff0c010-64807060<\/p>\n

\u5f20\u8001\u5e08\uff0c18920027879\uff08\u540c\u5fae\u4fe1\uff09<\/p>\n

\u6b22\u8fce\u6765\u7535\u6216\u8005\u90ae\u4ef6\u54a8\u8be2\uff01<\/p>\n

\n
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\n
\n
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