{"id":36639,"date":"2025-01-15T15:00:15","date_gmt":"2025-01-15T07:00:15","guid":{"rendered":"https:\/\/17aitech.com\/?p=36639"},"modified":"2025-01-15T15:00:15","modified_gmt":"2025-01-15T07:00:15","slug":"ai%e9%9d%a2%e4%b8%b4%e7%9a%84%e4%ba%94%e4%b8%aa%e8%9b%8b%e7%99%bd%e8%b4%a8%e8%ae%be%e8%ae%a1%e9%97%ae%e9%a2%98%ef%bc%8cnature%e6%89%be%e4%ba%86%e4%b8%80%e7%be%a4%e4%b8%93%e5%ae%b6%e6%9d%a5%e8%ae%a8","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=36639","title":{"rendered":"AI\u9762\u4e34\u7684\u4e94\u4e2a\u86cb\u767d\u8d28\u8bbe\u8ba1\u95ee\u9898\uff0cNature\u627e\u4e86\u4e00\u7fa4\u4e13\u5bb6\u6765\u8ba8\u8bba"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:AI\u9762\u4e34\u7684\u4e94\u4e2a\u86cb\u767d\u8d28\u8bbe\u8ba1\u95ee\u9898\uff0cNature\u627e\u4e86\u4e00\u7fa4\u4e13\u5bb6\u6765\u8ba8\u8bba<\/a><\/p>\n

<\/a><\/section>\n

\u7f16\u8f91 | \u767d\u83dc\u53f6<\/p>\n

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\u673a\u5668\u5b66\u4e60<\/mark>\u7b97\u6cd5\u5f7b\u5e95\u6539\u53d8\u4e86\u6e38\u620f\u89c4\u5219\u3002\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u4f7f\u7528\u4eba\u5de5\u667a\u80fd<\/mark>\uff08AI\uff09\u9a71\u52a8\u7684\u5de5\u5177\uff08\u4f8b\u5982 RFdiffusion \u548c Chroma\uff09\u5728\u7b14\u8bb0\u672c\u7535\u8111\u4e0a\u751f\u6210\u65b0\u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u8fd9\u4e9b\u5de5\u5177\u5df2\u5728\u86cb\u767d\u8d28\u6570\u636e\u5e93<\/mark>\uff08PDB\uff09\u4e2d\u7684\u6570\u5341\u4e07\u79cd\u7ed3\u6784\u4e0a\u8fdb\u884c\u8bad\u7ec3\u3002<\/p>\n

\u4ed6\u4eec\u53ef\u4ee5\u4f7f\u7528 ProteinMPNN \u7b49\u7b97\u6cd5\u8bc6\u522b\u4e0e\u8be5\u7ed3\u6784\u5339\u914d\u7684\u5e8f\u5217\u3002RoseTTAFold \u548c AlphaFold<\/mark> \u53ef\u4ee5\u6839\u636e\u5e8f\u5217\u8ba1\u7b97\u7ed3\u6784\uff0c\u9884\u6d4b\u65b0\u86cb\u767d\u8d28\u662f\u5426\u53ef\u80fd\u6b63\u786e\u6298\u53e0\u3002\u53ea\u6709\u8fd9\u6837\uff0c\u7814\u7a76\u4eba\u5458\u624d\u9700\u8981\u5408\u6210\u7269\u7406\u86cb\u767d\u8d28\u5e76\u6d4b\u8bd5\u5176\u662f\u5426\u6309\u9884\u671f\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n

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\u86cb\u767d\u8d28 – \u86cb\u767d\u8d28\u7ed3\u5408\u7b97\u6cd5\u4e4b\u6240\u4ee5\u6210\u529f\uff0c\u662f\u56e0\u4e3a\u5b83\u4eec\u7684\u8bed\u8a00\u5f88\u7b80\u5355\uff1a\u6240\u6709\u5929\u7136\u86cb\u767d\u8d28\u90fd\u7531\u76f8\u540c\u7684 20 \u79cd\u6c28\u57fa\u9178\u7ec4\u6210\u3002\u9a6c\u8428\u8bf8\u585e\u5dde\u8428\u9ed8\u7ef4\u5c14\u7684 Generate Biomedicines \u516c\u53f8\u4f7f\u7528 AI \u8bbe\u8ba1\u7597\u6cd5\uff0c\u5176\u8ba1\u7b97\u673a\u79d1\u5b66\u5bb6 John Ingraham \u8868\u793a\uff0cPDB \u4e2d\u6709\u6570\u5341\u4e07\u79cd\u7ed3\u6784\u548c\u86cb\u767d\u8d28 – \u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff0c\u300c\u8fd9\u5c31\u50cf\u662f\u673a\u5668\u5b66\u4e60<\/mark>\u7684\u7406\u60f3\u60c5\u51b5\u300d\u3002\u79d1\u5b66\u5bb6\u4eec\u4e00\u76f4\u5728\u7814\u7a76\u4f7f\u7528\u4eba\u5de5\u667a\u80fd<\/mark>\u5de5\u5177\u8bbe\u8ba1\u5927\u578b\u7b80\u5355\u7ed3\u5408\u86cb\u767d\u5e93\u3002<\/p>\n

