{"id":37786,"date":"2025-02-04T14:00:57","date_gmt":"2025-02-04T06:00:57","guid":{"rendered":"https:\/\/17aitech.com\/?p=37786"},"modified":"2025-02-04T14:00:57","modified_gmt":"2025-02-04T06:00:57","slug":"%e6%a8%a1%e6%8b%9f5%e4%ba%bf%e5%b9%b4%e8%bf%9b%e5%8c%96%e7%9a%84esm3%e5%9c%a8science%e5%8f%91%e5%b8%83%e4%ba%86%ef%bc%8c%e5%8f%af%e6%8e%a8%e7%90%86%e8%9b%8b%e7%99%bd%e8%b4%a8%e5%ba%8f%e5%88%97","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=37786","title":{"rendered":"\u6a21\u62df5\u4ebf\u5e74\u8fdb\u5316\u7684ESM3\u5728Science\u53d1\u5e03\u4e86\uff0c\u53ef\u63a8\u7406\u86cb\u767d\u8d28\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u6a21\u62df5\u4ebf\u5e74\u8fdb\u5316\u7684ESM3\u5728Science\u53d1\u5e03\u4e86\uff0c\u53ef\u63a8\u7406\u86cb\u767d\u8d28\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd<\/a><\/p>\n

<\/a><\/a><\/p>\n

\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

2024 \u5e74\u590f\u5929 EvolutionaryScale \u63a8\u51fa\u4e86 ESM3\uff0c\u4e00\u6b3e\u9762\u5411\u86cb\u767d\u8d28\u8bed\u8a00\u7684\u5927\u6a21\u578b\uff0c\u6210\u529f\u5728\u81ea\u7136\u8fdb\u5316\u672a\u66fe\u6d89\u8db3\u7684\u533a\u57df\u8bbe\u8ba1\u51fa\u529f\u80fd\u6027\u86cb\u767d\u3002<\/a>\u540c\u671f\u4e0a\u7ebf\u4e86\u8be5\u7814\u7a76\u7684\u9884\u5370\u7248\u672c\u3002<\/p>\n

\u65f6\u9694\u534a\u5e74\uff0c\u8be5\u7814\u7a76\u4ee5\u300cSimulating 500 million years of evolution with a language model<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 1 \u6708 16 \u65e5\u5728\u300aScience<\/em>\u300b\u53d1\u5e03\u3002<\/p>\n

<\/a><\/p>\n

\u8ba9\u6211\u4eec\u7b80\u5355\u56de\u987e\u4e00\u4e0b\u3002<\/p>\n

\u8d85\u8fc7 30 \u4ebf\u5e74\u7684\u8fdb\u5316\u4ea7\u751f\u4e86\u7f16\u7801\u5728\u5929\u7136\u86cb\u767d\u8d28\u7a7a\u95f4\u4e2d\u7684\u751f\u7269\u56fe\u50cf\u3002<\/p>\n

\u8bba\u6587\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u5c55\u793a\u4e86\u5728\u8fdb\u5316\u6570\u636e\u4e0a\u8fdb\u884c\u5927\u89c4\u6a21\u8bad\u7ec3\u7684\u8bed\u8a00\u6a21\u578b<\/mark>\uff0c\u53ef\u4ee5\u751f\u6210\u8fdc\u79bb\u5df2\u77e5\u86cb\u767d\u8d28\u7684\u529f\u80fd\u6027\u86cb\u767d\u8d28\u3002<\/p>\n

\u4ed6\u4eec\u63d0\u51fa\u4e86 ESM3\uff0c\u8fd9\u662f\u4e00\u79cd\u524d\u6cbf\u7684\u591a\u6a21\u6001\u751f\u6210\u8bed\u8a00\u6a21\u578b<\/mark>\uff0c\u53ef\u63a8\u7406\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aESM3 \u53ef\u4ee5\u540c\u65f6\u63a8\u7406\u86cb\u767d\u8d28\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

ESM3 \u53ef\u4ee5\u7ed3\u5408\u5176\u6a21\u6001\u6765\u9075\u5faa\u590d\u6742\u7684\u63d0\u793a\uff0c\u5e76\u4e14\u5bf9\u751f\u7269\u5b66\u5bf9\u9f50\uff08biological alignment\uff09\u53cd\u5e94\u7075\u654f\uff0c\u4ece\u800c\u63d0\u9ad8\u5176\u4fdd\u771f\u5ea6\u3002<\/p>\n

