{"id":36097,"date":"2025-01-05T22:00:15","date_gmt":"2025-01-05T14:00:15","guid":{"rendered":"https:\/\/17aitech.com\/?p=36097"},"modified":"2025-01-05T22:00:15","modified_gmt":"2025-01-05T14:00:15","slug":"nature%e5%ad%90%e5%88%8a%ef%bc%8c%e9%a6%99%e6%b8%af%e6%b5%b8%e5%a4%a7%e3%80%81%e8%8b%b1%e4%bc%9f%e8%be%be%e5%9b%a2%e9%98%9f%e5%a4%9a%e6%a8%a1%e6%80%81%e6%b7%b1%e5%ba%a6%e8%af%ad%e8%a8%80%e6%a8%a1","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=36097","title":{"rendered":"Nature\u5b50\u520a\uff0c\u9999\u6e2f\u6d78\u5927\u3001\u82f1\u4f1f\u8fbe\u56e2\u961f\u591a\u6a21\u6001\u6df1\u5ea6\u8bed\u8a00\u6a21\u578b\uff0c\u7528\u4e8e\u590d\u6742\u7684\u5b8f\u57fa\u56e0\u7ec4\u7814\u7a76"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:Nature\u5b50\u520a\uff0c\u9999\u6e2f\u6d78\u5927\u3001\u82f1\u4f1f\u8fbe\u56e2\u961f\u591a\u6a21\u6001\u6df1\u5ea6\u8bed\u8a00\u6a21\u578b\uff0c\u7528\u4e8e\u590d\u6742\u7684\u5b8f\u57fa\u56e0\u7ec4\u7814\u7a76<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

\u5b8f\u57fa\u56e0\u7ec4\u7ec4\u88c5\u57fa\u56e0\u7ec4 (MAG) \u4e3a\u5229\u7528\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u63a2\u7d22\u5fae\u751f\u7269\u300c\u6697\u7269\u8d28\u300d\u63d0\u4f9b\u4e86\u5b9d\u8d35\u7684\u89c1\u89e3\u3002<\/p>\n

\u7136\u800c\uff0c\u4eba\u4eec\u8d8a\u6765\u8d8a\u62c5\u5fc3 MAG \u4e2d\u7684\u6c61\u67d3\u53ef\u80fd\u4f1a\u4e25\u91cd\u5f71\u54cd\u4e0b\u6e38\u5206\u6790\u7684\u7ed3\u679c\u3002\u76ee\u524d\u7684 MAG \u51c0\u5316\u5de5\u5177\u4e3b\u8981\u4f9d\u8d56\u4e8e\u6807\u8bb0\u57fa\u56e0\uff0c\u5e76\u6ca1\u6709\u5145\u5206\u5229\u7528\u57fa\u56e0\u7ec4\u5e8f\u5217\u7684\u80cc\u666f\u4fe1\u606f\u3002<\/p>\n

\u4e3a\u4e86\u514b\u670d\u8fd9\u4e00\u9650\u5236\uff0c\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\uff08Hong Kong Baptist University\uff09\u548c\u82f1\u4f1f\u8fbe AI \u6280\u672f\u4e2d\u5fc3\uff08NVIDIA AI Technology Center\uff09\u7684\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86 Deepurify \u6765\u8fdb\u884c MAG \u51c0\u5316\u3002<\/p>\n

Deepurify \u4f7f\u7528\u591a\u6a21\u6001\u6df1\u5ea6\u8bed\u8a00\u6a21\u578b\u548c\u5bf9\u6bd4\u5b66\u4e60\u6765\u5339\u914d\u5fae\u751f\u7269\u57fa\u56e0\u7ec4\u5e8f\u5217\u4e0e\u5176\u5206\u7c7b\u8c31\u7cfb\u3002\u5b83\u5c06 MAG \u5185\u7684\u00a0contig \u5206\u914d\u7ed9 MAG \u5206\u79bb\u6811\uff0c\u5e76\u5e94\u7528\u6811\u904d\u5386\u7b97\u6cd5\u5c06 MAG \u5212\u5206\u4e3a\u5b50 MAG\uff0c\u76ee\u7684\u662f\u6700\u5927\u5316\u9ad8\u8d28\u91cf\u548c\u4e2d\u8d28\u91cf\u5b50 MAG \u7684\u6570\u91cf\u3002<\/p>\n

