{"id":36794,"date":"2025-01-18T19:00:34","date_gmt":"2025-01-18T11:00:34","guid":{"rendered":"https:\/\/17aitech.com\/?p=36794"},"modified":"2025-01-18T19:00:34","modified_gmt":"2025-01-18T11:00:34","slug":"%e6%97%a0%e9%9c%80%e9%a2%84%e8%ae%ad%e7%bb%83%ef%bc%8c%e4%ba%b2%e5%92%8c%e5%8a%9b%e4%b8%8e%e5%a4%a9%e7%84%b6%e8%9b%8b%e7%99%bd%e7%9b%b8%e5%bd%93%ef%bc%8c%e4%b8%ad%e5%9b%bd%e7%a7%91%e5%a4%a7%e7%9a%84","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=36794","title":{"rendered":"\u65e0\u9700\u9884\u8bad\u7ec3\uff0c\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u4e2d\u56fd\u79d1\u5927\u7684\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u65b9\u6cd5\u767bNature\u5b50\u520a"},"content":{"rendered":"<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:<a href=\"https:\/\/www.jiqizhixin.com\/articles\/2024-11-22-7\" target=\"_blank\">\u65e0\u9700\u9884\u8bad\u7ec3\uff0c\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u4e2d\u56fd\u79d1\u5927\u7684\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u65b9\u6cd5\u767bNature\u5b50\u520a<\/a><\/p>\n<section><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-12143aa4d39c13857260c224393b5529.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-12143aa4d39c13857260c224393b5529.png\"><\/a><\/section>\n<p>\u7f16\u8f91 | \u767d\u83dc\u53f6<\/p>\n<p>\u5728\u8fc7\u53bb\u7684 2-3 \u5e74\u91cc\uff0c\u53bb\u566a\u6269\u6563\u6982\u7387\u6a21\u578b (DDPM) \u5728\u751f\u6210\u9ad8\u8d28\u91cf\u6587\u672c\u3001\u56fe\u50cf\u548c\u89c6\u9891\u65b9\u9762\u53d6\u5f97\u4e86\u524d\u6240\u672a\u6709\u7684\u6210\u529f\u3002\u8fd9\u6fc0\u53d1\u4e86\u4eba\u4eec\u5bf9\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u4ece\u5934\u8bbe\u8ba1\u4e2d\u4f7f\u7528\u751f\u6210\u5f0f DDPM \u7684\u70ed\u60c5\u3002<\/p>\n<p>\u7136\u800c\uff0c\u5927\u591a\u6570\u6b64\u7c7b\u7814\u7a76\u90fd\u9047\u5230\u4e86\u76f8\u5f53\u5927\u7684\u56f0\u96be\uff0c\u65e0\u6cd5\u83b7\u5f97\u53ef\u4ee5\u8f7b\u677e\u751f\u6210\u53ef\u901a\u8fc7\u9ad8\u5206\u8fa8\u7387\u7ed3\u6784\u5206\u6790\u9a8c\u8bc1\u7684\u65e0\u7f3a\u9677\u86cb\u767d\u8d28\u7ed3\u6784\u7684 DDPM\u3002<\/p>\n<p>\u5728\u8fd9\u91cc\uff0c\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u5b66\u90e8\u5218\u6d77\u71d5\u6559\u6388\u3001\u9648\u6cc9\u6559\u6388\u56e2\u961f\u63d0\u51fa\u4e86 SCUBA-diffusion\uff08SCUBA-D\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u86cb\u767d\u8d28\u4e3b\u94fe\u53bb\u566a\u6269\u6563\u6982\u7387\u6a21\u578b\uff0c\u901a\u8fc7\u8003\u8651\u5e8f\u5217\u8868\u793a\u7684\u5171\u6269\u6563\u8fdb\u884c\u65b0\u8bad\u7ec3\uff0c\u4ee5\u589e\u5f3a\u6a21\u578b<mark