{"id":36862,"date":"2025-01-20T02:00:37","date_gmt":"2025-01-19T18:00:37","guid":{"rendered":"https:\/\/17aitech.com\/?p=36862"},"modified":"2025-01-20T02:00:37","modified_gmt":"2025-01-19T18:00:37","slug":"%e5%8e%8b%e7%bc%a9%e7%8e%87%e8%be%be10%e7%9a%8448%e6%ac%a1%e6%96%b9%ef%bc%8c%e5%ae%9e%e7%8e%b0%e8%9b%8b%e7%99%bd%e5%ba%8f%e5%88%97%e7%a9%ba%e9%97%b4%e6%9e%81%e7%ab%af%e5%8e%8b%e7%bc%a9%ef%bc%8c","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=36862","title":{"rendered":"\u538b\u7f29\u7387\u8fbe10\u768448\u6b21\u65b9\uff0c\u5b9e\u73b0\u86cb\u767d\u5e8f\u5217\u7a7a\u95f4\u6781\u7aef\u538b\u7f29\uff0c\u6e05\u534eEvoAI\u767bNature\u5b50\u520a"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u538b\u7f29\u7387\u8fbe10\u768448\u6b21\u65b9\uff0c\u5b9e\u73b0\u86cb\u767d\u5e8f\u5217\u7a7a\u95f4\u6781\u7aef\u538b\u7f29\uff0c\u6e05\u534eEvoAI\u767bNature\u5b50\u520a<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

\u8bbe\u8ba1\u529f\u80fd\u66f4\u4f73\u7684\u86cb\u767d\u8d28\u9700\u8981\u6df1\u5165\u4e86\u89e3\u5e8f\u5217\u548c\u529f\u80fd\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u8fd9\u662f\u4e00\u4e2a\u96be\u4ee5\u63a2\u7d22\u7684\u5e7f\u9614\u7a7a\u95f4\u3002\u901a\u8fc7\u8bc6\u522b\u529f\u80fd\u4e0a\u91cd\u8981\u7684\u7279\u5f81\u6765\u6709\u6548\u538b\u7f29\u8fd9\u4e00\u7a7a\u95f4\u7684\u80fd\u529b\u6781\u5176\u5b9d\u8d35\u3002<\/p>\n

\u6e05\u534e\u5927\u5b66<\/mark>\u7684\u7814\u7a76\u56e2\u961f\u5efa\u7acb\u4e86\u4e00\u79cd\u79f0\u4e3a EvoScan \u7684\u65b9\u6cd5\uff0c\u7528\u4e8e\u5168\u9762\u5206\u5272\u548c\u626b\u63cf\u9ad8\u9002\u5e94\u5ea6\u5e8f\u5217\u7a7a\u95f4\uff0c\u4ee5\u83b7\u5f97\u80fd\u591f\u6355\u6349\u5176\u57fa\u672c\u7279\u5f81\uff08\u5c24\u5176\u662f\u5728\u9ad8\u7ef4\u5ea6\u4e2d\uff09\u7684\u951a\u70b9\u3002<\/p>\n

\u8be5\u65b9\u6cd5\u9002\u7528\u4e8e\u4efb\u4f55\u80fd\u591f\u4e0e\u8f6c\u5f55\u8f93\u51fa\u8026\u5408\u7684\u751f\u7269\u5206\u5b50\u529f\u80fd\u7814\u7a76\u3002<\/p>\n

\u7136\u540e\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u6df1\u5ea6\u5b66\u4e60<\/mark>\u548c\u5927\u578b\u8bed\u8a00\u6a21\u578b<\/mark>\uff0c\u4ee5\u4ece\u8fd9\u4e9b\u951a\u70b9\u51c6\u786e\u5730\u91cd\u5efa\u7a7a\u95f4\uff0c\u4ece\u800c\u65e0\u9700\u5148\u524d\u7684\u540c\u6e90\u6027\u6216\u7ed3\u6784\u4fe1\u606f\u5373\u53ef\u8ba1\u7b97\u9884\u6d4b\u65b0\u7684\u3001\u9ad8\u5ea6\u62df\u5408\u7684\u5e8f\u5217\u3002<\/p>\n

\u4ed6\u4eec\u5c06\u8fd9\u79cd\u6df7\u5408\u5b9e\u9a8c\u8ba1\u7b97\u65b9\u6cd5\uff08\u79f0\u4e3a EvoAI\uff09\u5e94\u7528\u4e8e\u963b\u904f\u86cb\u767d\uff0c\u53d1\u73b0\u4ec5 82 \u4e2a\u951a\u70b9\u5c31\u8db3\u4ee5\u538b\u7f29\u9ad8\u9002\u5e94\u5ea6\u5e8f\u5217\u7a7a\u95f4\uff0c\u538b\u7f29\u7387\u4e3a 1048<\/sup>\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cEvoAI enables extreme compression and reconstruction of the protein sequence space<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2024 \u5e74 11 \u6708 11 \u65e5\u53d1\u5e03\u5728\u300aNature Methods<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

