{"id":39050,"date":"2025-02-28T13:01:37","date_gmt":"2025-02-28T05:01:37","guid":{"rendered":"https:\/\/17aitech.com\/?p=39050"},"modified":"2025-02-28T13:01:37","modified_gmt":"2025-02-28T05:01:37","slug":"ai-%e7%a7%91%e5%ad%a6%e5%ae%b6%e8%8e%b7%e8%af%ba%e5%a5%96%e5%90%8e%ef%bc%9a%e4%bb%8e-casp-%e7%9c%8b%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%bb%93%e6%9e%84%e9%a2%84%e6%b5%8b%e7%9a%84%e6%9c%ba%e9%81%87%e4%b8%8e","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=39050","title":{"rendered":"AI \u79d1\u5b66\u5bb6\u83b7\u8bfa\u5956\u540e\uff1a\u4ece CASP \u770b\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u673a\u9047\u4e0e\u6311\u6218\u4e28GAIR Live"},"content":{"rendered":"<p>\u4f5c\u8005\u4e28\u6731\u53ef\u8f69<\/p>\n<p>\u7f16\u8f91\u4e28\u9648\u5f69\u5a34<\/p>\n<p>\u201cAlphaGo\u3001ChatGPT \u90fd\u662f\u65b0\u79d1\u6280\u7a81\u7834\u7684\u4ee3\u8868\u6027\u5de5\u5177\u3002\u800c\u5728\u79d1\u5b66\u9886\u57df\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u83b7\u5f97\u8bfa\u5956\u5c31\u662f AI \u5de8\u5927\u7a81\u7834\u7684\u9ad8\u5149\u65f6\u523b\uff0c\u8bfa\u5956\u4e4b\u540e\u00a0AlphaFold\u00a0\u7684\u7814\u53d1\u6a21\u5f0f\u5df2\u7ecf\u6210\u4e3a AI for Science \u7684\u6837\u677f\u3002\u201d\u7a0b\u5efa\u6797\u8bf4\u9053\u3002<\/p>\n<p>2025 \u5e74 1 \u6708 5 \u65e5\uff0c\u96f7\u5cf0\u7f51\u3001AI \u79d1\u6280\u8bc4\u8bbaGAIR Live \u54c1\u724c\u4e0e CASP \u8bc4\u4f30\u7684\u4f18\u79c0\u534e\u4eba\u56e2\u961f\u8054\u5408\u4e3e\u529e\u4e86\u4e00\u573a\u4e3b\u9898\u4e3a\u201c\u8bfa\u5956\u4e4b\u540e\u7684\u65b0\u7bc7\u7ae0\uff1a\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u673a\u9047\u4e0e\u6311\u6218\u201d\u7684\u7ebf\u4e0a\u5706\u684c\u6c99\u9f99\u3002<\/p>\n<p>\u5706\u684c\u4e3b\u6301\u4eba\u4e3a\u6c5f\u82cf\u7406\u5de5\u5b66\u9662\u6559\u6388\u5e38\u73ca\uff0c\u5e76\u9080\u8bf7\u4e86\u5bc6\u82cf\u91cc\u5927\u5b66\u8ba1\u7b97\u673a\u7cfb\u6559\u6388\u7a0b\u5efa\u6797\u3001\u5c71\u4e1c\u5927\u5b66\u6559\u6388\u6768\u5efa\u76ca\u3001\u5357\u5f00\u5927\u5b66\u7edf\u8ba1\u4e0e\u6570\u636e\u79d1\u5b66\u5b66\u9662\u6559\u6388\u90d1\u4f1f\u3001\u6d59\u6c5f\u5de5\u4e1a\u5927\u5b66\u4fe1\u606f\u5de5\u7a0b\u5b66\u9662\u6559\u6388\u5f20\u8d35\u519b\u4ee5\u53ca\u6c5f\u82cf\u7406\u5de5\u5b66\u9662\u7814\u7a76\u5458\u5b54\u97e7\u5171\u540c\u5f00\u542f\u4e86\u4e00\u573a\u6df1\u5ea6\u5bf9\u8bdd\u3002<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/01\/frc-df885730bf152495443431244d4da421.jpeg\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/01\/frc-df885730bf152495443431244d4da421.jpeg\"><\/a><\/p>\n<p>\u5e38\u73ca\u662f\u6c5f\u82cf\u7406\u5de5\u5b66\u9662\u6559\u6388\uff0c\u73b0\u4efb\u4e2d\u56fd\u7ec6\u80de\u751f\u7269\u5b66\u5b66\u4f1a\u529f\u80fd\u57fa\u56e0\u7ec4\u4fe1\u606f\u5b66\u4e0e\u7cfb\u7edf\u751f\u7269\u5b66\u5206\u4f1a\u59d4\u5458\uff0c\u4e2d\u56fd\u75ab\u82d7\u884c\u4e1a\u534f\u4f1a\u75ab\u82d7\u57fa\u7840\u7814\u7a76\u4e13\u59d4\u4f1a\u59d4\u5458\uff0c\u4e2d\u56fd\u4e2d\u533b\u836f\u4fe1\u606f\u5b66\u4f1a\u4e2d\u533b\u4e34\u5e8a\u836f\u5b66\u5206\u4f1a\u7406\u4e8b\u3002<\/p>\n<p>\u7a0b\u5efa\u6797\u6559\u6388\u76ee\u524d\u4f9b\u804c\u4e8e\u7f8e\u56fd\u5bc6\u82cf\u91cc\u5927\u5b66\u8ba1\u7b97\u673a\u7cfb\uff0c\u4ed6 1999 \u5e74\u8d74\u7f8e\u7559\u5b66\uff0c2006 \u5e74\u5728\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u5c14\u6e7e\u5206\u6821\u83b7\u5f97\u4e86\u535a\u58eb\u5b66\u4f4d\uff0c\u5e76\u5728 2004 \u5e74\u4fbf\u5f00\u59cb\u53c2\u52a0 CASP\uff0c\u5148\u540e\u5df2\u7ecf\u53c2\u52a0\u4e86 11 \u5c4a\u3002<\/p>\n<p>\u6768\u5efa\u76ca\u5219\u662f\u5c71\u4e1c\u5927\u5b66\u6559\u6388\uff0c\u4ed6\u81ea 2011 \u5e74\u5f00\u59cb\u5728\u5bc6\u897f\u6839\u5927\u5b66\u8ddf\u5f20\u9633\u6559\u6388\u505a\u7ed3\u6784\u9884\u6d4b\uff0c\u81f3\u4eca\u5df2\u6709\u5341\u4f59\u5e74\u3002\u5357\u5f00\u5927\u5b66\u7edf\u8ba1\u4e0e\u6570\u636e\u79d1\u5b66\u5b66\u9662\u6559\u6388\uff0c\u4f20\u67d3\u75c5\u9884\u9632\u4e0e\u6eaf\u6e90\u5168\u56fd\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u6210\u5458\uff0c\u90d1\u4f1f\u6559\u6388\u4e5f\u662f\u5728\u5f20\u9633\u6559\u6388\u5b9e\u9a8c\u5ba4\u5f00\u59cb\u7684\u7ed3\u6784\u9884\u6d4b\u7684\u65c5\u7a0b\uff0c\u4ece CASP12 \u8d77\u5df2\u7ecf\u53c2\u52a0\u4e865\u6b21 CASP\u2014\u2014\u8fd1 10 \u5e74\u7684\u6bd4\u8d5b\u3002<\/p>\n<p>\u5f20\u8d35\u519b\u662f\u6d59\u6c5f\u5de5\u4e1a\u5927\u5b66\u4fe1\u606f\u5de5\u7a0b\u5b66\u9662\u6559\u6388\uff0c\u505a\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u6709\u5341\u51e0\u5e74\u65f6\u95f4\u4e86\uff0c\u5148\u540e\u53c2\u52a0\u4e86\u4e24\u5c4a CASP\u3002\u5b54\u97e7\u5f53\u524d\u662f\u6c5f\u82cf\u7406\u5de5\u5b66\u9662\u7684\u7814\u7a76\u5458\uff0c\u535a\u58eb\u5f00\u59cb\u548c\u5e38\u73ca\u6559\u6388\u4e00\u540c\u5728\u5317\u4eac\u5de5\u4e1a\u5927\u5b66\u738b\u5b58\u65b0\u6559\u6388\u7684\u5b9e\u9a8c\u5ba4\u505a\u5206\u5b50\u6a21\u62df\u4ee5\u53ca\u86cb\u767d\u8d28\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u30022015 \u5e74\u56de\u56fd\u540e\uff0c\u540c\u5e38\u73ca\u6559\u6388\u5728\u6c5f\u82cf\u7406\u5de5\u5b66\u9662\u7ec4\u5efa\u4e86\u7814\u7a76\u6240\uff0c\u4ece CASP13 \u5f00\u59cb\u53c2\u52a0\u3002<\/p>\n<p>\u51e0\u4f4d\u5609\u5bbe\u90fd\u53c2\u52a0\u4e86\u672c\u6b21\u7b2c\u5341\u516d\u5c4a CASP\uff08Critical Assessment of Protein Structure Prediction\uff09\u3002CASP \u4f5c\u4e3a\u81ea 1994 \u5e74\u4ee5\u6765\u6bcf\u4e24\u5e74\u8fdb\u884c\u4e00\u6b21\u7684\u5168\u7403\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7ade\u8d5b\uff0c\u6768\u5efa\u76ca\u5c06\u5176\u6bd4\u4f5c\u8bfa\u5956\u7684\u201c\u5b75\u5316\u5668\u201d\u548c\u79d1\u5b66\u7814\u7a76\u7684\u5965\u6797\u5339\u514b\u3002<\/p>\n<p>\u5728\u6b64\u6b21\u5706\u684c\u4f1a\u4e0a\uff0c\u5927\u5bb6\u4e00\u4e00\u5206\u4eab\u4e86\u53c2\u52a0 CASP \u7684\u5fc3\u5f97\uff0c\u4ee5\u53ca\u5bf9\u4e8e\u9886\u57df\u524d\u6cbf\u8fdb\u5c55\u548c\u7a81\u7834\u7684\u6d1e\u5bdf\uff0c\u5355\u5e8f\u5217\u7ed3\u6784\u9884\u6d4b\u3001\u591a\u6784\u8c61\u9884\u6d4b\u3001RNA \u7ed3\u6784\u9884\u6d4b\u3001\u86cb\u767d\u8d28-\u5c0f\u5206\u5b50\u590d\u5408\u4f53\u9884\u6d4b\u7b49\u4e5f\u6210\u4e3a\u4e86\u4e0b\u4e00\u9636\u6bb5\u4e9f\u5f85\u5f97\u5230\u7a81\u7834\u7684\u95ee\u9898\uff1a<\/p>\n<p>\u90d1\u4f1f\u8bf4\u9053\uff0c\u201c\u4eca\u5e74\u6574\u4f53\u770b RNA \u8d5b\u9053\u65e0\u8bba\u662f\u96be\u5ea6\u3001\u6570\u91cf\u8fd8\u662f\u7ec6\u5316\u4e0a\u53d8\u5316\u90fd\u975e\u5e38\u660e\u663e\u3002\u4e5f\u53ef\u4ee5\u770b\u51fa\u6574\u4e2a\u9886\u57df\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u53d1\u5c55\u5f97\u76f8\u5bf9\u6765\u8bf4\u6bd4\u8f83\u6210\u719f\u7684\u60c5\u51b5\u4e0b\uff0c\u5927\u5bb6\u7684\u5173\u6ce8\u70b9\u53ef\u80fd\u6e10\u6e10\u8981\u5f80 RNA \u7ed3\u6784\u9884\u6d4b\u4e0a\u4ea7\u751f\u4e00\u5b9a\u503e\u659c\u4e86\u3002\u201d<\/p>\n<p>\u540c\u65f6\uff0c\u201c\u591a\u6784\u8c61\u4e5f\u662f CASP \u4e00\u76f4\u60f3\u8981\u589e\u52a0\u7684\u8d5b\u9053\uff0c\u4f46\u662f\u9274\u4e8e\u5f80\u5e74\u591a\u6784\u8c61\u7684\u6570\u636e\u4e0d\u592a\u597d\u91c7\u96c6\uff0c\u4eca\u5e74\u662f\u9996\u6b21\u4f5c\u4e3a\u72ec\u7acb\u8d5b\u9053\u8bbe\u7f6e\u4e86\u6bd4\u8d5b\uff0c\u9884\u6d4b\u597d\u591a\u6784\u8c61\u5bf9\u540e\u7eed\u7684\u6574\u4e2a\u52a8\u6001\u8fc7\u7a0b\u9884\u6d4b\u5f88\u91cd\u8981\u3002\u201d\u4f46\u5f53\u524d\u56ff\u4e8e\u771f\u5b9e\u6570\u636e\u7684\u4e0d\u8db3\uff0c\u8fd8\u672a\u80fd\u5b9e\u73b0\u5927\u7684\u7a81\u7834\u3002<\/p>\n<p>\u800c\u5728\u5c0f\u5206\u5b50\u9884\u6d4b\u65b9\u9762\uff0c\u636e\u5b54\u97e7\u4ecb\u7ecd\uff0c\u201c