{"id":37526,"date":"2025-01-30T09:00:56","date_gmt":"2025-01-30T01:00:56","guid":{"rendered":"https:\/\/17aitech.com\/?p=37526"},"modified":"2025-01-30T09:00:56","modified_gmt":"2025-01-30T01:00:56","slug":"science%e5%ad%90%e5%88%8a%ef%bc%8c%e6%96%af%e5%9d%a6%e7%a6%8fai%e6%96%b9%e6%b3%95%e8%a1%a8%e7%a4%ba%e8%9b%8b%e7%99%bd%e4%ba%92%e4%bd%9c%e8%8a%82%e7%82%b9%ef%bc%8c%e5%a2%9e%e5%bc%ba%e5%8a%9f%e8%83%bd","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=37526","title":{"rendered":"Science\u5b50\u520a\uff0c\u65af\u5766\u798fAI\u65b9\u6cd5\u8868\u793a\u86cb\u767d\u4e92\u4f5c\u8282\u70b9\uff0c\u589e\u5f3a\u529f\u80fd\u8bc6\u522b\u4e0ePPI\u63a8\u7406"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:Science\u5b50\u520a\uff0c\u65af\u5766\u798fAI\u65b9\u6cd5\u8868\u793a\u86cb\u767d\u4e92\u4f5c\u8282\u70b9\uff0c\u589e\u5f3a\u529f\u80fd\u8bc6\u522b\u4e0ePPI\u63a8\u7406<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91 | \u767d\u83dc\u53f6<\/p>\n

\u751f\u7269\u7f51\u7edc\u901a\u8fc7\u8be6\u7ec6\u63cf\u7ed8\u57fa\u56e0\u3001\u86cb\u767d\u8d28\u53ca\u5176\u4ed6\u7ec6\u80de\u6210\u5206\u4e4b\u95f4\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\uff0c\u4e3a\u5efa\u6a21\u751f\u7269\u7cfb\u7edf\u63d0\u4f9b\u4e86\u91cd\u8981\u5de5\u5177\u3002<\/p>\n

\u8fd9\u4e9b\u7f51\u7edc\u5c06\u5b9e\u4f53\u8868\u793a\u4e3a\u8282\u70b9\uff0c\u5c06\u5176\u76f8\u4e92\u4f5c\u7528\uff08\u4ece\u7269\u7406\u8fde\u63a5\u5230\u529f\u80fd\u5173\u8054\uff09\u8868\u793a\u4e3a\u8fb9\uff0c\u4ece\u800c\u4e3a\u89e3\u6790\u751f\u7269\u7cfb\u7edf\u548c\u8fc7\u7a0b\u7684\u590d\u6742\u6027\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n

\u4f8b\u5982\uff0c\u5728\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08PPI\uff09\u7f51\u7edc\u4e2d\uff0c\u590d\u6742\u7684\u8fde\u63a5\u5173\u7cfb\u5305\u542b\u4e86\u7406\u89e3\u7ec6\u80de\u8fc7\u7a0b\u548c\u75be\u75c5\u673a\u5236\u7684\u5173\u952e\u4fe1\u606f\u3002\u7136\u800c\uff0c\u89e3\u8bfb\u8fd9\u4e9b\u7f51\u7edc\u4ee5\u83b7\u53d6\u751f\u7269\u5b66\u6d1e\u5bdf\u4ecd\u9762\u4e34\u5de8\u5927\u6311\u6218\u3002<\/p>\n

\u5728\u6700\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u65af\u5766\u798f\u5927\u5b66\uff08Stanford University\uff09\u7684\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86\u4e00\u79cd\u81ea\u76d1\u7763\u7f51\u7edc\u5d4c\u5165\u6846\u67b6\uff0c\u79f0\u4e3a\u5224\u522b\u7f51\u7edc\u5d4c\u5165 (DNE\uff0cdiscriminative network embedding)\u3002<\/p>\n

\u4e0e\u4e3b\u8981\u5173\u6ce8\u76f4\u63a5\u6216\u6709\u9650\u9636\u8282\u70b9\u90bb\u8fd1\u5ea6\u7684\u4f20\u7edf\u65b9\u6cd5\u4e0d\u540c\uff0cDNE \u901a\u8fc7\u5229\u7528\u90bb\u8fd1\u8282\u70b9\u548c\u8fdc\u8ddd\u79bb\u8282\u70b9\u7684\u8868\u793a\u4e4b\u95f4\u7684\u5bf9\u6bd4\u6765\u5728\u672c\u5730\u548c\u5168\u5c40\u4e0a\u8868\u5f81\u8282\u70b9\u3002<\/p>\n