\u86cb\u767d\u8d28\u5de5\u7a0b\u548c\u8bbe\u8ba1\u53ef\u4ee5\u521b\u5efa\u5177\u6709\u4f18\u5316\u529f\u80fd\u7684\u86cb\u767d\u8d28\uff0c\u7528\u4e8e\u751f\u7269\u6280\u672f\u3001\u533b\u5b66\u548c\u5408\u6210\u751f\u7269\u5b66\u7684\u5404\u79cd\u5e94\u7528\u3002<\/p>\n

\u86cb\u767d\u8d28\u5de5\u7a0b\u7684\u57fa\u672c\u6311\u6218\u662f\u7406\u89e3\u548c\u64cd\u7eb5\u86cb\u767d\u8d28\u9002\u5e94\u5ea6\u666f\u89c2\uff0c\u8fd9\u662f\u4e00\u4e2a\u9ad8\u7ef4\u4e14\u590d\u6742\u7684\u7a7a\u95f4\uff0c\u5305\u542b\u5927\u91cf\u53ef\u80fd\u7684\u5e8f\u5217\u548c\u529f\u80fd\u3002<\/p>\n

\u5c3d\u7ba1\u8fc7\u53bb\u51e0\u5341\u5e74\u6765\u79d1\u5b66\u5bb6\u4eec\u8fdb\u884c\u4e86\u5927\u91cf\u5c1d\u8bd5\u6765\u5bfb\u627e\u8fd9\u4e2a\u7a7a\u95f4\u4e2d\u7684\u9ad8\u9002\u5e94\u5ea6\u5e8f\u5217\uff0c\u4f46\u6211\u4eec\u5bf9\u8fd9\u4e2a\u7a7a\u95f4\u7684\u89c4\u5219\u548c\u7279\u5f81\u7684\u7406\u89e3\u4ecd\u7136\u6bd4\u8f83\u6d45\u5c42\u3002<\/p>\n

\u867d\u7136\u73b0\u6709\u7684\u5b9a\u5411\u8fdb\u5316\u6280\u672f\u80fd\u63d0\u4f9b\u6709\u4ef7\u503c\u7684\u4fe1\u606f\uff0c\u4f46\u8fd9\u4e9b\u5b9e\u9a8c\u65b9\u6cd5\u9700\u8981\u5728\u7cbe\u786e\u5ea6\u4e0e\u8986\u76d6\u5ea6\u4e4b\u95f4\u8fdb\u884c\u6743\u8861\uff0c\u4e14\u901a\u5e38\u65e0\u6cd5\u5145\u5206\u8003\u8651\u9ad8\u7ef4\u7a7a\u95f4\u4e2d\u7684\u81ea\u7136\u9009\u62e9\u538b\u529b\u3002<\/p>\n

\u8ba1\u7b97\u65b9\u6cd5\uff0c\u5982\u57fa\u4e8e\u7ed3\u6784\u6216\u5e8f\u5217\u7684\u5efa\u6a21\uff0c\u867d\u7136\u80fd\u8bc4\u4f30\u66f4\u5927\u7684\u5e8f\u5217\u7a7a\u95f4\uff0c\u4f46\u53d7\u9650\u4e8e\u8bad\u7ec3\u6570\u636e\u7684\u53ef\u7528\u6027\uff0c\u4e14\u5f80\u5f80\u5ffd\u7565\u4e86\u751f\u7269\u5b66\u56e0\u7d20\u3002<\/p>\n

EvoAI<\/strong><\/p>\n

\u7406\u60f3\u7684\u65b9\u6848\u5e94\u7ed3\u5408\u9ad8\u901a\u91cf\u5b9e\u9a8c\u6570\u636e\u548c\u9ad8\u6548\u7684\u8ba1\u7b97\u6a21\u578b\uff0c\u901a\u8fc7\u8bc6\u522b\u300c\u951a\u70b9\u300d\u6765\u538b\u7f29\u8bbe\u8ba1\u7a7a\u95f4\uff0c\u4e3a\u6df1\u5ea6\u5b66\u4e60<\/mark>\u6a21\u578b\u63d0\u4f9b\u6307\u5bfc\uff0c\u63a2\u7d22\u6574\u4e2a\u9002\u5e94\u6027\u666f\u89c2\u3002<\/p>\n