data-id=\"c51052b5-4cd8-4df0-99bb-5aa643c2f027\" data-type=\"concepts\">\u6b63\u5219\u5316<\/mark>\u548c\u5bf9\u6297\u6027\u635f\u5931\uff0c\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u6570\u636e\u5206\u5e03\u5916\u8bef\u5dee\u3002<\/p>\n<p>\u5728\u751f\u6210\u5b9e\u9a8c\u53ef\u5b9e\u73b0\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u65b9\u9762\uff0cSCUBA-D \u4e0e\u57fa\u4e8e\u9884\u8bad\u7ec3 RoseTTAFold \u7684 RFdiffusion \u7684\u6027\u80fd\u76f8\u5f53\uff0c\u4f46\u5b83\u53ef\u4ee5\u8f7b\u677e\u751f\u6210\u5c1a\u672a\u89c2\u5bdf\u5230\u7684\u6574\u4f53\u6298\u53e0\u4e0e RoseTTAFold \u53ef\u9884\u6d4b\u7684\u6298\u53e0\u4e0d\u540c\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002<\/p>\n<p>SCUBA-D \u7684\u51c6\u786e\u6027\u5df2\u901a\u8fc7 16 \u79cd\u8bbe\u8ba1\u86cb\u767d\u8d28\u548c\u4e00\u79cd\u86cb\u767d\u8d28\u590d\u5408\u7269\u7684 X \u5c04\u7ebf\u7ed3\u6784\u4ee5\u53ca\u9a8c\u8bc1\u8bbe\u8ba1\u7684\u8840\u7ea2\u7d20\u7ed3\u5408\u86cb\u767d\u548c Ras \u7ed3\u5408\u86cb\u767d\u7684\u5b9e\u9a8c\u5f97\u5230\u8bc1\u5b9e\u3002<\/p>\n<p>\u8fd9\u9879\u5de5\u4f5c\u8868\u660e\uff0c\u901a\u8fc7\u89e3\u51b3\u6570\u636e\u5206\u5e03\u8bef\u5dee\u7b49\u7a81\u51fa\u95ee\u9898\uff0c\u56fe\u50cf\u6216\u6587\u672c\u7684<mark data-id=\"77c3d598-259e-4ecc-9617-bd27ca2098fd\" data-type=\"tech_methods\">\u6df1\u5ea6\u751f\u6210\u6a21\u578b<\/mark>\u53ef\u4ee5\u6709\u6548\u5730\u6269\u5c55\u5230\u86cb\u767d\u8d28\u7ed3\u6784\u7b49\u590d\u6742\u7684\u7269\u7406\u5bf9\u8c61\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u4ee5\u300c<em>De novo protein design with a denoising diffusion network independent of pretrained structure prediction models<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2024 \u5e74 10 \u6708 9 \u65e5\u53d1\u5e03\u5728\u300a<em>Nature Methods<\/em>\u300b\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-bbe738e13fffc58d734df7c94e8cd341.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-bbe738e13fffc58d734df7c94e8cd341.png\"><\/a><\/p>\n<p>\u4ece\u5934\u86cb\u767d\u8d28\u8bbe\u8ba1\u65e8\u5728\u751f\u6210\u9488\u5bf9\u7279\u5b9a\u529f\u80fd\u7684\u4eba\u5de5\u86cb\u767d\u8d28\uff0c\u5176\u4e3b\u8981\u95ee\u9898\u662f\u751f\u6210\u53ef\u8bbe\u8ba1\u4e14\u7269\u7406\u4e0a\u5408\u7406\u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u5373\u53ef\u88ab\u67d0\u4e9b\u6c28\u57fa\u9178\u5e8f\u5217\u81ea\u4e3b\u91c7\u7528\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002<\/p>\n<p>\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u552f\u4e00\u80fd\u591f\u5e94\u5bf9\u8fd9\u4e2a\u4efb\u52a1\u7684 DDPM\uff08\u81f3\u5c11\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\uff09\u662f RFdiffusion\uff0c\u5b83\u4f9d\u8d56\u4e8e\u5bf9\u9884\u8bad\u7ec3\u7ed3\u6784\u9884\u6d4b\u7f51\u7edc RoseTTAFold \u8fdb\u884c\u5fae\u8c03\uff0c\u4ee5\u5b8c\u6210\u5404\u79cd\u7ed3\u6784\u53bb\u566a\u4efb\u52a1\u3002<\/p>\n<p>\u4e3a\u4e86\u907f\u514d\u6f5c\u5728\u504f\u5dee\u7684\u7ee7\u627f\uff0c\u8fd9\u662f\u9884\u8bad\u7ec3\u7ed3\u6784\u9884\u6d4b\u7f51\u7edc\u7684\u4e00\u4e2a\u9650\u5236\uff0c\u79d1\u5b66\u5bb6\u65e8\u5728\u5f00\u53d1\u65b0\u8bad\u7ec3\u7684 DDPM\uff0c\u5176\u6027\u80fd\u81f3\u5c11\u4e0e RFdiffusion \u76f8\u5f53\uff0c\u4f46\u4e0d\u4f9d\u8d56\u4e8e\u4ee5\u524d\u7684\u7ed3\u6784\u9884\u6d4b\u7f51\u7edc\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u79d1\u5b66\u5bb6\u8fd8\u5e0c\u671b\u4ece\u6b64\u7c7b\u7814\u7a76\u4e2d\u83b7\u5f97\u7684\u6d1e\u5bdf\u529b\u548c\u7406\u89e3\u5c06\u52a0\u901f\u672a\u6765\u7528\u4e8e\u751f\u7269\u5206\u5b50\u7ed3\u6784\u9884\u6d4b\u7684\u751f\u6210\u5f0f DDPM \u7684\u53d1\u5c55\u3002<\/p>\n<p>\u5728\u8fd9\u91cc\uff0c\u901a\u8fc7\u7ed3\u5408\u6570\u636e\u6062\u590d\u548c\u6700\u5c0f\u5316\u5bf9\u6297\u635f\u5931\u7684\u76ee\u6807\u8fdb\u884c\u8bad\u7ec3\uff0c\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\u5218\u6d77\u71d5\u6559\u6388\u3001\u9648\u6cc9\u6559\u6388\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u8bad\u7ec3\u7684 DDPM\uff0c\u5b83\u53ef\u4ee5\u751f\u6210\u591a\u6837\u5316\u7684\u86cb\u767d\u8d28\u9aa8\u67b6\u3002\u8be5\u6a21\u578b\u88ab\u547d\u540d\u4e3a SCUBA-D\uff08sidechain unknown backbone arrangement-diffusion\uff09\uff0c\u56e0\u4e3a\u5b83\u53ef\u4ee5\u751f\u6210\u53ef\u8bbe\u8ba1\u7684\u9aa8\u67b6\u800c\u65e0\u9700\u9884\u5148\u786e\u5b9a\u6c28\u57fa\u9178\u5e8f\u5217\u3002<\/p>\n<p>\u5728\u524d\u671f\u5de5\u4f5c\u4e2d\uff0c<a data-itemshowtype=\"0\" data-linktype=\"2\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3MjM3ODk0NQ==&amp;mid=2247489593&amp;idx=1&amp;sn=dfc33d4c84f6bf2242d3b6562ca6789f&amp;chksm=eb322517dc45ac01ea1ac474e1dfbfedb0c801d7c98353a24b0836196f46a7e30258f7560c96&amp;scene=21#wechat_redirect\" target=\"_blank\">\u8be5\u56e2\u961f\u5efa\u7acb\u5e76\u5b9e\u9a8c\u9a8c\u8bc1\u4e86\u5229\u7528<mark data-id=\"72b0bcc0-d8f9-4edd-919f-fa7c2560388c\" data-type=\"tech_methods\">\u795e\u7ecf\u7f51\u7edc<\/mark>\u80fd\u91cf\u51fd\u6570\u4ece\u5934\u8bbe\u8ba1\u4e3b\u94fe\u7ed3\u6784\u7684 SCUBA \u6a21\u578b\uff08Nature 2022\uff09<\/a>\uff0cSCUBA-D \u662f\u57fa\u4e8e<mark data-id=\"01946acc-d031-4c0e-909c-f062643b7273\" data-type=\"tech_methods\">\u6df1\u5ea6\u5b66\u4e60<\/mark>\u7684\u4e3b\u94fe\u8bbe\u8ba1\u7b97\u6cd5\u7684\u8fed\u4ee3\u5347\u7ea7\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-f70bc8ba49104260c6f8be367116c545.