{"id":37870,"date":"2025-02-06T02:00:56","date_gmt":"2025-02-05T18:00:56","guid":{"rendered":"https:\/\/17aitech.com\/?p=37870"},"modified":"2025-02-06T02:00:56","modified_gmt":"2025-02-05T18:00:56","slug":"%e7%81%b5%e6%95%8f%e5%ba%a6%e9%ab%98%e8%be%be94-9%ef%bc%81%e7%89%9b%e6%b4%a5%e5%9b%a2%e9%98%9fai%e5%a4%9a%e6%a8%a1%e6%80%81ctdna%e6%a3%80%e6%b5%8b%e6%96%b9%e6%b3%95%ef%bc%8c%e8%bf%9b%e8%a1%8c%e7%99%8c","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=37870","title":{"rendered":"\u7075\u654f\u5ea6\u9ad8\u8fbe94.9%\uff01\u725b\u6d25\u56e2\u961fAI\u591a\u6a21\u6001ctDNA\u68c0\u6d4b\u65b9\u6cd5\uff0c\u8fdb\u884c\u764c\u75c7\u65e9\u671f\u7b5b\u67e5"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u7075\u654f\u5ea6\u9ad8\u8fbe94.9%\uff01\u725b\u6d25\u56e2\u961fAI\u591a\u6a21\u6001ctDNA\u68c0\u6d4b\u65b9\u6cd5\uff0c\u8fdb\u884c\u764c\u75c7\u65e9\u671f\u7b5b\u67e5<\/a><\/p>\n

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\u7f16\u8f91 | 2049<\/p>\n

\u5728\u764c\u75c7\u8bca\u7597\u7684\u6f2b\u957f\u5f81\u7a0b\u4e2d\uff0c\u65e9\u671f\u68c0\u6d4b\u59cb\u7ec8\u662f\u6700\u5177\u6311\u6218\u6027\u7684\u73af\u8282\u4e4b\u4e00\uff0c\u6db2\u4f53\u6d3b\u68c0\u6280\u672f\u56e0\u5176\u65e0\u521b\u6027\u548c\u9ad8\u7075\u654f\u5ea6\u800c\u5907\u53d7\u5173\u6ce8\u3002\u7136\u800c\uff0c\u73b0\u6709\u7684\u68c0\u6d4b\u65b9\u6cd5\u5927\u591a\u4f9d\u8d56\u4e8e\u6df1\u5ea6\u9776\u5411\u6d4b\u5e8f\uff0c\u96be\u4ee5\u540c\u65f6\u6574\u5408\u591a\u6a21\u6001\u6570\u636e\uff0c\u5bfc\u81f4\u68c0\u6d4b\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u53d7\u9650\u3002<\/p>\n

\u6b63\u662f\u57fa\u4e8e\u8fd9\u4e00\u6280\u672f\u75db\u70b9\uff0c\u725b\u6d25\u5927\u5b66\u7684\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u4e8e\u5168\u57fa\u56e0\u7ec4 TET \u8f85\u52a9\u5421\u5576\u787c\u70f7\u6d4b\u5e8f\uff08TAPS\uff09\u7684\u591a\u6a21\u6001\u5faa\u73af\u80bf\u7624 DNA\uff08ctDNA\uff09\u68c0\u6d4b\u65b9\u6cd5\u3002<\/p>\n

\u8be5\u65b9\u6cd5\u4e0d\u4ec5\u80fd\u591f\u540c\u65f6\u5206\u6790\u57fa\u56e0\u7ec4\u548c\u7532\u57fa\u5316\u6570\u636e\uff0c\u8fd8\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u8bca\u65ad\u4e2d\u8868\u73b0\u51fa\u9ad8\u8fbe 94.9% \u7684\u7075\u654f\u5ea6\u548c 88.8% \u7684\u7279\u5f02\u6027\u3002\u8fd9\u4e00\u7a81\u7834\u6027\u6280\u672f\u4e3a\u764c\u75c7\u65e9\u671f\u7b5b\u67e5\u548c\u60a3\u8005\u5206\u5c42\u63d0\u4f9b\u4e86\u65b0\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cMultimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 1 \u6708 8 \u65e5\u53d1\u5e03\u5728\u300aNature Communications<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n

