{"id":38687,"date":"2025-02-21T03:00:53","date_gmt":"2025-02-20T19:00:53","guid":{"rendered":"https:\/\/17aitech.com\/?p=38687"},"modified":"2025-02-21T03:00:53","modified_gmt":"2025-02-20T19:00:53","slug":"%e9%87%8d%e5%bb%ba170%e4%b8%87%e4%b8%aa%e7%bb%86%e8%83%9e%e5%8f%91%e8%82%b2%e8%bd%a8%e8%bf%b9%ef%bc%8c%e6%94%af%e6%8c%81%e5%a4%9a%e6%a8%a1%e6%80%81%ef%bc%8cai%e7%bb%98%e5%88%b6%e7%bb%86%e8%83%9e","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=38687","title":{"rendered":"\u91cd\u5efa170\u4e07\u4e2a\u7ec6\u80de\u53d1\u80b2\u8f68\u8ff9\uff0c\u652f\u6301\u591a\u6a21\u6001\uff0cAI\u7ed8\u5236\u7ec6\u80de\u65f6\u7a7a\u56fe\u8c31\uff0c\u767bNature"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u91cd\u5efa170\u4e07\u4e2a\u7ec6\u80de\u53d1\u80b2\u8f68\u8ff9\uff0c\u652f\u6301\u591a\u6a21\u6001\uff0cAI\u7ed8\u5236\u7ec6\u80de\u65f6\u7a7a\u56fe\u8c31\uff0c\u767bNature<\/a><\/p>\n

<\/a><\/p>\n

\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u6280\u672f\u80fd\u591f\u8de8\u65f6\u95f4\u548c\u7a7a\u95f4\u7ef4\u5ea6\u5bf9\u6570\u767e\u4e07\u4e2a\u7ec6\u80de\u8fdb\u884c\u591a\u6a21\u6001\u5206\u6790\u3002<\/p>\n

\u4e0d\u8fc7\uff0c\u5b9e\u9a8c\u9650\u5236\u963b\u788d\u4e86\u5728\u5929\u7136\u65f6\u95f4\u52a8\u6001\u548c\u5929\u7136\u7a7a\u95f4\u7ec4\u7ec7\u73af\u5883\u4e2d\u5bf9\u7ec6\u80de\u8fdb\u884c\u5168\u9762\u6d4b\u91cf\u3002<\/p>\n

\u6700\u4f73\u8fd0\u8f93\u662f\u89e3\u51b3\u8fd9\u4e9b\u9650\u5236\u7684\u6709\u529b\u5de5\u5177\uff0c\u5e76\u6709\u52a9\u4e8e\u6062\u590d\u539f\u59cb\u7ec6\u80de\u73af\u5883\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u6700\u4f18\u4f20\u8f93\u5e94\u7528\u65e0\u6cd5\u6574\u5408\u591a\u6a21\u6001\u4fe1\u606f\u6216\u6269\u5c55\u5230\u5355\u7ec6\u80de\u56fe\u8c31\u3002<\/p>\n

\u5728\u8fd9\u91cc\uff0c\u6765\u81ea\u6155\u5c3c\u9ed1\u5de5\u4e1a\u5927\u5b66\uff08TUM\uff09\u3001\u6155\u5c3c\u9ed1\u4ea5\u59c6\u970d\u5179\u5927\u5b66\u3001\u82cf\u9ece\u4e16\u8054\u90a6\u7406\u5de5\u5b66\u9662\u7b49\u7ec4\u6210\u7684\u8de8\u5b66\u79d1\u7814\u7a76\u56e2\u961f\u63d0\u51fa\u4e86\u591a\u7ec4\u5b66\u5355\u7ec6\u80de\u6700\u4f18\u4f20\u8f93\uff08Moscot\uff0cMulti-Omics Single-Cell Optimal Transport\uff09\uff0c\u8fd9\u662f\u4e00\u4e2a\u53ef\u6269\u5c55\u7684\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u5b66\u6700\u4f18\u4f20\u8f93\u6846\u67b6\uff0c\u652f\u6301\u6240\u6709\u5e94\u7528\u4e2d\u7684\u591a\u6a21\u6001\u6027\u3002<\/p>\n