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-f70bc8ba49104260c6f8be367116c545.png\"><\/a><\/p>\n<section>\u56fe\u793a\uff1aSCUBA-D \u4f7f\u7528\u7ecf\u8fc7\u5bf9\u6297\u635f\u5931\u8bad\u7ec3\u7684\u53bb\u566a\u6269\u6563\u7f51\u7edc\u6765\u751f\u6210\u53ef\u8bbe\u8ba1\u7684\u86cb\u767d\u8d28\u4e3b\u94fe\u7ed3\u6784\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n<p>\u7814\u7a76\u4eba\u5458\u8bc1\u660e SCUBA-D \u53ef\u4ee5\u6267\u884c\u5404\u79cd\u86cb\u767d\u8d28\u8bbe\u8ba1\u4efb\u52a1\uff0c\u5305\u62ec\u4ece\u968f\u673a\u566a\u58f0\u4e2d\u751f\u6210\u53ef\u8bbe\u8ba1\u7684\u4e3b\u94fe\uff08\u65e0\u6761\u4ef6\u751f\u6210\uff09\u3001\u56f4\u7ed5\u7528\u6237\u7ed8\u5236\u7684\u3001\u4e0d\u53ef\u8bbe\u8ba1\u7684\u521d\u59cb\u4e3b\u94fe\u751f\u6210\u53ef\u8bbe\u8ba1\u7684\u4e3b\u94fe\uff08\u57fa\u4e8e\u8349\u56fe\u8f93\u5165\u7684\u751f\u6210\uff09\u4ee5\u53ca\u751f\u6210\u4e3b\u94fe\u4ee5\u652f\u6491\u9884\u5b9a\u4e49\u57fa\u5e8f\uff0c\u5177\u6709\u7ed3\u5408\u5c0f\u5206\u5b50\u6216\u7ed3\u5408\u5176\u4ed6\u86cb\u767d\u8d28\u7684\u529f\u80fd\uff08\u57fa\u5e8f\u652f\u67b6\uff09\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-001633dac02b1961b957d1747f4ecaad.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-001633dac02b1961b957d1747f4ecaad.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u65e0\u6761\u4ef6\u6216\u6709\u504f\u5dee\u7684\u4e8c\u7ea7\u7ed3\u6784\u5206\u5e03\u7684\u7ed3\u6784\u751f\u6210\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p>\u56e2\u961f\u5bf9 SCUBA-D \u5728\u591a\u7c7b\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u4efb\u52a1\u4e2d\u7684\u5e94\u7528\u8fdb\u884c\u4e86\u5b9e\u9a8c\u9a8c\u8bc1\u3002\u9488\u5bf9\u5355\u4f53\u7ed3\u6784\u4ece\u5934\u8bbe\u8ba1\u4efb\u52a1\uff0c\u56e2\u961f\u5bf9\u5171\u8ba170\u6761\u8bbe\u8ba1\u5e8f\u5217\u8fdb\u884c\u4e86\u5b9e\u9a8c\u8868\u5f81\uff0c\u5176\u4e2d\u8fd1 80% \u7684\u5e8f\u5217\uff0853 \u6761\uff09\u53ef\u6eb6\u8868\u8fbe\uff0c\u5b9e\u9a8c\u89e3\u6790\u7684 16 \u4e2a\u9ad8\u5206\u8fa8\u6676\u4f53\u7ed3\u6784\u4e0e\u76ee\u6807\u7ed3\u6784\u9ad8\u5ea6\u4e00\u81f4\uff08\u4e3b\u94fe\u539f\u5b50\u4f4d\u7f6e\u5747\u65b9\u6839\u4f4d\u79fb\u5728 0.96 \u5230 2.11\u00c5 \u4e4b\u95f4\uff09\u3002<\/p>\n<p>\u5728\u5c0f\u5206\u5b50\u7ed3\u5408\u86cb\u767d\u8bbe\u8ba1\u4efb\u52a1\u4e2d\uff0c\u56e2\u961f\u5bf9\u975e\u7ecf\u5178\u8840\u7ea2\u7d20\u964d\u89e3\u9176\u8fdb\u884c\u4e86\u4fdd\u7559\u7ed3\u5408\u4f4d\u70b9\u7684\u4e3b\u94fe\u7ed3\u6784\u91cd\u8bbe\u8ba1\uff0c\u5bf9\u8bbe\u8ba1\u7684 12 \u6761\u5e8f\u5217\u8fdb\u884c\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u5176\u4e2d 5 \u6761\u5177\u6709\u4e0e\u8840\u7ea2\u7d20\u7684\u7ed3\u5408\u80fd\u529b\uff0c\u4e09\u6761\u5e8f\u5217\u4e0e\u8840\u7ea2\u7d20\u7684\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\u6216\u9ad8\u4e8e\u5929\u7136\u86cb\u767d\u3002<\/p>\n<p>\u5728\u7ed3\u5408\u86cb\u767d\u8bbe\u8ba1\u4efb\u52a1\u4e2d\uff0c30\u4e2a\u4eba\u5de5\u8bbe\u8ba1\u7684 Ras \u7ed3\u5408\u86cb\u767d 14 \u4e2a\u4e0e Ras \u6709\u76f8\u4e92\u4f5c\u7528\uff0c\u5176\u4e2d 3 \u4e2a\u8bbe\u8ba1\u86cb\u767d\u4e0e Ras \u7684\u7ed3\u5408\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u590d\u5408\u7269\u6676\u4f53\u7ed3\u6784\u66f4\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u8bbe\u8ba1\u7684\u7cbe\u786e\u5ea6\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-b1beb5d0571d1349fb5ade318589b2e3.