\u764c\u75c7\u7684\u65e9\u671f\u68c0\u6d4b\u5bf9\u6539\u5584\u60a3\u8005\u9884\u540e\u81f3\u5173\u91cd\u8981\u3002\u7136\u800c\uff0c\u73b0\u6709\u7684\u7b5b\u67e5\u9879\u76ee\u4ec5\u8986\u76d6\u4e0d\u5230 30% \u7684\u764c\u75c7\u7c7b\u578b\uff0c\u4e14\u4f9d\u8d56\u4e8e\u4fb5\u5165\u6027\u68c0\u67e5\uff0c\u5bfc\u81f4\u63a5\u53d7\u5ea6\u8f83\u4f4e\u3002\u591a\u764c\u79cd\u65e9\u671f\u68c0\u6d4b\uff08MCED\uff09\u6280\u672f\u901a\u8fc7\u6db2\u4f53\u6d3b\u68c0\u5b9e\u73b0\u65e0\u521b\u68c0\u6d4b\uff0c\u4f46\u5176\u5728\u65e0\u75c7\u72b6\u4eba\u7fa4\u4e2d\u7684\u5047\u9633\u6027\u7387\u8f83\u9ad8\uff0c\u9650\u5236\u4e86\u5176\u5e7f\u6cdb\u5e94\u7528\u3002<\/p>\n

\u4f20\u7edf\u7684 ctDNA \u68c0\u6d4b\u65b9\u6cd5\u4e3b\u8981\u4f9d\u8d56\u4e8e\u9776\u5411\u6df1\u5ea6\u6d4b\u5e8f\uff0c\u867d\u7136\u7075\u654f\u5ea6\u8f83\u9ad8\uff0c\u4f46\u4ec5\u80fd\u68c0\u6d4b\u7279\u5b9a\u7c7b\u578b\u7684\u764c\u75c7\u548c\u7a81\u53d8\uff0c\u65e0\u6cd5\u5145\u5206\u5229\u7528\u591a\u6a21\u6001\u6570\u636e\u3002\u6b64\u5916\uff0c\u5e38\u7528\u7684\u4e9a\u786b\u9178\u6c22\u76d0\u6d4b\u5e8f\u6280\u672f\u4f1a\u7834\u574f 80% \u7684 ctDNA\uff0c\u663e\u8457\u964d\u4f4e\u68c0\u6d4b\u7075\u654f\u5ea6\u3002<\/p>\n

\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\uff0c\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u4e8e TAPS \u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u65b9\u6cd5\uff0c\u80fd\u591f\u5728\u5355\u6b21\u6d4b\u5e8f\u4e2d\u540c\u65f6\u5206\u6790\u57fa\u56e0\u7ec4\u548c\u7532\u57fa\u5316\u6570\u636e\uff0c\u4ece\u800c\u663e\u8457\u63d0\u9ad8\u68c0\u6d4b\u7684\u51c6\u786e\u6027\u548c\u9002\u7528\u8303\u56f4\u3002<\/p>\n

TAPS \u6280\u672f\u7684\u6838\u5fc3\u7406\u5ff5\u4e0e\u7406\u8bba\u57fa\u7840<\/strong><\/p>\n

TAPS \u662f\u4e00\u79cd\u57fa\u4e8e\u78b1\u57fa\u5206\u8fa8\u7387\u7684\u65b0\u578b\u6d4b\u5e8f\u6280\u672f\uff0c\u80fd\u591f\u68c0\u6d4b 5-\u7532\u57fa\u80de\u5627\u5576\u548c 5-\u7f9f\u7532\u57fa\u80de\u5627\u5576\u3002\u4e0e\u4f20\u7edf\u7684\u4e9a\u786b\u9178\u6c22\u76d0\u6d4b\u5e8f\u4e0d\u540c\uff0cTAPS \u901a\u8fc7 TET \u9176\u548c\u787c\u70f7\u7684\u7ec4\u5408\uff0c\u4ec5\u5c06 5% \u7684\u7532\u57fa\u5316\u80de\u5627\u5576\u8f6c\u5316\u4e3a\u80f8\u817a\u5627\u5576\uff0c\u4ece\u800c\u4fdd\u7559\u4e86\u57fa\u56e0\u7ec4\u4fe1\u606f\uff0c\u5e76\u5141\u8bb8\u5728\u540c\u4e00\u6d4b\u5e8f\u6570\u636e\u4e2d\u540c\u65f6\u8fdb\u884c\u57fa\u56e0\u7ec4\u548c\u7532\u57fa\u5316\u5206\u6790\u3002<\/p>\n

