{"id":38023,"date":"2025-02-08T14:00:52","date_gmt":"2025-02-08T06:00:52","guid":{"rendered":"https:\/\/17aitech.com\/?p=38023"},"modified":"2025-02-08T14:00:52","modified_gmt":"2025-02-08T06:00:52","slug":"%e5%ae%9e%e7%8e%b05a%e5%85%a8%e5%8e%9f%e5%ad%90rmsd%ef%bc%8c%e6%99%ae%e6%b8%a1%e5%a4%a7%e5%ad%a6%e6%b7%b1%e5%ba%a6%e5%ad%a6%e4%b9%a0%e6%96%b9%e6%b3%95%e5%87%86%e7%a1%ae%e9%a2%84%e6%b5%8brna%e4%b8%89","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=38023","title":{"rendered":"\u5b9e\u73b05\u00c5\u5168\u539f\u5b50RMSD\uff0c\u666e\u6e21\u5927\u5b66\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u51c6\u786e\u9884\u6d4bRNA\u4e09\u7ea7\u7ed3\u6784\uff0c\u767bNature\u5b50\u520a"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u5b9e\u73b05\u00c5\u5168\u539f\u5b50RMSD\uff0c\u666e\u6e21\u5927\u5b66\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u51c6\u786e\u9884\u6d4bRNA\u4e09\u7ea7\u7ed3\u6784\uff0c\u767bNature\u5b50\u520a<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

\u975e\u7f16\u7801 RNA \u5728\u5404\u79cd\u751f\u7269\u529f\u80fd\u4e2d\u53d1\u6325\u7740\u8c03\u63a7\u4f5c\u7528\uff0c\u5e76\u4e14\u4e0e\u4eba\u7c7b\u5065\u5eb7\u3001\u836f\u7269\u8bbe\u8ba1\u7b49\u9886\u57df\u606f\u606f\u76f8\u5173\u3002<\/p>\n

\u4e86\u89e3\u529f\u80fd\u7684\u673a\u68b0\u673a\u5236\u9700\u8981\u4e09\u7ea7\u7ed3\u6784\u4fe1\u606f\uff0c\u7136\u800c\uff0c\u901a\u8fc7\u5b9e\u9a8c\u786e\u5b9a RNA \u4e09\u7ef4\u7ed3\u6784\u6210\u672c\u9ad8\u6602\u4e14\u8017\u65f6\uff0c\u5bfc\u81f4 RNA \u5e8f\u5217\u548c\u7ed3\u6784\u6570\u636e\u4e4b\u95f4\u5b58\u5728\u5de8\u5927\u5dee\u8ddd\u3002<\/p>\n

\u4e3a\u4e86\u5e94\u5bf9\u8fd9\u4e00\u6311\u6218\uff0c\u666e\u6e21\u5927\u5b66\uff08Purdue University West Lafayette\uff09\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86 NuFold \u6765\u51c6\u786e\u9884\u6d4b RNA \u4e09\u7ea7\u7ed3\u6784\u3002<\/p>\n

NuFold \u662f\u4e00\u4e2a\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc<\/mark>\uff0c\u9488\u5bf9\u8f93\u5165\u5e8f\u5217\u7684\u8f93\u51fa\u7ed3\u6784\u8fdb\u884c\u7aef\u5230\u7aef\u8bad\u7ec3;\u5b83\u91c7\u7528\u4e86\u78b1\u57fa\u4e2d\u5fc3\u8868\u793a\u6cd5\uff0c\u53ef\u5b9e\u73b0\u6838\u7cd6\u73af\u7684\u7075\u6d3b\u6784\u8c61\u3002<\/p>\n

NuFold \u5728\u6784\u5efa\u6b63\u786e\u7684 RNA \u5c40\u90e8\u51e0\u4f55\u7ed3\u6784\u65b9\u9762\u8868\u73b0\u51fa\u7279\u6b8a\u4f18\u52bf\u3002\u6b64\u5916\uff0cNuFold \u8fd8\u80fd\u591f\u901a\u8fc7\u94fe\u63a5\u8f93\u5165\u5e8f\u5217\u6765\u9884\u6d4b RNA \u7684\u591a\u805a\u4f53\u590d\u5408\u7ed3\u6784\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cNuFold: end-to-end approach for RNA tertiary structure prediction with flexible nucleobase center representation<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 1 \u6708 21\u00a0\u65e5\u53d1\u5e03\u5728\u300aNature Communications<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

