{"id":38165,"date":"2025-02-11T11:00:55","date_gmt":"2025-02-11T03:00:55","guid":{"rendered":"https:\/\/17aitech.com\/?p=38165"},"modified":"2025-02-11T11:00:55","modified_gmt":"2025-02-11T03:00:55","slug":"llm%e6%97%b6%e4%bb%a3%ef%bc%8c%e8%ae%a1%e7%ae%97%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%a7%91%e5%ad%a6%e8%bf%9b%e5%b1%95%e5%a6%82%e4%bd%95%ef%bc%9f%e9%a6%99%e6%b8%af%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=38165","title":{"rendered":"LLM\u65f6\u4ee3\uff0c\u8ba1\u7b97\u86cb\u767d\u8d28\u79d1\u5b66\u8fdb\u5c55\u5982\u4f55\uff1f\u9999\u6e2f\u7406\u5de5\u5927\u5b66\u7b49\u53d1\u5e03\u7cfb\u7edf\u6027\u7efc\u8ff0"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:LLM\u65f6\u4ee3\uff0c\u8ba1\u7b97\u86cb\u767d\u8d28\u79d1\u5b66\u8fdb\u5c55\u5982\u4f55\uff1f\u9999\u6e2f\u7406\u5de5\u5927\u5b66\u7b49\u53d1\u5e03\u7cfb\u7edf\u6027\u7efc\u8ff0<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91\u4e28coisini<\/p>\n

\u4f5c\u4e3a\u751f\u547d\u7684\u57fa\u672c\u6784\u5efa\u5355\u5143\uff0c\u86cb\u767d\u8d28\u5728\u51e0\u4e4e\u6240\u6709\u57fa\u672c\u751f\u547d\u6d3b\u52a8\u4e2d\u626e\u6f14\u7740\u4e0d\u53ef\u6216\u7f3a\u7684\u89d2\u8272\uff0c\u4f8b\u5982\u65b0\u9648\u4ee3\u8c22\u3001\u4fe1\u53f7\u4f20\u5bfc\u3001\u514d\u75ab\u53cd\u5e94\u7b49\u3002\u5982\u4e0b\u56fe\u6240\u793a\uff0c\u86cb\u767d\u8d28\u9075\u5faa\u5e8f\u5217 – \u7ed3\u6784 – \u529f\u80fd\u8303\u5f0f\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u6ce8\uff1a\u86cb\u767d\u8d28\u9075\u5faa\u5e8f\u5217-\u7ed3\u6784-\u529f\u80fd\u8303\u5f0f\u3002\uff08\u56fe\u6e90\uff1a\u8bba\u6587\uff09<\/em><\/p>\n

\u968f\u7740\u79d1\u5b66\u63a2\u7d22\u7684\u4e0d\u65ad\u63a8\u8fdb\uff0c\u7834\u8bd1\u86cb\u767d\u8d28\u8bed\u8a00\u5e76\u5e94\u7528\u86cb\u767d\u8d28\u5e8f\u5217 – \u7ed3\u6784 – \u529f\u80fd\u4e4b\u95f4\u7684\u4fe1\u606f\u6d41\u52a8\u89c4\u5219\u9762\u4e34\u66f4\u5927\u7684\u6311\u6218\u3002\u7814\u7a76\u4eba\u5458\u79ef\u6781\u5f15\u5165\u5f3a\u5927\u7684 LLM \u6280\u672f\u6765\u63a8\u52a8\u8ba1\u7b97\u86cb\u767d\u8d28\u79d1\u5b66\u7684\u53d1\u5c55\uff0c\u5f00\u53d1\u4e86\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b<\/mark>\uff08pLMs\uff09\uff0c\u8fd9\u4e9b\u6a21\u578b\u5de7\u5999\u5730\u638c\u63e1\u4e86\u86cb\u767d\u8d28\u7684\u57fa\u7840\u77e5\u8bc6\uff0c\u5e76\u80fd\u591f\u6709\u6548\u5730\u6cdb\u5316\u4ee5\u89e3\u51b3\u5404\u79cd\u5e8f\u5217 – \u7ed3\u6784 – \u529f\u80fd\u63a8\u7406\u95ee\u9898\u3002<\/p>\n

