{"id":36215,"date":"2025-01-07T18:00:17","date_gmt":"2025-01-07T10:00:17","guid":{"rendered":"https:\/\/17aitech.com\/?p=36215"},"modified":"2025-01-07T18:00:17","modified_gmt":"2025-01-07T10:00:17","slug":"nature%e5%ad%90%e5%88%8a%ef%bc%8c%e5%8c%97%e5%a4%a7%e9%99%88%e8%af%ad%e8%b0%a6%e5%9b%a2%e9%98%9f%e6%8f%90%e5%87%ba%e5%a4%9a%e6%a8%a1%e6%80%81%e5%8d%95%e7%bb%86%e8%83%9e%e6%95%b0%e6%8d%ae%e6%95%b4","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=36215","title":{"rendered":"Nature\u5b50\u520a\uff0c\u5317\u5927\u9648\u8bed\u8c26\u56e2\u961f\u63d0\u51fa\u591a\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u6574\u5408\u548c\u63d2\u8865\u7684\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:Nature\u5b50\u520a\uff0c\u5317\u5927\u9648\u8bed\u8c26\u56e2\u961f\u63d0\u51fa\u591a\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u6574\u5408\u548c\u63d2\u8865\u7684\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91\u00a0| ScienceAI<\/p>\n

\u4eca\u5929\u4e3a\u5927\u5bb6\u4ecb\u7ecd\u7684\u662f\u6765\u81ea\u5317\u4eac\u5927\u5b66<\/mark>\u4fe1\u606f\u5de5\u7a0b\u5b66\u9662\u3001\u5316\u5b66\u751f\u7269\u5b66\u4e0e\u751f\u7269\u6280\u672f\u5b66\u9662\u7701\u90e8\u5171\u5efa\u80bf\u7624\u5316\u5b66\u57fa\u56e0\u7ec4\u5b66\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u3001\u9e4f\u57ce\u56fd\u5bb6\u5b9e\u9a8c\u5ba4\u5408\u8058\u7814\u7a76\u5458\u548c AI4S \u5e73\u53f0\u4e2d\u5fc3\u4e3b\u4efb\u9648\u8bed\u8c26\u6559\u6388\u56e2\u961f\u53d1\u8868\u5728\u300aNature Communications<\/em>\u300b\u7684\u8bba\u6587\u3002<\/p>\n

\u8be5\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u591a\u6a21\u6001\u6574\u5408\u65b9\u6cd5\uff0c\u80fd\u591f\u5b9e\u73b0\u591a\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u7684\u6574\u5408\u4e0e\u63d2\u8865\uff0c\u8fd9\u4e00\u6210\u679c\u53ef\u4ee5\u4fc3\u8fdb\u591a\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u7684\u5206\u6790\u3002<\/p>\n

<\/a><\/p>\n

\u6587\u7ae0\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41467-024-53355-6<\/em><\/p>\n

\u80cc\u666f\u4ecb\u7ecd<\/strong><\/p>\n

\u5f02\u6784\u7279\u5f81\u7a7a\u95f4\u548c\u6280\u672f\u566a\u58f0\u963b\u788d\u4e86\u7ec6\u80de\u6570\u636e\u7684\u6574\u5408\u548c\u63d2\u8865\u3002\u8de8\u6a21\u6001\u83b7\u53d6\u914d\u5bf9\u6570\u636e\u7684\u9ad8\u6210\u672c\u8fdb\u4e00\u6b65\u9650\u5236\u4e86\u5206\u6790\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u6df1\u5ea6\u5b66\u4e60<\/mark>\u65b9\u6cd5\u6765\u6709\u6548\u5730\u6574\u5408\u548c\u63d2\u8865\u4e0d\u914d\u5bf9\u7684\u591a\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u3002<\/p>\n

\u5728\u6b64\uff0c\u4f5c\u8005\u8bbe\u8ba1\u4e86\u6a21\u6001\u8054\u7ed3\u81ea\u7f16\u7801\u5668 Monae\u3002Monae \u8054\u7ed3\u6a21\u6001\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u5e76\u5728\u7279\u5b9a\u6a21\u6001\u4e2d\u91c7\u7528\u5bf9\u6bd4\u5b66\u4e60\uff0c\u589e\u5f3a\u8054\u5408\u7a7a\u95f4\u4e2d\u7684\u7ec6\u80de\u8868\u793a\u3002Monae \u7684\u6574\u5408\u90e8\u5206\u63d0\u4f9b\u6a21\u6001\u4e92\u8865\u7684\u7ec6\u80de\u8868\u793a\uff0c\u63d2\u8865\u90e8\u5206\u5229\u7528\u7ec6\u80de\u8868\u793a\u751f\u6210\u5177\u6709\u751f\u7269\u5f02\u8d28\u6027\u7684\u6a21\u6001\u5185\u548c\u8de8\u6a21\u6001\u8ba1\u6570\u3002<\/p>\n

