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\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

\u4f20\u7edf\u7684\u86cb\u767d\u8d28\u5de5\u7a0b\u65b9\u6cd5\uff08\u5982\u5b9a\u5411\u8fdb\u5316\uff09\u867d\u7136\u6709\u6548\uff0c\u4f46\u901a\u5e38\u901f\u5ea6\u7f13\u6162\u4e14\u52b3\u52a8\u5bc6\u96c6\u3002\u673a\u5668\u5b66\u4e60\u548c\u300c\u81ea\u52a8\u5316\u751f\u7269\u5de5\u5382\u300d\u7684\u8fdb\u6b65\u4e3a\u4f18\u5316\u8fd9\u4e9b\u8fc7\u7a0b\u63d0\u4f9b\u4e86\u65b0\u7684\u673a\u4f1a\u3002<\/p>\n

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\u8be5\u7cfb\u7edf\u5927\u5927\u63d0\u9ad8\u4e86\u86cb\u767d\u8d28\u8fdb\u5316\u7684\u901f\u5ea6\u548c\u51c6\u786e\u6027\uff0c\u63a8\u52a8\u4e86\u86cb\u767d\u8d28\u5de5\u7a0b\u5728\u5de5\u4e1a\u5e94\u7528\u65b9\u9762\u7684\u5feb\u901f\u53d1\u5c55\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cIntegrating protein language models and automatic biofoundry for enhanced protein evolution<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 2 \u6708 11 \u65e5\u53d1\u5e03\u5728\u300aNature Communications<\/em>\u300b\u3002<\/p>\n

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\u86cb\u767d\u8d28\u5728\u533b\u836f\u3001\u5316\u5b66\u5236\u9020\u3001\u80fd\u6e90\u3001\u519c\u4e1a\u548c\u6d88\u8d39\u54c1\u7b49\u5404\u4e2a\u9886\u57df\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u5de5\u4e1a\u5e94\u7528\uff0c\u86cb\u767d\u8d28\u901a\u5e38\u9700\u8981\u8fdb\u884c\u5de5\u7a0b\u6539\u9020\u4ee5\u589e\u5f3a\u5176\u7a33\u5b9a\u6027\u3001\u6d3b\u6027\u3001\u9009\u62e9\u6027\u548c\u7ed3\u5408\u4eb2\u548c\u529b\u7b49\u7279\u6027\u3002<\/p>\n

\u86cb\u767d\u8d28\u5de5\u7a0b\u5df2\u5f00\u53d1\u51fa\u591a\u79cd\u7b56\u7565\uff0c\u5b9a\u5411\u8fdb\u5316\u662f\u4e00\u79cd\u6210\u719f\u4e14\u6709\u6548\u7684\u65b9\u6cd5\u3002\u4f20\u7edf\u7684\u5b9a\u5411\u8fdb\u5316\u4f9d\u8d56\u4e8e\u968f\u673a\u8bf1\u53d8\u548c\u9ad8\u901a\u91cf\u7b5b\u9009\u7684\u8fed\u4ee3\u5faa\u73af\u6765\u8bc6\u522b\u5177\u6709\u6240\u9700\u7279\u6027\u7684\u53d8\u4f53\u3002<\/p>\n

\u867d\u7136\u8fd9\u4e00\u8fc7\u7a0b\u975e\u5e38\u6709\u6548\uff0c\u4f46\u8017\u65f6\u4e14\u8d39\u529b\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u5b9a\u5411\u8fdb\u5316\u901a\u5e38\u4e00\u6b21\u5f15\u5165\u4e00\u4e2a\u7a81\u53d8\uff0c\u56e0\u6b64\u53ef\u80fd\u9677\u5165\u5c40\u90e8\u9002\u5e94\u5ea6\u6700\u4f18\uff0c\u4ece\u800c\u9650\u5236\u8fdb\u4e00\u6b65\u4f18\u5316\u3002<\/p>\n

\u5728\u6700\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6d59\u6c5f\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86\u4e00\u79cd\u86cb\u767d\u8d28\u5de5\u7a0b\u7b56\u7565\u79f0\u4e3a PLMeAE\uff08protein language model-enabled automatic evolution\uff09\uff0c\u5c06\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b \uff08PLM\uff09\u7684\u9884\u6d4b\u80fd\u529b\u4e0e\u300c\u81ea\u52a8\u5316\u751f\u7269\u5de5\u5382\u300d\u7684\u8fd0\u8425\u6548\u7387\u76f8\u7ed3\u5408\u3002<\/p>\n