\u8fd1\u671f\uff0c\u4e3a\u4e86\u5e2e\u52a9\u5177\u6709 AI \u6216\u751f\u7269\u5b66\u80cc\u666f\u7684\u7814\u7a76\u4eba\u5458\u5feb\u901f\u4e86\u89e3\u76f8\u5173\u8fdb\u5c55\u5e76\u83b7\u5f97\u542f\u53d1\uff0c\u6765\u81ea\u9999\u6e2f\u7406\u5de5\u5927\u5b66\u7b49\u673a\u6784\u7684\u7814\u7a76\u56e2\u961f\u5bf9 LLM \u6280\u672f\u652f\u6301\u4e0b\u7684\u8ba1\u7b97\u86cb\u767d\u8d28\u79d1\u5b66\u8fdb\u884c\u4e86\u7cfb\u7edf\u6027\u7684\u7efc\u8ff0\u3002<\/p>\n

<\/a><\/p>\n

\u8bba\u6587\u5730\u5740\uff1ahttps:\/\/arxiv.org\/pdf\/2501.10282<\/em><\/p>\n

\u8fd9\u7bc7\u7efc\u8ff0\u9996\u5148\u6982\u8ff0\u4e86\u86cb\u767d\u8d28\u5efa\u6a21\u4e2d\u7684\u751f\u7269\u5b66\u57fa\u7840\u548c\u6570\u636e\u6982\u51b5\uff0c\u5176\u6b21\u56de\u987e\u4e86\u4e09\u7c7b\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b<\/mark>\uff08pLMs\uff09\uff0c\u8fd9\u4e9b\u6a21\u578b\u80fd\u591f\u7406\u89e3\u6c28\u57fa\u9178\u5e8f\u5217\u3001\u8bc6\u522b\u7ed3\u6784\u548c\u529f\u80fd\u4fe1\u606f\uff0c\u5e76\u8fde\u63a5\u591a\u79cd\u751f\u7269\u533b\u5b66\u8bed\u8a00\uff0c\u63a5\u7740\u8be5\u7efc\u8ff0\u4ecb\u7ecd\u4e86 pLMs \u7684\u5229\u7528\u548c\u9002\u5e94\u6027\uff0c\u91cd\u70b9\u5f3a\u8c03\u4e86 pLMs \u5728\u7ed3\u6784\u9884\u6d4b\u3001\u529f\u80fd\u9884\u6d4b\u548c\u86cb\u767d\u8d28\u8bbe\u8ba1\u4e2d\u7684\u91cd\u5927\u5f71\u54cd\u3002\u7136\u540e\uff0c\u8be5\u7efc\u8ff0\u8be6\u7ec6\u8bf4\u660e\u4e86 pLMs \u5728\u6297\u4f53\u8bbe\u8ba1\u3001\u9176\u8bbe\u8ba1\u548c\u836f\u7269\u9776\u70b9\u53d1\u73b0\u4e2d\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u6700\u540e\u5206\u4eab\u4e86\u8fd9\u4e00\u5feb\u901f\u53d1\u5c55\u9886\u57df\u7684\u672a\u6765\u65b9\u5411\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u6ce8\uff1a\u751f\u7269\u5b66\u57fa\u7840\u4e0e\u6570\u636e\u6982\u51b5\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/em><\/p>\n

\u4e0b\u9762\u662f\u7efc\u8ff0\u4e3b\u8981\u5185\u5bb9\u6982\u89c8\u3002<\/p>\n

\u9884\u8bad\u7ec3\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b<\/mark><\/strong><\/p>\n

\u8be5\u7efc\u8ff0\u5c06\u73b0\u6709\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b<\/mark>\uff08pLMs\uff09\u5206\u7c7b\u4e3a\u57fa\u4e8e\u5e8f\u5217\u7684\u6a21\u578b\u3001\u7ed3\u6784\u4e0e\u529f\u80fd\u589e\u5f3a\u7684\u6a21\u578b\u4ee5\u53ca\u591a\u6a21\u6001\u6a21\u578b\u3002<\/p>\n