\u7814\u7a76\u8868\u660e\u00a0Moscot\u00a0\u80fd\u591f\u6709\u6548\u91cd\u5efa 20 \u4e2a\u65f6\u95f4\u70b9\u7684 170 \u4e07\u4e2a\u5c0f\u9f20\u80da\u80ce\u7ec6\u80de\u7684\u53d1\u80b2\u8f68\u8ff9\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cMapping cells through time and space with moscot<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 1 \u6708 22 \u65e5\u53d1\u5e03\u5728\u300aNature<\/em>\u300b\u3002<\/p>\n

<\/a><\/p>\n

\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u6280\u672f\u589e\u8fdb\u4e86\u79d1\u5b66\u5bb6\u5bf9\u7ec6\u80de\u5206\u5316\u548c\u7ec4\u7ec7\u7ec4\u7ec7\u52a8\u6001\u7684\u7406\u89e3\u3002\u5355\u7ec6\u80de\u5206\u6790\uff08\u5982\u5355\u7ec6\u80de RNA \u6d4b\u5e8f (scRNA-seq)\uff09\u53ef\u4ee5\u9ad8\u5206\u8fa8\u7387\u5206\u6790\u5355\u4e2a\u7ec6\u80de\u7684\u5206\u5b50\u72b6\u6001\uff0c\u800c\u7a7a\u95f4\u5206\u6790\u53ef\u4ee5\u6062\u590d\u5176\u7a7a\u95f4\u7ec4\u7ec7\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u5b9e\u9a8c\u6d89\u53ca\u7ec6\u80de\u7834\u574f\uff0c\u5e76\u4e14\u4ec5\u6355\u83b7\u4e00\u5c0f\u90e8\u5206\u5206\u5b50\u4fe1\u606f\u3002\u56e0\u6b64\uff0c\u5fc5\u987b\u91cd\u65b0\u8c03\u6574\u7ec6\u80de\u56fe\u8c31\u3002<\/p>\n

\u5148\u524d\u7684\u7814\u7a76\u901a\u8fc7\u4f7f\u7528\u6700\u4f18\u4f20\u8f93 (OT) \u89e3\u51b3\u4e86\u8fd9\u4e9b\u95ee\u9898\uff0c\u8fd9\u662f\u4e00\u4e2a\u6d89\u53ca\u6620\u5c04<\/mark>\u548c\u6bd4\u8f83\u6982\u7387\u5206\u5e03<\/mark>\u7684\u9886\u57df\u3002OT \u5728\u63cf\u8ff0\u7ec6\u80de\u91cd\u7f16\u7a0b\u8fc7\u7a0b\u3001\u901a\u8fc7\u4f7f\u7528\u5355\u7ec6\u80de\u53c2\u8003\u589e\u5f3a\u7a7a\u95f4\u6570\u636e\u91cd\u5efa\u7ec4\u7ec7\u7ed3\u6784\u4ee5\u53ca\u901a\u8fc7\u5bf9\u9f50\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6784\u5efa\u751f\u7269\u7cfb\u7edf\u7684\u901a\u7528\u5750\u6807\u6846\u67b6 (CCF) \u65b9\u9762\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n

\u867d\u7136\u57fa\u4e8e OT \u7684\u65b9\u6cd5\u6709\u6f5c\u529b\u89e3\u51b3\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u5b66\u4e2d\u7684\u6620\u5c04<\/mark>\u95ee\u9898\uff0c\u4f46\u5b83\u4eec\u7684\u4f7f\u7528\u9762\u4e34\u4e09\u4e2a\u5173\u952e\u6311\u6218\uff1a\u9996\u5148\uff0c\u57fa\u4e8e OT \u7684\u5de5\u5177\u7684\u5b9e\u73b0\u9762\u5411\u5355\u5cf0\u6570\u636e\u3002\u5176\u6b21\uff0c\u5f53\u524d\u5728\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u5b66\u4e2d\u4f7f\u7528\u7684 OT \u65b9\u6cd5\u8ba1\u7b97\u6210\u672c\u9ad8\u6602\u3002\u7b2c\u4e09\uff0c\u73b0\u6709\u5de5\u5177\u5efa\u7acb\u5728\u5f02\u6784\u5b9e\u73b0\u7684\u57fa\u7840\u4e0a\uff0c\u8fd9\u4f7f\u5f97\u5f88\u96be\u8c03\u6574\u6216\u7ec4\u5408\u65b0\u95ee\u9898\u7684\u65b9\u6cd5\u3002<\/p>\n