Deepurify \u5728\u6a21\u62df\u6570\u636e\u3001CAMI \u6570\u636e\u96c6\u548c\u590d\u6742\u7a0b\u5ea6\u5404\u5f02\u7684\u771f\u5b9e\u6570\u636e\u96c6\u4e0a\u7684\u8868\u73b0\u5747\u4f18\u4e8e\u7ade\u54c1\uff08MDMclearer \u548c MAGpurify\uff09\u3002\u5728\u571f\u58e4\u3001\u6d77\u6d0b\u3001\u690d\u7269\u3001\u6de1\u6c34\u548c\u4eba\u7c7b\u7caa\u4fbf\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u96c6\u4e2d\uff0cDeepurify \u5206\u522b\u4f7f\u9ad8\u8d28\u91cf MAG \u7684\u6570\u91cf\u589e\u52a0\u4e86 20.0%\u300145.1%\u300145.5%\u300133.8% \u548c 28.5%\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cA multi-modal deep language model for contaminant removal from metagenome-assembled genomes<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2024 \u5e74 10 \u6708 7 \u65e5\u53d1\u5e03\u5728\u300aNature Machine Intelligence<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

\u5229\u7528\u77ed\u8bfb\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u8fdb\u884c\u57fa\u56e0\u7ec4\u7ec4\u88c5\u5df2\u6210\u4e3a\u7814\u7a76\u590d\u6742\u73af\u5883\u4e2d\u5fae\u751f\u7269\u6697\u7269\u8d28\u7684\u5e38\u7528\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u5355\u4e2a\u91cd\u53e0\u7fa4\u4ec5\u6355\u83b7\u5b8c\u6574\u5fae\u751f\u7269\u57fa\u56e0\u7ec4\u7684\u4e00\u4e2a\u7247\u6bb5\u3002\u56e0\u6b64\uff0c\u9700\u8981\u8fdb\u884c\u91cd\u53e0\u7fa4\u5206\u7bb1\uff0c\u5c06\u5177\u6709\u76f8\u4f3c\u5e8f\u5217\u7279\u5f81\u548c\u4e30\u5ea6\u7684\u91cd\u53e0\u7fa4\u5206\u7ec4\u4ee5\u4ee3\u8868\u5fae\u751f\u7269\u57fa\u56e0\u7ec4\u3002<\/p>\n

\u6709\u7814\u7a76\u8868\u660e\uff0cMAG \u6c61\u67d3\u662f\u5b8f\u57fa\u56e0\u7ec4\u7ec4\u88c5\u4e2d\u91cd\u53e0\u7fa4\u5206\u7bb1\u8fc7\u7a0b\u4e2d\u7684\u4e00\u5927\u6311\u6218\u3002\u5df2\u7ecf\u5f00\u53d1\u51fa MAGpurify \u548c MDMcleaner \u7b49\u5de5\u5177\u6765\u89e3\u51b3\u6b64\u95ee\u9898\uff0c\u65b9\u6cd5\u662f\u4ece MAG \u4e2d\u53bb\u9664\u53d7\u6c61\u67d3\u7684\u91cd\u53e0\u7fa4\u3002<\/p>\n

\u7136\u800c\uff0c\u8fd9\u4e9b\u5de5\u5177\u6709\u4e00\u4e9b\u5c40\u9650\u6027\u3002\u5982\u679c\u6838\u5fc3\u57fa\u56e0\u7ec4\u548c\u53d7\u6c61\u67d3\u57fa\u56e0\u7ec4\u7684\u00a0LCA \u5c5e\u4e8e\u540c\u4e00\u79d1\u6216\u5c5e\uff0c\u5b83\u4eec\u5f88\u96be\u533a\u5206\u91cd\u53e0\u7fa4\u3002<\/p>\n

\u540c\u65f6\uff0c\u8fd8\u6709\u6765\u81ea\u6e90\u57fa\u56e0\u7ec4\u7684\u91cd\u53e0\u7fa4\u7684\u6311\u6218\uff0c\u8fd9\u4e9b\u91cd\u53e0\u7fa4\u5728\u53c2\u8003\u6570\u636e\u5e93\u4e2d\u662f\u4e0d\u5b58\u5728\u7684\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u5de5\u5177\u4e3b\u8981\u5173\u6ce8\u57fa\u56e0\uff0c\u800c\u5ffd\u7565\u4e86\u57fa\u56e0\u987a\u5e8f\u548c\u57fa\u56e0\u7ec4\u91cd\u6392\u7b49\u57fa\u56e0\u7ec4\u53d8\u5f02\u3002<\/p>\n

\u5728\u6700\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\u548c\u82f1\u4f1f\u8fbe AI \u6280\u672f\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86 Deepurify\uff0c\u4e00\u79cd\u591a\u6a21\u6001\u6df1\u5ea6\u8bed\u8a00\u6a21\u578b\uff0c\u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u548c\u5e7f\u4e49\u7684 MAG \u51c0\u5316\u3002<\/p>\n