\u57fa\u4e8e\u5e8f\u5217\u7684 pLMs<\/strong><\/p>\n

\u901a\u7528 LLM \u80fd\u591f\u6355\u6349\u5b50\u8bcd token \u4e4b\u95f4\u7684\u76f8\u4e92\u4f9d\u8d56\u5173\u7cfb\uff0c\u5e76\u6df1\u5165\u7406\u89e3\u6587\u672c\u7684\u8bed\u6cd5\u548c\u8bed\u4e49\u3002\u7c7b\u4f3c\u5730\uff0c\u57fa\u4e8e\u5e8f\u5217\u7684 pLMs \u80fd\u591f\u6355\u6349\u6c28\u57fa\u9178\uff08AA\uff09token \u4e4b\u95f4\u7684\u76f8\u4e92\u4f9d\u8d56\u5173\u7cfb\uff0c\u63d0\u53d6\u6709\u5229\u7684\u5e8f\u5217\u6a21\u5f0f\uff0c\u5e76\u638c\u63e1\u9690\u542b\u7684\u7ed3\u6784\u548c\u529f\u80fd\u4fe1\u606f\u3002\u57fa\u4e8e\u5e8f\u5217\u7684 pLMs \u53ef\u4ee5\u8fdb\u4e00\u6b65\u5206\u4e3a\u57fa\u4e8e\u5355\u5e8f\u5217\u7684\u6a21\u578b\u548c\u57fa\u4e8e\u591a\u5e8f\u5217\u7684\u6a21\u578b\u3002\u524d\u8005\u901a\u8fc7\u76f8\u5e94\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u63cf\u8ff0\u6bcf\u4e2a\u86cb\u767d\u8d28\uff0c\u540e\u8005\u5219\u91c7\u7528\u68c0\u7d22\u589e\u5f3a\u7684\u601d\u60f3\uff0c\u901a\u8fc7\u8fdb\u5316\u6216\u5408\u6210\u4e2d\u7684\u591a\u4e2a\u76f8\u5173\u5e8f\u5217\u6765\u63cf\u8ff0\u6bcf\u4e2a\u86cb\u767d\u8d28\u3002\u4e0b\u8868\u63d0\u4f9b\u4e86\u57fa\u4e8e\u5e8f\u5217\u7684 pLMs \u7684\u5168\u9762\u603b\u7ed3\uff0c\u6982\u8ff0\u4e86\u6bcf\u4e2a pLM \u7684\u8f93\u5165\u6570\u636e\u3001\u7f51\u7edc\u67b6\u6784\u548c\u9884\u8bad\u7ec3\u76ee\u6807\u3002<\/p>\n

\u8868\u6ce8\uff1a\u57fa\u4e8e\u5e8f\u5217\u7684 pLMs\u3002<\/em>\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/em><\/p>\n

<\/a><\/p>\n

\u7ed3\u6784\u4e0e\u529f\u80fd\u589e\u5f3a\u7684 pLMs<\/strong><\/strong><\/p>\n

\u57fa\u4e8e\u5e8f\u5217\u7684\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b<\/mark>\u901a\u8fc7\u5927\u89c4\u6a21\u9884\u8bad\u7ec3\u5c55\u793a\u4e86\u4ece\u86cb\u767d\u8d28\u5e8f\u5217\u4e2d\u6355\u6349\u9690\u542b\u7ed3\u6784\u548c\u529f\u80fd\u8bed\u4e49\u7684\u80fd\u529b\uff0c\u800c\u8fdb\u4e00\u6b65\u6574\u5408\u663e\u5f0f\u77e5\u8bc6\u53ef\u4ee5\u5728\u66f4\u5168\u9762\u7684\u5c42\u6b21\u4e0a\u589e\u5f3a\u5176\u5bf9\u86cb\u767d\u8d28\u7684\u7406\u89e3\u3002\u8be5\u7efc\u8ff0\u4ecb\u7ecd\u4e86\u6784\u5efa\u7ed3\u6784\u4e0e\u529f\u80fd\u589e\u5f3a\u7684 pLMs \u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u5206\u522b\u89e3\u91ca\u4e86\u86cb\u767d\u8d28\u7ed3\u6784\u548c\u529f\u80fd\u7684\u6570\u636e\u5f62\u5f0f\uff0c\u5e76\u4ecb\u7ecd\u4e86\u76f8\u5e94\u7684\u6574\u5408\u65b9\u6cd5\u3002<\/p>\n

\u8868\u6ce8\uff1a\u7ed3\u6784\u4e0e\u529f\u80fd\u589e\u5f3a\u7684 pLMs\u3002<\/em>\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/em><\/p>\n

