{"id":36439,"date":"2025-01-11T11:00:24","date_gmt":"2025-01-11T03:00:24","guid":{"rendered":"https:\/\/17aitech.com\/?p=36439"},"modified":"2025-01-11T11:00:24","modified_gmt":"2025-01-11T03:00:24","slug":"%e7%99%bbnature%ef%bc%8cai%e8%ae%be%e8%ae%a1dna%e5%bc%80%e5%85%b3%ef%bc%8cmit%e5%9b%a2%e9%98%9f%e5%ae%9e%e7%8e%b0%e7%b2%be%e7%a1%ae%e7%9a%84%e7%bb%86%e8%83%9e%e6%8e%a7%e5%88%b6","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=36439","title":{"rendered":"\u767bNature\uff0cAI\u8bbe\u8ba1DNA\u5f00\u5173\uff0cMIT\u56e2\u961f\u5b9e\u73b0\u7cbe\u786e\u7684\u7ec6\u80de\u63a7\u5236"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u767bNature\uff0cAI\u8bbe\u8ba1DNA\u5f00\u5173\uff0cMIT\u56e2\u961f\u5b9e\u73b0\u7cbe\u786e\u7684\u7ec6\u80de\u63a7\u5236<\/a><\/p>\n

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\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4ee5\u53ca\u5404\u79cd\u57fa\u56e0\u6cbb\u7597\u65b9\u6cd5\u4f7f\u79d1\u5b66\u5bb6\u80fd\u591f\u6539\u53d8\u6d3b\u7ec6\u80de\u5185\u7684\u57fa\u56e0\u3002\u7136\u800c\uff0c\u53ea\u5f71\u54cd\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u6216\u7ec4\u7ec7\u4e2d\u7684\u57fa\u56e0\uff0c\u800c\u4e0d\u662f\u5f71\u54cd\u6574\u4e2a\u751f\u7269\u4f53\u7684\u57fa\u56e0\uff0c\u4e00\u76f4\u5f88\u56f0\u96be\u3002\u90e8\u5206\u539f\u56e0\u662f\u4eba\u4eec\u5bf9\u63a7\u5236\u57fa\u56e0\u8868\u8fbe\u548c\u6291\u5236\u7684 DNA \u5f00\u5173 [\u5373\u987a\u5f0f\u8c03\u63a7\u5143\u4ef6 (CRE\uff09] \u7684\u7406\u89e3\u4ecd\u9762\u4e34\u6311\u6218\u3002<\/p>\n

\u6770\u514b\u900a\u5b9e\u9a8c\u5ba4\uff08JAX\uff0cThe Jackson Laboratory\uff09\u3001\u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff08MIT\uff09\u548c\u54c8\u4f5b\u5927\u5b66\u5e03\u7f57\u5fb7\u7814\u7a76\u6240\u4ee5\u53ca\u8036\u9c81\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5229\u7528\u4eba\u5de5\u667a\u80fd<\/mark>\u8bbe\u8ba1\u4e86\u6570\u5343\u4e2a\u65b0\u7684 DNA \u5f00\u5173\uff0c\u53ef\u4ee5\u7cbe\u786e\u63a7\u5236\u57fa\u56e0\u5728\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u8868\u8fbe\u3002\u4ed6\u4eec\u7684\u65b0\u65b9\u6cd5\u5f00\u542f\u4e86\u63a7\u5236\u57fa\u56e0\u5728\u4f53\u5185\u4f55\u65f6\u4f55\u5730\u8868\u8fbe\u7684\u53ef\u80fd\u6027\uff0c\u4ee5\u524d\u6240\u672a\u6709\u7684\u65b9\u5f0f\u9020\u798f\u4eba\u7c7b\u5065\u5eb7\u548c\u533b\u5b66\u7814\u7a76\u3002<\/p>\n

\u300c\u8fd9\u4e9b\u5408\u6210\u8bbe\u8ba1\u7684\u5143\u7d20\u7684\u7279\u522b\u4e4b\u5904\u5728\u4e8e\uff0c\u5b83\u4eec\u5bf9\u5176\u8bbe\u8ba1\u7684\u76ee\u6807\u7ec6\u80de\u7c7b\u578b\u8868\u73b0\u51fa\u4e86\u663e\u8457\u7684\u7279\u5f02\u6027\u3002\u300d\u6770\u514b\u900a\u5b9e\u9a8c\u5ba4\u526f\u6559\u6388\u517c\u8bba\u6587\u5171\u540c\u901a\u8baf\u4f5c\u8005 Ryan Tewhey \u535a\u58eb\u8bf4\uff0c\u300c\u8fd9\u4e3a\u6211\u4eec\u521b\u9020\u4e86\u673a\u4f1a\uff0c\u8ba9\u6211\u4eec\u53ef\u4ee5\u5728\u4e0d\u5f71\u54cd\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\u7684\u60c5\u51b5\u4e0b\uff0c\u4ec5\u5728\u4e00\u79cd\u7ec4\u7ec7\u4e2d\u63d0\u9ad8\u6216\u964d\u4f4e\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u300d<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cMachine-guided design of cell-type-targeting cis-regulatory elements<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2024 \u5e74 10 \u6708 23 \u65e5\u53d1\u5e03\u5728\u300aNature<\/em>\u300b\u3002<\/p>\n