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-b1beb5d0571d1349fb5ade318589b2e3.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1aSCUBA-D \u7528\u4e8e\u8bbe\u8ba1\u86cb\u767d\u8d28\u7ed3\u5408\u86cb\u767d\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p>\u4e0e\u5176\u4ed6\u521a\u8bad\u7ec3\u597d\u7684\u86cb\u767d\u8d28\u7ed3\u6784 DDPM \u4e0d\u540c\uff0cSCUBA-D \u4e0d\u53ea\u8003\u8651\u4e86\u901a\u5e38\u7684\u6570\u636e\u6062\u590d\u76ee\u6807\uff0c\u8fd8\u8003\u8651\u4e86\u6700\u5c0f\u5316\u5bf9\u6297\u635f\u5931\u8fd9\u4e00\u989d\u5916\u76ee\u6807\u3002\u8fd9\u4f7f\u5f97 SCUBA-D \u80fd\u591f\u751f\u6210\u6bd4\u5176\u4ed6\u521a\u8bad\u7ec3\u597d\u7684 DDPM \u5177\u6709\u66f4\u9ad8\u53ef\u8bbe\u8ba1\u6027\u7684\u4e3b\u5e72\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u53ea\u6709 Chroma \u548c SCUBA-D \u80fd\u591f\u901a\u8fc7\u5b9e\u9a8c\u89e3\u51b3\u4f7f\u7528\u65b0\u8bad\u7ec3\u7684 DDPM \u8bbe\u8ba1\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002Chroma \u7814\u7a76\u8003\u8651\u4e86 300 \u591a\u79cd\u8bbe\u8ba1\u86cb\u767d\u8d28\u8fdb\u884c\u5b9e\u9a8c\u8868\u5f81\uff0c\u5e76\u4ec5\u62a5\u544a\u4e86\u4e24\u79cd\u5168\u87ba\u65cb\u86cb\u767d\u8d28\u7684\u6676\u4f53\u7ed3\u6784\uff0c\u8fd9\u53cd\u6620\u4e86\u4f7f\u7528\u5e38\u89c4\u6570\u636e\u6062\u590d\u76ee\u6807\u8bad\u7ec3\u7684 DDPM \u5728\u751f\u6210\u53ef\u901a\u8fc7\u9ad8\u5206\u8fa8\u7387\u5b9e\u9a8c\u786e\u8ba4\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u65b9\u9762\u5b58\u5728\u56f0\u96be\u3002<\/p>\n<p>\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u7531\u4e8e\u6a21\u578b\u8bad\u7ec3\u65f6\u589e\u52a0\u4e86\u6700\u5c0f\u5316\u5bf9\u6297\u635f\u5931\u7684\u76ee\u6807\uff0cSCUBA-D \u53d6\u5f97\u4e86\u6bd4\u5176\u4ed6\u521a\u8bad\u7ec3\u597d\u7684 DDPM \u66f4\u5e7f\u6cdb\u7684\u5b9e\u9a8c\u6210\u529f\u7387\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u4f7f\u7528 SCUBA-D \u6210\u529f\u8bbe\u8ba1\u5168 \u03b2 \u86cb\u767d\u8d28\u53ef\u88ab\u89c6\u4e3a\u4f7f\u7528 DDPM \u8bbe\u8ba1\u86cb\u767d\u8d28\u9aa8\u67b6\u7684\u91cd\u8981\u4e00\u6b65\u3002\u8fd9\u4e9b\u7ed3\u679c\u5f3a\u8c03\u4e86\u8003\u8651\u7269\u7406\u7ea6\u675f\u5bf9\u8c61\uff08\u4f8b\u5982\u86cb\u767d\u8d28\u7ed3\u6784\uff09\u4e0e\u975e\u7269\u7406\u7ea6\u675f\u5bf9\u8c61\uff08\u4f8b\u5982\u56fe\u50cf\u548c\u6587\u672c\uff09\u4e4b\u95f4\u7684\u4e0d\u540c\u5bb9\u9519\u80fd\u529b\u7684\u91cd\u8981\u6027\u3002<\/p>\n<p>\u8fd9\u79cd\u6d1e\u5bdf\u529b\u53ef\u7528