\u6d4b\u8bd5\u663e\u793a DNE \u5728\u5404\u79cd\u5173\u952e\u7f51\u7edc\u5206\u6790\uff08\u5305\u62ec PPI \u63a8\u7406\u548c\u86cb\u767d\u8d28\u529f\u80fd\u6a21\u5757\u7684\u8bc6\u522b\uff09\u4e2d\u5747\u6bd4\u73b0\u6709\u6280\u672f\u8868\u73b0\u4f18\u5f02\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cDeep representation learning of protein-protein interaction networks for enhanced pattern discovery<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2024 \u5e74 12 \u6708 18 \u65e5\u53d1\u5e03\u5728\u300aScience Advance<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528 (PPI) \u7f51\u7edc\u662f\u7406\u89e3\u751f\u7269\u7cfb\u7edf\u52a8\u6001\u7684\u57fa\u7840\uff0c\u5176\u4e2d\u8282\u70b9\u4ee3\u8868\u86cb\u767d\u8d28\uff0c\u8fb9\u4ee3\u8868\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u65e0\u6570\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\u867d\u7136\u5b83\u4eec\u5728\u73b0\u4ee3\u751f\u7269\u5b66\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\uff0c\u4f46\u4ece\u8fd9\u4e9b\u76f8\u4e92\u4ea4\u7ec7\u7684\u7f51\u7edc\u4e2d\u53ef\u9760\u5730\u8fa8\u522b\u6a21\u5f0f\u4ecd\u7136\u662f\u4e00\u9879\u8270\u5de8\u7684\u6311\u6218\u3002<\/p>\n

\u6311\u6218\u7684\u672c\u8d28\u5728\u4e8e\u5168\u9762\u63cf\u8ff0\u7f51\u7edc\u4e2d\u6bcf\u4e2a\u8282\u70b9\u4e0e\u5176\u4ed6\u8282\u70b9\u7684\u5173\u7cfb\uff0c\u5e76\u6709\u6548\u5730\u5229\u7528\u8fd9\u4e9b\u4fe1\u606f\u8fdb\u884c\u51c6\u786e\u7684\u6a21\u5f0f\u53d1\u73b0\u3002<\/p>\n

\u65b0\u65b9\u6cd5 DNE<\/strong><\/p>\n

\u6700\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u65af\u5766\u798f\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u4ecb\u7ecd\u4e86\u4e00\u4e2a\u901a\u7528\u7684\u56fe\u8868\u793a\u5b66\u4e60\u6846\u67b6\uff0c\u8be5\u6846\u67b6\u4f7f\u7528\u6df1\u5ea6\u5b66\u4e60<\/mark>\u5728\u4f4e\u7ef4\u7a7a\u95f4\u4e2d\u4fdd\u7559\u7f51\u7edc\u7684\u975e\u7ebf\u6027\u548c\u591a\u9762\u7ed3\u6784\uff0c\u4ee5\u4fbf\u5bf9\u751f\u7269\u7f51\u7edc\u8fdb\u884c\u9ad8\u6027\u80fd\u5206\u6790\u3002\u8be5\u65b9\u6cd5\u79f0\u4e3a\u5224\u522b\u7f51\u7edc\u5d4c\u5165 (DNE)\uff0c\u901a\u8fc7\u5176\u76f4\u63a5\u76f8\u90bb\u548c\u7f51\u7edc\u4e2d\u8f83\u8fdc\u8282\u70b9\u7684\u8868\u793a\u4e4b\u95f4\u7684\u975e\u7ebf\u6027\u5bf9\u6bd4\u6765\u8868\u5f81\u6bcf\u4e2a\u8282\u70b9\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aDNE \u6982\u8ff0\u3002(\u6765\u6e90\uff1a\u8bba\u6587)<\/section>\n