\u5728\u8bbe\u8ba1-\u6784\u5efa-\u6d4b\u8bd5-\u5b66\u4e60\u5468\u671f\u4e2d\uff0c\u5b66\u4e60\u548c\u8bbe\u8ba1\u9636\u6bb5\u5229\u7528 PLM \u7684\u89c1\u89e3\u6765\u9610\u660e\u86cb\u767d\u8d28\u5e8f\u5217\u9002\u5e94\u5ea6\u5173\u7cfb\u5e76\u91c7\u6837\u65b0\u7a81\u53d8\u4f53\uff0c\u800c\u6784\u5efa\u548c\u6d4b\u8bd5\u9636\u6bb5\u5219\u4f7f\u7528\u81ea\u52a8\u5316\u751f\u7269\u5de5\u5382\u9ad8\u6548\u8fdb\u884c\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u652f\u6301\u7684\u81ea\u52a8\u86cb\u767d\u8d28\u8fdb\u5316\u6982\u8ff0\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

PLMeAE \u6982\u8ff0<\/strong><\/p>\n

PLMeAE \u5e73\u53f0\u662f\u4e00\u4e2a\u5728\u8bbe\u8ba1-\u6784\u5efa-\u6d4b\u8bd5-\u5b66\u4e60\uff08DBTL\uff09\u5faa\u73af\u5185\u8fdb\u884c\u81ea\u52a8\u5316\u86cb\u767d\u8d28\u5de5\u7a0b\u7684\u95ed\u73af\u7cfb\u7edf\u3002\u8be5\u5e73\u53f0\u91c7\u7528 PLM \u6765\u4fc3\u8fdb\u5b66\u4e60\u548c\u8bbe\u8ba1\u9636\u6bb5\uff0c\u800c\u6784\u5efa\u548c\u6d4b\u8bd5\u9636\u6bb5\u5219\u7531\u300c\u81ea\u52a8\u5316\u751f\u7269\u5de5\u5382\u300d\u6267\u884c\u3002<\/p>\n

\u8be5\u6d41\u7a0b\u4ece\u521b\u5efa\u53d8\u4f53\u5e93\u5f00\u59cb\uff0c\u5728\u8bbe\u8ba1\u9636\u6bb5\u91c7\u7528 PLM \u542f\u7528\u7684\u96f6\u6837\u672c\u5b66\u4e60\u65b9\u6cd5\u3002\u5177\u4f53\u6765\u8bf4\uff0cPLM \u89e3\u51b3\u4e86\u4e24\u4e2a\u96f6\u6837\u672c\u4efb\u52a1\uff0c\u5177\u4f53\u53d6\u51b3\u4e8e\u7a81\u53d8\u76ee\u6807\u4f4d\u70b9\u7684\u53ef\u7528\u6027\u3002<\/p>\n

\u9996\u5148\uff0c\u5728\u6ca1\u6709\u5173\u4e8e\u76ee\u6807\u86cb\u767d\u7684\u5148\u9a8c\u4fe1\u606f\u7684\u60c5\u51b5\u4e0b\uff0cPLM \u7528\u4e8e\u5728\u96f6\u6837\u672c\u8bbe\u7f6e\u4e2d\u9884\u6d4b\u9ad8\u9002\u5e94\u5ea6\u5355\u7a81\u53d8\u4f53\u3002\u5176\u6b21\uff0c\u5f53\u7a81\u53d8\u4f4d\u70b9\u5df2\u6839\u636e\u4e4b\u524d\u7684\u5b9e\u9a8c\u6216\u901a\u8fc7\u7269\u7406\u5efa\u6a21\u6280\u672f\uff08\u4f8b\u5982\u5bf9\u63a5\u3001\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\uff09\u786e\u5b9a\u65f6\uff0cPLM \u7528\u4e8e\u5728\u7ed9\u5b9a\u76ee\u6807\u4f4d\u70b9\u9884\u6d4b\u96f6\u6837\u672c\u9ad8\u9002\u5e94\u5ea6\u591a\u7a81\u53d8\u53d8\u4f53\u3002<\/p>\n

\u968f\u540e\uff0c\u5728\u6784\u5efa\u548c\u6d4b\u8bd5\u6b65\u9aa4\u4e2d\uff0c\u901a\u8fc7 biofoundry \u7684\u81ea\u52a8\u5316\u8bbe\u65bd\u5408\u6210\u3001\u8868\u8fbe\u548c\u6d4b\u8bd5\u6240\u63d0\u51fa\u7684\u5e93\u3002\u5728\u6536\u96c6\u5b9e\u9a8c\u6570\u636e\u540e\uff0c\u5728\u5b66\u4e60\u9636\u6bb5\uff0cPLM \u5bf9\u86cb\u767d\u8d28\u5e8f\u5217\u8fdb\u884c\u7f16\u7801\uff0c\u5e76\u8bad\u7ec3\u76d1\u7763\u673a\u5668\u5b66\u4e60\u6a21\u578b\u4ee5\u5c06\u8fd9\u4e9b\u53d8\u4f53\u4e0e\u5176\u9002\u5e94\u5ea6\u6c34\u5e73\u76f8\u5173\u8054\u3002<\/p>\n