\u8fd9\u4e00\u6280\u672f\u7684\u6838\u5fc3\u4f18\u52bf\u5728\u4e8e\u5176\u975e\u7834\u574f\u6027\uff0c\u80fd\u591f\u5728\u4f4e ctDNA \u542b\u91cf\uff08\u4f4e\u81f3 0.7%\uff09\u7684\u60c5\u51b5\u4e0b\u4ecd\u4fdd\u6301\u9ad8\u7075\u654f\u5ea6\u3002\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u5bf9 61 \u4f8b\u764c\u75c7\u60a3\u8005\u548c 30 \u4f8b\u975e\u764c\u75c7\u5bf9\u7167\u7684\u6837\u672c\u8fdb\u884c\u6df1\u5ea6\u6d4b\u5e8f\uff0880x\uff09\uff0c\u9a8c\u8bc1\u4e86 TAPS \u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u7684\u8bca\u65ad\u51c6\u786e\u6027\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u7814\u7a76\u6982\u8ff0\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u591a\u6a21\u6001\u6570\u636e\u6574\u5408\u4e0e\u5206\u6790\u65b9\u6cd5<\/strong><\/p>\n

\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u5957\u591a\u6a21\u6001\u6570\u636e\u5206\u6790\u6d41\u7a0b\uff0c\u6574\u5408\u4e86\u62f7\u8d1d\u6570\u53d8\u5f02\uff08CNA\uff09\u3001\u4f53\u7ec6\u80de\u7a81\u53d8\u548c\u7532\u57fa\u5316\u4fe1\u53f7\uff0c\u4ee5\u63d0\u9ad8 ctDNA \u68c0\u6d4b\u7684\u7075\u654f\u5ea6\u3002<\/p>\n

\u9996\u5148\uff0c\u901a\u8fc7\u5c06\u57fa\u56e0\u7ec4\u5212\u5206\u4e3a 1 kb \u7684\u975e\u91cd\u53e0\u533a\u95f4\uff0c\u7edf\u8ba1\u6bcf\u4e2a\u533a\u95f4\u7684\u9ad8\u8d28\u91cf\u6bd4\u5bf9\u8bfb\u6570\uff0c\u5e76\u8fdb\u884c\u53bb\u566a\u5904\u7406\uff0c\u4ee5\u53bb\u9664 GC \u542b\u91cf\u548c\u53ef\u6620\u5c04\u6027\u5f15\u5165\u7684\u7cfb\u7edf\u504f\u5dee\u3002\u968f\u540e\uff0c\u5229\u7528\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u5bf9\u975e\u764c\u75c7\u6837\u672c\u7684\u80cc\u666f\u566a\u58f0\u8fdb\u884c\u5efa\u6a21\uff0c\u5e76\u901a\u8fc7 Savitzky-Golay \u6ee4\u6ce2\u5668\u8fdb\u4e00\u6b65\u5e73\u6ed1\u6570\u636e\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u62f7\u8d1d\u6570\u53d8\u5f02\u5206\u6790\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u5728\u4f53\u7ec6\u80de\u7a81\u53d8\u5206\u6790\u4e2d\uff0c\u7814\u7a76\u56e2\u961f\u91c7\u7528\u6df1\u5ea6\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0880x\uff09\u7b56\u7565\uff0c\u7ed3\u5408 TAPS \u7279\u5f02\u6027\u8f6f\u4ef6\uff0c\u6709\u6548\u533a\u5206\u4e86\u4f53\u7ec6\u80de\u7a81\u53d8\u548c\u6d4b\u5e8f\u8bef\u5dee\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u4f53\u7ec6\u80de\u7a81\u53d8\u8d1f\u62c5\u5206\u6790\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u7532\u57fa\u5316\u5206\u6790\u5219\u57fa\u4e8e TCGA \u6570\u636e\u5e93\u4e2d\u7684\u9ad8\u7532\u57fa\u5316\u533a\u57df\uff0c\u901a\u8fc7\u7247\u6bb5\u4e2d\u5fc3\u7684\u65b9\u6cd5\u63d0\u9ad8\u4e86\u4f4e ctDNA \u542b\u91cf\u4e0b\u7684\u68c0\u6d4b\u7075\u654f\u5ea6\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u7532\u57fa\u5316\u4fe1\u53f7\u5206\u6790\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u5b9e\u9a8c\u7ed3\u679c\u4e0e\u6027\u80fd\u8bc4\u4f30<\/strong><\/p>\n