\u6765\u52a0\u901f\u6df1\u5ea6\u751f\u6210\u65b9\u6cd5\u7684\u6269\u5c55\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u5728\u751f\u6210\u8ba1\u7b97\u673a\u5bf9\u8c61\u65b9\u9762\u5177\u6709\u660e\u663e\u7684\u4f18\u52bf\uff0c\u53ef\u4ee5\u751f\u6210\u9700\u8981\u7269\u7406\u4e0a\u5408\u7406\u7684\u5bf9\u8c61\uff0c\u5305\u62ec\u53ef\u8bbe\u8ba1\u7684\u6838\u9178\u7ed3\u6784\u548c\u86cb\u767d\u8d28-\u6838\u9178\u590d\u5408\u7269\u3002<\/p>\n<p>\u76f8\u5173\u5185\u5bb9\uff1a<em>https:\/\/www.nature.com\/articles\/s41592-024-02465-6<\/em><\/p>\n<p>\u8bba\u6587\u94fe\u63a5\uff1a<em>https:\/\/www.nature.com\/articles\/s41592-024-02437-w<\/em><\/p>\n<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:<a href=\"https:\/\/www.jiqizhixin.com\/articles\/2024-11-22-7\" target=\"_blank\">\u65e0\u9700\u9884\u8bad\u7ec3\uff0c\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u4e2d\u56fd\u79d1\u5927\u7684\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u65b9\u6cd5\u767bNature\u5b50\u520a<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u65e0\u9700\u9884\u8bad\u7ec3\uff0c\u4eb2\u548c\u529b\u4e0e\u5929 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[27],"tags":[65],"class_list":["post-36794","post","type-post","status-publish","format-standard","hentry","category-news","tag-65"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u65e0\u9700\u9884\u8bad\u7ec3\uff0c\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u4e2d\u56fd\u79d1\u5927\u7684\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u65b9\u6cd5\u767bNature\u5b50\u520a - \u4e00\u8d77AI\u6280\u672f<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/17aitech.com\/?p=36794\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/17aitech.com\/?p=36794\",\"url\":\"https:\/\/17aitech.com\/?p=36794\",\"name\":\"\u65e0\u9700\u9884\u8bad\u7ec3\uff0c\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u4e2d\u56fd\u79d1\u5927\u7684\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u65b9\u6cd5\u767bNature\u5b50\u520a - \u4e00\u8d77AI\u6280\u672f\",\"isPartOf\":{\"@id\":\"https:\/\/17aitech.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/17aitech.com\/?p=36794#primaryimage\"},\"image\":{\"@id\":\"https:\/\/17aitech.com\/?p=36794#primaryimage\"},\"thumbnailUrl\":\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-12143aa4d39c13857260c224393b5529.png\",\"datePublished\":\"2025-01-18T11:00:34+00:00\",\"author\":{\"@id\":\"https:\/\/17aitech.com\/#\/schema\/person\/60225458499e817ae0af73e67e440b9d\"},\"breadcrumb\":{\"@id\":\"https:\/\/17aitech.com\/?p=36794#breadcrumb\"},\"inLanguage\":\"zh-Hans\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/17aitech.com\/?p=36794\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-Hans\",\"@id\":\"https:\/\/17aitech.com\/?p=36794#primaryimage\",\"url\":\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-12143aa4d39c13857260c224393b5529.png\",\"contentUrl\":\"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-12143aa4d39c13857260c224393b5529.