\u5728\u6700\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6e05\u534e\u5927\u5b66<\/mark>\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86 EvoAI\uff0c\u8fd9\u662f\u4e00\u79cd\u7ecf\u9a8c\u6027\u5730\u8be2\u95ee\u5e8f\u5217\u7a7a\u95f4\uff0c\u7136\u540e\u5bf9\u5176\u8fdb\u884c\u5efa\u6a21\u3001\u538b\u7f29\u548c\u91cd\u5efa\u7684\u65b9\u6cd5\u3002\u8be5\u65b9\u6cd5\u7ed3\u5408\u4e86\u9ad8\u901a\u91cf\u5b9e\u9a8c\u8fdb\u5316\u548c\u8ba1\u7b97\u65b9\u6cd5\u6765\u6355\u6349\u548c\u5b66\u4e60\u7a7a\u95f4\u7684\u57fa\u672c\u7279\u5f81\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aEvoScan \u65b9\u6848\uff0c\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u8fdb\u5316\u7684\u5f00\u53d1\u548c\u9a8c\u8bc1\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u7814\u7a76\u4eba\u5458\u9996\u5148\u5f00\u53d1\u4e86\u4e00\u79cd\u8fdb\u5316\u626b\u63cf\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u901a\u8fc7\u7ed3\u5408\u57fa\u4e8e\u00a0EvolvR\u00a0\u7684\u5206\u6bb5\u8bf1\u53d8\u7cfb\u7edf\u6765\u9002\u5e94\u566c\u83cc\u4f53\u8f85\u52a9\u975e\u8fde\u7eed\u8fdb\u5316 (PANCE)\u3002<\/p>\n

\u7136\u540e\uff0c\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u4e2a\u6df1\u5ea6\u5b66\u4e60<\/mark>\u548c\u5927\u578b\u8bed\u8a00\u6a21\u578b<\/mark>\uff0c\u4ece\u8fd9\u4e9b\u951a\u70b9\u91cd\u5efa\u5e8f\u5217\u7a7a\u95f4\u5e76\u8bbe\u8ba1\u65b0\u7684\u86cb\u767d\u8d28\uff0c\u6240\u6709\u5341\u79cd\u86cb\u767d\u8d28\u90fd\u8868\u73b0\u51fa\u6bd4\u91ce\u751f\u578b\uff08WT\uff09\u5927\u5927\u63d0\u9ad8\u7684\u6d3b\u6027\uff08\u9ad8\u8fbe 11 \u500d\uff09\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u5c06 EvoAI \u5e94\u7528\u4e8e\u963b\u904f\u86cb\u767d\uff0c\u7ed3\u679c\u663e\u793a\u4ec5 82 \u4e2a\u951a\u70b9\u5c31\u8db3\u4ee5\u538b\u7f29\u9ad8\u9002\u5e94\u5ea6\u5e8f\u5217\u7a7a\u95f4\uff0c\u538b\u7f29\u7387\u4e3a 1048<\/sup>\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aEvoScan \u751f\u6210\u7684 82 \u4e2a\u951a\u70b9\u7684\u9057\u4f20\u5173\u7cfb\u548c\u7279\u5f81\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u51e0\u4e2a\u91cd\u8981\u4f18\u52bf<\/strong><\/p>\n

\u4e0e\u73b0\u6709\u65b9\u6cd5\u76f8\u6bd4\uff0c\u8be5\u65b9\u6cd5\u6709\u51e0\u4e2a\u91cd\u8981\u4f18\u52bf\u3002<\/p>\n

\u9996\u5148\uff0c\u5b83\u5e73\u8861\u4e86\u73b0\u5b9e\u7684\u9002\u5e94\u5ea6\u4f18\u5316\u548c\u5e8f\u5217\u7a7a\u95f4\u7684\u5747\u5300\u91c7\u6837\uff0c\u53ef\u4ee5\u5feb\u901f\u63a2\u7d22\u9ad8\u7ef4\u5ea6\uff0c\u751f\u6210\u66f4\u591a\u6837\u5316\u548c\u529f\u80fd\u6027\u7684\u53d8\u4f53\uff0c\u5e76\u63d0\u4f9b\u6709\u5173\u5e8f\u5217\u529f\u80fd\u5173\u7cfb\u7684\u66f4\u4e30\u5bcc\u4fe1\u606f\u3002<\/p>\n