DNE \u65b9\u6cd5\u5141\u8bb8\u4ece\u6574\u4f53\u4e0a\u770b\u5f85\u7f51\u7edc\u4e2d\u6bcf\u4e2a\u8282\u70b9\u7684\u4f5c\u7528\uff1a\u5b83\u7a81\u51fa\u663e\u793a\u8282\u70b9\u7684\u76f4\u63a5\u8fde\u63a5\uff0c\u4f8b\u5982 PPI \u7f51\u7edc\u4e2d\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u53ca\u7f51\u7edc\u5185\u7684\u793e\u533a\u5173\u7cfb\uff0c\u4f8b\u5982\u86cb\u767d\u8d28\u529f\u80fd\u6a21\u5757\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u56db\u4e2a PPI \u57fa\u51c6<\/mark>\u4e2d\u4e0d\u540c\u94fe\u63a5\u9884\u6d4b\u65b9\u6cd5\u7684\u8868\u73b0\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u4e0e\u4e3b\u8981\u5173\u6ce8\u8282\u70b9\u95f4\u6709\u9650\u9636\u63a5\u8fd1\u5ea6\u7684\u4f20\u7edf\u65b9\u6cd5\u4e0d\u540c\uff0cDNE \u6839\u636e\u5176\u8fd1\u90bb\u548c\u8f83\u8fdc\u8282\u70b9\u7684\u8868\u793a\u4e4b\u95f4\u7684\u5bf9\u6bd4\u6765\u8868\u5f81\u6bcf\u4e2a\u8282\u70b9\u3002\u901a\u8fc7\u540c\u65f6\u8003\u8651\u5c40\u90e8\u8fde\u63a5\u6a21\u5f0f\u548c\u4e0e\u66f4\u5e7f\u6cdb\u7f51\u7edc\u7684\u4ea4\u4e92\uff0cDNE \u53ef\u4ee5\u66f4\u5168\u9762\u5730\u4e86\u89e3\u7f51\u7edc\u5185\u7684\u8282\u70b9\u5173\u7cfb\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u5728\u591a\u4e2a PPI \u6570\u636e\u96c6\u4e0a\u5bf9 DNE \u7684\u8bc4\u4f30\u8868\u660e\uff0c\u5b83\u5728\u51c6\u786e\u9884\u6d4b PPI \u548c\u8bc6\u522b\u529f\u80fd\u6a21\u5757\u65b9\u9762\u7684\u80fd\u529b\u4f18\u4e8e\u73b0\u6709\u65b9\u6cd5\u3002DNE \u8fd8\u8868\u73b0\u51fa\u5bf9\u7f51\u7edc\u6270\u52a8\u7684\u7a33\u5065\u6027\uff0c\u5e76\u4e14\u5728\u4e0d\u540c\u7684\u6270\u52a8\u7387\u4e0b\u59cb\u7ec8\u4f18\u4e8e\u5176\u4ed6\u65b9\u6cd5\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u7a33\u5065\u6027\u8bc4\u4f30\u663e\u793a\uff0cDNE \u7684 ROC-AUC \u5206\u6570\u4e0e\u5176\u4ed6\u4e5d\u79cd\u7f51\u7edc\u5d4c\u5165\u65b9\u6cd5\u76f8\u6bd4\uff0c\u53ef\u62b5\u6297\u94fe\u63a5\u6270\u52a8\uff0c\u5176\u4e2d\u94fe\u63a5\u4ee5\u4e0d\u540c\u7684\u6bd4\u7387\u968f\u673a\u5220\u9664\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u540c\u65f6\uff0cDNE \u901a\u8fc7\u5176\u5d4c\u5165\u53cd\u6620\u86cb\u767d\u8d28\u5728 PPI n \u8df3\u8ddd\u79bb\u548c\u57fa\u56e0\u672c\u4f53<\/mark>\u529f\u80fd\u76f8\u4f3c\u6027\u65b9\u9762\u7684\u63a5\u8fd1\u5ea6\uff0c\u6709\u6548\u5730\u6355\u83b7\u4e86\u5177\u6709\u751f\u7269\u5b66\u610f\u4e49\u7684\u4fe1\u53f7\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aDNE \u86cb\u767d\u8d28\u5d4c\u5165\u7684\u53ef\u89c6\u5316\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u867d\u7136 DNE \u80fd\u591f\u4ec5\u4ece\u7f51\u7edc\u7684\u7ed3\u6784\u4fe1\u606f\u4e2d\u5f97\u51fa\u8282\u70b9\u5d4c\u5165\uff0c\u4f46\u5f53\u8fd9\u4e9b\u7279\u5f81\u53ef\u7528\u65f6\uff0c\u5b83\u8fd8\u53ef\u4ee5\u7075\u6d3b\u5730\u5c06\u8282\u70b9\u7279\u5f81\u5408\u5e76\u5230\u5d4c\u5165\u8fc7\u7a0b\u4e2d\u3002<\/p>\n

\u5728\u50cf PPI \u8fd9\u6837\u7684\u751f\u7269\u7f51\u7edc\u4e2d\uff0c\u6bcf\u4e2a\u8282\u70b9\u4ee3\u8868\u4e00\u79cd\u86cb\u767d\u8d28\uff0c\u8282\u70b9\uff08\u6216\u86cb\u767d\u8d28\uff09\u7279\u5f81\u53ef\u4ee5\u6765\u81ea\u591a\u79cd\u6765\u6e90\uff0c\u4f8b\u5982\u6c28\u57fa\u9178\u5e8f\u5217\u3001\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\uff083D\uff09\u7ed3\u6784\u548c\u86cb\u767d\u8d28\u5b9a\u4f4d\uff0c\u4ece\u800c\u63d0\u4f9b\u7f51\u7edc\u5185\u86cb\u767d\u8d28\u62d3\u6251\u529f\u80fd\u4e4b\u5916\u7684\u9644\u52a0\u4fe1\u606f\u3002<\/p>\n