\u5728\u8bad\u7ec3\u8fc7\u7a0b\u4e2d\uff0cDeepurify \u4f7f\u7528\u4e24\u4e2a\u7f16\u7801\u5668\uff0cGseqFormer \u548c\u957f\u77ed\u671f\u8bb0\u5fc6 (LSTM)\uff0c\u5206\u522b\u751f\u6210\u57fa\u56e0\u7ec4\u5e8f\u5217\u53ca\u5176\u6e90\u57fa\u56e0\u7ec4\u5206\u7c7b\u8c31\u7cfb\u7684\u5d4c\u5165\u3002\u7136\u540e\uff0c\u8fd9\u4e9b\u5d4c\u5165\u7528\u4e8e\u5bf9\u6bd4\u5b66\u4e60\uff0c\u4ee5\u5efa\u7acb\u8fd9\u4e24\u79cd\u7c7b\u578b\u7684\u6a21\u6001\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aDeepurify \u8bad\u7ec3\u6d41\u7a0b\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u5728\u51c0\u5316\u8fc7\u7a0b\u4e2d\uff0cDeepurify \u9996\u5148\u6839\u636e\u9884\u6d4b\u7684\u5206\u7c7b\u8c31\u7cfb\u8bc4\u4f30 MAG \u4e2d\u91cd\u53e0\u7fa4\u7684\u5206\u7c7b\u76f8\u4f3c\u6027\u3002\u9884\u6d4b\u7684\u5206\u7c7b\u8c31\u7cfb\u7528\u4e8e\u6784\u5efa MAG \u5206\u79bb\u6811\uff0c\u5176\u4e2d\u6bcf\u4e2a\u8282\u70b9\u5305\u542b\u7279\u5b9a\u5206\u7c7b\u7fa4\u4e2d\u5177\u6709\u76f8\u540c\u5206\u7c7b\u8c31\u7cfb\u7684\u91cd\u53e0\u7fa4\u3002\u6bcf\u4e2a\u8282\u70b9\u7684\u91cd\u53e0\u7fa4\u6839\u636e\u5176\u5e8f\u5217\u5d4c\u5165\u548c\u6ce8\u91ca\u7684\u5355\u62f7\u8d1d\u57fa\u56e0 (SCG) \u5206\u7ec4\u4e3a\u5b50 MAG\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aDeepurify \u7528\u4e8e MAG \u51c0\u5316\u7684\u5de5\u4f5c\u6d41\u7a0b\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86\u4e00\u79cd\u6811\u904d\u5386\u7b97\u6cd5\u6765\u9009\u62e9\u5b50 MAG\uff0c\u65e8\u5728\u4ece\u6811\u4e2d\u6700\u5927\u5316\u9ad8\u8d28\u91cf\u548c\u4e2d\u7b49\u8d28\u91cf MAG \u7684\u603b\u6570\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u5b9e\u65bd\u4e86\u4e00\u79cd\u540d\u4e3a Deepurify_Iter \u7684\u8fed\u4ee3\u51c0\u5316\u7b56\u7565\uff0c\u4ee5\u4fc3\u8fdb\u6765\u81ea\u591a\u4e2a\u5206\u7bb1\u5de5\u5177\u7684 MAG \u7684\u9010\u6b65\u51c0\u5316\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aDeepurify_Iter \u4e2d\u4f7f\u7528\u7684\u8fed\u4ee3\u51c0\u5316\u7b56\u7565\u7684\u5de5\u4f5c\u6d41\u7a0b\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u5bf9\u4e8e\u6a21\u62df\u6570\u636e\uff0cDeepurify \u5728 MAG \u51c0\u5316\u65b9\u9762\u7684\u8868\u73b0\u4f18\u4e8e\u4e24\u79cd\u6700\u5148\u8fdb\u7684\u5de5\u5177 MAGpurify \u548c MDMcleaner\uff0c\u5982\u4e0b\u56fe\u6240\u793a\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u4e0d\u540c\u6c61\u67d3\u7387\u4e0b\u5e73\u8861\u5b8f\u89c2 F1 \u5f97\u5206\u7684\u5e73\u5747\u6570\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