\u6b64\u5916\uff0c\u989d\u5916\u8bbe\u8ba1\u7684 Monae-E \u662f Monae \u7684\u4e00\u79cd\u53d8\u4f53\uff0c\u652f\u6301\u66f4\u5feb\u6536\u655b<\/mark>\u5e76\u63d0\u4f9b\u53ef\u89e3\u91ca\u6027\u3002\u5728\u5404\u79cd\u6570\u636e\u96c6\u4e0a\u7684\u8bc4\u4f30\u9a8c\u8bc1\u4e86 Monae \u5728\u591a\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u6574\u5408\u548c\u63d2\u8865\u4e2d\u7684\u51c6\u786e\u6027\u3002<\/p>\n

\u6a21\u578b\u67b6\u6784<\/strong><\/p>\n

Monae \u662f\u4e00\u4e2a\u7531\u81ea\u7f16\u7801\u5668\u6784\u5efa\u7684\u591a\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u5b66\u4e60\u6846\u67b6\uff0c\u5982\u56fe 1 \u6240\u793a\u3002Monae \u57fa\u4e8e\u4e0d\u540c\u6a21\u6001\u4e4b\u95f4\u7684\u8c03\u63a7\u5173\u7cfb\u6784\u5efa\u4e00\u4e2a\u6a21\u6001\u8054\u7ed3\u56fe\u3002\u56fe\u4e2d\u7684\u8282\u70b9\u5bf9\u5e94\u4e8e\u7279\u5b9a\u6a21\u6001\u4e2d\u7684\u5355\u4e2a\u72ec\u7acb\u7279\u5f81\u3002Monae \u4e2d\u7684\u56fe\u81ea\u7f16\u7801\u5668\u5b66\u4e60\u6bcf\u4e2a\u8282\u70b9\u7684\u8868\u793a\uff0c\u5982\u56fe 1a \u6240\u793a\u3002<\/p>\n

\u5728 Monae \u4e2d\uff0c\u4e0d\u540c\u7684\u81ea\u7f16\u7801\u5668\u7f16\u7801\u5404\u4e2a\u6a21\u6001\uff0c\u5176\u4e2d\u7684\u975e\u5bf9\u79f0\u7f51\u7edc\u751f\u6210\u5bf9\u6bd4\u5b66\u4e60\u4e2d\u7684\u6b63\u6837\u672c\u548c\u8d1f\u6837\u672c\uff0c\u5982\u56fe 1b \u6240\u793a\u3002\u81ea\u9002\u5e94\u805a\u7c7b<\/mark>\u7528\u4e8e\u589e\u5f3a Monae \u5bf9\u6bd4\u5b66\u4e60\u7684\u7ec6\u80de\u8868\u793a\uff0c\u589e\u52a0\u5f02\u8d28\u7c07\u4e4b\u95f4\u7684\u5224\u522b\u6027\uff0c\u5982\u56fe 1c \u6240\u793a\u3002<\/p>\n

\u4ece Monae \u83b7\u5f97\u56fe\u8054\u7ed3\u8282\u70b9\u5d4c\u5165\u548c\u5bf9\u6bd4\u5b66\u4e60\u7684\u7ec6\u80de\u5d4c\u5165\u540e\uff0c\u540e\u8005\u7528\u4f5c\u591a\u6a21\u6001\u6574\u5408\u7684\u7ec6\u80de\u8868\u793a\uff08\u5982\u56fe 1d \u6240\u793a\uff09\u3002<\/p>\n

\u5bf9\u4e8e\u63d2\u8865\uff0cMonae \u5c06\u6765\u81ea\u8054\u5408\u7a7a\u95f4\u7684\u7ec6\u80de\u8868\u793a\u4e0e\u6a21\u6001\u8054\u7ed3\u8282\u70b9\u7279\u5f81\u878d\u5408\u4ee5\u63a8\u7406\u63d2\u8865\u8ba1\u6570\u3002\u5bf9\u4e8e\u53d8\u4f53 Monae-E\uff0c\u53ef\u4ee5\u5c06\u591a\u6a21\u6001\u7ec6\u80de\u4f5c\u4e3a\u8282\u70b9\u6dfb\u52a0\u5230\u56fe 1a \u4e2d\u7684\u56fe\u8054\u7ed3\u4e2d\u3002<\/p>\n