<\/p>\n

<\/a><\/p>\n

\u591a\u6a21\u6001 pLMs<\/strong><\/strong><\/p>\n

\u4e0a\u8ff0\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b<\/mark>\u80fd\u591f\u89e3\u6790\u86cb\u767d\u8d28\u5e8f\u5217\u5e76\u7406\u89e3\u5176\u7ed3\u6784\u548c\u529f\u80fd\u4fe1\u606f\uff0c\u5176\u4e2d\u4e00\u4e9b\u6a21\u578b\u6574\u5408\u4e86\u4e0e\u86cb\u767d\u8d28\u76f8\u5173\u7684\u6587\u672c\u63cf\u8ff0\uff0c\u4f46\u5b83\u4eec\u7684\u4e3b\u8981\u5173\u6ce8\u70b9\u4ecd\u7136\u662f\u56f4\u7ed5\u86cb\u767d\u8d28\u7684\u8bed\u4e49\u3002\u8be5\u7efc\u8ff0\u63a5\u4e0b\u6765\u4ecb\u7ecd\u4e86\u5728\u5916\u5728\u8bed\u8a00\u4e2d\u8868\u73b0\u51fa\u8272\u7684 pLMs\uff0c\u8fd9\u4e9b\u5916\u5728\u8bed\u8a00\u5305\u62ec\u5305\u542b\u4e16\u754c\u77e5\u8bc6\u7684\u81ea\u7136\u8bed\u8a00\u3001\u5316\u5b66\u5206\u5b50\u8bed\u8a00\u7b49\u3002\u7531\u4e8e\u8fd9\u4e9b\u8bed\u8a00\u4f20\u8fbe\u4e86\u6781\u4e3a\u591a\u6837\u5316\u7684\u8bed\u4e49\uff0c\u8be5\u7efc\u8ff0\u5c06\u5b83\u4eec\u89c6\u4e3a\u4e0d\u540c\u7684\u6a21\u6001\u3002\u4e0b\u8868\u5bf9\u591a\u6a21\u6001 pLMs \u8fdb\u884c\u4e86\u603b\u7ed3\u3002<\/p>\n

\u8868\u6ce8\uff1a\u591a\u6a21\u6001 pLMs\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/em><\/em><\/p>\n

<\/a><\/p>\n

\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b<\/mark>\u7684\u5229\u7528\u548c\u9002\u5e94<\/strong><\/p>\n

\u8be5\u7efc\u8ff0\u901a\u8fc7\u8003\u8651\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u3001\u86cb\u767d\u8d28\u529f\u80fd\u9884\u6d4b\u548c\u86cb\u767d\u8d28\u8bbe\u8ba1\u4e2d\u7684\u5f85\u89e3\u51b3\u95ee\u9898\uff0c\u603b\u7ed3\u4e86 pLMs \u7684\u5229\u7528\u548c\u9002\u5e94\u65b9\u6cd5\u3002<\/p>\n

\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b<\/strong><\/p>\n

\u8fc4\u4eca\u4e3a\u6b62\uff0c\u86cb\u767d\u8d28\u6570\u636e\u5e93<\/mark>\uff08Protein Data Bank\uff09\u4e2d\u4ec5\u6536\u96c6\u4e86\u7ea6\u4e8c\u5341\u4e07\u4e2a\u901a\u8fc7\u5b9e\u9a8c\u786e\u5b9a\u7684\u7ed3\u6784\u3002\u4ee5\u8fd9\u79cd\u53d1\u5c55\u901f\u5ea6\uff0c\u8981\u5206\u6790\u6570\u4ebf\u4e2a\u5df2\u6d4b\u5e8f\u4f46\u7ed3\u6784\u672a\u77e5\u7684\u5929\u7136\u86cb\u767d\u8d28\uff0c\u5c06\u9700\u8981\u6570\u767e\u4e07\u4e2a\u7814\u7a76\u5e74\u3002\u5982\u679c\u8ba1\u7b97\u6a21\u578b\u80fd\u591f\u4ece\u6c28\u57fa\u9178\u5e8f\u5217\u4e2d\u51c6\u786e\u63a8\u65ad\u51fa\u86cb\u767d\u8d28\u7684\u539f\u5b50\u7ea7\u4e09\u7ef4\u7ed3\u6784\uff0c\u4eba\u7c7b\u5bf9\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u7406\u89e3\u8fdb\u7a0b\u5c06\u5927\u5927\u52a0\u5feb\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u4eba\u5de5\u667a\u80fd<\/mark>\u548c\u8ba1\u7b97\u80fd\u529b\u7684\u5feb\u901f\u53d1\u5c55\u6781\u5927\u5730\u63a8\u52a8\u4e86\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u8fdb\u6b65\u3002\u8bf8\u5982 AlphaFold<\/mark>2 \u548c\u00a0RoseTTAFold\u00a0\u7b49\u7a81\u7834\u6027\u65b9\u6cd5\u5728\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u65b9\u9762\u5c55\u73b0\u4e86\u63a5\u8fd1\u5b9e\u9a8c\u7cbe\u5ea6\u7684\u524d\u6240\u672a\u6709\u7684\u6c34\u5e73\u3002\u5b83\u4eec\u5df2\u6210\u4e3a\u79d1\u5b66\u5bb6\u5728\u6570\u5341\u5206\u949f\u5185\u83b7\u5f97\u53ef\u9760\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u91cd\u8981\u5de5\u5177\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u6ce8\uff1aAlphaFold<\/mark>2 \u548c ESMFold \u7684\u5de5\u4f5c\u6d41\u7a0b\u6982\u8ff0\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/em><\/p>\n

<\/p>\n

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