\u968f\u540e\uff0c\u5e94\u7528\u4f18\u5316\u7b97\u6cd5\u63a2\u7d22\u53d8\u4f53\u524d\u666f\uff0c\u4fc3\u8fdb\u5408\u7406\u8bbe\u8ba1\u5e76\u786e\u5b9a\u6709\u5e0c\u671b\u8fdb\u884c\u540e\u7eed\u6d4b\u8bd5\u7684\u53d8\u4f53\u3002\u8fd9\u79cd\u7c7b\u4f3c\u4e8e\u4e3b\u52a8\u5b66\u4e60\u7b56\u7565\u7684\u8fed\u4ee3\u8fc7\u7a0b\u6301\u7eed\u8fdb\u884c\uff0c\u76f4\u5230\u5f00\u53d1\u51fa\u6700\u4f73\u53d8\u4f53\u3002<\/p>\n

\u7528\u4e8e\u86cb\u767d\u8d28\u53d8\u4f53\u8bbe\u8ba1\u7684 PLM<\/strong><\/p>\n

\u5728\u5c06 PLM \u5e94\u7528\u4e8e\u86cb\u767d\u8d28\u53d8\u4f53\u8bbe\u8ba1\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e24\u4e2a\u6a21\u5757\uff0c\u5206\u522b\u7528\u4e8e\u9884\u6d4b\u4e0d\u77e5\u9053\u7a81\u53d8\u4f4d\u70b9\u7684\u86cb\u767d\u8d28\u7684\u9ad8\u9002\u5e94\u5ea6\u7a81\u53d8\u4f53\u548c\u5df2\u77e5\u7a81\u53d8\u4f4d\u70b9\u7684\u86cb\u767d\u8d28\u3002<\/p>\n

\u6a21\u5757 I \u7528\u4e8e\u6ca1\u6709\u5148\u524d\u786e\u5b9a\u7684\u7a81\u53d8\u4f4d\u70b9\u7684\u86cb\u767d\u8d28\u3002\u5728\u6b64\u6a21\u5757\u4e2d\uff0cPLM \u9884\u6d4b\u5177\u6709\u9ad8\u9002\u5e94\u6027\u53ef\u80fd\u6027\u7684\u5355\u4e2a\u7a81\u53d8\u4f53\uff0c\u5e76\u5c06\u6b64\u53ef\u80fd\u6027\u4f5c\u4e3a\u9002\u5e94\u6027\u6c34\u5e73\u7684\u4ee3\u8868\u3002\u7136\u540e\u4f7f\u7528\u8fd9\u4e9b\u9ad8\u53ef\u80fd\u6027\u7a81\u53d8\u4f53\u6765\u8bc6\u522b\u5173\u952e\u7a81\u53d8\u4f4d\u70b9\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u6a21\u5757 II \u9488\u5bf9\u5177\u6709\u5df2\u77e5\u7a81\u53d8\u4f4d\u70b9\u7684\u86cb\u767d\u8d28\uff0c\u5e76\u4f7f\u7528 PLM \u6765\u62bd\u53d6\u6709\u7528\u7684\u7a81\u53d8\u4f53\u8fdb\u884c\u5b9e\u9a8c\u8868\u5f81\u3002\u6b64\u5916\uff0cPLM \u7528\u4e8e\u7f16\u7801\u86cb\u767d\u8d28\u5e8f\u5217\u4ee5\u8bad\u7ec3\u9002\u5e94\u5ea6\u9884\u6d4b\u5668\u3002\u6a21\u5757 I \u548c\u6a21\u5757 II \u53ef\u4ee5\u7ec4\u5408\u4f7f\u7528\u6216\u72ec\u7acb\u4f7f\u7528\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u7528\u4e8e\u86cb\u767d\u8d28\u81ea\u52a8\u8fdb\u5316\u7684\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u81ea\u52a8\u5316\u751f\u7269\u5de5\u5382<\/strong><\/p>\n

\u8be5\u56e2\u961f\u7684\u673a\u5668\u4eba\u7cfb\u7edf\u64c5\u957f\u6784\u5efa\u86cb\u767d\u8d28\u53d8\u4f53\u5e76\u6301\u7eed\u6536\u96c6\u86cb\u767d\u8d28\u53d8\u4f53\u529f\u80fd\u6570\u636e\uff0c\u901a\u8fc7\u5168\u9762\u7684\u5143\u6570\u636e\u8ddf\u8e2a\u548c\u5b9e\u65f6\u6570\u636e\u5171\u4eab\u786e\u4fdd\u9ad8\u53ef\u91cd\u590d\u6027\u3002<\/p>\n

