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<\/a><\/p>\n

\u7f16\u8f91 | 2049<\/p>\n

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\u6709\u6ca1\u6709\u4e00\u79cd\u65b9\u6cd5\u53ef\u4ee5\u6446\u8131\u8fd9\u4e9b\u300c\u6ee4\u955c\u300d\uff0c\u8ba9\u663e\u5fae\u955c\u53d8\u5f97\u66f4\u667a\u80fd\u3001\u66f4\u9ad8\u6548\u5462\uff1f\u6700\u8fd1\uff0c\u6765\u81ea\u4e0a\u6d77\u7406\u5de5\u5927\u5b66\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u3001\u675c\u514b\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86\u4e00\u9879\u7531 AI \u9a71\u52a8\u7684\u521b\u65b0\u6280\u672f\u2014\u2014\u65e0\u6ee4\u5149\u7247\u8367\u5149\u663e\u5fae\u955c DL-F^3 M \u2014\u2014\u6b63\u5728\u6539\u53d8\u8fd9\u4e00\u73b0\u72b6\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cDeep learning-enabled filter-free fluorescence microscope<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 1 \u6708 1 \u65e5\u53d1\u5e03\u5728\u300aScience Advances<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n

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\u8fd1\u5e74\u6765\uff0c\u4eba\u5de5\u667a\u80fd<\/mark>\u6280\u672f\u5728\u663e\u5fae\u6210\u50cf\u9886\u57df\u53d6\u5f97\u4e86\u4e00\u7cfb\u5217\u7a81\u7834\uff0c\u5305\u62ec\u63d0\u5347\u7a7a\u95f4\u5206\u8fa8\u7387\u3001\u5b9e\u73b0\u81ea\u52a8\u5bf9\u7126\u3001\u6269\u5c55\u666f\u6df1\u7b49\u3002\u57fa\u4e8e\u8fd9\u4e9b\u8fdb\u5c55\uff0c\u7814\u7a76\u56e2\u961f\u63d0\u51fa\u4e86\u4e00\u79cd\u521b\u65b0\u65b9\u6848\uff1a\u6df1\u5ea6\u5b66\u4e60<\/mark>\u4f7f\u80fd\u7684\u65e0\u6ee4\u5149\u7247\u8367\u5149\u663e\u5fae\u955c DL-F^3 M \u3002\u8fd9\u4e00\u6280\u672f\u81f4\u529b\u4e8e\u89e3\u51b3\u8367\u5149\u663e\u5fae\u955c\u7684\u6838\u5fc3\u95ee\u9898\uff1a\u5982\u4f55\u5728\u4e0d\u4f7f\u7528\u4f20\u7edf\u6ee4\u5149\u7247\u7684\u60c5\u51b5\u4e0b\uff0c\u51c6\u786e\u63d0\u53d6\u8367\u5149\u4fe1\u53f7\u3002<\/p>\n

\u6280\u672f\u521b\u65b0<\/strong><\/p>\n

\u5728\u7cfb\u7edf\u67b6\u6784\u4e0a\uff0cDL-F^3 M \u91c7\u7528\u7b80\u5316\u7684\u5149\u8def\u8bbe\u8ba1\uff0c\u4f7f\u7528\u53ef\u8c03 LED \u5149\u6e90\u66ff\u4ee3\u4f20\u7edf\u94a8\u5364\u706f\uff0c\u901a\u8fc7\u8bbe\u7f6e\u5165\u5c04\u89d2 \u03b2 \u5927\u4e8e\u7269\u955c\u534a\u89d2\u5b54\u5f84 \u03b1 \u6765\u6700\u5c0f\u5316\u6fc0\u53d1\u5149\u8fdb\u5165\u7269\u955c\u7684\u8026\u5408\u3002\u7cfb\u7edf\u5229\u7528\u5f69\u8272\u76f8\u673a\u7684\u6ee4\u5149\u9635\u5217\uff08Bayer filter\uff09\u76f4\u63a5\u68c0\u6d4b\u8367\u5149\u53d1\u5c04\u3002<\/p>\n

\u5176\u6838\u5fc3\u662f\u4e24\u9636\u6bb5\u6df1\u5ea6\u5b66\u4e60<\/mark>\u6846\u67b6\uff1a\u9996\u5148\u662f\u57fa\u4e8e MobileNetV2 \u6846\u67b6\u7684\u8f7b\u91cf\u7ea7 NetFCS\uff0c\u5305\u542b 32 \u4e2a\u6ee4\u6ce2\u5668\u548c 17 \u4e2a\u6b8b\u5dee\u74f6\u9888\u5c42\uff0c\u7528\u4e8e\u81ea\u52a8\u8bc6\u522b\u8367\u5149\u901a\u9053\uff1b\u5176\u6b21\u662f\u6570\u5b57\u5149\u8c31\u6ee4\u6ce2\u7f51\u7edc\u5e93\uff0c\u91c7\u7528\u4e09\u4e2a\u5377\u79ef\u7f51\u7edc\u3001\u6b8b\u5dee\u7f51\u7edc\u4e0e\u8de8\u9636\u6bb5\u90e8\u5206\u7f51\u7edc\uff0c\u4ee5\u53ca\u4e24\u4e2a\u8f6c\u7f6e\u5377\u79ef\u7f51\u7edc\u7684\u7ec4\u5408\u67b6\u6784\u3002<\/p>\n