Deepurify \u8fd8\u5c55\u793a\u4e86\u51fa\u8272\u7684\u6cdb\u5316\u80fd\u529b\uff0c\u5373\u4f7f\u8bad\u7ec3\u96c6\u4e2d\u6ca1\u6709\u6e90\u57fa\u56e0\u7ec4\uff0c\u4e5f\u80fd\u51c6\u786e\u8bc6\u522b\u53d7\u6c61\u67d3\u7684\u91cd\u53e0\u7fa4\uff0c\u5982\u4e0b\u56fe\u3002\u5bf9\u4e8e\u5b8f\u57fa\u56e0\u7ec4\u89e3\u91ca\u7684\u5173\u952e\u8bc4\u4f30 (CAMI) I \u548c\u771f\u5b9e\u4e16\u754c\u7684\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u96c6\uff0c\u7814\u7a76\u56e2\u961f\u4f7f\u7528 GUNC \u6765\u8bc4\u4f30\u51c0\u5316\u540e\u7684 MAG \u7684\u6c61\u67d3\u6c34\u5e73\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u4e0d\u540c\u6c61\u67d3\u7387\u4e0b\u5e73\u8861\u5b8f\u89c2 F1 \u5f97\u5206\u7684\u5e73\u5747\u6570\uff08\u8bad\u7ec3\u96c6\u4e2d\u6ca1\u6709\u6e90\u57fa\u56e0\u7ec4\uff09\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u5bf9\u4e8e CAMI I \u6570\u636e\u96c6\uff0c\u7814\u7a76\u4eba\u5458\u5c06 MAGpurify\u3001MDMcleaner\u3001Deepurify \u548c Deepurify_Iter \u5e94\u7528\u4e8e\u7531\u4e09\u4e2a contig \u5206\u7bb1\u5de5\u5177\u751f\u6210\u7684 MAG\uff1aCONCOCT\u3001MetaBAT2 \u548c SemiBin2\u3002<\/p>\n

\u7ed3\u679c\u8868\u660e\uff0cDeepurify \u548c Deepurify_Iter \u663e\u8457\u51cf\u5c11\u4e86 MAG \u7684\u6c61\u67d3\uff0c\u5728\u6240\u6709\u5206\u7bb1\u5de5\u5177\u4e2d\u90fd\u8d85\u8fc7\u4e86 MAGpurify \u548c MDMcleaner\uff0c\u5982\u4e0b\u56fe\u6240\u793a\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u901a\u8fc7 GUNC \u6c61\u67d3\u6807\u51c6\u7684\u9ad8\u8d28\u91cf\u548c\u4e2d\u7b49\u8d28\u91cf MAG \u7684\u6570\u91cf\uff0c\u4ee5\u53ca CAMI I \u548c\u4e94\u4e2a\u771f\u5b9e\u4e16\u754c\u6570\u636e\u96c6\u7684\u8d28\u91cf\u5f97\u5206\uff081k = 1,000\uff09\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u540c\u65f6\uff0c\u4ed6\u4eec\u5c06 Deepurify_Iter \u5e94\u7528\u4e8e\u73b0\u5b9e\u4e16\u754c\u4e2d\u590d\u6742\u7a0b\u5ea6\u5404\u5f02\u7684\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u96c6\uff0c\u5305\u62ec\u6765\u81ea\u571f\u58e4\u3001\u6d77\u6d0b\u3001\u690d\u7269\u3001\u6de1\u6c34\u548c\u4eba\u7c7b\u7caa\u4fbf\u7684\u6837\u672c\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cDeepurify_Iter \u663e\u8457\u63d0\u9ad8\u4e86\u6240\u6709\u8fd9\u4e9b\u6837\u672c\u4e2d MAG \u7684\u8d28\u91cf\uff0c\u9ad8\u8d28\u91cf MAG \u5206\u522b\u589e\u52a0\u4e86 20.0%\u300145.1%\u300145.5%\u300133.8% \u548c 28.5%\u3002\u5e76\u4e14\uff0c\u5373\u4f7f\u5904\u7406\u6765\u81ea\u9ad8\u5ea6\u590d\u6742\u751f\u6001\u7cfb\u7edf\u7684 MAG\uff0cDeepurify_Iter \u7684\u6027\u80fd\u4ecd\u7136\u4fdd\u6301\u7a33\u5065\u3002<\/p>\n

\u603b\u4e4b\uff0c\u8be5\u56e2\u961f\u8bc1\u660e\u4e86 Deepurify \u5728\u4ece\u77ed\u8bfb\u957f\u5b8f\u57fa\u56e0\u7ec4\u7ec4\u88c5\u4e2d\u53bb\u9664 MAG \u65b9\u9762\u5177\u6709\u663e\u8457\u7684\u6548\u679c\u3002<\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s42256-024-00908-5<\/em><\/p>\n

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