AlphaFold \u76f8\u5bf9\u4e8e\u4f20\u7edf\u5bf9\u63a5\u65b9\u6cd5\uff0c\u5df2\u7ecf\u8868\u73b0\u51fa\u4f18\u52bf\uff0c\u5728\u67d0\u4e9b\u9776\u70b9\u4e0a\u6bd4\u4f20\u7edf\u5bf9\u63a5\u65b9\u6cd5\u8981\u5f3a\uff0c\u5c06\u6765\u611f\u89c9\u53ef\u4ee5\u628a\u4f20\u7edf\u7684\u5bf9\u63a5\u65b9\u6cd5\u548c AlphaFold \u7684\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u7ed3\u5408\u8d77\u6765\u505a\u7efc\u5408\u8003\u8651\u548c\u4f7f\u7528\u3002\u201d<\/p>\n<p>\u4e0d\u8fc7\uff0c AlphaFold3 \u5728\u4f7f\u7528\u6a21\u7248\u548c\u9009\u62e9\u6a21\u578b\u7b49\u65b9\u9762\u4ecd\u5b58\u4e0d\u5c11\u63d0\u5347\u7a7a\u95f4\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5609\u5bbe\u4eec\u4e5f\u9488\u5bf9\u8bfa\u5956\u201c\u9884\u5907\u5f79\u201d\u5c55\u5f00\u4e86\u63a2\u8ba8\uff0c\u5176\u4e2d\u5355\u5e8f\u5217\u7ed3\u6784\u9884\u6d4b\u88ab\u5c61\u6b21\u63d0\u53ca\uff1a<\/p>\n<p>\u6768\u5efa\u76ca\u8ba4\u4e3a\uff0c\u201c\u5355\u5e8f\u5217\u7ed3\u6784\u9884\u6d4b\u7814\u7a76\u7684\u662f\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\uff0cAlphaFold \u4e0e ESMFold \u7b49\u65b9\u6cd5\u672c\u8d28\u4e0a\u662f\u6570\u636e\u9a71\u52a8\u7684\u7ed3\u679c\uff0c\u5e76\u672a\u6d89\u53ca\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u3002\u5982\u679c\u672a\u6765\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u89e3\u51b3\u4e86\uff0c\u4e5f\u5c06\u4f1a\u662f\u8bfa\u5956\u7ea7\u7684\u5de5\u4f5c\u3002\u201d<\/p>\n<p>\u7a0b\u5efa\u6797\u540c\u6837\u770b\u597d\uff0c\u4ed6\u8868\u793a\uff0c\u201c\u5355\u5e8f\u5217\u7684\u7ed3\u6784\u9884\u6d4b\u662f\u7ecf\u5178\u95ee\u9898\uff0c\u5f53\u524d AlphaFold3\u3001AlphaFold2 \u90fd\u4f9d\u8d56\u4e8e\u591a\u5e8f\u5217\u8f93\u5165\uff0c\u4f46\u662f\u5f88\u591a\u65f6\u5019\u53ea\u80fd\u627e\u5230\u4e00\u4e2a\u5e8f\u5217\uff0c\u80fd\u5426\u7cbe\u786e\u9884\u6d4b\u51fa\u7ed3\u6784\uff0c\u8fd9\u751a\u81f3\u53ef\u80fd\u4ea7\u751f\u7b2c\u4e8c\u4e2a\u8bfa\u5956\u3002\u201d<\/p>\n<p>\u4ee5\u4e0b\u662f\u6b64\u6b21\u5706\u684c\u8ba8\u8bba\u7684\u7cbe\u5f69\u5206\u4eab\uff0cAI \u79d1\u6280\u8bc4\u8bba\u8fdb\u884c\u4e86\u4e0d\u6539\u539f\u610f\u7684\u7f16\u8f91\u6574\u7406\uff1a<\/p>\n<p><\/p>\n<p style=\"text-align: center\"><span style=\"font-size: 20px\"><strong>CASP 16\u00a0\u7684\u8fdb\u6b65\u4e0e\u7a81\u7834<\/strong><\/span><\/p>\n<p><strong><span style=\"font-size: 16px\">\u5e38\u73ca\uff1a<\/span><\/strong><span style=\"font-size: 16px\">\u6211\u4eec\u8fd9\u6b21\u5706\u684c\u4e13\u6ce8\u4e8e\u7ed3\u6784\u9884\u6d4b\u65b9\u5411\uff0c\u4e3b\u8981\u662f\u53d7\u5230 CASP \u8bc4\u4f30\u4f1a\u7684\u542f\u53d1\uff0c\u7ed3\u6784\u9884\u6d4b\u8fd8\u6709\u5f88\u591a\u53ef\u4ee5\u63a2\u8ba8\u7684\u95ee\u9898\u3002\u4eca\u5929\u4e00\u5171\u6709\u516b\u4e2a\u8bae\u9898\uff0c\u56db\u4e2a\u504f\u4e13\u4e1a\uff0c\u56db\u4e2a\u504f\u79d1\u666e\u3002\u8fd9\u6b21\u5f88\u591a\u534e\u4eba\u56e2\u961f\u90fd\u7ebf\u4e0b\u53c2\u52a0 CASP \u8bc4\u4f30\u4f1a\uff0c\u5bf9 CASP16 \u8bc4\u4f30\u4f1a\u6709\u54ea\u4e9b\u5370\u8c61\u6df1\u523b\u7684\u4e8b\u60c5\uff1f<\/span><\/p>\n<p><strong><span style=\"font-size: 16px\">\u7a0b\u5efa\u6797\uff1a<\/span><\/strong><span style=\"font-size: 16px\">\u8fd9\u6b21 CASP \u7ed9\u6211\u7684\u5370\u8c61\u4e00\u662f\u53c2\u52a0\u7684\u56e2\u961f\u6bd4\u4ee5\u524d\u591a\uff0c\u4e8c\u662f\u5927\u9646\u79d1\u5b66\u5bb6\u53d6\u5f97\u4e86\u4e86\u4e0d\u8d77\u7684\u6210\u5c31\uff0c\u5305\u62ec\u5728\u5ea7\u7684\u8001\u5e08\uff0c\u8fd9\u6b21 CASP \u5927\u5bb6\u5728\u6240\u6709\u9886\u57df\u90fd\u8fbe\u5230\u4e86\u4e16\u754c\u524d\u5217\u7684\u6c34\u5e73\u3002<\/span><\/p>\n<p><strong><span style=\"font-size: 16px\">\u6768\u5efa\u76ca\uff1a<\/span><\/strong><span style=\"font-size: 16px\">2024 \u5e74\u662f\u6211\u7b2c\u4e00\u6b21\u7ebf\u4e0b\u53c2\u52a0 CASP\uff0c\u4ece\u89c2\u4f17\u89d2\u5ea6\u6765\u8bb2\uff0c\u6211\u5370\u8c61\u6700\u6df1\u7684\u662f\u4f1a\u8bae\u5168\u7a0b\u56db\u5929\uff0c\u53c2\u52a0\u4f1a\u8bae\u7684\u4eba\u90fd\u5728\uff0c\u4e0d\u50cf\u5f88\u591a\u4f1a\u8bae\u5927\u5bb6\u53c2\u52a0\u5230\u4e00\u534a\u5c31\u8d70\u4e86\uff0c\u8fd9\u662f\u5f88\u5927\u7684\u533a\u522b\u3002\u4ece\u7ec4\u7ec7\u8005\u5230\u62a5\u544a\u4eba\u5927\u5bb6\u90fd\u975e\u5e38\u4e13\u6ce8\uff0cCASP \u80fd\u575a\u6301 16 \u5c4a 30 \u591a\u5e74\uff0c\u6211\u5f88\u611f\u52a8\u3002\u611f\u89c9 CASP \u6709\u70b9\u50cf\u8bfa\u5956\u7684\u5b75\u5316\u5668\uff0c\u5927\u91cf\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\u3001\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\u575a\u6301\u957f\u671f\u4e3b\u4e49\uff0c\u8270\u82e6\u594b\u6597\uff0c\u957f\u671f\u91cf\u53d8\u7684\u79ef\u7d2f\u624d\u6709\u4e86\u4eca\u5929\u7684\u7a81\u7834\u3002<\/span><\/p>\n<p><strong><span style=\"font-size: 16px\">\u90d1\u4f1f\uff1a<\/span><\/strong><span style=\"font-size: 16px\">\u521a\u624d\u5efa\u6797\u8001\u5e08\u63d0\u5230\uff0c\u4e2d\u56fd\u5927\u9646\u7684\u53c2\u8d5b\u56e2\u961f\u660e\u663e\u53d8\u591a\uff0c\u6211\u60f3\u8865\u5145\u4e00\u4e0b\uff0c\u5176\u5b9e\u6574\u4e2a\u4e9a\u6d32\u7684\u56e2\u961f\u6570\u91cf\u90fd\u662f\u660e\u663e\u53d8\u591a\u7684\uff0c\u4e0a\u5c4a\u65e5\u672c\u7684\u56e2\u961f\u4e0d\u5c11\uff0c\u8fd9\u5c4a\u660e\u663e\u611f\u89c9\u97e9\u56fd\u7684\u53c2\u8d5b\u56e2\u961f\u6570\u91cf\u4e0d\u5c11\uff0c\u6574\u4e2a\u4e9a\u6d32\u7684\u56e2\u961f\u6570\u91cf\u53ef\u80fd\u5dee\u4e0d\u591a\u548c\u6b27\u7f8e\u7684\u6301\u5e73\uff0c\u751a\u81f3\u5feb\u53cd\u8d85\u4e86\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px\">\u8fd1\u5e74 CASP \u66f4\u503e\u5411\u4e8e\u89e3\u51b3\u5b9e\u9645\u7684\u751f\u7269\u5b66\u95ee\u9898\uff0c\u5b83\u7684\u91cd\u8981\u610f\u4e49\u5728\u4e8e\u80fd\u6307\u5bfc\u7ed3\u6784\u751f\u7269\u5b66\u6574\u4f53\u7684\u53d1\u5c55\u65b9\u5411\uff0c\u5305\u62ec\u8ba1\u7b97\u7ed3\u6784\u751f\u7269\u5b66\u91cc\u6211\u4eec\u5230\u5e95\u5e94\u8be5\u505a\u4ec0\u4e48\u3001\u8fd9\u4e2a\u65b9\u5411\u7684\u53d1\u5c55\u524d\u666f\u662f\u4ec0\u4e48\u3002\u6bd4\u8d5b\u5176\u5b9e\u66f4\u5173\u6ce8\u8fd9\u79cd\u672c\u8d28\u7684\u95ee\u9898\uff0c\u800c\u4e0d\u662f\u4e3a\u4e86\u6bd4\u8d5b\u800c\u6bd4\u8d5b\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px\">\u7ebf\u4e0b\u8bc4\u4f30\u4f1a\u4e3b\u8981\u5728\u8ba8\u8bba\u8d5b\u5236\u6216\u4e0b\u4e00\u5c4a\u6bd4\u8d5b\u5e94\u8be5\u600e\u4e48\u505a\uff0c\u8fd9\u4e5f\u662f\u5f88\u591a\u5b66\u8005\u4e0d\u613f\u79bb\u5f00\u4f1a\u573a\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u7136\u540e\u662f\u8fd1\u4e9b\u5e74\u5c24\u5176\u662f CASP16 \u5de5\u4e1a\u754c\u8bfe\u9898\u7ec4\u53c2\u8d5b\u70ed\u60c5\u5176\u5b9e\u660e\u663e\u4e0b\u964d\u4e86\uff0c\u5927\u5bb6\u53ef\u80fd\u90fd\u53bb\u5377\u5927\u6a21\u578b\u4e86\uff0c\u5269\u4e0b\u5b66\u672f\u754c\u8bfe\u9898\u7ec4\u8fd8\u5728\u575a\u5b88\u672c\u5fc3\uff08\u7b11\uff09\u3002<\/span><\/p>\n<p><strong><span style=\"font-size: 16px\">\u5f20\u8d35\u519b\uff1a<\/span><\/strong><span