Monae-E \u4ece\u56fe\u81ea\u7f16\u7801\u5668\u83b7\u5f97\u6240\u6709\u8282\u70b9\u7684\u5d4c\u5165\uff0c\u5305\u62ec\u7ec6\u80de\u5d4c\u5165\u548c\u7279\u5f81\u5d4c\u5165\uff0c\u518d\u4f7f\u7528\u7ec6\u80de\u5d4c\u5165\u6765\u66ff\u6362 Monae \u4e2d\u975e\u5bf9\u79f0\u7f51\u7edc\u7684\u8ba1\u6570\u8f93\u5165\uff0c\u540e\u7eed\u8fc7\u7a0b\u4e0e Monae \u4e00\u81f4\uff0c\u5982\u56fe 1e \u6240\u793a\u3002<\/p>\n

<\/a><\/p>\n

\u56fe 1\uff1a\u6a21\u578b\u67b6\u6784\u548c\u5de5\u4f5c\u6d41\u7a0b<\/section>\n

\u591a\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u6574\u5408<\/strong><\/p>\n

\u4f5c\u8005\u5728\u591a\u4e2a\u6570\u636e\u96c6\u4e0a\u8bc4\u4f30 Monae \u548c\u57fa\u7ebf\u65b9\u6cd5\uff0c\u8fd9\u4e9b\u6570\u636e\u96c6\u5305\u62ec\u914d\u5bf9\u548c\u4e0d\u914d\u5bf9\u573a\u666f\u3002<\/p>\n

\u4e0e\u57fa\u7ebf\u65b9\u6cd5\u76f8\u6bd4\uff0cMonae \u548c Monae-E \u5728\u4e24\u4e2a\u6574\u5408\u6307\u6807\u6279\u6b21<\/mark>\u53bb\u9664\u548c\u751f\u7269\u5f02\u8d28\u6027\u4e0a\u8868\u73b0\u66f4\u597d\uff0c\u5e76\u4e14\u5bf9\u4e0d\u540c\u7684\u968f\u673a\u6570\u636e\u5212\u5206\u5177\u6709\u9c81\u68d2\u6027\uff0c\u5982\u56fe 2b \u6240\u793a\u3002<\/p>\n

\u4e3a\u4e86\u8bc4\u4f30\u6570\u636e\u96c6\u89c4\u6a21\u7684\u5f71\u54cd\uff0c\u4f5c\u8005\u9996\u5148\u968f\u673a\u91c7\u6837\u5e76\u83b7\u5f97\u4e0d\u540c\u89c4\u6a21\u7684\u6570\u636e\u96c6\u5b50\u96c6\u3002\u6240\u6709\u65b9\u6cd5\u5728\u5b50\u96c6\u4e0a\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u5982\u56fe 2c \u548c d \u6240\u793a\u3002<\/p>\n

Monae \u548c Monae-E \u53ef\u4ee5\u53d6\u5f97\u66f4\u597d\u7684\u6027\u80fd\u3002\u968f\u7740\u5b50\u96c6\u89c4\u6a21\u7684\u589e\u52a0\uff0c\u6240\u6709\u65b9\u6cd5\u7684\u8868\u73b0\u90fd\u4f1a\u5f97\u5230\u63d0\u9ad8\u3002\u56fe 2e \u4e2d\u5c55\u793a\u4e86\u5176\u4ed6\u6570\u636e\u96c6\u4e0a\u7684\u7ed3\u679c\u6bd4\u8f83\uff0c\u8bc4\u4f30\u6807\u51c6\u4e3a\u6279\u6b21<\/mark>\u53bb\u9664\u548c\u751f\u7269\u5f02\u8d28\u6027\u7684\u6574\u4f53\u5f97\u5206\u3002<\/p>\n

<\/a><\/p>\n

\u56fe 2\uff1a\u591a\u6a21\u6001\u6574\u5408\u57fa\u51c6<\/mark><\/section>\n

\u591a\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u7684\u63d2\u8865<\/strong><\/p>\n

RNA \u6a21\u6001\u63d2\u8865\u5bf9\u5e94\u4e8e\u6a21\u6001\u5185\u63d2\u8865\u3002\u4f5c\u8005\u4f7f\u7528 MultiVI \u4ee5\u53ca\u4e13\u7528\u4e8e\u6a21\u6001\u5185\u63d2\u8865\u7684\u65b9\u6cd5\uff1aMAGIC \u548c DCA \u4f5c\u4e3a\u57fa\u7ebf\u65b9\u6cd5\uff0c\u5728 Muto-2021 \u4e0a\u8bc4\u4f30\u57fa\u7ebf\u65b9\u6cd5\u548cMonae\u3002<\/p>\n