\u901a\u8fc7\u5c06 PLM \u7684\u9ad8\u7ea7\u9884\u6d4b\u529f\u80fd\u4e0e\u673a\u5668\u4eba\u7cfb\u7edf\u7684\u9ad8\u901a\u91cf\u529f\u80fd\u76f8\u7ed3\u5408\uff0c\u8be5\u65b9\u6cd5\u65e8\u5728\u8d85\u8d8a\u4f20\u7edf\u9650\u5236\u5e76\u52a0\u5feb\u53d1\u73b0\u548c\u589e\u5f3a\u5bf9\u5de5\u4e1a\u5e94\u7528\u81f3\u5173\u91cd\u8981\u7684\u86cb\u767d\u8d28\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1a\u81ea\u52a8\u86cb\u767d\u8d28\u53d8\u4f53\u6784\u5efa\u548c\u6d4b\u8bd5\u7684\u6982\u8ff0\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u5b9e\u8df5\u4e0e\u9a8c\u8bc1<\/strong><\/p>\n

\u7814\u7a76\u4eba\u5458\u6210\u529f\u5229\u7528 PLMeAE \u6539\u9020 pCNF-RS\uff0c\u63d0\u9ad8\u9176\u6d3b\u6027\uff0c\u63d0\u9ad8 ncAAs \u63ba\u5165\u86cb\u767d\u8d28\u7684\u6548\u7387\u3002\u7ecf\u8fc7\u56db\u8f6e\u8fdb\u5316\uff0c\u83b7\u5f97\u7684\u6700\u4f73 pCNF-RS \u53d8\u4f53\u4f7f\u9176\u6d3b\u6027\u63d0\u9ad8\u4e86 2.4 \u500d\uff0c\u63ba\u5165 pAcF \u7684\u86cb\u767d\u8d28\u4ea7\u91cf\u63d0\u9ad8\u4e86 12.2 \u500d\u3002<\/p>\n

\u81ea\u52a8\u8fdb\u5316\u8fc7\u7a0b\u4e2d\uff0c\u4e00\u8f6e\u81ea\u52a8\u6784\u5efa\u5e76\u68c0\u6d4b\u4e86 96 \u4e2a\u7a81\u53d8\u4f53\uff0c\u4e0ebiofoundry\u4e2d\u81ea\u52a8\u5316\u7684 96 \u901a\u9053\u7535\u5b50\u79fb\u6db2\u5668\u76f8\u5bf9\u5e94\u3002\u56db\u8f6e\u8fdb\u5316\u5171\u6784\u5efa\u5e76\u68c0\u6d4b\u4e86 384\u4e2a \u7a81\u53d8\u4f53\u3002<\/p>\n

\u4ee5\u5de5\u7a0b pCNF-RS \u4e3a\u4f8b\uff0c\u8be5\u56e2\u961f\u7684\u751f\u7269\u5de5\u5382\u4e00\u8f6e\u5b9e\u9a8c\u6d4b\u8bd5\u5927\u7ea6\u9700\u8981 59 \u5c0f\u65f6\uff0c\u5176\u4e2d\u5305\u62ec\u5927\u7ea6 24 \u5c0f\u65f6\u7684\u5f15\u7269\u8fd0\u9001\u5ef6\u8fdf\uff0c\u800c ML \u6a21\u578b\u8bad\u7ec3\u548c\u65b0\u53d8\u4f53\u9884\u6d4b\u5219\u9700\u8981\u4e0d\u5230 1 \u5c0f\u65f6\u3002\u56db\u4e2a\u8bbe\u8ba1-\u6784\u5efa-\u6d4b\u8bd5-\u5b66\u4e60\u5468\u671f\u4ec5\u82b1\u8d39 240 \u5c0f\u65f6\uff0c\u5927\u7ea6 10 \u5929\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1apCNF-RS \u7684\u81ea\u52a8\u8fdb\u5316\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u6574\u4e2a\u8fc7\u7a0b\u5927\u7ea6\u9700\u8981 5 \u5929\u7684\u51c6\u5907\u65f6\u95f4\u30017 \u5929\u7684\u4e00\u6b21\u6b63\u5411\u9009\u62e9\u65f6\u95f4\u30017 \u5929\u7684\u4e00\u6b21\u8d1f\u5411\u9009\u62e9\u65f6\u95f4\u4ee5\u53ca 5 \u5929\u7684\u57fa\u4e8e\u8367\u5149\u7684\u6700\u7ec8\u7b5b\u9009\u65f6\u95f4\uff0c\u4e24\u8f6e\u9009\u62e9\u603b\u5171\u9700\u8981 38 \u5929\u3002<\/p>\n

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\u8ba8\u8bba<\/strong><\/p>\n

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\u5e94\u7528\u6f5c\u529b<\/strong><\/p>\n

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\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41467-025-56751-8<\/em><\/p>\n

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