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/17aitech.com\/?p=36794#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/17aitech.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u65e0\u9700\u9884\u8bad\u7ec3\uff0c\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u4e2d\u56fd\u79d1\u5927\u7684\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u65b9\u6cd5\u767bNature\u5b50\u520a\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/17aitech.com\/#website\",\"url\":\"https:\/\/17aitech.com\/\",\"name\":\"\u4e00\u8d77AI\u6280\u672f\",\"description\":\"\u8ba9AI\u77e5\u8bc6\u89e6\u624b\u53ef\u53ca\",\"alternateName\":\"\u4e00\u8d77AI\u6280\u672f\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/17aitech.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-Hans\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/17aitech.com\/#\/schema\/person\/60225458499e817ae0af73e67e440b9d\",\"name\":\"AI\u5c0f\u52a9\u624b\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-Hans\",\"@id\":\"https:\/\/17aitech.com\/#\/schema\/person\/image\/\",\"url\":\"\/\/17aitech.com\/wp-content\/uploads\/2024\/04\/robot_3.png\",\"contentUrl\":\"\/\/17aitech.com\/wp-content\/uploads\/2024\/04\/robot_3.png\",\"caption\":\"AI\u5c0f\u52a9\u624b\"},\"description\":\"\u8fd9\u4e2a\u4eba\u5f88\u61d2\uff0c\u4ec0\u4e48\u90fd\u6ca1\u6709\u7559\u4e0b\uff5e\",\"url\":\"https:\/\/17aitech.com\/?page_id=33738&user=3\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u65e0\u9700\u9884\u8bad\u7ec3\uff0c\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u4e2d\u56fd\u79d1\u5927\u7684\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u65b9\u6cd5\u767bNature\u5b50\u520a - \u4e00\u8d77AI\u6280\u672f","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/17aitech.com\/?p=36794","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/17aitech.com\/?p=36794","url":"https:\/\/17aitech.com\/?p=36794","name":"\u65e0\u9700\u9884\u8bad\u7ec3\uff0c\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u4e2d\u56fd\u79d1\u5927\u7684\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u65b9\u6cd5\u767bNature\u5b50\u520a - \u4e00\u8d77AI\u6280\u672f","isPartOf":{"@id":"https:\/\/17aitech.