\u5728\u56fe 3a \u4e2d\uff0c\u4f7f\u7528 PCA \u964d\u7ef4<\/mark>\u63d2\u8865\u8ba1\u6570\uff0c\u5e76\u7528 UMAP \u53ef\u89c6\u5316\uff0cMonae \u548c Monae-E \u63d2\u8865\u540e\u7684\u7ec6\u80de\u7c07\u5f7c\u6b64\u5206\u79bb\u5f97\u66f4\u5f00\uff0c\u5177\u6709\u66f4\u597d\u7684\u5224\u522b\u6027\u3002\u8bc4\u4f30\u7ed3\u679c\u5982\u56fe 3b \u6240\u793a\uff0cMonae \u548c Monae-E \u7684\u6574\u4f53\u6027\u80fd\u4f18\u4e8e\u57fa\u7ebf\u65b9\u6cd5\u3002<\/p>\n

\u5bf9\u4e8e\u8de8\u6a21\u6001\u63d2\u8865\uff0c\u4f5c\u8005\u4f7f\u7528 scButterfly\u3001MultiVI\u3001JAMIE\u3001UnitedNet \u548c BABEL \u4f5c\u4e3a\u57fa\u7ebf\u3002\u5c06 Muto-2021 \u4e0a\u7684 RNA \u6a21\u6001\u6570\u636e\u8f6c\u6362\u4e3a ATAC \u6a21\u6001\u3002<\/p>\n

\u8de8\u6a21\u6001\u63d2\u8865\u7684\u8bc4\u4f30\u7ed3\u679c\u5982\u56fe 3c \u6240\u793a\u3002\u8fd9\u4e9b\u7ed3\u679c\u4f53\u73b0\u51fa Monae \u6062\u590d\u4e86 ATAC \u6a21\u6001\u4e0b\u7684\u751f\u7269\u5f02\u8d28\u6027\u3002<\/p>\n

\u603b\u4f53\u800c\u8a00\uff0cMonae \u548c Monae-E \u7ffb\u8bd1\u7684\u56fe\u8c31\u80fd\u591f\u8868\u5f81\u7ec6\u80de\u7c07\u4e4b\u95f4\u7684\u5dee\u5f02\uff0c\u4ece\u800c\u4fc3\u8fdb\u7ec6\u80de\u7c7b\u578b\u8bc6\u522b\u7b49\u4e0b\u6e38\u4efb\u52a1\u3002<\/p>\n

\u540c\u6837\u7684\u65b9\u5f0f\uff0c\u4f5c\u8005\u8bc4\u4f30\u4e86\u4ece ATAC \u6a21\u6001\u7ffb\u8bd1\u5230 RNA \u6a21\u6001\u7684\u63d2\u8865\u7ed3\u679c\u3002Muto-2021 \u4e0a\u7684\u8de8\u6a21\u6001\u63d2\u8865\u7684\u8bc4\u4f30\u7ed3\u679c\u5982\u56fe 3d \u6240\u793a\u3002\u867d\u7136 scButterfly \u8868\u73b0\u66f4\u597d\uff0c\u4f46\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cMonae \u548c Monae-E \u7684\u6027\u80fd\u63a5\u8fd1 scButterfly\u3002<\/p>\n

<\/a><\/p>\n

\u56fe 3\uff1a\u591a\u6a21\u6001\u63d2\u8865\u57fa\u51c6<\/mark><\/section>\n

\u7ed3\u8bba<\/strong><\/p>\n

\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u4ecb\u7ecd\u4e86 Monae\uff0c\u4e00\u79cd\u7528\u4e8e\u591a\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u6574\u5408\u548c\u63d2\u8865\u7684\u6df1\u5ea6\u5b66\u4e60<\/mark>\u65b9\u6cd5\u3002<\/p>\n

Monae \u7684\u8bbe\u8ba1\u9075\u5faa\u4e24\u4e2a\u52a8\u673a\uff1a\uff081\uff09\u5bf9\u4e8e\u6574\u5408\uff0c\u5b66\u4e60\u6a21\u6001\u4e4b\u95f4\u7684\u8054\u7ed3\u5173\u7cfb\u53ef\u4ee5\u4fc3\u8fdb\u8054\u5408\u7a7a\u95f4\u4e2d\u7684\u5bf9\u6bd4\u5b66\u4e60\u5e76\u6d88\u9664\u6a21\u6001\u4e4b\u95f4\u7684\u5dee\u8ddd\u3002\uff082\uff09\u5bf9\u4e8e\u63d2\u8865\uff0c\u5f53\u524d\u6a21\u6001\u4e2d\u7f3a\u5931\u7684\u4fe1\u606f\u53ef\u4ee5\u901a\u8fc7\u5176\u4ed6\u6a21\u6001\u6765\u8865\u5145\u3002<\/p>\n

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