\u300c\u73b0\u6709\u7684\u65b9\u6cd5\u53ea\u80fd\u63d0\u4f9b\u5c11\u6570\u7ec6\u80de\u7684\u5feb\u7167\uff0c\u6216\u8005\u65e0\u6cd5\u5c06\u7a7a\u95f4\u548c\u65f6\u95f4\u4e0a\u7684\u52a8\u6001\u8fc7\u7a0b\u8054\u7cfb\u8d77\u6765\u3002\u300d\u8fd9\u9879\u7814\u7a76\u7684\u4e3b\u8981\u4f5c\u8005\u4e4b\u4e00\u3001\u4ea5\u59c6\u970d\u5179\u6155\u5c3c\u9ed1\u8ba1\u7b97\u751f\u7269\u5b66\u7814\u7a76\u6240\u7684\u535a\u58eb\u5019\u9009\u4eba\u3001\u6155\u5c3c\u9ed1\u5de5\u4e1a\u5927\u5b66\uff08TUM\uff09\u7684\u7814\u7a76\u5458 Dominik Klein \u89e3\u91ca\u8bf4\uff0c\u300c\u8fd9\u6781\u5927\u5730\u9650\u5236\u4e86\u6211\u4eec\u5bf9\u5668\u5b98\u53d1\u80b2\u548c\u75be\u75c5\u8fc7\u7a0b\u4e2d\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u7684\u7406\u89e3\u3002\u300d<\/p>\n

Dominik Klein \u4e0e Giovanni Palla\uff08\u6155\u5c3c\u9ed1\u4ea5\u59c6\u970d\u5179\u5927\u5b66\uff09\u3001Marius Lange\uff08\u82cf\u9ece\u4e16\u8054\u90a6\u7406\u5de5\u5b66\u9662\uff09\u3001Michal Klein\uff08\u82f9\u679c\u516c\u53f8\uff09\u548c Zoe Piran\uff08\u8036\u8def\u6492\u51b7\u5e0c\u4f2f\u6765\u5927\u5b66\uff09\u9886\u5bfc\u7684\u8de8\u5b66\u79d1\u56e2\u961f\u4e00\u8d77\u5f00\u53d1\u4e86 Moscot\u3002\u8be5\u56e2\u961f\u501f\u9274\u4e86 18 \u4e16\u7eaa\u53d1\u5c55\u8d77\u6765\u7684\u4e00\u9879\u7406\u8bba\uff1a\u6700\u4f18\u4f20\u8f93\u7406\u8bba\uff0c\u8be5\u7406\u8bba\u63cf\u8ff0\u4e86\u7269\u4f53\u5982\u4f55\u4ee5\u6700\u9ad8\u6548\u7684\u65b9\u5f0f\u4ece\u4e00\u4e2a\u5730\u65b9\u79fb\u52a8\u5230\u53e6\u4e00\u4e2a\u5730\u65b9\uff0c\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u65f6\u95f4\u3001\u80fd\u6e90\u6216\u6210\u672c\u3002<\/p>\n