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<\/a><\/p>\n

\u8c37\u6b4c DeepMind<\/mark> \u4f26\u6566\u5206\u90e8\u7684\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6 Jue Wang \u8868\u793a\uff0c\u73b0\u6709\u7684\u516c\u5f00\u6570\u636e\u5e76\u4e0d\u603b\u662f\u6ce8\u91ca\u826f\u597d\uff0c\u53ef\u7528\u7684\u7ed3\u6784\u5f80\u5f80\u53ea\u4ee3\u8868\u5c11\u6570\u5206\u5b50\u7c7b\u522b\u3002\u300c\u4f7f\u7528\u4ee5\u6b64\u4e3a\u57fa\u7840\u8bad\u7ec3\u7684\u6a21\u578b\uff0c\u4f60\u4e0d\u4e00\u5b9a\u80fd\u5b66\u5230\u6709\u5173\u5316\u5b66\u7684\u826f\u597d\u4e00\u822c\u89c4\u5219\u3002\u300d\u4ed6\u8bf4\u3002<\/p>\n

\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\uff0cDeepMind<\/mark> \u53d1\u5e03\u4e86\u8be5\u8f6f\u4ef6\u7684\u6700\u65b0\u7248\u672c AlphaFold<\/mark>3\uff0c\u5b83\u53ef\u4ee5\u9884\u6d4b\u86cb\u767d\u8d28\u4e0e\u5c0f\u5206\u5b50\u7684\u7ed3\u5408\u5982\u4f55\u5f71\u54cd\u5176\u5f62\u72b6\u3002\u8be5\u516c\u53f8\u8868\u793a\uff1a\u300c\u5bf9\u4e8e\u86cb\u767d\u8d28\u4e0e\u5176\u4ed6\u5206\u5b50\u7c7b\u578b\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4e0e\u73b0\u6709\u9884\u6d4b\u65b9\u6cd5\u76f8\u6bd4\uff0c\u6211\u4eec\u7684\u9884\u6d4b\u51c6\u786e\u7387<\/mark>\u81f3\u5c11\u63d0\u9ad8\u4e86 50%\uff0c\u5bf9\u4e8e\u4e00\u4e9b\u91cd\u8981\u7684\u76f8\u4e92\u4f5c\u7528\u7c7b\u522b\uff0c\u6211\u4eec\u7684\u9884\u6d4b\u51c6\u786e\u7387<\/mark>\u63d0\u9ad8\u4e86\u4e00\u500d\u3002\u300d<\/p>\n

\u4f46 Baker \u8868\u793a\uff0c\u8fd9\u4e00\u96be\u9898\u5c1a\u672a\u5b8c\u5168\u89e3\u51b3\u3002\u4f8b\u5982\uff0c\u67d0\u79cd\u7269\u8d28\u7ed3\u5408\u826f\u597d\u5e76\u4e0d\u610f\u5473\u7740\u5b83\u80fd\u6309\u9884\u671f\u53d1\u6325\u4f5c\u7528\u3002Khmelinskaia \u8868\u793a\uff0c\u7ed3\u5408\u86cb\u767d\u53ef\u4ee5\u6fc0\u6d3b\u6216\u963b\u65ad\u5176\u9776\u6807\uff0c\u4f46 AlphaFold<\/mark> \u7b49\u7a0b\u5e8f\u4e0d\u4e00\u5b9a\u80fd\u5206\u8fa8\u51fa\u4e24\u8005\u7684\u533a\u522b\u3002\uff08\u5979\u6307\u51fa\uff0c\u4e00\u4e9b\u7b97\u6cd5\u786e\u5b9e\u7ed3\u5408\u4e86\u529f\u80fd\uff0c\u5305\u62ec ESM3\u3002\u8be5\u8f6f\u4ef6\u7531\u7ebd\u7ea6\u5e02\u4e00\u5bb6\u540d\u4e3a EvolutionaryScale \u7684\u516c\u53f8\u5f00\u53d1\uff0c\u7ecf\u8fc7\u4e86 27 \u4ebf\u4e2a\u86cb\u767d\u8d28\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u7684\u8bad\u7ec3\u3002\uff09<\/p>\n

\u751f\u6210\u5f0f\u4eba\u5de5\u667a\u80fd<\/mark>\u7cfb\u7edf\u8fd8\u6709\u5176\u4ed6\u5c40\u9650\u6027\uff0c\u5305\u62ec\u503e\u5411\u4e8e\u300c\u4ea7\u751f\u5e7b\u89c9\u300d\uff0c\u4ea7\u751f\u81ea\u7136\u754c\u4e2d\u4e0d\u53ef\u80fd\u5b58\u5728\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u7ebd\u7ea6\u5e02\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u7684\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6 Mohammed AlQuraishi \u8bf4\uff0c\u4eba\u5de5\u667a\u80fd<\/mark>\u300c\u603b\u662f\u8bd5\u56fe\u53d6\u60a6\u522b\u4eba\u300d\uff0c\u300c\u5b83\u6c38\u8fdc\u4e0d\u4f1a\u8bf4\u300e\u4e0d\uff0c\u8fd9\u4e0d\u53ef\u884c\u300f\u3002\u300d<\/p>\n

Ingraham \u8bf4\uff0c\u66f4\u597d\u5730\u4e86\u89e3\u751f\u7269\u7269\u7406\u5b66\u53ef\u80fd\u4f1a\u6709\u6240\u5e2e\u52a9\uff0c\u4f46\u6709\u5173\u86cb\u767d\u8d28\u5982\u4f55\u4e0e\u5206\u5b50\u7ed3\u5408\u7684\u66f4\u591a\u66f4\u597d\u7684\u6570\u636e\u4e5f\u4f1a\u6709\u6240\u5e2e\u52a9\u3002\u4ed6\u7684\u516c\u53f8\u6b63\u5728\u901a\u8fc7\u5f3a\u529b\u624b\u6bb5\u653b\u514b\u8fd9\u4e00\u96be\u9898\uff0c\u5c3d\u53ef\u80fd\u591a\u5730\u4f7f\u7528\u6709\u5173\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u548c\u529f\u80fd\u7684\u6570\u636e\uff0c\u5e76\u5c06\u5176\u4e0e\u7531\u4ed6\u4eec\u7684\u6a21\u578b\u751f\u6210\u7684\u8bbe\u8ba1\u9ad8\u901a\u91cf\u6570\u636e\u76f8\u7ed3\u5408\u3002<\/p>\n