\u7814\u7a76\u56e2\u961f\u901a\u8fc7 ROC \u66f2\u7ebf\u5206\u6790\u8bc4\u4f30\u4e86\u8be5\u65b9\u6cd5\u7684\u6027\u80fd\u3002\u5728\u6a21\u62df\u6570\u636e\u4e2d\uff0c\u5f53 ctDNA \u542b\u91cf\u4f4e\u81f3 0.7% \u65f6\uff0cAUC \u503c\u8fbe\u5230 86%\uff0c\u8868\u660e\u8be5\u65b9\u6cd5\u5728\u4f4e ctDNA \u542b\u91cf\u4e0b\u4ecd\u5177\u6709\u8f83\u9ad8\u7684\u533a\u5206\u80fd\u529b\u3002\u5728\u4e34\u5e8a\u6837\u672c\u4e2d\uff0c\u6574\u5408\u591a\u6a21\u6001\u6570\u636e\u7684\u68c0\u6d4b\u7075\u654f\u5ea6\u8fbe\u5230 85.2%\uff0c\u663e\u8457\u9ad8\u4e8e\u5355\u4e00\u6570\u636e\u6a21\u6001\u7684\u68c0\u6d4b\u7ed3\u679c\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u7528\u4e8e ctDNA \u68c0\u6d4b\u7684\u57fa\u56e0\u7ec4\u6570\u636e\u6a21\u5f0f\u7684\u6574\u5408\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u6b64\u5916\uff0c\u7814\u7a76\u56e2\u961f\u8fd8\u5f00\u53d1\u4e86\u4e00\u4e2a\u591a\u7c7b\u5206\u7c7b\u5668\uff0c\u7528\u4e8e\u9884\u6d4b\u764c\u75c7\u7c7b\u578b\uff0c\u5176\u5e73\u8861\u5206\u7c7b\u51c6\u786e\u7387\u8fbe\u5230 71.7%\u3002\u5728\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u672f\u540e\u76d1\u6d4b\u4e2d\uff0c\u8be5\u65b9\u6cd5\u6210\u529f\u8ffd\u8e2a\u4e86 ctDNA \u7684\u52a8\u6001\u53d8\u5316\uff0c\u5e76\u4e0e\u4e34\u5e8a\u7ed3\u679c\u9ad8\u5ea6\u4e00\u81f4\u3002\u4f8b\u5982\uff0c\u5728\u4e00\u4f8b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\uff0c\u672f\u540e 1 \u5e74\u68c0\u6d4b\u5230\u7684 ctDNA \u4e0e 3 \u5e74\u540e\u53d1\u73b0\u7684\u8f6c\u79fb\u6027\u764c\u75c7\u76f8\u5173\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u591a\u6a21\u5f0f ctDNA \u68c0\u6d4b\u7528\u4e8e\u65e0\u5339\u914d\u80bf\u7624\u7684\u7ed3\u76f4\u80a0\u764c\u672f\u540e MRD \u548c\u8f85\u52a9\u6cbb\u7597\u53cd\u5e94\u8ddf\u8e2a\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u7ed3\u8bed<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u57fa\u4e8e TAPS \u7684\u591a\u6a21\u6001 ctDNA \u68c0\u6d4b\u65b9\u6cd5\u5728\u764c\u75c7\u65e9\u671f\u68c0\u6d4b\u548c\u672f\u540e\u76d1\u6d4b\u4e2d\u8868\u73b0\u51fa\u663e\u8457\u7684\u4f18\u52bf\u3002\u5176\u9ad8\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u4e3a\u764c\u75c7\u7b5b\u67e5\u548c\u60a3\u8005\u5206\u5c42\u63d0\u4f9b\u4e86\u65b0\u7684\u5de5\u5177\u3002<\/p>\n

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\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41467-024-55428-y<\/em><\/p>\n

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