Moscot \u57fa\u4e8e\u4e09\u4e2a\u8bbe\u8ba1\u539f\u5219\u6765\u514b\u670d\u5f53\u524d\u7684\u5c40\u9650\u6027\u3002Moscot \u652f\u6301\u591a\u6a21\u6001\u6570\u636e\uff0c\u63d0\u9ad8\u4e86\u53ef\u6269\u5c55\u6027\uff0c\u5e76\u7edf\u4e00\u4e86 OT \u5728\u65f6\u95f4\u548c\u7a7a\u95f4\u57df\u4e2d\u7684\u5148\u524d\u5355\u7ec6\u80de\u5e94\u7528\u3002\u56e2\u961f\u8fd8\u5f15\u5165\u4e86\u4ee5\u524d\u672a\u63cf\u8ff0\u7684\u65f6\u7a7a\u5e94\u7528\u3002\u76f4\u89c2\u7684\u5e94\u7528\u7a0b\u5e8f\u7f16\u7a0b\u63a5\u53e3\u00a0(API) \u4e0e\u66f4\u5e7f\u6cdb\u7684 scverse \u751f\u6001\u7cfb\u7edf\u4ea4\u4e92\uff0c\u4f7f\u8fd9\u4e9b\u529f\u80fd\u53d8\u5f97\u53ef\u7528\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aMoscot \u53ef\u5728\u5355\u7ec6\u80de\u5e94\u7528\u4e2d\u5b9e\u73b0\u9ad8\u6548\u7684\u591a\u6a21\u6001 OT\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

Moscot<\/strong><\/p>\n

\u5177\u4f53\u800c\u8a00\uff0cMoscot \u5c06\u751f\u7269\u6620\u5c04<\/mark>\u548c\u6bd4\u5bf9\u4efb\u52a1\u8f6c\u5316\u4e3a OT \u95ee\u9898\uff0c\u5e76\u4f7f\u7528\u4e00\u7ec4\u4e00\u81f4\u7684\u7b97\u6cd5\u6765\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u3002Moscot \u5c06\u4e0d\u6210\u5bf9\u7684\u6570\u636e\u96c6\u4f5c\u4e3a\u8f93\u5165\uff0c\u540c\u65f6\u63a5\u53d7\u751f\u7269\u5b66\u77e5\u8bc6\uff08\u4f8b\u5982\u7ec6\u80de\u751f\u957f\u7387\uff09\u6765\u6307\u5bfc\u6620\u5c04<\/mark>\u8fc7\u7a0b\u3002<\/p>\n

\u5b83\u89e3\u51b3\u4e86 OT \u95ee\u9898\u5e76\u751f\u6210\u4e86\u8026\u5408\u77e9\u9635\uff0c\u8be5\u77e9\u9635\u4ee5\u6982\u7387\u65b9\u5f0f\u5173\u8054\u6bcf\u4e2a\u6570\u636e\u96c6\u4e2d\u7684\u6837\u672c\u3002\u6709\u4e86\u8be5\u8026\u5408\u77e9\u9635\uff0cMoscot \u63d0\u4f9b\u4e86\u5404\u79cd\u7279\u5b9a\u4e8e\u5e94\u7528\u7684\u4e0b\u6e38\u5206\u6790\u529f\u80fd\u3002<\/p>\n

Moscot \u4ee5\u4e09\u79cd OT \u6982\u5ff5\u4e3a\u57fa\u7840\uff0c\u4ee5\u89e3\u51b3\u5404\u79cd\u751f\u7269\u5b66\u95ee\u9898\u3002\u8fd9\u4e9b\u6982\u5ff5\u5728\u6837\u672c\u8de8\u7ec6\u80de\u5206\u5e03\u7684\u5173\u8054\u65b9\u5f0f\u4e0a\u6709\u6240\u4e0d\u540c\uff1a<\/p>\n

Wasserstein \u578b (W \u578b) OT \u6bd4\u8f83\u4e24\u7ec4\u5177\u6709\u76f8\u540c\u7ec6\u80de\u7279\u5f81\u7684\u7ec6\u80de\uff1b<\/p>\n

Gromov\u2013Wasserstein \u578b (GW \u578b) OT \u6bd4\u8f83\u751f\u6d3b\u5728\u4e0d\u540c\u7a7a\u95f4\u7684\u7ec6\u80de\u5206\u5e03\uff1b<\/p>\n

\u878d\u5408 Gromov\u2013Wasserstein \u578b (FGW \u578b) OT \u6bd4\u8f83\u5177\u6709\u90e8\u5206\u5171\u540c\u7279\u5f81\u7684\u7ec6\u80de\u3002<\/p>\n