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\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41586-024-08070-z<\/em><\/p>\n

\u987a\u5f0f\u8c03\u63a7\u5143\u4ef6 (CRE) \u63a7\u5236\u57fa\u56e0\u8868\u8fbe\uff0c\u534f\u8c03\u7ec4\u7ec7\u8eab\u4efd\u3001\u53d1\u80b2\u65f6\u95f4\u548c\u523a\u6fc0\u53cd\u5e94\uff0c\u8fd9\u4e9b\u5171\u540c\u51b3\u5b9a\u4e86\u4f53\u5185\u6570\u5343\u79cd\u72ec\u7279\u7684\u7ec6\u80de\u7c7b\u578b\u3002\u867d\u7136\u5728\u9700\u8981\u7ec4\u7ec7\u7279\u5f02\u6027\u7684\u6cbb\u7597\u6216\u751f\u7269\u6280\u672f\u5e94\u7528\u4e2d\u6218\u7565\u6027\u5730\u6574\u5408 CRE \u5177\u6709\u5de8\u5927\u6f5c\u529b\uff0c\u4f46\u4e0d\u80fd\u4fdd\u8bc1\u81ea\u7136\u4ea7\u751f\u51fa\u9002\u5408\u8fd9\u4e9b\u9884\u671f\u76ee\u7684\u7684\u6700\u4f73 CRE\u3002<\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u77e5\u9053\uff0c\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u6709\u6570\u5343\u79cd\u4e0d\u540c\u7684 CRE\uff0c\u6bcf\u79cd\u90fd\u53d1\u6325\u7740\u7565\u6709\u4e0d\u540c\u7684\u4f5c\u7528\u3002\u4f46 CRE \u7684\u8bed\u6cd5\u4e00\u76f4\u5f88\u96be\u5f04\u6e05\u695a\uff0c\u300c\u6ca1\u6709\u7b80\u5355\u7684\u89c4\u5219\u6765\u63a7\u5236\u6bcf\u4e2a CRE \u7684\u4f5c\u7528\u3002\u300dJAX Tewhey \u5b9e\u9a8c\u5ba4\u7684\u8ba1\u7b97\u79d1\u5b66\u5bb6\uff0c\u8bba\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u4e4b\u4e00 Rodrigo Castro \u535a\u58eb\u89e3\u91ca\u8bf4\uff0c\u300c\u8fd9\u9650\u5236\u4e86\u6211\u4eec\u8bbe\u8ba1\u4ec5\u5f71\u54cd\u4eba\u4f53\u67d0\u4e9b\u7ec6\u80de\u7c7b\u578b\u7684\u57fa\u56e0\u7597\u6cd5\u7684\u80fd\u529b\u3002\u300d<\/p>\n

\u300c\u5982\u679c\u6211\u4eec\u4ece\u8bed\u8a00\u7684\u89d2\u5ea6\u6765\u601d\u8003\uff0c\u8fd9\u4e9b\u5143\u7d20\u7684\u8bed\u6cd5\u548c\u53e5\u6cd5\u5c31\u5f88\u96be\u7406\u89e3\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5c1d\u8bd5\u6784\u5efa\u673a\u5668\u5b66\u4e60<\/mark>\u65b9\u6cd5\uff0c\u4ee5\u4fbf\u5b66\u4e60\u6bd4\u6211\u4eec\u81ea\u5df1\u80fd\u5b66\u4e60\u7684\u66f4\u590d\u6742\u7684\u4ee3\u7801\u3002\u300d<\/p>\n