<\/section>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aESM3 \u901a\u8fc7\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u7684\u591a\u6a21\u6001\u63d0\u793a\u4e3a PETase \u6d3b\u6027\u4f4d\u70b9\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u652f\u67b6\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u7814\u7a76\u4eba\u5458\u4f7f\u7528 ESM3 \u8bbe\u8ba1\u4e86\u4e00\u79cd\u540d\u4e3a esmGFP \u7684\u65b0\u8367\u5149\u86cb\u767d\uff0c\u5b83\u4e0e\u5df2\u77e5\u6700\u76f8\u4f3c\u7684\u8367\u5149\u86cb\u767d\u5e8f\u5217\u540c\u6e90\u6027\u4ec5\u4e3a 58%\uff0c\u8fd9\u5728\u4ee5\u5f80\u7684\u4eba\u5de5\u8bbe\u8ba1\u4e2d\u662f\u6781\u4e3a\u7f55\u89c1\u7684\u3002<\/p>\n

\u901a\u8fc7\u6307\u5bfc ESM3 \u5173\u6ce8\u8367\u5149\u86cb\u767d\u5f62\u6210\u548c\u50ac\u5316\u8272\u7d20\u4f53\u53cd\u5e94\u6240\u5fc5\u9700\u7684\u5e8f\u5217\u548c\u7ed3\u6784\u7279\u5f81\uff0c\u6a21\u578b\u7ecf\u8fc7\u4e00\u7cfb\u5217\u8fed\u4ee3\u8bbe\u8ba1\uff0c\u6700\u7ec8\u4ea7\u751f\u4e86\u5177\u6709\u660e\u4eae\u8367\u5149\u6548\u679c\u7684 esmGFP\u3002<\/p>\n

<\/a><\/section>\n
\u56fe\u793a\uff1aesmGFP \u4e0e\u5df2\u77e5\u8367\u5149\u86cb\u767d\u6bd4\u8f83\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u8be5\u86cb\u767d\u4e0d\u4ec5\u5728\u5e8f\u5217\u4e0a\u4e0e\u5df2\u77e5\u86cb\u767d\u6709\u663e\u8457\u5dee\u5f02\uff0c\u800c\u4e14\u5728\u5b9e\u9a8c\u4e2d\u5c55\u73b0\u51fa\u4e0e\u5e38\u89c1\u8367\u5149\u86cb\u767d\u76f8\u4f3c\u7684\u8367\u5149\u5f3a\u5ea6\u3002\u8fd9\u76f8\u5f53\u4e8e\u8de8\u8d8a\u4e86\u8d85\u8fc7 5 \u4ebf\u5e74\u7684\u81ea\u7136\u8fdb\u5316\u8ddd\u79bb\u3002<\/p>\n

\u5173\u4e8e EvolutionaryScale<\/strong><\/p>\n

EvolutionaryScale \u662f\u4e00\u5bb6\u975e\u76c8\u5229\u516c\u53f8\u3002\u4ed6\u4eec\u7684\u4f7f\u547d\u662f\u901a\u8fc7\u4e0e\u79d1\u5b66\u754c\u5408\u4f5c\u4ee5\u53ca\u5f00\u653e\u3001\u5b89\u5168\u548c\u8d1f\u8d23\u4efb\u7684\u7814\u7a76\uff0c\u5f00\u53d1\u4eba\u5de5\u667a\u80fd<\/mark>\u6765\u7406\u89e3\u751f\u7269\u5b66\uff0c\u9020\u798f\u4eba\u7c7b\u5065\u5eb7\u548c\u793e\u4f1a\u3002<\/p>\n

\u81ea\u6210\u7acb\u4ee5\u6765\uff0cESM \u9879\u76ee\u4e00\u76f4\u81f4\u529b\u4e8e\u901a\u8fc7\u4ee3\u7801\u548c\u6a21\u578b\u53d1\u5e03\u6765\u5f00\u653e\u79d1\u5b66\uff0c\u8be5\u56e2\u961f\u627f\u8bfa\u5c06\u7ee7\u7eed\u575a\u6301\u4e0b\u53bb\u3002<\/p>\n

\u8be5\u516c\u53f8\u6210\u7acb\u4e8e 2023 \u5e74 7 \u6708\u5df2\u7ecf\u5b8c\u6210 1.42 \u4ebf\u7f8e\u5143\u79cd\u5b50\u8f6e\u878d\u8d44\uff0c\u5e76\u5df2\u7ecf\u4e0e\u4e9a\u9a6c\u900a\uff08Amazon<\/mark>\uff09\u548c\u82f1\u4f1f\u8fbe\uff08NVIDIA\uff09\u516c\u53f8\u8fbe\u6210\u5408\u4f5c\u3002<\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1a\u00a0https:\/\/www.science.org\/doi\/10.1126\/science.ads0018<\/em><\/p>\n

\u76f8\u5173\u5185\u5bb9\uff1a<\/section>\n
https:\/\/x.com\/ScienceMagazine\/status\/1880012426503962927<\/em><\/section>\n
https:\/\/www.evolutionaryscale.ai\/blog\/esm3-release<\/em><\/section>\n

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