\u300c\u6211\u4eec\u6b63\u5728\u5c1d\u8bd5\u5bfb\u627e\u901a\u7528\u89e3\u51b3\u65b9\u6848\u3002\u300d\u4ed6\u8bf4\uff0c\u300c\u7136\u540e\u5c3d\u53ef\u80fd\u591a\u5730\u5229\u7528\u86cb\u767d\u8d28\u4fe1\u606f\u3002\u300d<\/p>\n

\u65b0\u7684\u50ac\u5316\u5242<\/strong><\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u5bf9\u8ba1\u7b97\u5de5\u5177\u5c06\u5e26\u6765\u5177\u6709\u5168\u65b0\u529f\u80fd\u7684\u9176\u5bc4\u4e88\u539a\u671b\uff1a\u4f8b\u5982\uff0c\u53ef\u4ee5\u4ece\u5927\u6c14\u4e2d\u6e05\u9664\u4e8c\u6c27\u5316\u78b3\u7684\u50ac\u5316\u5242\uff0c\u6216\u8005\u53ef\u4ee5\u6709\u6548\u5206\u89e3\u73af\u5883\u5851\u6599\u7684\u9176\u3002\u5408\u4e4e\u903b\u8f91<\/mark>\u7684\u8d77\u70b9\u662f\u5177\u6709\u7c7b\u4f3c\u529f\u80fd\u7684\u5929\u7136\u9176\u3002\u4f8b\u5982\uff0c\u4e00\u79cd\u7834\u574f\u6c22\u7845\u952e\u7684\u9176\u53ef\u80fd\u6210\u4e3a\u7834\u574f\u78b3\u7845\u952e\u7684\u4eba\u5de5\u9176\u7684\u652f\u67b6\u3002<\/p>\n

\u4f46\u76f8\u4f3c\u7684\u86cb\u767d\u8d28\u5f62\u72b6\u5e76\u4e0d\u4e00\u5b9a\u610f\u5473\u7740\u76f8\u4f3c\u7684\u529f\u80fd\uff0c\u800c\u5916\u89c2\u5b8c\u5168\u4e0d\u540c\u7684\u9176\u53ef\u4ee5\u6267\u884c\u76f8\u540c\u7684\u4efb\u52a1\u3002AlQuraishi \u8bf4\uff0c\u627e\u51fa\u8fd9\u4e9b\u8054\u7cfb\u4ee5\u53ca\u5982\u4f55\u91cd\u5efa\u529f\u80fd\u662f\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u4e00\u4e2a\u91cd\u5927\u6311\u6218\u3002\u300c\u6211\u4eec\u4e0d\u8ba8\u8bba\u529f\u80fd\uff0c\u6211\u4eec\u8ba8\u8bba\u7ed3\u6784\u3002\u300d<\/p>\n

\u6b64\u5916\uff0c\u5929\u7136\u9176\u4e0d\u4e00\u5b9a\u662f\u65b0\u6d3b\u52a8\u7684\u7406\u60f3\u8d77\u70b9\u3002\u9a6c\u8428\u8bf8\u585e\u5dde\u6ce2\u58eb\u987f\u54c8\u4f5b\u533b\u5b66\u9662\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u5bb6 Debora Marks \u5c06\u91cd\u65b0\u5229\u7528\u9176\u6bd4\u4f5c\u5728\u57ce\u5e02\u73b0\u6709\u7684\u9648\u65e7\u5e03\u5c40\u4e0a\u4fee\u5efa\u73b0\u4ee3\u9053\u8def\u7cfb\u7edf\u3002\u300c\u5982\u679c\u4f60\u53ef\u4ee5\u91cd\u65b0\u5f00\u59cb\uff0c\u4f60\u4e0d\u4e00\u5b9a\u4f1a\u8fd9\u6837\u505a\u3002\u300d\u5979\u8bf4\u3002<\/p>\n

<\/a><\/p>\n

\u5c3d\u7ba1\u5982\u6b64\uff0c\u5929\u7136\u9176\u7684\u751f\u7269\u7269\u7406\u5b66\u53ef\u4ee5\u4e3a\u4ece\u5934\u8bbe\u8ba1\u63d0\u4f9b\u4fe1\u606f\uff0cMarks \u8bf4\uff1a\u300c\u5927\u81ea\u7136\u5df2\u7ecf\u4e3a\u4f60\u505a\u4e86\u6570\u5341\u4ebf\u6b21\u8fdb\u5316\u5b9e\u9a8c\u3002\u300d\u901a\u5e38\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u5206\u6790\u9176\u5728\u4e0d\u540c\u7269\u79cd\u4e4b\u95f4\u7684\u76f8\u4f3c\u7a0b\u5ea6\u6765\u786e\u5b9a\u9176\u7684\u54ea\u4e9b\u90e8\u5206\u662f\u91cd\u8981\u7684\u3002\u8fdb\u5316\u4fdd\u5b88\u7684\u5e8f\u5217\u901a\u5e38\u5177\u6709\u76f8\u4f3c\u7684\u7ed3\u6784\uff0c\u800c\u4e0d\u76f8\u4f3c\u7684\u5e8f\u5217\u53ef\u80fd\u53ea\u662f\u51cf\u6162\u9176\u901f\u5ea6\u7684\u5783\u573e\u3002<\/p>\n