\u6838\u7cd6\u6838\u9178 (RNA) \u662f\u751f\u7269\u4f53\u7684\u57fa\u672c\u5206\u5b50\u3002\u9664\u4e86\u4f5c\u4e3a\u8f6c\u5f55\u4e2d\u4f7f\u7528\u7684\u4fe1\u4f7f RNA \u53d1\u6325\u6838\u5fc3\u4f5c\u7528\u5916\uff0cRNA \u5206\u5b50\u8fd8\u4ee5\u975e\u7f16\u7801 RNA (ncRNA) \u7684\u5f62\u5f0f\u53d1\u6325\u5404\u79cd\u751f\u7269\u5b66\u529f\u80fd\uff0c\u5b83\u4eec\u53c2\u4e0e\u57fa\u56e0\u8c03\u63a7\u548c\u4fee\u9970\u7b49\u529f\u80fd\u3002<\/p>\n

RNACentral \u6570\u636e\u5e93<\/mark>\u76ee\u524d\u5305\u542b\u8d85\u8fc7\u4e09\u5343\u4e07\u4e2a ncRNA \u5e8f\u5217\u3002ncRNA \u5728\u836f\u7269\u8bbe\u8ba1\u4e2d\u4e5f\u5907\u53d7\u5173\u6ce8\uff0c\u56e0\u4e3a\u65b0\u836f\u53ef\u80fd\u88ab\u8bbe\u8ba1\u6210\u6291\u5236\u6216\u6a21\u4eff\u529f\u80fd\u6027 RNA \u7684\u6d3b\u6027\u3002<\/p>\n

\u5728\u6700\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u666e\u6e21\u5927\u5b66\u7684\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u4f7f\u7528\u7aef\u5230\u7aef\u6df1\u5ea6\u7f51\u7edc\u67b6\u6784\u7684\u4ece\u5934 RNA \u7ed3\u6784\u9884\u6d4b\u65b9\u6cd5 NuFold\u3002\u8be5\u65b9\u6cd5\u91c7\u7528\u76ee\u6807 RNA \u5e8f\u5217\uff0c\u5e76\u901a\u8fc7\u7ecf\u8fc7\u5168\u9762\u8bad\u7ec3\u7684\u5355\u4e2a\u7f51\u7edc\u751f\u6210\u4e09\u7ea7\u7ed3\u6784\u6a21\u578b\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aNuFold \u6982\u8ff0\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u8be5\u7f51\u7edc\u67b6\u6784\u57fa\u4e8e AlphaFold<\/mark>2\uff08AF2\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u65b9\u6cd5\uff0c\u5728 2020 \u5e74\u7684 CASP14\uff08\u7ed3\u6784\u9884\u6d4b\u5173\u952e\u8bc4\u4f30\uff09\u4e2d\u53d6\u5f97\u4e86\u51fa\u8272\u7684\u8868\u73b0\u3002<\/p>\n

\u5728 AF2 \u67b6\u6784\u7684\u57fa\u7840\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u91cd\u5927\u4fee\u6539\u3002\u8fd9\u4e9b\u4fee\u6539\u5305\u62ec\u8c03\u6574\u6838\u9178\u5e8f\u5217\uff0c\u4ee5\u4e8c\u7ea7\u7ed3\u6784\u4f5c\u4e3a\u8f93\u5165\uff0c\u4fee\u6539\u9884\u6d4b RNA \u7279\u5b9a\u78b1\u57fa\u95f4\u89d2\u5ea6\u3001\u8ddd\u79bb\u548c\u539f\u5b50\u4f4d\u7f6e\u7684\u65b9\u6cd5\uff0c\u4ee5\u53ca\u5141\u8bb8 RNA \u7ed3\u6784\u8868\u793a\u5177\u6709\u5b8c\u5168\u7684\u7075\u6d3b\u6027\u3002<\/p>\n

\u8be5\u56e2\u961f\u7684\u5b9e\u73b0\u65b9\u6cd5\u79f0\u4e3a\u6838\u78b1\u57fa\u4e2d\u5fc3\u8868\u793a\uff0c\u53ef\u4ee5\u4f18\u5316\u6838\u78b1\u57fa\u6240\u6709\u53ef\u65cb\u8f6c\u952e\u7684\u89d2\u5ea6\u3002\u8fd9\u79cd\u8868\u793a\u4f7f\u4ed6\u4eec\u80fd\u591f\u91cd\u73b0\u78b1\u57fa\u9aa8\u67b6\u4e2d\u5b58\u5728\u7684\u4efb\u4f55\u7075\u6d3b\u6027\uff0c\u4e3a\u7cbe\u786e\u7684\u78b1\u57fa\u6784\u8c61\u5efa\u6a21\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n