DNE \u65b9\u6cd5\u901a\u8fc7\u6574\u5408\u6765\u81ea\u9884\u8bad\u7ec3\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b<\/mark>\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u7279\u5f81\u6765\u589e\u5f3a\u7f51\u7edc\u5d4c\u5165\uff0c\u4e3a\u9884\u6d4b PPI \u63d0\u4f9b\u4e86\u4e00\u79cd\u5353\u8d8a\u7684\u65b9\u6cd5\u3002\u4e0e\u4ec5\u4f9d\u8d56\u5e8f\u5217\u6570\u636e\u7684\u73b0\u6709\u65b9\u6cd5\u76f8\u6bd4\uff0c\u8fd9\u79cd\u6574\u5408\u5927\u5927\u63d0\u9ad8\u4e86 PPI \u9884\u6d4b\u51c6\u786e\u6027\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u8bc4\u4f30\u9884\u6d4b\u590d\u5408\u7269\u4e0e\u6807\u51c6 Retromer \u590d\u5408\u7269\u4e4b\u95f4\u7684\u91cd\u53e0\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

DNE \u7684\u4f18\u52bf<\/strong><\/p>\n

\u603b\u4f53\u800c\u8a00\uff0cDNE \u4e3a\u7f51\u7edc\u5206\u6790\u63d0\u4f9b\u4e86\u51e0\u4e2a\u4f18\u52bf\u3002<\/p>\n

\u7b2c\u4e00\uff0c\u5b83\u751f\u6210\u66f4\u5177\u5224\u522b\u6027\u7684\u5d4c\u5165\uff0c\u4e0d\u4ec5\u53ef\u4ee5\u6355\u83b7\u6bcf\u4e2a\u8282\u70b9\u7684\u5c40\u90e8\u8fde\u63a5\u6a21\u5f0f\uff0c\u8fd8\u53ef\u4ee5\u5c06\u8fd9\u4e9b\u6a21\u5f0f\u4e0e\u7f51\u7edc\u5176\u4ed6\u90e8\u5206\u7684\u6a21\u5f0f\u533a\u5206\u5f00\u6765\u3002\u8fd9\u53ef\u4ee5\u66f4\u51c6\u786e\u5730\u8868\u793a\u6bcf\u4e2a\u8282\u70b9\u7684\u7ed3\u6784\u89d2\u8272\u548c\u793e\u533a\u6210\u5458\u8eab\u4efd\uff0c\u4ece\u800c\u964d\u4f4e\u8fc7\u5ea6\u62df\u5408\u5c40\u90e8\u7f51\u7edc\u566a\u58f0\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

\u7b2c\u4e8c\uff0c\u901a\u8fc7\u6574\u5408\u6765\u81ea\u8fd1\u90bb\u4ee5\u53ca\u5176\u4ed6\u7f51\u7edc\u6bb5\u7684\u6570\u636e\uff0cDNE \u63d0\u4f9b\u4e86\u6574\u4e2a\u7f51\u7edc\u7684\u66f4\u5168\u9762\u7684\u89c6\u56fe\u3002<\/p>\n

\u7b2c\u4e09\uff0cDNE \u53ef\u4ee5\u5229\u7528\u7f51\u7edc\u7ed3\u6784\u548c\u8282\u70b9\u7279\u5f81\u6765\u751f\u6210\u66f4\u4e30\u5bcc\u7684\u5d4c\u5165\u3002<\/p>\n

\u7814\u7a76\u4e2d\uff0c\u8fd9\u4e9b\u5d4c\u5165\u7528\u4e8e\u63a8\u65ad\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u5e76\u8bc6\u522b\u529f\u80fd\u6a21\u5757\u3002\u8fdb\u4e00\u6b65\u7684\u5e94\u7528\u53ef\u80fd\u5305\u62ec\u75be\u75c5\u57fa\u56e0\u9884\u6d4b\uff0c\u5176\u4e2d\u5d4c\u5165\u6709\u52a9\u4e8e\u8bc6\u522b\u4e0e\u75be\u75c5\u673a\u5236\u76f8\u5173\u7684\u86cb\u767d\u8d28\uff0c\u4ee5\u53ca\u86cb\u767d\u8d28\u529f\u80fd\u9884\u6d4b\uff0c\u4ee5\u4fc3\u8fdb\u5bf9\u65b0\u6d4b\u5e8f\u57fa\u56e0\u7ec4\u4e2d\u7684\u86cb\u767d\u8d28\u8fdb\u884c\u6ce8\u91ca\u3002<\/p>\n

<\/a><\/p>\n

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\u7ed3\u8bed<\/strong><\/p>\n

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\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.science.org\/doi\/10.1126\/sciadv.adq4324<\/em><\/p>\n

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