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/17aitech.com\/?p=36794#primaryimage"},"image":{"@id":"https:\/\/17aitech.com\/?p=36794#primaryimage"},"thumbnailUrl":"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-12143aa4d39c13857260c224393b5529.png","datePublished":"2025-01-18T11:00:34+00:00","author":{"@id":"https:\/\/17aitech.com\/#\/schema\/person\/60225458499e817ae0af73e67e440b9d"},"breadcrumb":{"@id":"https:\/\/17aitech.com\/?p=36794#breadcrumb"},"inLanguage":"zh-Hans","potentialAction":[{"@type":"ReadAction","target":["https:\/\/17aitech.com\/?p=36794"]}]},{"@type":"ImageObject","inLanguage":"zh-Hans","@id":"https:\/\/17aitech.com\/?p=36794#primaryimage","url":"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-12143aa4d39c13857260c224393b5529.png","contentUrl":"https:\/\/17aitech.com\/wp-content\/uploads\/2024\/11\/frc-12143aa4d39c13857260c224393b5529.png"},{"@type":"BreadcrumbList","@id":"https:\/\/17aitech.com\/?p=36794#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/17aitech.com\/"},{"@type":"ListItem","position":2,"name":"\u65e0\u9700\u9884\u8bad\u7ec3\uff0c\u4eb2\u548c\u529b\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u4e2d\u56fd\u79d1\u5927\u7684\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u65b9\u6cd5\u767bNature\u5b50\u520a"}]},{"@type":"WebSite","@id":"https:\/\/17aitech.com\/#website","url":"https:\/\/17aitech.com\/","name":"\u4e00\u8d77AI\u6280\u672f","description":"\u8ba9AI\u77e5\u8bc6\u89e6\u624b\u53ef\u53ca","alternateName":"\u4e00\u8d77AI\u6280\u672f","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/17aitech.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-Hans"},{"@type":"Person","@id":"https:\/\/17aitech.com\/#\/schema\/person\/60225458499e817ae0af73e67e440b9d","name":"AI\u5c0f\u52a9\u624b","image":{"@type":"ImageObject","inLanguage":"zh-Hans","@id":"https:\/\/17aitech.com\/#\/schema\/person\/image\/","url":"\/\/17aitech.com\/wp-content\/uploads\/2024\/04\/robot_3.png","contentUrl":"\/\/17aitech.com\/wp-content\/uploads\/2024\/04\/robot_3.png","caption":"AI\u5c0f\u52a9\u624b"},"description":"\u8fd9\u4e2a\u4eba\u5f88\u61d2\uff0c\u4ec0\u4e48\u90fd\u6ca1\u6709\u7559\u4e0b\uff5e","url":"https:\/\/17aitech.com\/?page_id=33738&user=3"}]}},"_links":{"self":[{"href":"https:\/\/17aitech.com\/index.php?rest_route=\/wp\/v2\/posts\/36794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/17aitech.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/17aitech.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/17aitech.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/17aitech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36794"}],"version-history":[{"count":0,"href":"https:\/\/17aitech.com\/index.php?rest_route=\/wp\/v2\/posts\/36794\/revisions"}],"wp:attachment":[{"href":"https:\/\/17aitech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36794"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/17aitech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36794"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/17aitech.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}