\u4f46 Ingraham \u8bf4\uff0c\u54ea\u4e9b\u90e8\u5206\u662f\u91cd\u8981\u7684\u5e76\u4e0d\u603b\u662f\u7acb\u5373\u663e\u800c\u6613\u89c1\u7684\u3002\u4f8b\u5982\uff0c\u9176\u4fa7\u770b\u4f3c\u65e0\u7528\u7684\u6c28\u57fa\u9178\u94fe\u53ef\u80fd\u4f1a\u5f71\u54cd\u86cb\u767d\u8d28\u4e0e\u5176\u4ed6\u5206\u5b50\u7684\u7ed3\u5408\u7d27\u5bc6\u7a0b\u5ea6\u6216\u5176\u5728\u6784\u8c61\u72b6\u6001\u4e4b\u95f4\u8f6c\u6362\u7684\u80fd\u529b\u3002<\/p>\n

\u4e00\u4e9b\u7814\u7a76\u4eba\u5458\u6b63\u5728\u5f00\u53d1\u5bfb\u627e\u8fd9\u4e9b\u6709\u7528\u90e8\u5206\u7684\u65b9\u6cd5\u3002\u5728 8 \u6708\u4efd\u7684\u9884\u5370\u672c\u4e2d\uff0cBaker\u56e2\u961f\u5229\u7528 RFdiffusion \u521b\u5efa\u4e86\u4e00\u7ec4\u79f0\u4e3a\u6c34\u89e3\u9176\u7684\u9176\uff0c\u8fd9\u4e9b\u9176\u901a\u8fc7\u591a\u6b65\u9aa4\u8fc7\u7a0b\u5229\u7528\u6c34\u6765\u7834\u574f\u5316\u5b66\u952e\u3002\u7814\u7a76\u4eba\u5458\u5229\u7528\u673a\u5668\u5b66\u4e60<\/mark>\u5206\u6790\u4e86\u9176\u7684\u54ea\u4e9b\u90e8\u5206\u6216\u57fa\u5e8f\u5728\u6bcf\u4e2a\u6b65\u9aa4\u4e2d\u5904\u4e8e\u6d3b\u8dc3\u72b6\u6001\u3002<\/p>\n

\u7136\u540e\uff0c\u4ed6\u4eec\u590d\u5236\u4e86\u8fd9\u4e9b\u57fa\u5e8f\uff0c\u5e76\u8981\u6c42 RFdiffusion \u56f4\u7ed5\u5b83\u4eec\u6784\u5efa\u5168\u65b0\u7684\u86cb\u767d\u8d28\u3002\u5f53\u7814\u7a76\u4eba\u5458\u6d4b\u8bd5\u4e86 20 \u79cd\u8bbe\u8ba1\u65f6\uff0c\u4ed6\u4eec\u53d1\u73b0\u5176\u4e2d\u4e24\u79cd\u80fd\u591f\u4ee5\u65b0\u7684\u65b9\u5f0f\u6c34\u89e3\u5e95\u7269\u3002\u300c\u8fd9\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u662f\u4e00\u4e2a\u76ee\u6807\uff0c\u73b0\u5728\u7ec8\u4e8e\u89e3\u51b3\u4e86\u3002\u300dWang \u8bf4\u3002<\/p>\n

\u4e0d\u8fc7\uff0c\u9996\u5c14\u56fd\u7acb\u5927\u5b66\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6 Martin Steinegger \u8b66\u544a\u79f0\uff0c\u5c06\u6d3b\u6027\u4f4d\u70b9\u79fb\u5165\u65b0\u7684\u86cb\u767d\u8d28\u73af\u5883\u53ef\u80fd\u5f88\u68d8\u624b\u3002\u5982\u679c\u6ca1\u6709\u5176\u4ed6\u86cb\u767d\u8d28\u6765\u7a33\u5b9a\u7ed3\u6784\u6216\u6267\u884c\u7814\u7a76\u4eba\u5458\u5c1a\u672a\u786e\u5b9a\u7684\u529f\u80fd\uff0c\u5b64\u7acb\u7684\u57fa\u5e8f\u53ef\u80fd\u4f1a\u4e0e\u5176\u76ee\u6807\u7ed3\u5408\uff0c\u6c38\u4e0d\u677e\u5f00\u3002Steinegger \u89e3\u91ca\u8bf4\uff0c\u86cb\u767d\u8d28\u4e0d\u662f\u9759\u6001\u7269\u4f53\uff0c\u800c\u662f\u52a8\u6001\u7684\u3002\u300c\u6bcf\u5f53\u52a8\u6001\u51fa\u73b0\u65f6\uff0c\u6211\u4eec\u90fd\u4e0d\u64c5\u957f\u5efa\u6a21\u3002\u300d<\/p>\n