\u5176\u6b21\uff0c\u901a\u8fc7\u5728 EvoAI \u4e2d\u96c6\u6210\u7ecf\u9a8c\u8fdb\u5316\u626b\u63cf\u548c\u6df1\u5ea6\u5b66\u4e60<\/mark>\u6a21\u578b\uff0c\u5b83\u53ef\u4ee5\u5229\u7528\u4e24\u79cd\u65b9\u6cd5\u7684\u4f18\u52bf\u3002\u5b83\u53ef\u4ee5\u5229\u7528\u6df1\u5ea6\u5b66\u4e60<\/mark>\u5b66\u5230\u7684\u5c5e\u6027\u6765\u52a8\u6001\u5730\u6307\u5bfc\u626b\u63cf\u8fc7\u7a0b\u3002\u53ef\u89e3\u91ca\u7684\u6df1\u5ea6\u5b66\u4e60<\/mark>\u7684\u672a\u6765\u53d1\u5c55\u53ef\u4ee5\u63ed\u793a\u6f5c\u5728\u7684\u89c4\u5219\u6216\u6a21\u5f0f\uff0c\u5e76\u6df1\u5165\u4e86\u89e3\u86cb\u767d\u8d28\u5982\u4f55\u9002\u5e94\u548c\u514b\u670d\u8fdb\u5316\u7684\u9650\u5236\u6216\u6743\u8861\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u5f7b\u5e95\u7684\u7247\u6bb5\u626b\u63cf\u4ee5\u4e86\u89e3\u86cb\u767d\u8d28-\u914d\u4f53\u76f8\u4e92\u4f5c\u7528\u7684\u6f14\u53d8\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u7b2c\u4e09\uff0c\u8be5\u65b9\u6cd5\u53ef\u4ee5\u62d3\u5c55\u548c\u7814\u7a76\u7f3a\u4e4f\u7ed3\u6784\u4fe1\u606f\u6216\u6d89\u53ca\u5177\u6709\u6311\u6218\u6027\u7684\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u3002\u5b9e\u9a8c\u8868\u660e\uff0cEvoScan \u53ef\u4ee5\u6355\u83b7\u5177\u6709\u591a\u79cd\u529f\u80fd\u7684\u86cb\u767d\u8d28\u7684\u951a\u70b9\uff0c\u4f8b\u5982\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u3001\u86cb\u767d\u8d28-\u914d\u4f53\u548c\u86cb\u767d\u8d28-\u6838\u9178\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\u7406\u8bba\u4e0a\uff0c\u8be5\u65b9\u6cd5\u5e94\u8be5\u4e0e\u4efb\u4f55\u53ef\u4ee5\u4e0e\u8f6c\u5f55\u8f93\u51fa\u8026\u5408\u7684\u751f\u7269\u5206\u5b50\u529f\u80fd\u517c\u5bb9\uff08\u4f8b\u5982\uff0c\u901a\u8fc7\u5c0f\u5206\u5b50\u4f20\u611f\u5668\u7684\u9176\uff09\uff0c\u56e0\u6b64\u53ef\u4ee5\u5e94\u7528\u4e8e\u7814\u7a76\u5404\u79cd\u751f\u7269\u5206\u5b50\u7684\u5e8f\u5217\u7a7a\u95f4\u3002<\/p>\n

\u540c\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u7814\u7a76\u4e2d\u6d4b\u8bd5\u7684\u5316\u5b66\u7a7a\u95f4\uff08\u4f8b\u5982\u9176\u53cd\u5e94\uff09\u6216\u914d\u4f53\u7a7a\u95f4\uff08\u4f8b\u5982\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff09\u53ef\u80fd\u6709\u6240\u4e0d\u540c\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n

\u4f18\u5316\u65b9\u5411\u4e0e\u5c55\u671b<\/strong><\/p>\n

\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u8be5\u65b9\u6cd5\u672a\u6765\u53ef\u4ee5\u8fdb\u4e00\u6b65\u4f18\u5316\u6539\u8fdb\u3002<\/p>\n

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\u6b64\u5916\uff0c\u5c06 EvoScan \u7684\u9776\u5411\u8bf1\u53d8\u65b9\u6cd5\u6574\u5408\u5230 PACE \u4e2d\u53ef\u80fd\u4f1a\u5b9e\u73b0\u5bf9\u5e8f\u5217\u7a7a\u95f4\u7247\u6bb5\u7684\u66f4\u6df1\u5165\u91c7\u6837\u3002\u5e76\u4e14\uff0c\u5c06 EvoScan \u4e0e Evoracle \u7b49\u57fa\u56e0\u578b\u91cd\u5efa\u65b9\u6cd5\u76f8\u7ed3\u5408\uff0c\u53ef\u4ee5\u66f4\u7cfb\u7edf\u3001\u66f4\u667a\u80fd\u5730\u63a2\u7d22\u5e8f\u5217\u7a7a\u95f4\u3002<\/p>\n

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