style=\"font-size: 16px\">\u6211\u4eca\u5e74\u6ca1\u6709\u53bb\u4f1a\u573a\uff0c\u4f46\u770b\u4e86\u73b0\u573a PPT \u4ee5\u540e\uff0c\u975e\u5e38\u8d5e\u6210 CASP \u662f\u5b9e\u9a8c\u800c\u4e0d\u662f\u7ade\u8d5b\u8fd9\u4e00\u539f\u5219\uff0c\u5b83\u66f4\u52a0\u5173\u6ce8\u7684\u662f\u751f\u7269\u5b66\u7684 insight\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u6392\u540d\uff0c\u8fd9\u4e5f\u4f30\u8ba1\u662f CASP \u8bc4\u4f30\u7684\u9b45\u529b\u6240\u5728\u3002<\/span><\/p>\n<p><strong><span style=\"font-size: 16px\">\u5b54\u97e7\uff1a<\/span><\/strong><span style=\"font-size: 16px\">\u6211\u662f\u7b2c\u4e00\u6b21\u5728\u7ebf\u4e0b\u53c2\u52a0 CASP\uff0c\u73b0\u573a\u6c1b\u56f4\u786e\u5b9e\u975e\u5e38\u597d\uff0c\u8ba8\u8bba\u4e5f\u5341\u5206\u6fc0\u70c8\u3002\u4ee5\u524d\u6211\u4eec\u603b\u8bf4\u6298\u53e0\u95ee\u9898\u6216\u8005\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\uff0c\u4ee5 AlphaFold3 \u4e3a\u4ee3\u8868\u7684\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u5bf9\u4e8e\u7ed3\u6784\u9884\u6d4b\u9886\u57df\u7684\u6bcf\u4e2a\u7279\u522b\u95ee\u9898\u90fd\u7ed9\u51fa\u4e86\u76f8\u5e94\u8f83\u597d\u7684\u89e3\u51b3\u65b9\u6848\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px\">\u7136\u540e\u6211\u542c\u4e86\u7b2c\u4e00\u5929\u4e3b\u5e2d\u8bb2\u7684\u5386\u53f2\uff0c\u4ed6\u575a\u6301\u5728\u8fd9\u4e2a\u65b9\u5411\u505a\u4e86 30 \u5e74\uff0c\u6574\u4e2a\u79d1\u7814\u751f\u6daf\u90fd\u575a\u6301\u5728\u89e3\u51b3\u7ed3\u6784\u9884\u6d4b\u7684\u95ee\u9898\uff0c\u6211\u5bf9\u6b64\u975e\u5e38\u611f\u6168\uff0c\u8fd9\u662f\u6211\u4eec\u751f\u547d\u79d1\u5b66\u9886\u57df\u975e\u5e38\u6838\u5fc3\u7684\u5b58\u5728\uff0c\u4efb\u4f55\u4e00\u4e2a\u7ec6\u80de\u6216\u52a8\u7269\u5c42\u9762\u7684\u751f\u7269\u7279\u5f81\uff0c\u8ffd\u5176\u6839\u672c\u662f\u751f\u7269\u5927\u5206\u5b50\u7684\u7ed3\u6784\u95ee\u9898\uff0c\u7ed3\u6784\u6b63\u5e38\u6216\u5f02\u5e38\u548c\u751f\u7269\u5b66\u529f\u80fd\u5173\u7cfb\u5bc6\u5207\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px\">\u5f80\u5c4a\u6bd4\u8d5b\u7b97\u6cd5\u8fd8\u4e0d\u592a\u53d1\u8fbe\uff0c\u6211\u4eec\u89e3\u51b3\u7684\u4e3b\u8981\u662f\u5355\u4f53\u7ed3\u6784\u95ee\u9898\uff0c\u4f46\u5728\u6574\u4e2a\u7ec6\u80de\u4f53\u7cfb\u4e2d\uff0c\u66f4\u591a\u7684\u662f\u86cb\u767d\u8d28 DNA\u3001\u86cb\u767d\u8d28 RNA \u6216\u8005\u5c0f\u5206\u5b50\u5f62\u6210\u7684\u590d\u6742\u4f53\u7cfb\uff0cCASP \u4e5f\u53ef\u4ee5\u770b\u5230\u89e3\u51b3\u590d\u6742\u4f53\u7cfb\u95ee\u9898\u7684\u8d8b\u5411\u4e86\u3002\u7136\u540e\u6574\u4e2a\u4f5c\u7528\u7684\u8fc7\u7a0b\u662f\u52a8\u6001\u7684\uff0c\u57fa\u4e8e\u6b64\uff0c\u7ec4\u59d4\u4f1a\u63d0\u51fa\u5c06\u6765\u8981\u53d1\u5c55\u7b97\u6cd5\u89e3\u51b3\u52a8\u6001\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\uff0c\u8fd9\u5bf9\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6765\u8bf4\u610f\u4e49\u91cd\u5927\u3002<\/span><\/p>\n<p><strong><span style=\"font-size: 16px\">\u5e38\u73ca\uff1a<\/span><\/strong><span style=\"font-size: 16px\">\u6211\u4eec\u8fdb\u5165\u4e0b\u4e00\u4e2a\u8bae\u9898\uff0c\u672c\u6b21\u6bd4\u8d5b\u5728\u86cb\u767d\u8d28\u9884\u6d4b\u65b9\u9762\u6709\u4ec0\u4e48\u65b0\u8fdb\u6b65\uff1f\u4ee5\u53ca\u4eca\u540e\u7684\u53d1\u5c55\u8d8b\u52bf\u662f\u600e\u6837\u7684\uff1f\u8fd9\u4e2a\u95ee\u9898\u8bf7\u6768\u5efa\u76ca\u548c\u7a0b\u5efa\u6797\u8001\u5e08\u6765\u8bb2\u4e00\u4e0b\u3002<\/span><\/p>\n<p><strong><span style=\"font-size: 16px\">\u6768\u5efa\u76ca\uff1a<\/span><\/strong><span style=\"font-size: 16px\">\u86cb\u767d\u8d28\u5355\u4f53\u7ed3\u6784\u9884\u6d4b\u662f CASP \u4ece\u7b2c\u4e00\u5c4a\u5230\u73b0\u5728\u4e00\u76f4\u90fd\u6709\u7684\u4e3b\u9898\uff0c\u8fd9\u4e00\u5c4a\u8ddf\u4ee5\u5f80\u7684\u533a\u522b\u5728\u4e8e\u5206\u9636\u6bb5\u9884\u6d4b\uff0c\u5206\u4e3a phase 0\u30011\u30012\uff0cphase0 \u53ea\u63d0\u4f9b\u5e8f\u5217\u4fe1\u606f\uff0c\u4f46\u4e0d\u77e5\u9053\u5316\u5b66\u8ba1\u91cf\uff0c\u8fd9\u4e2a\u9884\u6d4b\u6bd4\u8f83\u6709\u6311\u6218\u6027\uff0c\u5982\u679c\u8fd9\u90e8\u5206\u9884\u6d4b\u9519\u4f1a\u4f7f\u7ed3\u6784\u9884\u6d4b\u5f97\u5f88\u5dee\u3002\u7b2c\u4e8c\u9636\u6bb5\u4f1a\u544a\u77e5\u5316\u5b66\u8ba1\u91cf\u4fe1\u606f\uff0c\u7b2c\u4e09\u9636\u6bb5\u63d0\u4f9b\u4e86 MassiveFold \u751f\u6210\u7684\u57fa\u4e8e AlphaFold2 \u7684 8000 \u4e2a\u7ed3\u6784\u6a21\u578b\uff0c\u4f9b\u9884\u6d4b\u8005\u6311\u9009\uff0c\u4ece\u800c\u6539\u8fdb\u9884\u6d4b\u7ed3\u679c\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px\">\u8fdb\u6b65\u65b9\u9762\u5176\u5b9e\u662f\u589e\u91cf\u6027\u7684\uff0c\u8bb8\u591a\u56e2\u961f\u90fd\u662f\u7528 AlphaFold3\u3001AlphaFold2 \u6216\u81ea\u5df1\u7684\u65b9\u6cd5\u7ed3\u5408\u8d77\u6765\uff0c\u5176\u4e2d\u6709\u4e24\u4e2a Baseline\uff0cAlphaFold3 \u7684 Baseline \u662f AF3-Server\uff0cAlphaFold2 \u7684 Baseline \u662f\u00a0ColabFold\uff0c\u4ece Baseline \u6765\u770b\uff0cAlphaFold3 \u548cAlphaFold2 \u76f8\u6bd4\u786e\u5b9e\u6709\u4e00\u5b9a\u6539\u8fdb\uff0c\u4f46\u5e76\u4e0d\u663e\u8457\uff0c\u4f46 AlphaFold3 \u529f\u80fd\u66f4\u5168\u3001\u53ef\u9884\u6d4b\u66f4\u591a\u7c7b\u578b\u7684\u751f\u7269\u5206\u5b50\u7ed3\u6784\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px\">\u8fd8\u6709\u4e2a\u8f83\u5927\u7684\u8fdb\u6b65\u5728\u4e8e\u6297\u4f53-\u6297\u539f\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u3002Dima \u56e2\u961f\u7ed3\u5408 AlphaFold3\u3001AlphaFold2\uff0c\u4ee5\u53ca\u7269\u7406\u91c7\u6837\u65b9\u6cd5 CluPro\uff0c\u901a\u8fc7 FFT \u5bf9\u63a5\uff0c\u751f\u6210\u5927\u91cf\u5019\u9009\u7ed3\u6784\u6a21\u578b\uff0c\u6700\u540e\u57fa\u4e8e\u805a\u7c7b\u548c\u6253\u5206\uff0c\u7b5b\u9009\u6700\u4f18\u7ed3\u6784\u6a21\u578b\u3002\u4f46\u8bc4\u4f30\u6570\u636e\u96c6\u8f83\u5c0f\uff0cCASP16 \u53ea\u5305\u542b 8 \u4e2a\u8bc4\u4f30\u5bf9\u8c61\uff0c\u4e0d\u786e\u5b9a\u8fd9\u7c7b\u65b9\u6cd5\u5bf9\u4e8e\u6297\u4f53-\u6297\u539f\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u7684\u6cdb\u5316\u80fd\u529b\u3002<\/span><\/p>\n<p><strong><span style=\"font-size: 16px\">\u5e38\u73ca\uff1a<\/span><\/strong><span style=\"font-size: 16px\">\u5176\u5b9e\u5927\u5bb6\u5e38\u6709\u8ba8\u8bba\u5728\u9884\u6d4b\u8fc7\u7a0b\u4e2d\uff0c\u4eba\u5de5\u5e72\u9884\u7a76\u7adf\u80fd\u8d77\u5230\u591a\u5927\u7684\u4f5c\u7528\uff1f<\/span><\/p>\n<p><strong><span style=\"font-size: 16px\">\u7a0b\u5efa\u6797\uff1a<\/span><\/strong><span style=\"font-size: 16px\">\u6211\u89c9\u5f97\u4eba\u5de5\u5e72\u9884\u5728\u9009\u6a21\u578b\u4e0a\u662f\u5f88\u96be\u7684\u4e8b\uff0c\u56e0\u4e3a\u5f53\u6709\u51e0\u4e2a\u5f88\u4e0d\u540c\u7684AlphaFold2 \u6216 AlphaFold3 \u4ea7\u751f\u7684\u7ed3\u6784\uff0c\u770b\u8d77\u6765\u90fd\u6709\u53ef\u80fd\uff0c\u5206\u6570\u4e5f\u5dee\u4e0d\u591a\uff0c\u5f88\u96be\u786e\u5b9a\u54ea\u4e2a\u7ed3\u6784\u66f4\u597d\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px\">\u4f46\u5728\u6709\u4e9b\u65b9\u9762\u4eba\u5de5\u5e72\u9884\u662f\u6709\u5e2e\u52a9\u7684\uff0c\u7279\u522b\u662f\u5316\u5b66\u8ba1\u91cf phase0 \u7684\u9884\u6d4b\uff0c\u8fd9\u662f\u4e2a\u65b0\u5f15\u8fdb\u7684\u9879\u76ee\u3002\u5f88\u591a\u65f6\u5019\u6211\u4eec\u4e0d\u77e5\u9053\u5316\u5b66\u8ba1\u91cf\uff0c\u800c\u8981\u9884\u6d4b\u7ed3\u6784\u9700\u8981\u5148\u9884\u6d4b\u5316\u5b66\u8ba1\u91cf\uff0c\u8fd9\u90e8\u5206\u4eba\u5de5\u5e72\u9884\u662f\u6709\u7528\u7684\uff0c\u56e0\u4e3a\u53ef\u4ee5\u53bb\u627e\u73b0\u6709\u7684\u6a21\u677f\uff0c\u8fd9\u4e2a\u6a21\u677f\u63d0\u4f9b\u6709\u6548\u7684\u4fe1\u606f\uff0c\u7136\u540e\u7ed3\u5408\u8fd9\u4e9b\u4fe1\u606f\u4ea7\u751f\u7ed3\u6784\u6a21\u578b\uff0c\u7528\u6a21\u578b\u7684\u5206\u6570\u6765\u8bc4\u4f30\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px\">\u7136\u540e\uff0c\u8fd9\u6b21\u8fd8\u6709\u4e00\u4e2a\u6311\u6218\u5728\u4e8e AlphaFold3 \u662f\u5728\u6bd4\u8d5b\u4e2d\u95f4\u653e\u51fa\u6765\u7684\uff0c\u5728\u6bd4\u8d5b\u524d\u5f88\u591a\u5b9e\u9a8c\u5ba4\u7684\u7cfb\u7edf\u5df2\u7ecf\u5728 AlphaFold2 \u7684\u57fa\u7840\u4e0a\u5efa\u597d\u4e86\uff0c\u90a3 AlphaFold3 \u51fa\u6765\u8981\u600e\u4e48\u53d8\u5316\u6216\u5feb\u901f\u53cd\u5e94\uff0c\u80fd\u4e0d\u80fd\u9a6c\u4e0a\u63a5\u53d7\u5e76\u6709\u6548\u4f7f\u7528\uff0c\u4e5f\u662f\u5f71\u54cd\u5b9e\u9a8c\u5ba4\u6210\u7ee9\u7684\u56e0\u7d20\u3002<\/span>\u90d1\u4f1f\u8001\u5e08\u5c31\u8ddf\u6211\u8bb2\u4ed6\u672c\u6765\u7528 AlphaFold2 \u505a\u5f97\u5f88\u597d\u7684\uff0c\u4f46\u662f\u5b8c\u5168\u6ca1\u6709\u7528\u00a0 AlphaFold3 \uff0c\u6240\u4ee5\u8868\u73b0\u5c31\u7a0d\u5fae\u4e0b\u964d\u4e86\u4e00\u70b9\u3002<\/p>\n<p>AlphaFold3 \u5176\u5b9e\u5728\u5927\u7684\u590d\u5408\u7269\u6298\u53e0\u4e0a\u529f\u80fd\u4e0a\u8981\u6bd4 AlphaFold2 \u597d\uff0c\u7279\u522b\u662f\u5f53\u6709\u5f88\u591a\u86cb\u767d\u8d28\u65f6\uff0cAlphaFold2 \u4ea7\u751f\u4e0d\u4e86\u5f88\u597d\u7684\u7ed3\u679c\u3002\u6b64\u5916\uff0c\u6211\u4e5f\u5173\u6ce8\u5230\u5728\u86cb\u767d\u8d28\u548c\u5c0f\u5206\u5b50\u590d\u5408\u7269\u7684\u9884\u6d4b\u4e2d\uff0c\u6709\u4e00\u9879\u8fdb\u5c55\u662f\u4eba\u5de5\u667a\u80fd\u65b9\u6cd5\u8d76\u4e0a\u751a\u81f3\u8d85\u8fc7\u4e86\u4f20\u7edf\u5bf9\u63a5\u65b9\u6cd5\uff0c\u4e0b\u5c4a CASP \u53ef\u80fd\u6574\u4e2a\u9886\u57df\u7684\u6c34\u5e73\u90fd\u4f1a\u4e0a\u4e00\u4e2a\u53f0\u9636\u3002<\/p>\n<p>\u6709\u5173\u53d1\u5c55\u8d8b\u52bf\u65b9\u9762\uff0c\u611f\u89c9\u7ed3\u6784\u6a21\u578b\u6392\u5e8f\u95ee\u9898\u3001\u9009\u62e9\u95ee\u9898\u548c\u8d28\u91cf\u8bc4\u4f30\u95ee\u9898\u90fd\u5f88\u6709\u6311\u6218\u6027\u3002\u4ee5\u524d\u9886\u57df\u4e2d\u4e3b\u8981\u969c\u788d\u5728\u4e8e\u5982\u4f55\u4ea7\u751f\u597d\u7684\u7ed3\u6784\u6a21\u578b\uff0c\u73b0\u5728\u5f88\u591a\u65f6\u5019\u80fd\u591f\u4ea7\u751f\u597d\u7684\u6a21\u578b\uff0c\u6297\u4f53\u3001\u6297\u539f\u90fd\u80fd\u4ea7\u751f\u6b63\u786e\u7684\u7ed3\u6784\uff0c\u4f46\u65e0\u6cd5\u9009\u62e9\u51fa\u6765\uff0c\u8fd9\u4e2a\u95ee\u9898\u6ca1\u6709\u5f7b\u5e95\u89e3\u51b3\u3002<\/p>\n<p>\u5316\u5b66\u8ba1\u91cf\u7684\u9884\u6d4b\u4e5f\u5f88\u91cd\u8981\uff0c\u76ee\u524d CASP16 \u4e2d\u6709\u7684\u65b9\u6cd5\u5df2\u7ecf\u80fd\u5728\u4e00\u5b9a\u7684\u4eba\u5de5\u652f\u6301\u4e0b\u5b9e\u73b0\u9ad8\u6027\u80fd\uff0c\u8fbe\u5230\u767e\u5206\u4e4b\u4e03\u5341\u51e0\u7684\u7cbe\u5ea6\uff0c\u4f46\u5982\u4f55\u81ea\u52a8\u5316\u4ee5\u53ca\u7ee7\u7eed\u63d0\u9ad8\u662f\u5f88\u91cd\u8981\u7684\u3002\u8fd8\u6709\u4e00\u4e2a\u95ee\u9898\u805a\u7126\u4e8e\u5927\u7684\u590d\u5408\u4f53\u9884\u6d4b\uff0c\u5c31\u662f\u5f53\u590d\u5408\u4f53\u4e2d\u6709\u51e0\u5341\u4e2a\u6216\u66f4\u591a\u86cb\u767d\u8d28\u5f62\u6210\u65f6\u8981\u600e\u6837\u9884\u6d4b\u7ed3\u6784\uff0cAlphaFold3\u3001AlphaFold2 \u4e5f\u6ca1\u6709\u5b8c\u5168\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u8fd9\u662f\u4e4b\u540e\u9700\u8981\u7a81\u7834\u7684\u91cd\u8981\u65b9\u5411\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u5355\u5e8f\u5217\u7684\u7ed3\u6784\u9884\u6d4b\u4e5f\u662f\u7ecf\u5178\u95ee\u9898\uff0c\u5f53\u524d AlphaFold3\u3001AlphaFold2 \u90fd\u4f9d\u8d56\u4e8e\u591a\u5e8f\u5217\u8f93\u5165\uff0c\u4f46\u5f88\u591a\u65f6\u5019\u53ea\u80fd\u627e\u5230\u4e00\u4e2a\u5e8f\u5217\uff0c\u80fd\u5426\u7cbe\u786e\u9884\u6d4b\u51fa\u7ed3\u6784\uff0c\u8fd9\u751a\u81f3\u53ef\u80fd\u4ea7\u751f\u7b2c\u4e8c\u4e2a\u8bfa\u5956\u3002<\/p>\n<p>\u6700\u540e\u662f\u4eba\u5de5\u667a\u80fd\uff0c\u5f53\u524d\u4eba\u5de5\u667a\u80fd\u5728\u86cb\u767d\u8d28\u548c\u5c0f\u5206\u5b50\u65b9\u9762\u90fd\u5df2\u53d6\u5f97\u4e86\u7a81\u7834\uff0c\u63a5\u4e0b\u6765\u4f1a\u6709\u5f88\u591a\u5e94\u7528\uff0c\u4f46\u6211\u6bd4\u8f83\u60ca\u8bb6\u7684\u662f\uff0c\u5728\u6838\u9178\u7ed3\u6784\u9884\u6d4b\u4e2d\u4eba\u5de5\u667a\u80fd\u8fd8\u672a\u8d85\u8fc7\u4f20\u7edf\u65b9\u6cd5\uff0c\u9648\u4e16\u6770\u8001\u5e08\u8fd9\u6b21\u5728\u6838\u9178 RNA \u7ed3\u6784\u9884\u6d4b\u4e2d\u53d6\u5f97\u4e86\u6700\u597d\u7684\u6210\u7ee9\uff0c\u4e5f\u7528\u4e86 AlphaFold3\uff0c\u4f46\u5927\u91cf\u4f7f\u7528\u7684\u8fd8\u662f\u4f20\u7edf\u65b9\u6cd5\uff0c\u8fd1\u4e24\u5e74\u53ef\u80fd\u4f1a\u770b\u5230\u4eba\u5de5\u667a\u80fd\u7684\u8d85\u8d8a\u3002<\/p>\n<p><\/p>\n<p style=\"text-align: center\"><span style=\"font-size: 20px\"><strong>\u86cb\u767d\u8d28\u9884\u6d4b\u65b0\u95ee\u9898\u7684\u6311\u6218\u548c\u8d8b\u52bf<\/strong><\/span><\/p>\n<p>\u5e38\u73ca\uff1a\u5355\u5e8f\u5217\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u6709\u53ef\u80fd\u63ed\u793a\u4e86\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u4e00\u4e9b\u673a\u5236\uff0c\u8fd9\u662f\u5f88\u91cd\u8981\u7684\uff0c\u6838\u9178\u7ed3\u6784\u9884\u6d4b\u6211\u4eec\u540e\u9762\u4e5f\u4f1a\u8ba8\u8bba\u5230\u3002\u7a0b\u8001\u5e08\u521a\u521a\u4e5f\u63d0\u5230\u4e86\u86cb\u767d\u8d28\u6a21\u578b\u7684\u6392\u5e8f\u3001\u8d28\u91cf\u8bc4\u4f30\uff0c\u8fd8\u6709\u86cb\u767d\u8d28\u7684\u591a\u6784\u8c61\u3001\u590d\u5408\u7269\u7684\u95ee\u9898\uff0c\u8fd9\u4e5f\u662f\u76ee\u524d\u6bd4\u8f83\u6709\u6311\u6218\u7684\u90e8\u5206\uff0c\u6b63\u597d\u5f15\u51fa\u4e86\u6211\u4eec\u7684\u7b2c\u4e09\u4e2a\u8bae\u9898\u86cb\u767d\u8d28\u590d\u5408\u7269\u7ec4\u88c5\u4ee5\u53ca\u591a\u6784\u8c61\u9884\u6d4b\uff0c\u86cb\u767d\u8d28\u6a21\u578b\u8d28\u91cf\u8bc4\u4f30\u7b49\u65b0\u95ee\u9898\uff0c\u8bf7\u90d1\u4f1f\u8001\u5e08\u548c\u5f20\u8d35\u519b\u8001\u5e08\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e0b\u6311\u6218\u548c\u53d1\u5c55\u8d8b\u52bf\u3002<\/p>\n<p><strong>\u90d1\u4f1f\uff1a<\/strong>\u6211\u5148\u8bb2\u4e00\u4e0b\u6a21\u578b\u8d28\u91cf\u8bc4\u4f30\uff0c\u76ee\u524d\u5728\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u4e2d\u6bd4\u8f83\u9ebb\u70e6\u7684\u95ee\u9898\u5728\u4e8e\uff0c\u6211\u4eec\u901a\u8fc7\u5927\u91cf\u91c7\u6837\uff0c\u590d\u5408\u7269\u5907\u9009\u7684\u6a21\u578b\u4e2d\u5176\u5b9e\u6709\u5f88\u591a\u662f\u63a5\u8fd1\u4e8e\u771f\u5b9e\u7ed3\u6784\u7684\uff0c\u4f46\u8fd8\u662f\u9ed8\u8ba4\u7684 QA \u6253\u5206\uff0c\u6a21\u578b\u7684\u7f6e\u4fe1\u7cfb\u6570\u6ca1\u6cd5\u628a\u6700\u597d\u7684\u6392\u5230\u524d\u9762\uff0c\u5728\u6211\u4eec\u5f00\u53d1\u7684\u65b9\u6cd5\u91cc\uff0c\u8fd9\u4e2a\u95ee\u9898\u6bd4\u8f83\u5927\u3002\u521a\u624d\u5efa\u76ca\u8001\u5e08\u4e5f\u63d0\u5230\u4e86\u6297\u4f53\u95ee\u9898\uff0c\u4eca\u5e74\u8d5b\u540e\u6211\u4eec\u770b\u4e86\u4e00\u4e0b\u6574\u4e2a\u6a21\u578b\u6c60\uff0c\u8fd9\u51e0\u4e2a\u6297\u4f53\u590d\u5408\u7269\u6211\u4eec\u4e5f\u505a\u4e86\u5927\u91cf\u91c7\u6837\uff0c\u7ed3\u679c\u4e5f\u6709\u5f88\u591a\u6b63\u786e\u7684\u6a21\u578b\uff0c\u4f46\u5b83\u4eec\u5728\u6392\u5e8f\u91cc\u5f88\u4f4e\uff0c\u8fd9\u5c31\u5f15\u51fa\u4e86\u72ec\u7acb