\u6784\u8c61\u53d8\u5316<\/strong><\/p>\n

\u86cb\u767d\u8d28\u901a\u5e38\u4e0d\u53ea\u6709\u4e00\u79cd\u5f62\u72b6\uff1b\u5b83\u4eec\u4f1a\u6253\u5f00\u3001\u5173\u95ed\u3001\u626d\u66f2\u548c\u5f2f\u66f2\u3002\u8fd9\u4e9b\u6784\u8c61\u4f1a\u6839\u636e\u6e29\u5ea6\u3001pH\u3001\u5316\u5b66\u73af\u5883\u4ee5\u53ca\u5b83\u4eec\u662f\u5426\u4e0e\u5176\u4ed6\u5206\u5b50\u7ed3\u5408\u7b49\u56e0\u7d20\u800c\u53d1\u751f\u53d8\u5316\u3002<\/p>\n

\u7136\u800c\uff0c\u5f53\u7814\u7a76\u4eba\u5458\u8bd5\u56fe\u901a\u8fc7\u5b9e\u9a8c\u89e3\u51b3\u86cb\u767d\u8d28\u7ed3\u6784\u65f6\uff0c\u4ed6\u4eec\u5f80\u5f80\u53ea\u80fd\u770b\u5230\u6700\u7a33\u5b9a\u7684\u6784\u8c61\uff0c\u800c\u8fd9\u4e0d\u4e00\u5b9a\u662f\u86cb\u767d\u8d28\u6d3b\u8dc3\u65f6\u7684\u5f62\u5f0f\u3002\u300c\u6211\u4eec\u62cd\u4e86\u8fd9\u4e9b\u5feb\u7167\uff0c\u4f46\u5b83\u4eec\u5f88\u4e0d\u7a33\u5b9a\u3002\u300d\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u5fae\u8f6f\u7814\u7a76\u9662\u7684\u673a\u5668\u5b66\u4e60<\/mark>\u79d1\u5b66\u5bb6 Kevin Yang \u8bf4\u3002<\/p>\n

Yang \u8868\u793a\uff0c\u4e3a\u4e86\u771f\u6b63\u7406\u89e3\u86cb\u767d\u8d28\u7684\u4f5c\u7528\u539f\u7406\uff0c\u7814\u7a76\u4eba\u5458\u9700\u8981\u4e86\u89e3\u5176\u6240\u6709\u6f5c\u5728\u7684\u8fd0\u52a8\u548c\u6784\u8c61\u2014\u2014\u8fd9\u4e9b\u66ff\u4ee3\u5f62\u5f0f\u4e0d\u4e00\u5b9a\u5728 PDB \u4e2d\u5206\u7c7b\u3002<\/p>\n

\u8ba1\u7b97\u86cb\u767d\u8d28\u53ef\u80fd\u79fb\u52a8\u7684\u6240\u6709\u65b9\u5f0f\u662f\u6781\u5176\u56f0\u96be\u7684\uff0c\u5373\u4f7f\u5bf9\u4e8e\u8d85\u7ea7\u8ba1\u7b97\u673a\u6765\u8bf4\u4e5f\u662f\u5982\u6b64\u3002<\/p>\n

\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684\u751f\u7269\u5de5\u7a0b\u5e08 Tanja Kortemme \u8868\u793a\uff0c\u4e00\u4e2a\u542b\u6709 100 \u4e2a\u6c28\u57fa\u9178\u7684\u86cb\u767d\u8d28\uff08\u4ee5\u86cb\u767d\u8d28\u6807\u51c6\u6765\u8bf4\u5f88\u5c0f\uff09\u81f3\u5c11\u53ef\u4ee5\u5448\u73b0 3100 \u79cd\u53ef\u80fd\u7684\u6784\u8c61\u3002\u300c\u6211\u4eec\u5bf9\u7269\u7406\u5b66\u7684\u7406\u89e3\u76f8\u5f53\u4e0d\u9519\uff0c\u4f46\u5c06\u5176\u878d\u5165\u5176\u4e2d\u53d7\u5230\u6211\u4eec\u9700\u8981\u8ba1\u7b97\u7684\u53ef\u80fd\u6027\u6570\u91cf\u7684\u9650\u5236\u3002\u300d<\/p>\n

\u673a\u5668\u5b66\u4e60<\/mark>\u53ef\u4ee5\u5e2e\u52a9\u7f29\u5c0f\u8303\u56f4\uff0c\u5fae\u8f6f\u548c\u5176\u4ed6\u516c\u53f8\u6b63\u5728\u5f00\u53d1\u52a0\u5feb\u5bfb\u627e\u86cb\u767d\u8d28\u6784\u8c61\u6240\u9700\u8ba1\u7b97\u7684\u65b9\u6cd5\u3002\u4f46\u4eba\u5de5\u667a\u80fd<\/mark>\u6a21\u578b\u53d7\u5230\u7f3a\u4e4f\u826f\u597d\u8bad\u7ec3\u6570\u636e\u7684\u9650\u5236\uff0cWang \u8bf4\uff1a\u300c\u4e8b\u5b9e\u901a\u5e38\u5e76\u4e0d\u5b58\u5728\uff0c\u90a3\u4e48\u4f60\u600e\u4e48\u77e5\u9053\u4f60\u5f97\u5230\u7684\u7b54\u6848\u662f\u6b63\u786e\u7684\u5462\uff1f\u300d<\/p>\n

<\/a><\/p>\n

Kortemme \u8868\u793a\uff0c\u8be5\u9886\u57df\u6b63\u5728\u901a\u8fc7\u8bbe\u8ba1\u5927\u578b\u86cb\u767d\u8d28\u5e93\uff08\u5305\u62ec\u5929\u7136\u548c\u5408\u6210\u7684\uff09\u5e76\u5bf9\u5176\u8fdb\u884c\u53d8\u5f02\u4ee5\u63ed\u793a\u5176\u52a8\u6001\u6765\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\u3002<\/p>\n