\u4e0e\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60<\/mark>\u7684\u65b9\u6cd5\u76f8\u6bd4\uff0cNuFold \u662f\u4e00\u79cd\u72ec\u7279\u7684\u7aef\u5230\u7aef\u6a21\u578b\uff0c\u5b83\u76f4\u63a5\u4ece MSA \u8f93\u51fa\u5b8c\u6574\u7684\u539f\u5b50\u6a21\u578b\u5e76\u9884\u6d4b\u4e8c\u7ea7\u7ed3\u6784\uff0c\u8fd9\u4e0e\u8bb8\u591a\u5176\u4ed6\u6df1\u5ea6\u5b66\u4e60<\/mark>\u6a21\u578b\u4e0d\u540c\uff0c\u8fd9\u4e9b\u6a21\u578b\u9700\u8981\u9884\u6d4b\u539f\u5b50\u95f4\u8ddd\u79bb\u548c\u89d2\u5ea6\u7ea6\u675f\u4ee5\u7528\u4e8e\u540e\u7eed\u7684\u7ed3\u6784\u5efa\u6a21\u8fc7\u7a0b\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u57fa\u51c6<\/mark>\u7ed3\u679c\u7528\u4e8e\u6bd4\u8f83\u9884\u6d4b\u65b9\u6cd5\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u76ee\u524d\u6765\u8bb2\uff0cRhoFold \u662f\u552f\u4e00\u4e00\u4e2a\u5177\u6709\u4e0e NuFold \u7c7b\u4f3c\u67b6\u6784\u7684\u5176\u4ed6\u7aef\u5230\u7aef\u6a21\u578b\u3002<\/p>\n

\u8fd9\u4e24\u4e2a\u67b6\u6784\u7684\u660e\u663e\u5dee\u5f02\u5728\u4e8e\uff0cRhoFold \u4f7f\u7528\u8bed\u8a00\u6a21\u578b<\/mark>\u6765\u5904\u7406\u8f93\u5165\u7684 MSA\uff0c\u800c NuFold \u4ee5\u7c7b\u4f3c\u4e8e AF2 \u7684\u66f4\u76f4\u63a5\u7684\u65b9\u5f0f\u83b7\u53d6 MSA\uff0c\u5e76\u4e14 NuFold \u5c06\u9884\u6d4b\u7684\u4e8c\u7ea7\u7ed3\u6784\u4fe1\u606f\u4f5c\u4e3a\u53e6\u4e00\u4e2a\u8f93\u5165\u3002<\/p>\n

RNA \u7ed3\u6784\u9884\u6d4b\u53ef\u80fd\u6bd4\u86cb\u767d\u8d28\u9884\u6d4b\u66f4\u56f0\u96be\uff0c\u56e0\u4e3a RNA \u5206\u5b50\u66f4\u7075\u6d3b\uff0c\u800c\u4e14\u4e0e\u86cb\u767d\u8d28\u76f8\u6bd4\uff0c\u53ef\u7528\u7684\u7ed3\u6784\u6570\u636e\u975e\u5e38\u6709\u9650\u3002\u8be5\u56e2\u961f\u7814\u7a76\u4e86\u51e0\u79cd\u514b\u670d\u8fd9\u4e00\u56f0\u96be\u7684\u65b9\u6cd5\uff1a\u4e3a\u4e86\u589e\u52a0\u8bad\u7ec3\u6570\u636e\u7684\u6570\u91cf\uff0c\u7814\u7a76\u4eba\u5458\u91c7\u7528\u4e86\u4e00\u79cd\u81ea\u63d0\u70bc\u6280\u672f\uff0c\u5c06\u88ab\u8ba4\u4e3a\u8db3\u591f\u51c6\u786e\u7684\u9884\u6d4b\u7ed3\u6784\u7eb3\u5165\u8bad\u7ec3\u96c6\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u76ee\u6807\u957f\u5ea6\u3001MSA \u6df1\u5ea6\u3001\u56de\u6536\u548c\u5b8f\u57fa\u56e0\u7ec4 MSA \u5bf9\u5efa\u6a21\u51c6\u786e\u6027\u7684\u5f71\u54cd\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u4e3a\u4e86\u589e\u52a0\u8f93\u5165 MSA \u7684\u6df1\u5ea6\uff0c\u79d1\u5b66\u5bb6\u52a0\u5165\u4e86\u5b8f\u57fa\u56e0\u7ec4\u5e8f\u5217\uff1b\u4e8b\u5b9e\u8bc1\u660e\uff0c\u5229\u7528\u5b8f\u57fa\u56e0\u7ec4\u5e8f\u5217\u4f5c\u4e3a\u8f93\u5165 MSA \u5e76\u4f18\u5316\u5faa\u73af\u6b21\u6570\u53ef\u63d0\u9ad8 NuFold \u7684\u9884\u6d4b\u6027\u80fd\u3002\u5728\u8bad\u7ec3\u8fc7\u7a0b\u4e2d\uff0c\u4ed6\u4eec\u91c7\u7528\u4e86\u52a8\u6001\u91c7\u6837\u7b56\u7565\uff0c\u5728\u6613\u76ee\u6807\u548c\u96be\u76ee\u6807\u4e4b\u95f4\u4fdd\u6301\u5e73\u8861\u3002<\/p>\n