\u4eba\u5de5\u667a\u80fd<\/mark>\u6765\u8bbe\u8ba1 CRE<\/strong><\/p>\n

Castro\u00a0\u6240\u5728\u7684\u8054\u5408\u7814\u7a76\u56e2\u961f\u521b\u5efa\u4e86 Malinois\uff0c\u8fd9\u662f\u4e00\u4e2a\u6df1\u5ea6\u5377\u79ef\u795e\u7ecf\u7f51\u7edc<\/mark>\u00a0(CNN)\uff0c\u7528\u4e8e\u9884\u6d4b\u4efb\u4f55\u5e8f\u5217\u7684\u7ec6\u80de\u7c7b\u578b\u76f8\u5173\u4fe1\u606f CRE \u6d3b\u6027\uff08\u901a\u8fc7 MPRA \u6d4b\u91cf\uff09\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aMalinois \u80fd\u591f\u51c6\u786e\u9884\u6d4b\u67d3\u8272\u4f53\u5916\u62a5\u544a\u57fa\u56e0\u4e2d CRE \u7684\u8f6c\u5f55\u6fc0\u6d3b\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u7814\u7a76\u56e2\u961f\u63d0\u51fa\u4e86\u4e00\u79cd\u4ece\u5934\u8bbe\u8ba1\u65b0\u578b\u5408\u6210 CRE \u7684\u65b9\u6cd5 CODA\uff0c\u8be5 CRE \u80fd\u591f\u5728\u4e09\u79cd\u8f6c\u5316\u7ec6\u80de\u7cfb\u4e2d\u9a71\u52a8\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u8f6c\u57fa\u56e0\u8868\u8fbe\u3002<\/p>\n

\u300c\u8be5\u9879\u76ee\u672c\u8d28\u4e0a\u63d0\u51fa\u4e86\u4e00\u4e2a\u95ee\u9898\uff1a\u300e\u6211\u4eec\u80fd\u5426\u5b66\u4f1a\u8bfb\u53d6\u548c\u7f16\u5199\u8fd9\u4e9b\u8c03\u63a7\u5143\u4ef6\u7684\u4ee3\u7801\uff1f\u300f\u300d\u8036\u9c81\u5927\u5b66\u9057\u4f20\u5b66\u52a9\u7406\u6559\u6388\u3001\u8be5\u7814\u7a76\u7684\u901a\u8baf\u4f5c\u8005\u4e4b\u4e00 Steven Reilly \u535a\u58eb\u8bf4\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aCODA \u6709\u6548\u5730\u8bbe\u8ba1\u4e86\u7279\u5b9a\u4e8e\u7ec6\u80de\u7c7b\u578b\u7684 CRE\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u6574\u5408\u4e4b\u524d\u5728\u8de8\u7ec6\u80de\u7c7b\u578b\u5efa\u6a21\u8c03\u63a7\u8bed\u6cd5\u3001\u9ad8\u6548\u5e8f\u5217\u7a7a\u95f4\u641c\u7d22\u548c\u53ef\u5e76\u884c\u9a8c\u8bc1\u6570\u5343\u4e2a CRE \u7684 MPRA \u5b9e\u9a8c\u7cfb\u7edf\u65b9\u9762\u7684\u521b\u65b0\u6765\u5b9e\u73b0\u8fd9\u4e00\u76ee\u6807\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86\u6700\u8fd1\u751f\u6210\u7684\u7edf\u4e00\u5904\u7406\u7684 MPRA \u5b9e\u9a8c\u6570\u636e\u5e93<\/mark>\uff0c\u8be5\u6570\u636e\u5e93<\/mark>\u8868\u5f81\u4e86\u524d\u6240\u672a\u6709\u7684\u6570\u91cf\u7684 CRE\uff0c\u4ee5\u8bad\u7ec3\u7cbe\u786e\u7684\u6df1\u5ea6\u5b66\u4e60<\/mark>\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u53ef\u4ee5\u5feb\u901f\u9884\u6d4b\u4efb\u4f55\u5e8f\u5217\u7684\u6d3b\u52a8\u3002<\/p>\n

\u300c\u5929\u7136\u7684 CRE \u867d\u7136\u6570\u91cf\u4f17\u591a\uff0c\u4f46\u53ea\u4ee3\u8868\u4e86\u53ef\u80fd\u7684\u9057\u4f20\u5143\u7d20\u7684\u4e00\u5c0f\u90e8\u5206\uff0c\u800c\u4e14\u5b83\u4eec\u7684\u529f\u80fd\u53d7\u5230\u81ea\u7136\u9009\u62e9\u7684\u9650\u5236\u3002\u300d\u8be5\u7814\u7a76\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3001Sabeti \u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\u7814\u7a76\u5458 Sager Gosai \u535a\u58eb\u8bf4\uff0c\u300c\u8fd9\u4e9b\u4eba\u5de5\u667a\u80fd<\/mark>\u5de5\u5177\u5728\u8bbe\u8ba1\u57fa\u56e0\u5f00\u5173\u65b9\u9762\u5177\u6709\u5de8\u5927\u6f5c\u529b\uff0c\u53ef\u4ee5\u7cbe\u786e\u8c03\u6574\u57fa\u56e0\u8868\u8fbe\uff0c\u4ee5\u5b9e\u73b0\u751f\u7269\u5236\u9020\u548c\u6cbb\u7597\u7b49\u8d85\u51fa\u8fdb\u5316\u538b\u529b\u8303\u56f4\u7684\u65b0\u5e94\u7528\u3002\u300d<\/p>\n