\u4f8b\u5982\uff0c\u5979\u3001Baker \u4ee5\u53ca\u4f17\u591a\u79d1\u5b66\u5bb6\u6b63\u5728\u7814\u7a76\u53ef\u4ee5\u901a\u8fc7\u6dfb\u52a0\u67d0\u4e9b\u5206\u5b50\u4f34\u4fa3\u5728\u4e24\u79cd\u6784\u8c61\u4e4b\u95f4\u624b\u52a8\u5207\u6362\u7684\u86cb\u767d\u8d28\u3002\u8fd9\u79cd\u8bbe\u8ba1\u86cb\u767d\u8d28\u4e0d\u4ec5\u53ef\u4ee5\u5e2e\u52a9\u8bad\u7ec3\u4eba\u5de5\u667a\u80fd<\/mark>\u6a21\u578b\uff0c\u8fd8\u53ef\u4ee5\u4f5c\u4e3a\u66f4\u590d\u6742\u7684\u5206\u5b50\u673a\u5668\u7684\u6784\u5efa\u6a21\u5757\uff0c\u4f8b\u5982\u5c06\u5316\u5b66\u80fd\u8f6c\u5316\u4e3a\u673a\u68b0\u80fd\u6765\u5b8c\u6210\u7ec6\u80de\u5de5\u4f5c\u7684\u9176\u3002<\/p>\n

\u5176\u4ed6\u56e2\u961f\u5df2\u7ecf\u5f00\u53d1\u51fa\u7b97\u6cd5\uff08\u5982 AF-Cluster\uff09\uff0c\u5728\u9884\u6d4b\u4e2d\u6ce8\u5165\u4e00\u5b9a\u7a0b\u5ea6\u7684\u968f\u673a\u6027\uff0c\u4ee5\u63a2\u7d22\u66ff\u4ee3\u6784\u8c61\u3002\u4f46 Steinegger \u8868\u793a\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u662f\u5426\u9002\u7528\u4e8e\u6240\u6709\u86cb\u767d\u8d28\u7c7b\u522b\u4ecd\u4e0d\u6e05\u695a\u3002<\/p>\n

\u590d\u6742\u521b\u4f5c<\/strong><\/p>\n

\u9176\u5e76\u4e0d\u662f\u7814\u7a76\u4eba\u5458\u552f\u4e00\u5173\u5fc3\u7684\u86cb\u767d\u8d28\u7c7b\u522b\u3002\u65b0\u86cb\u767d\u8d28\u8fd8\u53ef\u4ee5\u4f5c\u4e3a\u6784\u5efa\u6a21\u5757\u4f7f\u7528\uff0c\u4f8b\u5982\u901a\u8fc7\u81ea\u7ec4\u88c5\u6210\u5c06\u8d27\u7269\u8fd0\u9001\u5230\u7ec6\u80de\u4e2d\u7684\u7ed3\u6784\u3001\u4ea7\u751f\u7269\u7406\u529b\u6216\u5c55\u5f00\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c7\u7b49\u75be\u75c5\u4e2d\u9519\u8bef\u6298\u53e0\u7684\u86cb\u767d\u8d28\u3002<\/p>\n

\u8fd9\u4e9b\u590d\u6742\u7ed3\u6784\u7684\u8ba1\u7b97\u8bbe\u8ba1\u5df2\u7ecf\u4ea7\u751f\u4e86\u5f71\u54cd\u30022022 \u5e74\u548c 2023 \u5e74\uff0c\u97e9\u56fd\u548c\u82f1\u56fd\u5206\u522b\u6279\u51c6\u7d27\u6025\u4f7f\u7528 COVID-19 \u75ab\u82d7\uff0c\u8fd9\u662f\u7b2c\u4e00\u79cd\u7531\u8ba1\u7b97\u8bbe\u8ba1\u7684\u86cb\u767d\u8d28\u5236\u6210\u7684\u533b\u7597\u4ea7\u54c1\u3002\u8fd9\u79cd\u75ab\u82d7\u540d\u4e3a SKYCovione\uff0c\u662f\u4e00\u79cd\u7eb3\u7c73\u9897\u7c92\uff0c\u542b\u6709\u4e24\u79cd\u86cb\u767d\u8d28\u6210\u5206\uff0c\u53ef\u5f15\u53d1\u9488\u5bf9 SARS-CoV-2 \u75c5\u6bd2\u523a\u7a81\u86cb\u767d\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cSKYCovione \u4ea7\u751f\u7684\u6297\u4f53\u6c34\u5e73\u662f\u5546\u7528\u75ab\u82d7\u7684\u4e09\u500d\uff0cKhmelinskaia \u8868\u793a\uff0c\u5b83\u7684\u6210\u529f\u8868\u660e\u8ba1\u7b97\u86cb\u767d\u8d28\u8bbe\u8ba1\u5df2\u51c6\u5907\u597d\u5e94\u7528\u4e8e\u73b0\u5b9e\u4e16\u754c\u3002\u300c\u73b0\u5728\u771f\u7684\u53ef\u4ee5\u5f00\u59cb\u7784\u51c6\u8bb8\u591a\u4ee5\u524d\u4e0d\u53ef\u80fd\u5b9e\u73b0\u7684\u6709\u8da3\u9014\u5f84\u4e86\u3002\u300d\u5979\u8bf4\u3002<\/p>\n