QA \u65b9\u5f0f\u7684\u95ee\u9898\u3002<\/p>\n<p>\u4eca\u5e74\u86cb\u767d\u8d28\u6a21\u578b\u8d28\u91cf\u8bc4\u4f30\u95ee\u9898\u4e0a\u6709\u51e0\u4e2a\u53d8\u5316\uff0c\u5f80\u5e74\u5927\u5bb6\u503e\u5411\u4e8e\u505a\u5176\u4ed6\u53c2\u8d5b\u8005\u63d0\u4ea4\u7684\u6a21\u578b\u6392\u5e8f\u4ee5\u53ca\u5e38\u89c4\u7684 QA \u8bc4\u6d4b\uff0c\u4eca\u5e74\u5f15\u5165\u4e86 MassiveFold \u7684\u6a21\u578b\u8d28\u91cf\u8bc4\u4f30\uff0c\u96c6\u6210\u4e86\u5404\u79cd\u6539\u9020\u7248\u7684 AlphaFold2 \u6a21\u578b\uff0c\u5927\u6982\u4ea7\u751f 8000 \u4e2a\u6a21\u578b\uff0cCASP \u6709\u4e00\u4e2a\u8d5b\u9053\u5c31\u662f\u5728\u8fd9\u4e9b\u6a21\u578b\u4e2d\u91cd\u65b0\u9009\u62e9\u7ed3\u679c\u6bd4\u8f83\u597d\u7684\u3002\u53e6\u5916\uff0c\u73b0\u5728\u7684 CASP \u53ef\u80fd\u4e5f\u66f4\u5173\u6ce8\u6a21\u578b\u7684\u81ea\u8bc4\u4f30\uff0c\u8fd9\u662f\u4ece CASP14 \u5f00\u59cb\u5f15\u5165\u7684\uff0c\u4f5c\u4e3a\u6700\u540e\u6240\u6709\u8bc4\u4f30\u53c2\u8d5b\u8868\u73b0\u7684\u5176\u4e2d\u4e00\u4e2a\u6307\u6807\uff0cQA \u5728\u6574\u4e2a\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u9886\u57df\u5176\u5b9e\u4e5f\u65e5\u6e10\u88ab\u91cd\u89c6\u3002<\/p>\n<p>\u4f46\u8fd9\u4e2a\u9886\u57df\u5f88\u96be\uff0c\u6211\u4eec\u4eca\u5e74\u4e5f\u5c1d\u8bd5\u4e86\u53c2\u8d5b\uff0c\u8d5b\u524d\u6211\u4eec\u505a\u4e86\u4e00\u4e2a QA \u8bc4\u4f30\uff0c\u60f3\u7528\u5176\u4ed6\u7b2c\u4e09\u65b9 QA \u6765\u7ed9\u6a21\u578b\u91cd\u65b0\u6253\u5206\uff0c\u4f46\u57fa\u672c\u6240\u6709\u7b2c\u4e09\u65b9\u90fd\u6ca1\u6cd5\u628a\u6211\u4eec\u7684\u6a21\u578b\u9009\u597d\uff0c\u6240\u4ee5\u6211\u4eec\u5c31\u60f3\u80fd\u4e0d\u80fd\u4e0d\u7528 QA \u9009\u6a21\u578b\uff0c\u800c\u662f\u7528\u6a21\u578b\u53cd\u4f5c QA\uff0c\u56e0\u6b64\u6211\u4eec\u6784\u5efa\u4e86\u4e00\u4e2a QA \u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff0c\u7136\u540e\u7528\u6211\u4eec\u7684\u6a21\u578b\u505a\u4e3a\u4e3b\u8981\u7684\u53c2\u8003\u5bf9\u5176\u4ed6\u6a21\u578b\u8fdb\u884c QA \u6253\u5206\uff0c\u8fd9\u53c8\u5f15\u51fa\u4e86\u4e00\u4e2a\u95ee\u9898\u662f QA \u5230\u5e95\u5e94\u4e0d\u5e94\u8be5\u8131\u79bb\u7ed3\u679c\u9884\u6d4b\u5355\u72ec\u53bb\u505a\uff0c\u4e0d\u8fc7\u8fd9\u90e8\u5206\u95ee\u9898\u53ef\u80fd\u8fd8\u9700\u8981\u548c\u5efa\u6797\u3001\u8d35\u519b\u8001\u5e08\u8ba8\u8bba\u4e00\u4e0b\u3002<\/p>\n<p>\u86cb\u767d\u8d28\u590d\u5408\u7269\u7ec4\u88c5\u8fd9\u90e8\u5206\u9664\u4e86\u52a0\u5165\u4e86 Phase0\u30011\u30012 \u4e4b\u5916\uff0c\u6574\u4f53\u7684\u4f53\u7cfb\u4e5f\u5728\u53d8\u5927\uff0c\u4ee5\u5f80\u590d\u5408\u7269\u7ec4\u88c5\u90fd\u662f\u6bd4\u8f83\u5c0f\u7684\u4f53\u7cfb\uff0c\u5c31\u662f\u4e24\u4e2a\u86cb\u767d\u6216\u8005\u8fd9\u4e24\u4e2a\u86cb\u767d copy \u6570\u4e0d\u592a\u591a\uff0c\u5316\u5b66\u8ba1\u91cf\u6570\u4e5f\u6bd4\u8f83\u5c0f\uff0cA1B1\u3001 A2B2 \u90fd\u7b97\u6bd4\u8f83\u5927\u7684\u4e86\uff0c\u6574\u4e2a\u4f53\u7cfb\u5c31\u662f\u4e00\u4e24\u5343\u4e2a\u6c28\u57fa\u9178\uff0c\u4eca\u5e74\u5927\u7684\u590d\u5408\u7269\u53d8\u5f97\u7279\u522b\u591a\uff0c\u6709\u7684\u4f53\u7cfb\u91cc\u53ef\u80fd\u5305\u542b\u4e86\u5341\u51e0\u4e2a\u86cb\u767d\uff0c\u751a\u81f3\u6709\u7684\u6574\u4e2a\u4f53\u7cfb\u4e0b\u6765\u4e03\u516b\u5343\u4e2a\u6c28\u57fa\u9178\u3002\u4eca\u5e74\u6574\u4e2a\u590d\u5408\u7269\u7684\u7ec4\u88c5\uff0c\u4e00\u662f\u5316\u5b66\u8ba1\u91cf\u53d8\u5f97\u66f4\u52a0\u590d\u6742\uff0c\u4e8c\u662f\u590d\u5408\u7269\u7684\u4f53\u7cfb\u53d8\u5f97\u66f4\u5927\uff0c\u6574\u4f53\u611f\u89c9\u53d8\u96be\u4e86\u3002<\/p>\n<p>\u591a\u6784\u8c61\u8fd9\u5757\u5176\u5b9e\u662f\u4eca\u5e74 CASP \u4e00\u76f4\u60f3\u8981\u589e\u52a0\u7684\u8d5b\u9053\uff0c\u4f46\u9274\u4e8e\u5f80\u5e74\u591a\u6784\u8c61\u6570\u636e\u4e0d\u592a\u597d\u91c7\u96c6\uff0c\u4eca\u5e74\u662f\u9996\u6b21\u4f5c\u4e3a\u72ec\u7acb\u8d5b\u9053\u8bbe\u7f6e\uff0c\u76f8\u5bf9\u5176\u4ed6\u8d5b\u9053\uff0c\u591a\u6784\u8c61\u4e0d\u5230 20 \u4e2a\u7ed3\u6784\uff0c\u6570\u91cf\u975e\u5e38\u5c11\u3002\u591a\u6784\u8c61\u5728\u751f\u7269\u5b66\u91cc\u5176\u5b9e\u5f88\u91cd\u8981\uff0c\u56e0\u4e3a\u751f\u7269\u8fc7\u7a0b\u4e0d\u662f\u9759\u6001\u7684\uff0c\u6211\u4eec\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u5176\u5b9e\u5927\u90e8\u5206\u90fd\u662f\u770b\u67d0\u4e00\u4e2a\u7ed3\u6784\u4e2d\u95f4\u7684\u72b6\u6001\uff0c\u662f\u9759\u6001\u7684\u8fc7\u7a0b\uff0c\u4f46\u591a\u6784\u8c61\u662f\u52a8\u6001\u7684\uff0c\u8fd9\u5bf9\u540e\u7eed\u6574\u4e2a\u52a8\u6001\u9884\u6d4b\u5f88\u91cd\u8981\u3002<\/p>\n<p>\u4f46\u4eca\u5e74\u4e00\u662f\u8d5b\u9898\u96be\u5ea6\u5927\uff0c\u4e8c\u662f\u6ca1\u6709\u660e\u786e\u7684\u8bc4\u6d4b\u6307\u6807\uff0c\u8fd8\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5\uff0c\u591a\u6784\u8c61\u9884\u6d4b\u76f8\u5bf9\u5176\u4ed6\u8d5b\u9053\u66f4\u96be\uff0c\u6570\u636e\u91cf\u6bd4\u8f83\u5c11\uff0c\u5f88\u96be\u8bad\u7ec3\u4e00\u4e2a\u6bd4\u8f83\u5e38\u89c4\u7684\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u9884\u6d4b\u6240\u6709\u591a\u6784\u8c61\u95ee\u9898\uff0c\u6240\u4ee5\u5904\u7406\u8d77\u6765\u8981 case by case\uff0c\u6bcf\u4e2a case \u90fd\u8981\u4eba\u5de5\u82b1\u8d39\u5f88\u591a\u7cbe\u529b\u3002<\/p>\n<p>\u4ece\u524d\u666f\u4e0a\u6765\u8bb2\uff0cAlphaFold3 \u91cc\u7528\u7684\u6269\u6563\u6a21\u578b\u7684\u7ed3\u6784\u6a21\u5757\u6bd4 AlphaFold2 \u57fa\u4e8e Transformer \u7684\u7ed3\u6784\u6a21\u5757\u5728 Benchmark \u7684\u65f6\u5019\u6548\u679c\u597d\u4e9b\uff0c\u591a\u6784\u8c61\u9884\u6d4b\u6bd4\u8f83\u597d\u7684\u53d1\u5c55\u65b9\u5411\u662f\u751f\u6210\u6a21\u578b\u6216 Diffusion \u6a21\u578b\u3002<\/p>\n<p><strong>\u5f20\u8d35\u519b\uff1a<\/strong>\u6a21\u578b\u8d28\u91cf\u8bc4\u4f30\u542c\u8d77\u6765\u7b80\u5355\uff0c\u4f46\u662f\u5b9e\u73b0\u5e76\u4e0d\u5bb9\u6613\uff0c\u73b0\u5728\u7684\u6307\u6807\u4f53\u7cfb\u4ece\u5355\u4f53\u8fc1\u5f99\u5230\u590d\u5408\u7269\u4e0a\u8fd8\u5b58\u5728\u5f88\u591a\u95ee\u9898\uff0c\u6240\u4ee5\u5728 CASP \u4e2d\u9488\u5bf9\u590d\u5408\u7269\u7684\u6a21\u578b\u8d28\u91cf\u8bc4\u4f30\u4e5f\u589e\u52a0\u4e86\u5f88\u591a\u7684\u6539\u8fdb\uff0c\u6bd4\u5982\u5728\u5c40\u90e8\u6307\u6807\u589e\u52a0\u4e86 PatchQS \u548c PatchDockQ \u6307\u6807\uff0c\u5728 CASP16 \u4e2d\uff0c\u6211\u4eec\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u4e86\u4e00\u4e2a\u57fa\u4e8e\u4e24\u4e2a\u5355\u6a21\u578b\u548c\u4e00\u4e2a\u5171\u8bc6\u65b9\u6cd5\u7684 QA \u6846\u67b6\uff0c\u4e00\u822c\u6765\u8bb2\uff0c\u901a\u8fc7\u5171\u8bc6\u65b9\u6cd5\u5224\u65ad\u6a21\u578b\u662f\u5426\u5408\u9002\u4f1a\u53d7\u9650\u4e8e\u9884\u6d4b\u65b9\u6cd5\uff0c\u56e0\u6b64\uff0c\u4ece EMA \u8d5b\u9053\u7684\u8bbe\u7f6e\u7684\u521d\u8877\u800c\u8a00\uff0c\u53d1\u5c55\u5355\u6a21\u578b\u65b9\u6cd5\u662f\u91cd\u70b9\u65b9\u5411\u4e4b\u4e00\u3002<\/p>\n<p>EMA \u6574\u4f53\u4e0a\u9700\u8981\u8003\u8651\u6253\u5206\u3001\u6392\u5e8f\u3001\u9009\u62e9\u4e09\u4e2a\u4e0d\u540c\u6b65\u9aa4\uff0c\u5b83\u4eec\u4e4b\u95f4\u662f\u6709\u533a\u522b\u7684\u3002\u5bf9\u4e8e\u4e00\u4e2a\u590d\u5408\u7269\u6a21\u578b\u800c\u8a00\uff0c\u6253\u5206\u7684\u5bf9\u8c61\u6709\u5f88\u591a\u79cd\uff0c\u5305\u62ec\u5168\u5c40\u3001\u5c40\u90e8\u3001\u63a5\u53e3\u6b8b\u57fa\u3001\u4fa7\u94fe\u3001\u539f\u5b50\u7684\u8bc4\u4f30\u5206\u6570\uff0c\u7136\u540e\u5c06\u8fd9\u4e9b\u5206\u6570\u9700\u8981\u6574\u5408\u6392\u5e8f\uff0c\u6700\u540e\u6839\u636e\u751f\u7269\u5b66\u9700\u8981\u6311\u9009\u51fa\u611f\u5174\u8da3\u7684\u6a21\u578b\u3002\u76ee\u524d\u65b9\u5f0f\u662f\u6311\u9009\u6700\u4f73\u6a21\u578b\uff0c\u4f46\u5728\u751f\u7269\u5b66\u529f\u80fd\u95ee\u9898\u4e2d\u65f6\uff0c\u5982\u679c\u5b58\u5728\u591a\u6784\u8c61\u95ee\u9898\u65f6\uff0c\u5355\u4e00\u7684 TOP1 \u9009\u62e9\u65b9\u5f0f\u5e76\u4e0d\u7406\u60f3\u3002\u56e0\u4e3a\u590d\u5408\u7269\u6a21\u578b\u53ef\u80fd\u5b58\u5728\u4e24\u79cd\u6216\u4ee5\u4e0a\u7684\u7a33\u5b9a\u529f\u80fd\u6784\u8c61\u3002\u6b64\u5916\uff0cCAPRI\u3001CASP \u5728\u6a21\u578b\u8d28\u91cf\u8bc4\u4f30\u53ca\u6253\u5206\u65b9\u9762\u7684\u6307\u6807\u4e5f\u662f\u6709\u533a\u522b\u7684\u3002\u5728\u672c\u5c4a CASP16 \u4e2d\uff0c\u9664\u4e86 Guijunlab-QA \u4e4b\u5916\uff0c\u6211\u4eec\u5b9e\u9a8c\u5ba4\u8fd8\u5206\u522b\u5f00\u53d1\u4e86 Guijunlab-Complex\u3001Guijunlab-DeepAssembly \u4e24\u4e2a\u670d\u52a1\u5668\u53c2\u52a0\u4e86\u590d\u5408\u7269\u5efa\u6a21\u7c7b\u522b\uff0c\u901a\u8fc7\u76f2\u6d4b\u5206\u522b\u9a8c\u8bc1\u4e00\u4e0b MSA \u548c\u6a21\u677f\u4e24\u4e2a\u56e0\u7d20\u5728\u9ad8\u7cbe\u5ea6\u5efa\u6a21\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n<p>\u90d1\u4f1f\u8001\u5e08\u7684\u5de5\u4f5c\u505a\u5f97\u975e\u5e38\u597d\uff0c\u8fd9\u4e5f\u8bf4\u660e\u4e86\u4ece\u76ee\u524d\u6765\u770b\u7ed3\u6784\u9884\u6d4b\u65b9\u6cd5\u662f\u8d85\u524d\u4e8e\u6a21\u578b\u8d28\u91cf\u8bc4\u4f30\u65b9\u6cd5\u7684\uff0c\u9884\u6d4b\u505a\u5f97\u5f88\u597d\uff0c\u9884\u6d4b\u7684\u8bc4\u4f30\u4e5f\u4f1a\u505a\u5f97\u5f88\u597d\u3002\u4f46\u4e5f\u4f1a\u5b58\u5728\u5168\u65b0\u3001\u9884\u6d4b\u505a\u5f97\u4e0d\u592a\u597d\u7684\u86cb\u767d\uff0c\u6216\u8005\u53c2\u8d5b\u961f\u4f0d\u95f4\u5dee\u5f02\u6027\u8f83\u5927\u7684\u60c5\u51b5\u3002\u6b64\u5916\uff0c\u8fd9\u5c4a CASP \u4e5f\u8003\u8651\u5230\u4e86\u5b9e\u9a8c\u7ed3\u6784\u7684\u53ef\u9760\u6027\uff0c\u4ece\u4e0a\u5c4a\u5f00\u59cb\u7ec4\u59d4\u4f1a\u5c31\u5df2\u7ecf\u5728\u8003\u8651\u662f\u6a21\u578b\u9884\u6d4b\u9519\u8bef\u8fd8\u662f\u5b9e\u9a8c\u7ed3\u6784\u6d4b\u5b9a\u8bef\u5dee\u7684\u95ee\u9898\u4e86\uff0c\u8fd9\u4e5f\u8868\u660e\u8ba1\u7b97\u5efa\u6a21\u65b9\u6cd5\u5df2\u7ecf\u6210\u4e3a\u5b9e\u9a8c\u6d4b\u5b9a\u65b9\u6cd5\u7684\u6709\u6548\u73af\u8282\u3002<\/p>\n<p>\u5316\u5b66\u8ba1\u91cf\u5b66\u7684\u8bc4\u4f30\u4e5f\u6bd4\u8f83\u91cd\u8981\u4e00\u4e2a\u65b0\u95ee\u9898\uff0c\u9884\u6d4b\u65b9\u9762\u51fa\u73b0\u7684\u65b0\u6311\u6218\u5728\u8bc4\u4f30\u65b9\u9762\u90fd\u5e94\u8be5\u8003\u8651\u3002\u6bd4\u5982\u4e8c\u805a\u4f53\u3001\u4e09\u805a\u4f53\u3001\u56db\u805a\u4f53\u7b49\u8ba1\u91cf\u5b66\u95ee\u9898\u4e0d\u4ec5\u53ef\u4ee5\u641c\u6a21\u677f\uff0c\u8fd8\u53ef\u80fd\u4ece MSA \u4e2d\u5206\u6790\u5f97\u5230\u63a5\u53e3\u6307\u7eb9\uff0c\u7136\u540e\u901a\u8fc7\u6307\u7eb9\u5224\u65ad\u4fdd\u5b88\u6027\u7684\u65b9\u5f0f\u53bb\u89e3\u51b3\u3002\u5982\u679c\u8003\u8651\u5230\u6a21\u677f\u548c MSA \u7684\u8bdd\uff0c\u5b9e\u9645\u4e0a\u53c8\u5f52\u5230\u5e8f\u5217\u5c42\u9762\u76f8\u4e92\u4f5c\u7528\u7684\u95ee\u9898\uff0c\u76ee\u524d\uff0c\u6211\u4eec\u4e5f\u5728\u9488\u5bf9\u57fa\u4e8e\u5e8f\u5217\u7684\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u65b9\u9762\u5f00\u5c55\u5de5\u4f5c\u3002<\/p>\n<p>\u53e6\u5916\u4e00\u4e2a\u9700\u8981\u5173\u6ce8\u7684\u6311\u6218\u662f\u591a\u6784\u8c61\u7684\u95ee\u9898\u3002\u6211\u4e00\u76f4\u60f3\u8ddf\u5927\u5bb6\u8ba8\u8bba MSA \u5728\u5efa\u6a21\u548c\u8bc4\u4f30\u65b9\u9762\u7684\u53cc\u5203\u5251\u95ee\u9898\u3002CASP \u591a\u6784\u8c61\u5efa\u6a21\u5b9e\u8df5\u8868\u660e\uff0c\u5728 AlphaFold \u4e2d\u4f7f\u7528\u4e0d\u540c\u7684 MSA \u914d\u5bf9\u786e\u5b9e\u53ef\u4ee5\u4ea7\u751f\u4e0d\u540c\u7684\u6784\u8c61\uff0c\u800c\u4e14\u5df2\u7ecf\u6709\u6210\u529f\u7684\u6848\u4f8b\uff0c\u662f\u76ee\u524d\u591a\u6784\u8c61\u9884\u6d4b\u7684\u57fa\u672c\u6d41\u7a0b\u3002\u4f46\u662f\uff0c\u4ece\u7b2c\u4e00\u6027\u539f\u7406\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u591a\u6784\u8c61\u4fe1\u606f\u5e94\u8be5\u5305\u542b\u5728\u5176\u5e8f\u5217\u4e4b\u4e2d\u3002\u6211\u89c9\u5f97\u591a\u6784\u8c61\u9884\u6d4b\u4e4b\u540e\u5e94\u8be5\u53ef\u4ee5\u4ece\u4ee5\u4e0b\u51e0\u4e2a\u8003\u8651\uff0c\u901a\u8fc7\u86cb\u767d\u8d28\u5e8f\u5217\u8bed\u8a00\u6a21\u578b\uff08\u4e5f\u5c31\u662f AI\uff09\u7684\u65b9\u5f0f\uff0c\u76f4\u63a5\u4ece\u5355\u5e8f\u5217\u51fa\u53d1\u6355\u83b7\u6784\u8c61\u53d8\u6362\u7684\u8bed\u4e49\u5173\u7cfb\uff1b\u7b2c\u4e8c\u4e2a\u65b9\u9762\u76f4\u63a5\u5728\u7b2c\u4e00\u6027\u539f\u7406\u4e0a\u57fa\u7840\u4e0a\uff0c\u8003\u8651\u6c28\u57fa\u9178\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\u53bb\u9884\u6d4b\u52a8\u6001\u6784\u8c61\u3002\u591a\u6784\u8c61\u6a21\u578b\u7cbe\u5ea6\u8bc4\u4f30\u540c\u6837\u9700\u8981\u8003\u8651\u4ee5\u4e0a\u95ee\u9898\uff0c\u4ece\u5e8f\u5217\u8bed\u4e49\u3001\u7269\u7406\u5316\u5b66\u7684\u7b2c\u4e00\u6027\u539f\u7406\u8003\u8651\u53bb\u7814\u7a76\u3002\u6700\u540e\u6211\u60f3\u8c08\u8c08 EMA \u8bc4\u4f30\u7684\u6307\u6807\u4f53\u7cfb\uff0c\u9664\u4e86\u76ee\u524d\u8003\u8651\u7684\u5168\u5c40\u3001\u5c40\u90e8\u3001\u6b8b\u57fa\u4e4b\u5916\uff0c\u5316\u5b66\u8ba1\u91cf\u5b66\u7684\u8bc4\u4f30\u6307\u6807\u4f53\u7cfb\u5efa\u7acb\u4e5f\u5f88\u5fc5\u8981\uff0c\u5728\u7b97\u6cd5\u6392\u5e8f\u4e2d\uff0c\u9009\u62e9 5 \u4e2a\u6a21\u578b\u4e2d\u7684 Best \u6a21\u578b\u53ef\u80fd\u66f4\u52a0\u5408\u9002\uff0c\u56e0\u4e3a\u591a\u6784\u8c61\u3001\u5b9e\u9a8c\u6d4b\u5b9a\u8bef\u5dee\u4ee5\u53ca\u7279\u5b9a\u751f\u7269\u5b66\u573a\u666f\u9700\u6c42\uff0c\u4f7f\u5f97 TOP1 \u6a21\u578b\u7684\u5e76\u4e0d\u662f\u6700\u7406\u60f3\u7684\u9009\u62e9\u3002<\/p>\n<p>\u8fd8\u6709\u4e00\u4e2a\u95ee\u9898\u6211\u4e5f\u60f3\u548c\u5404\u4f4d\u8001\u5e08\u63a2\u8ba8\uff0c\u4ece\u6211\u4eec\u73b0\u5728\u7684 EMA \u89d2\u5ea6\u6765\u770b\uff0c\u63a5\u53e3\u6b8b\u57fa\u7684\u8fa8\u8bc6\u7387\u548c\u7cbe\u5ea6\u4e24\u4e2a\u6307\u6807\u5728 CASP 16 \u91cc\u5b58\u5728\u51b2\u7a81\u3002\u672c\u5c4a CASP 16 \u7ed9\u51fa\u4e86\u8fd9\u4e24\u4e2a\u6307\u6807\uff0c\u4f46\u586b\u5199\u7cbe\u5ea6\u6570\u636e\u65f6\u53ea\u7ed9\u4e86\u4e00\u4e2a\u5730\u65b9\u586b\u5199\uff0c\u73b0\u6709\u7684 PatchQA \u548c PatchDockQ \u662f\u5426\u6709\u8db3\u591f\u7684\u60e9\u7f5a\u4f7f\u5f97\u4e24\u4e2a\u6307\u6807\u4e00\u81f4\uff1f\u5176 Rank \u6743\u91cd\u80fd\u5426\u771f\u6b63\u4f53\u73b0\u7cbe\u5ea6\u5c31\u662f\u63a5\u53e3\u7684\u53ef\u80fd\u6027\u3002\u6700\u8fd1\u6211\u4eec\u91cd\u73b0\u4e86\u4e00\u4e0b\uff0c\u5982\u679c\u4e0d\u592a\u8003\u8651\u7cbe\u5ea6\u7684\u8bdd\uff0c\u63a5\u53e3\u8fa8\u8bc6\u6210\u529f\u7387\u662f\u53ef\u4ee5\u63d0\u5347\u5f88\u591a\u7684\u4f46\u7cbe\u5ea6\u4f1a\u4e0b\u964d\u5f88\u591a\u3002<\/p>\n<p>\u5728\u86cb\u767d\u8d28\u590d\u5408\u7269\u9884\u6d4b\u65b9\u9762\uff0c\u6211\u4eec\u4e13\u95e8\u4ece\u00a0MSA\u00a0\u6539\u8fdb\u65b9\u9762\u5f00\u53d1\u4e86\u4e00\u4e2a Guijunlab-Complex \u670d\u52a1\u5668\uff0c\u4ece\u6a21\u677f\u6539\u8fdb\u65b9\u9762\uff0c\u5f00\u53d1\u4e86\u4e00\u4e2a