<\/a><\/p>\n

\u56fe1\uff1aDL-F^3 M\u7cfb\u7edf\u5de5\u4f5c\u539f\u7406\u793a\u610f\u56fe\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u8bad\u7ec3\u91c7\u7528\u6761\u4ef6\u751f\u6210\u5bf9\u6297\u7f51\u7edc\u6846\u67b6\uff0c\u5305\u62ec\u7528\u4e8e\u91cd\u5efa\u8367\u5149\u56fe\u50cf\u7684\u751f\u6210\u5668\u548c\u57fa\u4e8e PatchGAN \u7684\u5224\u522b\u5668\u3002\u8bad\u7ec3\u4f7f\u7528 Adam \u4f18\u5316\u5668<\/mark>\uff0c\u521d\u59cb\u5b66\u4e60\u7387<\/mark>\u4e3a 2\u00d710^-4\uff0c\u901a\u8fc7\u7ed3\u5408\u50cf\u7d20\u7ea7\u635f\u5931\u548c\u5bf9\u6297\u6027\u635f\u5931\u4f18\u5316\u7f51\u7edc\u6027\u80fd\u3002<\/p>\n

<\/a><\/p>\n

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\u5b9e\u9a8c\u9a8c\u8bc1<\/strong><\/p>\n

\u4e3a\u4e86\u9a8c\u8bc1 DL-F^3 M \u7684\u6027\u80fd\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u591a\u9879\u5b9e\u9a8c\u3002\u5b9e\u9a8c\u6837\u672c\u5305\u62ec HEK293T \u7ec6\u80de\u30014T1 \u5c0f\u9f20\u4e73\u817a\u764c\u7ec6\u80de\u548c BALB\/3T3 \u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u5206\u522b\u6807\u8bb0\u4e86\u4e0d\u540c\u7684\u8367\u5149\u67d3\u6599\u3002\u5b9e\u9a8c\u4e2d\u4f7f\u7528\u4e0d\u540c\u653e\u5927\u500d\u6570\u7684\u7269\u955c\uff085\u00d7\u300110\u00d7\u548c20\u00d7\uff09\u8fdb\u884c\u6210\u50cf\uff0c\u4ee5\u8bc4\u4f30 DL-F^3 M \u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684\u8868\u73b0\u3002<\/p>\n

\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0cDL-F^3 M \u80fd\u591f\u51c6\u786e\u5730\u9884\u6d4b\u8367\u5149\u4fe1\u53f7\uff0c\u5176\u654f\u611f\u6027\u548c\u7279\u5f02\u6027\u5747\u8fbe\u5230\u4e86\u9ad8\u6c34\u5e73\u3002\u4f8b\u5982\uff0c\u5728\u89c2\u5bdf\u8f6c\u67d3\u4e86\u7eff\u8272\u8367\u5149\u86cb\u767d\uff08GFP\uff09\u7684\u7ec6\u80de\u65f6\uff0cDL-F^3 M \u80fd\u591f\u6e05\u6670\u5730\u8bc6\u522b\u51fa\u8367\u5149\u4fe1\u53f7\uff0c\u4e14\u4e0e\u4f20\u7edf\u7684\u8367\u5149\u663e\u5fae\u955c\u7ed3\u679c\u9ad8\u5ea6\u4e00\u81f4\u3002\u6b64\u5916\uff0cDL-F^3 M \u8fd8\u6210\u529f\u5e94\u7528\u4e8e\u514d\u75ab\u8367\u5149\u5b9e\u9a8c\uff0c\u5b9a\u91cf\u5206\u6790\u4e86\u6210\u7ea4\u7ef4\u7ec6\u80de\u8f6c\u5316\u8fc7\u7a0b\u4e2d\u7684\u751f\u7269\u6807\u5fd7\u7269\u8868\u8fbe\u53d8\u5316\u3002<\/p>\n

DL-F^3 M \u7684\u521b\u65b0\u6548\u679c\u901a\u8fc7\u7ed3\u6784\u76f8\u4f3c\u6027\u6307\u6570\uff08SSIM\uff09\u548c\u4fe1\u566a\u6bd4\uff08SNR\uff09\u7b49\u6307\u6807\u8fdb\u884c\u4e86\u9a8c\u8bc1\u3002\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0cDL-F^3 M \u751f\u6210\u7684\u8367\u5149\u56fe\u50cf\u4e0e\u771f\u5b9e\u56fe\u50cf\u7684SSIM\u503c\u8d85\u8fc7 0.87\uff0cSNR\u503c\u8d85\u8fc7 31.7\uff0c\u8bc1\u660e\u4e86\u5176\u9ad8\u7cbe\u5ea6\u548c\u53ef\u9760\u6027\u3002<\/p>\n

<\/a><\/p>\n

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\u7ed3\u8bed<\/strong><\/p>\n

DL-F^3 M \u6280\u672f\u4e0d\u4ec5\u7a81\u7834\u4e86\u4f20\u7edf\u8367\u5149\u663e\u5fae\u6210\u50cf\u7684\u7269\u7406\u5c40\u9650\uff0c\u8fd8\u5f00\u521b\u4e86\u5149\u5b66\u7cfb\u7edf\u4e0e\u4eba\u5de5\u667a\u80fd<\/mark>\u6df1\u5ea6\u878d\u5408\u7684\u65b0\u8303\u5f0f\u3002\u8fd9\u4e00\u521b\u65b0\u65b9\u6cd5\u5728\u751f\u7269\u533b\u5b66\u6210\u50cf\u9886\u57df\u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\uff0c\u53ef\u671b\u63a8\u52a8\u6574\u4e2a\u9886\u57df\u7684\u6280\u672f\u9769\u65b0\u3002<\/p>\n

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