Khmelinskaia \u7684\u5b9e\u9a8c\u5ba4\u6b63\u5728\u4f7f\u7528\u673a\u5668\u5b66\u4e60<\/mark>\u7b97\u6cd5\u5f00\u53d1\u7a7a\u5fc3\u7eb3\u7c73\u7c92\u5b50\uff0c\u8fd9\u79cd\u7c92\u5b50\u53ef\u4ee5\u643a\u5e26\u836f\u7269\u6216\u6bd2\u7d20\u8fdb\u5165\u7ec6\u80de\uff0c\u6216\u8005\u9694\u79bb\u4e0d\u9700\u8981\u7684\u5206\u5b50\u3002\u5979\u8bf4\uff0c\u8fd9\u9700\u8981\u4e86\u89e3\u8bbe\u8ba1\u86cb\u767d\u8d28\u7684\u6784\u8c61\u52a8\u529b\u5b66\uff0c\u56e0\u4e3a\u7c92\u5b50\u53ca\u5176\u6709\u6548\u8f7d\u8377\u9700\u8981\u80fd\u591f\u7a7f\u8fc7\u7ec6\u80de\u819c\u7136\u540e\u6253\u5f00\uff08\u6216\u5173\u95ed\uff09\u3002<\/p>\n

\u4f46\u8fd9\u53ea\u662f\u5176\u4e2d\u4e00\u79cd\u529f\u80fd\u3002\u5bf9\u4e8e\u7ec6\u83cc\u97ad\u6bdb\u7b49\u66f4\u590d\u6742\u7684\u7ed3\u6784\uff0c\u673a\u5668\u5b66\u4e60<\/mark>\u80fd\u505a\u7684\u6709\u9650\u2014\u2014\u56e0\u4e3a\u6ca1\u6709\u8db3\u591f\u7684\u6613\u4e8e\u7406\u89e3\u7684\u4f8b\u5b50\u53ef\u4f9b\u53c2\u8003\u3002\u300c\u5982\u679c\u6211\u4eec\u6709 10 \u4e07\u6216 100 \u4e07\u79cd\u4e0d\u540c\u7684\u5206\u5b50\u673a\u5668\uff0c\u4e5f\u8bb8\u6211\u4eec\u53ef\u4ee5\u8bad\u7ec3\u4e00\u79cd\u751f\u6210\u5f0f\u4eba\u5de5\u667a\u80fd<\/mark>\u65b9\u6cd5\uff0c\u4ece\u5934\u5f00\u59cb\u751f\u6210\u673a\u5668\uff0c\u4f46\u4e8b\u5b9e\u5e76\u975e\u5982\u6b64\u3002\u300dBaker \u8bf4\u3002<\/p>\n

<\/a><\/p>\n

\u8fd9\u610f\u5473\u7740\u4eba\u7c7b\u7814\u7a76\u4eba\u5458\u9700\u8981\u8003\u8651\u7ec4\u6210\u5206\u5b50\u673a\u5668\u7684\u7ec4\u4ef6\uff08\u4f8b\u5982\u9a6c\u8fbe\u6216\u6cbf\u7740\u53e6\u4e00\u79cd\u86cb\u767d\u8d28\u300c\u884c\u8d70\u300d\u7684\u86cb\u767d\u8d28\uff09\uff0c\u5e76\u4f7f\u7528\u8bbe\u8ba1\u5de5\u5177\u9010\u4e2a\u521b\u5efa\u8fd9\u4e9b\u6784\u4ef6\u3002\u8fd9\u4e9b\u7ec4\u4ef6\u53ef\u80fd\u5305\u62ec\u5206\u5b50\u5f00\u5173\u3001\u8f6e\u5b50\u548c\u8f74\uff0c\u6216\u4ec5\u5728\u7279\u5b9a\u6761\u4ef6\u4e0b\u8d77\u4f5c\u7528\u7684\u300c\u903b\u8f91<\/mark>\u95e8\u300d\u7cfb\u7edf\u3002<\/p>\n

Kortemme \u89e3\u91ca\u9053\uff1a\u300c\u6bcf\u6b21\u5236\u9020\u590d\u6742\u7684\u673a\u5668\u65f6\uff0c\u4f60\u4e0d\u9700\u8981\u91cd\u65b0\u53d1\u660e\u8f6e\u5b50\u3002\u300d\u5979\u7684\u5b9e\u9a8c\u5ba4\u6b63\u5728\u8bbe\u8ba1\u53ef\u4ee5\u6574\u5408\u5230\u5408\u6210\u4fe1\u53f7\u8f6c\u5bfc\u7ea7\u8054\u4e2d\u7684\u7ec6\u80de\u4fe1\u53f7\u5206\u5b50\u3002<\/p>\n

Wang \u8bf4\uff0c\u6b63\u662f\u5728\u8fd9\u4e9b\u90e8\u4ef6\u7684\u5de7\u5999\u7ec4\u5408\u4e2d\uff0c\u4eba\u7c7b\u7684\u521b\u9020\u529b\u624d\u4f1a\u8131\u9896\u800c\u51fa\u3002\u300c\u6211\u4eec\u5f00\u59cb\u7528\u86cb\u767d\u8d28\u5236\u9020\u87ba\u4e1d\u3001\u87ba\u6813\u3001\u6760\u6746\u548c\u6ed1\u8f6e\u3002\u300d\u4ed6\u8868\u793a\uff0c\u300c\u4f46\u4f60\u8981\u7528\u90a3\u4e2a\u6ed1\u8f6e\u505a\u4ec0\u4e48\u5462\uff1f\u8fd9\u662f\u6700\u6709\u8da3\u4e5f\u662f\u6700\u5177\u6311\u6218\u6027\u7684\u65b9\u9762\u3002\u300d<\/p>\n