\u4e09\u79cd\u7ec6\u80de\u7cfb\u4e2d\u6d4b\u8bd5<\/strong><\/p>\n

\u7ed3\u5408\u5e8f\u5217\u751f\u6210\u7b97\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u90e8\u7f72\u4ed6\u4eec\u7684\u6a21\u578b\u5728\u4e09\u79cd\u7ec6\u80de\u7cfb\u4e2d\u751f\u6210\u5177\u6709\u7a0b\u5e8f\u7279\u5f02\u6027\u7684\u6570\u5343\u79cd\u5408\u6210 CRE\uff0c\u5e76\u4f7f\u7528 MPRA \u5728\u4f53\u5916\u5bf9\u5176\u8fdb\u884c\u529f\u80fd\u9a8c\u8bc1\uff0c\u5e76\u901a\u8fc7\u63a2\u6d4b\u5c0f\u9f20\u548c\u6591\u9a6c\u9c7c\u7684\u751f\u7406\u76f8\u5173\u7ec4\u7ec7\u5728\u4f53\u5185\u5bf9\u5176\u8fdb\u884c\u529f\u80fd\u9a8c\u8bc1\u3002<\/p>\n

\u5728\u8f6c\u5316\u7ec6\u80de\u7cfb\u4e2d\u68c0\u6d4b\u7684\u62a5\u544a\u7cfb\u7edf\u4e2d\uff0cCODA \u8bbe\u8ba1\u7684\u5408\u6210\u5e8f\u5217\u5728\u9a71\u52a8\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u57fa\u56e0\u8868\u8fbe\u65b9\u9762\u786e\u5b9e\u4f18\u4e8e\u5929\u7136\u5e8f\u5217\u3002\u7814\u7a76\u4eba\u5458\u8868\u660e\uff0cCODA \u53ef\u4ee5\u8bc6\u522b\u51fa\u901a\u5e38\u8868\u73b0\u4f18\u4e8e\u5929\u7136\u5e8f\u5217\u7684\u5408\u6210\u5e8f\u5217\uff0c\u5176\u6548\u7387\u8fdc\u9ad8\u4e8e\u968f\u673a\u641c\u7d22<\/mark>\uff0c\u4f46\u65e0\u6cd5\u786e\u5b9a\u5168\u5c40\u6700\u4f18\u503c\u3002<\/p>\n

CODA \u8bbe\u8ba1\u7684\u5408\u6210 CRE \u901a\u8fc7\u4ee5\u72ec\u7279\u7684\u7ec4\u5408\u90e8\u7f72\u9776\u5411\u6fc0\u6d3b\u548c\u8131\u9776\u6291\u5236 TF \u6765\u5b9e\u73b0\u66f4\u9ad8\u7684\u7279\u5f02\u6027\uff0c\u800c\u8fd9\u79cd\u7ec4\u5408\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u5e76\u4e0d\u5e38\u89c1\u3002\u8fd9\u8bf4\u660e\u8be5\u6a21\u578b\u5df2\u7ecf\u5b66\u4e60\u4e86\u63a7\u5236 CRE \u7684\u57fa\u672c\u89c4\u5219\u7684\u4e00\u90e8\u5206\uff0c\u5e76\u4e14\u80fd\u591f\u5c06\u8fd9\u4e9b\u77e5\u8bc6\u63a8\u5e7f\u5230\u5f88\u5c11\u89c2\u5bdf\u5230\u7684 TF \u7ec4\u5408\u3002<\/p>\n

\u4f7f\u7528 Malinois\uff08CRE \u8f6c\u5f55\u8f93\u51fa\u7684\u76f4\u63a5\u6a21\u578b\uff09\uff0c\u8be5\u56e2\u961f\u80fd\u591f\u8bc6\u522b\u5177\u6709\u4e2d\u7b49\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u6d3b\u6027\u7684\u57fa\u56e0\u7ec4\u5e8f\u5217\uff0c\u5c3d\u7ba1\u7a0b\u5ea6\u4f4e\u4e8e\u5408\u6210\u5e8f\u5217\u3002<\/p>\n

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