\u6b64\u5916\uff0c\u56e2\u961f\u8fd8\u6d4b\u8bd5\u4e86\u51e0\u4e2a\u8f83\u5c0f\u7684\u7f51\u7edc\uff0c\u56e0\u4e3a\u4ed6\u4eec\u62e5\u6709\u7684\u8bad\u7ec3\u6570\u636e\u6bd4\u539f\u59cb AF2 \u4e2d\u4f7f\u7528\u7684\u86cb\u767d\u8d28\u6570\u636e\u96c6\u8981\u5c0f\u3002NuFold \u5bf9\u5927\u591a\u6570\u6d4b\u8bd5\u76ee\u6807\u5b9e\u73b0\u4e86 5 \u00c5 \u6216\u66f4\u4f4e\u7684\u5168\u539f\u5b50 RMSD\uff0c\u51e0\u4e4e\u5b8c\u7f8e\u5730\u6784\u5efa\u4e86\u6784\u8c61\uff0c\u67d4\u6027\u672b\u7aef\u548c\u73af\u72b6\u533a\u57df\u9664\u5916\u3002<\/p>\n

\u672a\u6765<\/p>\n

\u867d\u7136 NuFold\u7684\u8868\u73b0\u660e\u663e\u4f18\u4e8e\u57fa\u4e8e\u80fd\u91cf\u6700\u5c0f\u5316\u7684\u65b9\u6cd5\uff0c\u4f46\u8868\u73b0\u7565\u5dee\u4e8e\u8fd1\u671f\u53d1\u5e03\u7684\u4e00\u4e9b\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60<\/mark>\u7684\u65b9\u6cd5\u3002<\/p>\n

\u4e00\u4e2a\u539f\u56e0\u662f\uff0c\u8bad\u7ec3\u6570\u636e\u91cf\u4e0d\u8db3\u4ee5\u652f\u6301\u8fd9\u79cd\u5b8c\u5168\u539f\u5b50\u7ea7\u8be6\u7ec6\u6a21\u578b\u3002\u8bad\u7ec3\u6570\u636e\u4e0d\u8db3\u5bf9\u4e8e\u4efb\u4f55 RNA \u7ed3\u6784\u9884\u6d4b\u65b9\u6cd5\u6765\u8bf4\u90fd\u662f\u4e00\u4e2a\u6311\u6218\uff0c\u4f46\u5bf9\u4e8e NuFold \u6765\u8bf4\uff0c\u8fd9\u53ef\u80fd\u66f4\u4e3a\u5173\u952e\uff0c\u56e0\u4e3a\u5b83\u76f4\u63a5\u4ece\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc<\/mark>\u5efa\u6a21\u5b8c\u6574\u7684\u539f\u5b50\u7ed3\u6784\u3002<\/p>\n

\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u7ed3\u5408\u4e0d\u540c\u7684\u6570\u636e\u6a21\u5f0f\u975e\u5e38\u91cd\u8981\uff0c\u4f8b\u5982\u63d0\u4f9b RNA \u4e8c\u7ea7\u7ed3\u6784\u6d1e\u5bdf\u7684\u5b9e\u9a8c\u6570\u636e\uff0c\u5982 DMS-MaPseq \u548c SHAPE-MaP\u3002<\/p>\n

\u5173\u4e8e\u672a\u6765\u7684\u5de5\u4f5c\uff0c\u7531\u4e8e RNA \u7684\u6784\u8c61\u4f1a\u53d7\u5230\u4e0e\u5176\u4ed6\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7684\u5f71\u54cd\uff0c\u56e0\u6b64\u591a\u94fe\u3001RNA \u548c\u86cb\u767d\u8d28\u7684\u7ed3\u5408\u662f NuFold \u7684\u4e00\u4e2a\u6269\u5c55\u3002\u9664\u4e86 RNA \u548c\u86cb\u767d\u8d28\u4e4b\u5916\uff0c\u4f7f\u7528\u5c0f\u5316\u5408\u7269\u5efa\u6a21\u4e5f\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u6269\u5c55\uff0c\u56e0\u4e3a RNA \u662f\u836f\u7269\u53d1\u73b0<\/mark>\u7684\u65b0\u5174\u76ee\u6807\u3002<\/p>\n

\u6e90\u4ee3\u7801\uff1ahttps:\/\/github.com\/kiharalab\/nufold\/<\/em><\/p>\n

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