\u4ece\u9519\u8bef\u4e2d\u5b66\u4e60<\/strong><\/p>\n

\u867d\u7136 Khmelinskaia \u8bbe\u60f3\u4e86\u300c\u81ea\u52a8\u552e\u8d27\u673a\u300d\uff0c\u4f46\u5373\u4f7f\u662f\u6700\u597d\u7684\u9884\u6d4b\u7b97\u6cd5\u4e5f\u79bb\u4e00\u6b21\u6027\u751f\u6210\u51c6\u786e\u86cb\u767d\u8d28\u8fd8\u6709\u4e00\u6bb5\u8ddd\u79bb\u3002<\/p>\n

\u300c\u4ee5\u524d\u7b97\u6cd5\u6709 99.99% \u7684\u65f6\u95f4\u65e0\u6cd5\u6b63\u5e38\u5de5\u4f5c\u3002\u300dAlQuraishi \u8bf4\uff0c\u300c\u73b0\u5728\u66f4\u50cf\u662f\u53ea\u6709 99% \u7684\u65f6\u95f4\u4f1a\u5931\u8d25\u3002\u300d<\/p>\n

Steinegger \u8bf4\uff0c\u8fd9\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u662f\u7269\u6d41\u95ee\u9898\u3002\u8ba1\u7b97\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u53cd\u590d\u8fd0\u884c\u4ed6\u4eec\u7684\u7b97\u6cd5\uff0c\u76f4\u5230\u627e\u5230\u770b\u8d77\u6765\u53ef\u884c\u7684\u7b97\u6cd5\uff0c\u800c\u50cf\u4ed6\u8fd9\u6837\u7684\u7b97\u6cd5\u8bbe\u8ba1\u56e2\u961f\u300c\u5927\u7ea6\u6bcf\u4e09\u56db\u4e2a\u6708\u5c31\u4f1a\u6709\u65b0\u7684\u521b\u65b0\u300d\u3002<\/p>\n

Steinegger \u4f30\u8ba1\uff0c\u5728\u751f\u7269\u7cfb\u7edf\u4e2d\u9a8c\u8bc1\u8bbe\u8ba1\u7684\u86cb\u767d\u8d28\u53ef\u80fd\u9700\u8981\u4e24\u5e74\u65f6\u95f4\uff0c\u5c4a\u65f6\u8f6f\u4ef6\u5df2\u5f00\u59cb\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n

\u8fd9\u79cd\u4e0d\u5339\u914d\u610f\u5473\u7740\u7b97\u6cd5\u5f88\u5c11\u6709\u673a\u4f1a\u4ece\u9519\u8bef\u4e2d\u5438\u53d6\u6559\u8bad\u3002\u7814\u7a76\u4eba\u5458\u5f80\u5f80\u4e0d\u4f1a\u53d1\u8868\u8d1f\u9762\u7ed3\u679c\uff0c\u5373\u4f7f\u8fd9\u4e9b\u5931\u8d25\u53ef\u80fd\u5e26\u6765\u6709\u7528\u7684\u4fe1\u606f\uff0c\u4f8b\u5982\u86cb\u767d\u8d28\u5728\u7279\u5b9a\u6761\u4ef6\u4e0b\u7684\u7ec6\u80de\u6bd2\u6027\u6216\u7a33\u5b9a\u6027\u3002<\/p>\n

\u9664\u975e\u79d1\u7814\u8d44\u52a9\u6a21\u5f0f\u53d1\u751f\u6839\u672c\u6027\u53d8\u5316\u4ee5\u6fc0\u52b1\u6b64\u7c7b\u62ab\u9732\uff0c\u5426\u5219\u7814\u7a76\u4eba\u5458\u5fc5\u987b\u53d1\u6325\u521b\u9020\u529b\u3002\u300c\u7ec4\u5efa\u4e00\u652f\u80fd\u591f\u540c\u65f6\u6db5\u76d6\u6240\u6709\u8fd9\u4e9b\u65b9\u9762\u7684\u56e2\u961f\u6781\u5177\u6311\u6218\u6027\u3002\u300dKhmelinskaia \u89e3\u91ca\u9053\uff0c\u5979\u6307\u7684\u662f\u86cb\u767d\u8d28\u8bbe\u8ba1\u7814\u7a76\u7684\u5b9e\u9a8c\u548c\u8ba1\u7b97\u65b9\u9762\u3002\u56e0\u6b64\uff0c\u5408\u4f5c\u662f\u5fc5\u987b\u7684\u3002<\/p>\n

\u300c\u6211\u4eec\u76ee\u524d\u5904\u4e8e\u8ba1\u7b97\u673a\u8d44\u6e90\u548c\u6570\u636e\u90fd\u51c6\u5907\u5c31\u7eea\u7684\u9636\u6bb5\uff0c\u8fd9\u4e5f\u662f\u4e3a\u4ec0\u4e48\u8fd9\u4e2a\u9886\u57df\u5982\u6b64\u53d7\u6b22\u8fce\u7684\u539f\u56e0\u3002\u300dYang \u8bf4\uff0c\u300c\u5408\u4f5c\u7684\u4eba\u8d8a\u591a\uff0c\u8fdb\u6b65\u5c31\u8d8a\u5feb\u3002\u300d<\/p>\n

\u76f8\u5173\u5185\u5bb9\uff1ahttps:\/\/www.nature.com\/articles\/d41586-024-03595-9<\/em><\/p>\n

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