\u4e3a\u4e86\u5728\u6574\u4e2a\u6846\u67b6\u4e2d\u652f\u6301\u591a\u6a21\u6001\u6027\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86\u5171\u4eab\u6f5c\u5728\u8868\u793a\u3002\u4e0e\u4e4b\u524d\u57fa\u4e8e OT \u7684\u5de5\u5177\u76f8\u6bd4\uff0c\u8be5\u56e2\u961f\u5c06 W \u578b\u3001GW \u578b\u548c FGW \u578b\u6982\u5ff5\u7684\u8ba1\u7b97\u65f6\u95f4\u548c\u5185\u5b58\u6d88\u8017\u51cf\u5c11\u4e86\u51e0\u4e2a\u6570\u91cf\u7ea7\uff0c\u4ece\u800c\u4f7f Moscot \u9002\u7528\u4e8e\u56fe\u96c6\u89c4\u6a21\u7684\u6570\u636e\u96c6\u3002<\/p>\n

\u9a8c\u8bc1\u4e0e\u5e94\u7528<\/strong><\/p>\n

\u56e2\u961f\u901a\u8fc7\u7814\u7a76\u5c0f\u9f20\u80da\u80ce\u53d1\u80b2\u8fc7\u7a0b\u4e2d 170 \u4e07\u4e2a\u7ec6\u80de\u7684\u751f\u957f\u60c5\u51b5\u6765\u5c55\u793a Moscot \u7684\u529f\u80fd\u3002<\/p>\n

<\/a><\/p>\n

\u56fe\u793a\uff1aMoscot \u7ed8\u5236\u4e86\u56fe\u96c6\u5c3a\u5ea6\u7684\u80da\u80ce\u7ec6\u80de\u751f\u957f\u8f68\u8ff9\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u901a\u8fc7\u6d4b\u5e8f (CITE-seq) \u5bf9\u8f6c\u5f55\u7ec4\u548c\u8868\u4f4d\u8fdb\u884c\u591a\u6a21\u6001\u7ec6\u80de\u7d22\u5f15\u7684\u4fe1\u606f\u6620\u5c04<\/mark>\u5230\u5c0f\u9f20\u809d\u810f\u7684\u9ad8\u5206\u8fa8\u7387\u7a7a\u95f4\u8bfb\u6570\uff0c\u5e76\u5c06\u5c0f\u9f20\u8111\u6837\u672c\u7684\u5927\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5207\u7247\u5bf9\u9f50\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u8054\u5408\u5206\u6790\u4e86\u5c0f\u9f20\u80f0\u817a\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u7684\u57fa\u56e0\u8868\u8fbe\u548c\u67d3\u8272\u8d28\u53ef\u53ca\u6027\uff0c\u5e76\u5e94\u7528 Moscot \u66f4\u597d\u5730\u63cf\u7ed8 delta \u7ec6\u80de\u548c epsilon \u7ec6\u80de\u7684\u7ec6\u80de\u8f68\u8ff9\u3002<\/p>\n

\u8be5\u7814\u7a76\u8bc1\u5b9e\uff0cNEUROD2 \u662f\u4eba\u7c7b\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u80f0\u5c9b\u7ec6\u80de\u5206\u5316\u6a21\u578b\u4e2d epsilon \u7956\u7ec6\u80de\u7684\u8c03\u8282\u5242\u3002<\/p>\n

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\u5728 SPATEO \u7684\u540c\u65f6\uff0c\u56e2\u961f\u5f15\u5165\u4e86\u65f6\u7a7a\u6620\u5c04<\/mark>\u7684\u6982\u5ff5\uff0c\u5e76\u4f7f\u7528\u5c0f\u9f20\u80da\u80ce\u53d1\u751f\u7684\u65f6\u7a7a\u56fe\u8c31\u5c55\u793a\u4e86\u5176\u4f18\u52bf\u3002<\/p>\n

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<\/a><\/p>\n

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\u7ed3\u8bed<\/strong><\/p>\n

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Moscot\uff1ahttps:\/\/moscot-tools.org<\/em><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41586-024-08453-2<\/em><\/p>\n

\u76f8\u5173\u62a5\u9053\uff1ahttps:\/\/phys.org\/news\/2025-01-ai-cell-technology-reveals-dynamics.html<\/em><\/p>\n

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