Guijunlab-DeepAssembly \u670d\u52a1\u5668\u8fdb\u884c\u6d4b\u8bd5\uff0c\u6b64\u5916\u8003\u8651\u5230\u8fdc\u7a0b\u6a21\u677f\u7684\u91cd\u8981\u6027\uff0c\u5f00\u53d1\u4e86\u4e00\u4e2a\u4e3b\u8981\u7528\u4e8e\u5355\u4f53\u9884\u6d4b\u7684 Guijunlab-Pathreader \u670d\u52a1\u5668\u3002\u4ece\u76f2\u6d4b\u6d4b\u8bd5\u6548\u679c\u4e0a\u6765\u770b\uff0c\u57fa\u4e8e MSA \u8be5\u8fdb\u7684\u6027\u80fd\u4f18\u52bf\u8fd8\u662f\u660e\u663e\u7684\uff0c\u8fd9\u8868\u660e\u76ee\u524d AlphaFold2 \u548c AlphaFold3 \u5728\u8fd9\u4e2a\u9886\u57df\u7684\u6210\u529f\u5e94\u7528\uff0cMSA \u7684\u6539\u8fdb\u4ecd\u7136\u662f\u76ee\u524d\u7684\u4e3b\u6d41\u65b9\u5f0f\u3002<\/p>\n<p>\u76ee\u524d\u9700\u8981\u52aa\u529b\u7684\u65b9\u5411\u5728\u4e8e\u5316\u5b66\u8ba1\u91cf\u5b66\u7684\u9884\u6d4b\uff0c\u8fd9\u90e8\u5206\u5de5\u4f5c\u7684\u5f00\u5c55\u9700\u8981\u7efc\u5408\u8003\u8651\u00a0MSA\u3001\u6a21\u677f\u7684\u56e0\u7d20\uff1b\u53e6\u5916\uff0c\u5f31\u7684\u4ea4\u4e92\u4f5c\u7528\u7684\u590d\u5408\u7269\u9884\u6d4b\u4e5f\u662f AI \u65b9\u6cd5\u7684\u6311\u6218\u6027\u95ee\u9898\uff0c\u4e4b\u524d\u6211\u4eec\u4e00\u76f4\u8ba4\u4e3a\u7f20\u7ed5\u86cb\u767d\u5f88\u96be\u9884\u6d4b\uff0c\u4f46 AI \u51fa\u73b0\u540e\u5df2\u7ecf\u6709\u4e86\u4e00\u4e9b\u6210\u529f\u6848\u4f8b\uff08\u7531\u4e8e\u5b58\u5728\u8f83\u5927\u7684\u63a5\u89e6\u9762\u79ef\uff09\uff0c\u4e0e\u6b64\u76f8\u53cd\uff0c\u63a5\u89e6\u9762\u6bd4\u8f83\u5c0f\u7684\u86cb\u767d\u5982\u679c\u91c7\u7528\u4f20\u7edf\u7ec4\u88c5\u65b9\u6cd5\u662f\u76f8\u5bf9\u5bb9\u6613\u5b9e\u73b0\uff0c\u4f20\u7edf\u65b9\u6cd5\u548c AI \u7684\u6574\u5408\uff0c\u53ef\u80fd\u662f\u5e94\u8be5\u6b64\u7c7b\u95ee\u9898\u7684\u4e00\u79cd\u6709\u6548\u65b9\u5f0f\u3002<\/p>\n<p>\u6211\u4e5f\u60f3\u8bf7\u6559\u7a0b\u8001\u5e08\uff0c\u591a\u6784\u8c61\u9884\u6d4b\u65b9\u6cd5\u76ee\u524d\u90fd\u662f\u4ee5\u4e0d\u540c\u7684 MSA \u914d\u5bf9\u3001\u9009\u7528\u4e0d\u7528\u6a21\u677f\u3001\u8c03\u53c2\u751f\u6210\u5927\u91cf\u6a21\u578b\uff0c\u66f4\u4e3a\u7406\u60f3\u65b9\u6cd5\u7684\u5e94\u8be5\u662f\u76f4\u63a5\u57fa\u4e8e\u5355\u5e8f\u5217\u3002\u5982\u679c\u662f\u57fa\u4e8e MSA \u65b9\u5f0f\u8bdd\uff0c\u5728\u4e0d\u540c\u7684\u5316\u5b66\u8ba1\u91cf\u5b66\u4e0b\uff0c\u53ef\u80fd\u5b58\u5728\u7684\u4e0d\u540c\u805a\u5408\u5173\u7cfb\uff0c\u8fd9\u79cd\u805a\u5408\u5173\u7cfb\u4f7f\u6211\u4eec\u5f88\u96be\u53bb\u5b8c\u6574\u9884\u6d4b\u6240\u6709\u7075\u6d3b\u6784\u8c61\u3002<\/p>\n<p>\u9664\u4e86\u521a\u624d\u8bf4\u7684\u8fd9\u4e9b\u95ee\u9898\u4e4b\u5916\uff0c\u8fd8\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u8bbe\u8ba1\u7684\u7b97\u6cd5\u5e94\u8be5\u662f\u4e00\u4e2a\u660e\u786e\u7684\u3001\u6709\u754c\u7684\u6b65\u9aa4\u3002\u76ee\u524d\u5e7f\u6cdb\u91c7\u7528 AlphaFold2\u3001AlphaFold3\uff0c\u867d\u7136\u8003\u8651\u4e86\u7cbe\u5ea6\uff0c\u4f46\u5e76\u6ca1\u6709\u5145\u5206\u5730\u8003\u8651\u65f6\u95f4\u590d\u6742\u5ea6\u548c\u7a7a\u95f4\u590d\u6742\u5ea6\u8fd9\u4e24\u4e2a\u7b97\u6cd5\u6307\u6807\u3002\u4e4b\u540e CASP \u6bd4\u8d5b\u4e2d\u5e94\u8be5\u4f1a\u8003\u8651\u7b97\u6cd5\u7684\u6548\u7387\u95ee\u9898\u3002\u53e6\u5916\u6211\u89c9\u5f97\u76ee\u524d\u591a\u6784\u8c61\u9884\u6d4b\u9886\u57df\u5b58\u5728\u7684\u6311\u6218\u8fd8\u662f\u6570\u636e\u95ee\u9898\uff0c\u73b0\u6709\u7684\u00a0MSA\u3001\u6a21\u677f\u6570\u636e\u662f\u5426\u80fd\u652f\u6491\u63a8\u65ad\u51fa\u52a8\u6001\u4fe1\u606f\uff0c\u6216\u8005\u662f\u5426\u6709\u826f\u597d\u6574\u7406\u7684\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u7684\u6570\u636e\u3002\u73b0\u5728 AI \u751f\u6210\u6a21\u578b\u5b58\u5728\u5e7b\u89c9\uff0c\u4f46\u86cb\u767d\u8d28\u662f\u4e0d\u5141\u8bb8\u5b58\u5728\u5e7b\u89c9\u7684\uff0cPDB \u5e93\u4e2d\u7684\u52a8\u6001\u7ed3\u6784\u3001\u826f\u597d\u7684 MD \u6570\u636e\u5c06\u4f1a\u6709\u6548\u5730\u514b\u670d\u8fd9\u4e00\u95ee\u9898\u3002<\/p>\n<p><strong>\u7a0b\u5efa\u6797\uff1a<\/strong>\u591a\u6784\u8c61\u9884\u6d4b\u73b0\u5728\u6709\u5f88\u591a\u4eba\u5f00\u59cb\u505a\uff0c\u6700\u8fd1\u5fae\u8f6f\u4e5f\u5f00\u53d1\u4e86\u4e00\u4e2a\u8f6f\u4ef6\u9884\u6d4b\u5206\u5b50\u52a8\u529b\u5b66\u7684\u6a21\u62df\u7ed3\u679c\uff0c\u8fd9\u4e2a\u9886\u57df\u975e\u5e38\u91cd\u8981\uff0c\u4f46\u95ee\u9898\u5728\u4e8e\u6ca1\u6709\u8db3\u591f\u7684\u771f\u5b9e\u5b9e\u9a8c\u6570\u636e\u6765\u8bad\u7ec3\u6a21\u578b\u3002<\/p>\n<p>\u7406\u8bba\u4e0a\u6765\u8bf4\u53ef\u4ee5\u7528\u591a\u6784\u8c61\u7684\u5b9e\u9a8c\u6570\u636e\u6765\u5fae\u8c03\u73b0\u6709\u7684\u6a21\u578b\uff0c\u6bd4\u5982\u5fae\u8c03\u00a0 AlphaFold2\u3001AlphaFold3\uff0c\u8ba9\u5176\u4ea7\u751f\u591a\u6784\u8c61\uff0c\u751a\u81f3\u4ece\u5355\u5e8f\u5217\u80fd\u591f\u4ea7\u751f\u591a\u6784\u8c61\u7684\u7ed3\u6784\uff0c\u4f46\u505a\u5b9e\u9a8c\u62ff\u5230\u591a\u6784\u8c61\u7684\u771f\u5b9e\u6570\u636e\u6bd4\u8f83\u56f0\u96be\uff0c\u6211\u4e0d\u77e5\u9053\u73b0\u5728\u86cb\u767d\u8d28\u7ed3\u6784 PDB \u6570\u636e\u5e93\u4e2d\u6709\u591a\u5c11\u8fd9\u6837\u7684\u6570\u636e\u80fd\u652f\u6491\u6211\u4eec\u7684\u8bad\u7ec3\uff0c\u8fd9\u662f\u5236\u7ea6\u9886\u57df\u53d1\u5c55\u7684\u91cd\u8981\u95ee\u9898\u3002<\/p>\n<p>\u8d28\u91cf\u8bc4\u4f30\u548c\u7ed3\u6784\u9884\u6d4b\u653e\u5728\u4e00\u8d77\u8fd8\u662f\u5206\u5f00\u8fd9\u4e2a\u95ee\u9898\u4e5f\u5f88\u91cd\u8981\u3002\u81ea\u6211\u7684\u8d28\u91cf\u8bc4\u4f30\u662f\u6709\u5fc5\u8981\u7684\uff0c\u4f46\u540c\u65f6\u4ece\u7528\u6237\u89d2\u5ea6\u6765\u8bf4\uff0c\u7528\u6237\u9700\u8981\u7528\u4e0d\u540c\u7684\u8f6f\u4ef6\u6765\u4ea7\u751f\u6a21\u578b\uff0c\u7136\u540e\u5f97\u5230\u8d28\u91cf\u7684\u8bc4\u4f30\uff0c\u4ed6\u4eec\u66f4\u9700\u8981\u7684\u662f\u72ec\u7acb\u7684\u3001\u751a\u81f3\u662f\u5355\u6a21\u578b\u7684\u8bc4\u4f30\u65b9\u6cd5\u5e2e\u52a9\u4ed6\u4eec\u9009\u62e9\u6a21\u578b\u3002\u53e6\u5916\u662f\u5171\u8bc6\u548c\u5355\u6a21\u578b\u7684\u8d28\u91cf\u8bc4\u4f30\u65b9\u6cd5\uff0c\u5171\u8bc6\u65b9\u6cd5\u5176\u5b9e\u662f\u5f88\u7b80\u5355\u7684\uff0c\u5c31\u662f\u770b\u6a21\u578b\u4e4b\u95f4\u7684\u76f8\u4f3c\u6027\uff0c\u7136\u540e\u8fdb\u884c\u6392\u5e8f\uff0c\u95ee\u9898\u5728\u4e8e\u5355\u6a21\u578b\u65b9\u6cd5\u8fd8\u6ca1\u6709\u7a81\u7834\u5171\u8bc6\u65b9\u6cd5\uff0c\u8fd9\u662f\u6211\u4eec\u9700\u8981\u505a\u7684\u5de5\u4f5c\u3002<\/p>\n<p><strong>\u5f20\u8d35\u519b\uff1a<\/strong>\u6240\u4ee5\u5e94\u8be5\u9f13\u52b1\u5355\u6a21\u578b\u65b9\u6cd5\uff0c\u800c\u4e0d\u662f\u5171\u8bc6\u57fa\u7ebf\u65b9\u6cd5\uff0c\u8fd9\u6837\u53ef\u80fd\u4f1a\u538b\u5236\u5355\u6a21\u578b\u65b9\u6cd5\u7684\u5f00\u53d1\u3002<\/p>\n<p><strong>\u7a0b\u5efa\u6797\uff1a<\/strong>\u662f\u7684\uff0c\u6211\u4eec\u4e5f\u8bd5\u4e86\u51e0\u79cd\u65b9\u6cd5\uff0c\u5171\u8bc6\u65b9\u6cd5\u3001\u5355\u6a21\u578b\u65b9\u6cd5\u548c\u5171\u8bc6\u3001\u5355\u6a21\u578b\u7684\u7ec4\u5408\u65b9\u6cd5\uff0c\u6700\u540e\u5728 CASP \u7684\u6bd4\u8d5b\u4e2d\u5171\u8bc6\u65b9\u6cd5\u8fd8\u662f\u8d85\u8fc7\u4e86\u5176\u4ed6\u65b9\u6cd5\uff0c\u867d\u7136\u5355\u6a21\u578b\u548c\u5171\u8bc6\u7ed3\u5408\u7684\u65b9\u6cd5\u5728\u6211\u4eec\u81ea\u5df1\u7684\u5b9e\u9a8c\u4e2d\u6bd4\u5171\u8bc6\u65b9\u6cd5\u597d\u3002\u5171\u8bc6\u65b9\u6cd5\u76ee\u524d\u6ca1\u6709\u4ec0\u4e48\u5927\u7684\u7a81\u7834\uff0c\u4f46\u662f\u8bbe\u4e86\u4e00\u4e2a\u5f88\u9ad8\u7684\u754c\u9650\uff0c\u5176\u4ed6\u7684\u65b9\u6cd5\u8fd8\u6ca1\u6709\u7cfb\u7edf\u5730\u8d85\u8fc7\u5b83\uff0c\u5982\u679c\u6709\u4e00\u5929\u5355\u6a21\u578b\u6216\u5c11\u6a21\u578b\u7684\u65b9\u6cd5\u80fd\u8d85\u8fc7\u5171\u8bc6\u65b9\u6cd5\u7684\u8bdd\uff0c\u8fd9\u4e2a\u9886\u57df\u624d\u7b97\u53d6\u5f97\u4e86\u91cd\u8981\u7a81\u7834\u3002<\/p>\n<p><strong>\u5f20\u8d35\u519b\uff1a<\/strong>\u90a3\u73b0\u5728\u81ea\u8bc4\u4f30 AlphaFold2 \u91cc\u5bf9\u4e00\u4e9b\u65e0\u5e8f\u7247\u6bb5\u7684\u8bc4\u4f30\u8d28\u91cf\u5e76\u4e0d\u662f\u592a\u9ad8\uff0c\u662f\u4e0d\u662f\u610f\u5473\u7740\u5b58\u5728\u72ec\u7acb\u4e8e AF \u7684\u7b2c\u4e09\u65b9\u7684\u9884\u6d4b\u548c\u8bc4\u4f30\u65b9\u6cd5\u662f\u975e\u5e38\u6709\u7684\u5fc5\u8981\u7684\u3002<\/p>\n<p><strong>\u7a0b\u5efa\u6797\uff1a<\/strong>\u6211\u89c9\u5f97\u5b8c\u5168\u6709\u5fc5\u8981\uff0c\u73b0\u5728\u81ea\u8bc4\u4f30\u5176\u5b9e\u4e5f\u4e0d\u9519\uff0c\u4f46\u6709\u65f6\u9ad8\u4f30\u4e00\u4e9b\u6a21\u578b\u7684\u8d28\u91cf\uff0c\u6240\u4ee5\u9700\u8981\u72ec\u7acb\u7684\u8d28\u91cf\u8bc4\u4f30\u3002\u9884\u6d4b\u95ee\u9898\u662f\u4ea7\u751f\u7ed3\u6784\u6a21\u578b\uff0c\u800c\u8bc4\u4f30\u662f\u9009\u62e9\u6700\u4f18\u6a21\u578b\uff0c\u8fd9\u662f\u4e24\u4e2a\u4e0d\u4e00\u6837\u7684\u95ee\u9898\uff0c\u90fd\u975e\u5e38\u96be\uff0c\u751a\u81f3\u96be\u5ea6\u53ef\u80fd\u662f\u4e00\u6837\u7684\uff0c\u53ea\u4e0d\u8fc7\u73b0\u5728\u5728\u7ed3\u6784\u4ea7\u751f\u4e0a\u53d6\u5f97\u4e86\u5f88\u5927\u7684\u8fdb\u5c55\uff0c\u800c\u8bc4\u4f30\u8fd8\u9700\u7a81\u7834\uff0c\u4f46\u7a81\u7834\u662f\u53ef\u80fd\u53d1\u751f\u7684\uff0c\u76ee\u524d\u8bc4\u4f30\u7684\u91cd\u8981\u6027\u5df2\u7ecf\u88ab CASP \u63d0\u5230\u4e86\u4e00\u4e2a\u9ad8\u5ea6\u3002<\/p>\n<p><\/p>\n<p style=\"text-align: center\"><span style=\"font-size: 20px\"><strong>RNA \u7ed3\u6784\u9884\u6d4b\u65b0\u8fdb\u5c55<\/strong><\/span><\/p>\n<p><strong>\u5e38\u73ca\uff1a<\/strong>\u6211\u4eec\u8fdb\u5165\u4e0b\u4e00\u4e2a\u8bae\u9898\uff0c\u5728 RNA \u7ed3\u6784\u9884\u6d4b\u3001\u6838\u9178\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u65b9\u9762\uff0c\u9884\u6d4b\u7684\u6570\u91cf\u548c\u96be\u5ea6\u662f\u4e0d\u662f\u90fd\u5728\u63d0\u5347\uff1fAlphaFold3 \u662f\u5426\u6709\u660e\u663e\u4f18\u52bf\uff1f\u8bf7\u90d1\u4f1f\u8001\u5e08\u548c\u6768\u5efa\u76ca\u8001\u5e08\u6765\u4ecb\u7ecd\u4e00\u4e0b\u8fdb\u5c55\u3002<\/p>\n<p><strong>\u90d1\u4f1f\uff1a<\/strong>\u6211\u4eec\u4eca\u5e74\u662f\u7b2c\u4e00\u6b21\u505a RNA \u8d5b\u9053\uff0c\u4eca\u5e74 CASP \u62d4\u9ad8\u4e86 RNA\uff0c\u4e0a\u4e00\u5c4a RNA \u53ea\u6709\u5341\u51e0\u4e2a target\uff0c\u5927\u90e8\u5206\u96c6\u4e2d\u5728 RNA \u5355\u4f53\u4e0a\uff0c\u590d\u6742\u5ea6\u4e5f\u4e0d\u9ad8\uff0c\u53ef\u80fd\u4e00\u4e24\u767e\u4e2a\u78b1\u57fa\u5df2\u7ecf\u7b97\u6bd4\u8f83\u591a\uff0c\u4f46\u8fd9\u5c4a RNA \u6216 DNA \u76f8\u5173\u5171\u6709 60 \u591a\u4e2a\u3002<\/p>\n<p>RNA \u548c\u86cb\u767d\u8d28\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u6709\u70b9\u50cf\uff0c\u4e5f\u5206\u4e3a phase0 \u548c phase1\uff0cphase0 \u4e0d\u544a\u77e5\u51e0\u805a\u4f53\uff0cphase1 \u518d\u544a\u77e5\uff0c\u4eca\u5e74\u6211\u4eec\u731c phase0 \u4e0d\u4f1a\u592a\u5927\uff0c\u4f46\u610f\u5916\u7684\u662f\u5927\u7684 RNA \u590d\u5408\u7269\u6bd4\u6bd4\u7686\u662f\uff0c14 \u4e2a\u6216 8 \u4e2a RNA \u5f62\u6210\u7684\u590d\u6742\u805a\u4f53\u975e\u5e38\u591a\u3002<\/p>\n<p>RNA \u6574\u4e2a\u4f53\u7cfb\u4e5f\u5f88\u5927\uff0c\u6709\u597d\u51e0\u4e2a target \u90fd\u8d85\u8fc7\u4e86 5000 \u4e2a\u6c28\u57fa\u9178\uff0c\u65e0\u8bba\u662f\u901a\u8fc7\u6211\u4eec\u81ea\u5df1\u7684\u65b9\u6cd5\u8fd8\u662f AlphaFold3\uff0c\u90fd\u6bd4\u8f83\u96be\u9884\u6d4b\u3002\u56e0\u4e3a\u5f53\u65f6 AlphaFold3 \u7684 Server \u7684\u6700\u5927\u63d0\u4ea4\u957f\u5ea6\u9608\u503c\u5927\u6982\u8bbe\u5728 5000\uff0c\u5f88\u591a target \u8d85\u8fc7 5000\uff0c\u53c2\u8d5b\u8005\u4e0d\u592a\u597d\u9884\u6d4b\u3002\u4eca\u5e74 RNA \u7ec6\u5206\u8d5b\u9053\u4e5f\u5f88\u591a\uff0c\u53bb\u5e74\u53ea\u6709 RNA \u5355\u4f53\uff0c\u590d\u5408\u7269\u5f88\u5c11\uff0c\u800c\u4e14\u53bb\u5e74\u53ea\u6709\u4e24\u4e2a\u86cb\u767d\u8d28-\u6838\u9178\u590d\u5408\u7269target\uff0c\u4eca\u5e74\u5927\u6982\u5341\u51e0\u4e2a target\u3002<\/p>\n<p>\u6838\u9178\u5c0f\u5206\u5b50\u4e0a\u6b21\u4e5f\u5b8c\u5168\u6ca1\u6709 target\uff0c\u4eca\u5e74\u4e5f\u8bbe\u4e86\u51e0\u4e2a\uff0c\u6574\u4f53\u770b RNA \u8d5b\u9053\u65e0\u8bba\u662f\u96be\u5ea6\u3001\u6570\u91cf\u8fd8\u662f\u7ec6\u5316\u4e0a\u53d8\u5316\u90fd\u5f88\u660e\u663e\u3002\u4e5f\u53ef\u4ee5\u770b\u51fa\u6574\u4e2a\u9886\u57df\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u53d1\u5c55\u5f97\u76f8\u5bf9\u6bd4\u8f83\u6210\u719f\u7684\u60c5\u51b5\u4e0b\uff0c\u5927\u5bb6\u7684\u5173\u6ce8\u70b9\u6e10\u6e10\u8981\u5f80 RNA \u7ed3\u6784\u9884\u6d4b\u4e0a\u4ea7\u751f\u503e\u659c\u4e86\u3002<\/p>\n<p>\u53e6\u5916 AlphaFold3 \u5728\u8fd9\u4e2a\u8d5b\u9053\u4e0a\u6ca1\u6709\u4f18\u52bf\uff0c\u4e0d\u5149\u8fd9\u4e2a\u8d5b\u9053\uff0cAlphaFold3 \u5728\u5404\u4e2a\u8d5b\u9053\u4e0a\u6574\u4f53\u6392\u540d\u5728 6 ~ 10 \u540d\u4e4b\u95f4\uff0c\u6574\u4f53\u7cbe\u5ea6\u6ca1\u90a3\u4e48\u7406\u60f3\uff0c\u6240\u4ee5\u5728\u7ed3\u6784\u9884\u6d4b\u8fd9\u4e2a\u9886\u57df\uff0c\u5373\u4f7f\u5927\u5bb6\u62ff\u5230\u4e86\u76f8\u540c\u7684 AlphaFold3 \u7684 Server\uff0c\u7528\u7684\u8fc7\u7a0b\u4e2d\u7ecf\u9a8c\u4e5f\u5f88\u91cd\u8981\uff0c\u8fd9\u4e5f\u662f\u5927\u5bb6\u6392\u540d\u4e0d\u4e00\u6837\u7684\u539f\u56e0\u3002<\/p>\n<p>\u86cb\u767d\u8d28\u6838\u9178\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u662f\u6211\u4eec\u4eca\u5e74\u6bd4\u8f83\u611f\u5174\u8da3\u7684\u65b9\u5411\uff0c\u5f80\u5c4a\u53d7\u9650\u4e8e\u65b9\u6cd5\uff0c\u5f88\u5c11\u6709\u505a\u86cb\u767d\u6838\u9178\u590d\u5408\u7269\u7684\u65b9\u6cd5\uff0c\u53d1\u5c55\u4e3b\u8981\u5728\u8fd1\u4e24\u5e74\uff0c\u4e4b\u524d\u4e5f\u6709\u4e00\u4e9b\u57fa\u4e8e Docking \u6216\u5176\u4ed6\u7684\u65b9\u6cd5\uff0c\u4f46\u7eaf AI \u5b8c\u5168\u4ece\u5934\u9884\u6d4b\u662f\u4ece David \u00a0Baker\u7684 RosettaFoldNA \u63d0\u51fa\u6765\u4e4b\u540e\u5f00\u59cb\u7684\uff0c\u7136\u540e AlphaFold3 \u628a\u8fd9\u4e2a\u4f53\u7cfb\u53d1\u5c55\u5f97\u76f8\u5bf9\u6765\u8bf4\u6bd4\u8f83\u597d\uff0c\u4f46\u6574\u4f53\u770b\u8fd9\u4e2a\u9886\u57df\u8fd8\u8f83\u96be\uff0c\u4e3b\u8981\u539f\u56e0\u5728\u4e8e\u6709\u6548\u7684\u3001\u80fd\u591f\u7528\u6765\u8bad\u7ec3\u7684\u86cb\u767d\u8d28\u6838\u9178\u590d\u5408\u7269\u6570\u91cf\u4e0d\u592a\u591a\uff0c\u5927\u6982 3 ~ 5 \u5343\u4e2a\uff0c\u8fd9\u662f\u5236\u7ea6\u86cb\u767d\u8d28\u6838\u9178\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u7cbe\u5ea6\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/p>\n<p>\u4eca\u5e74\u5176\u5b9e\u8fd8\u6709\u51e0\u4e2a target \u662f\u6297\u4f53\u86cb\u767d\u52a0\u6838\u9178\u7684\u590d\u5408\u7269\uff0c\u6574\u4f53\u6765\u770b\uff0c\u5927\u5bb6\u9884\u6d4b\u51fa\u7684\u7ed3\u679c\u6bd4\u86cb\u767d\u8d28\u6297\u4f53-\u6297\u539f\u590d\u5408\u7269\u7cbe\u5ea6\u5dee\u5f88\u591a\uff0c\u5c24\u5176\u5728\u6838\u9178\u8fd9\u90e8\u5206\uff0c\u57fa\u672c\u5927\u5bb6\u9884\u6d4b\u7684\u7ed3\u679c\u76f8\u5bf9\u6765\u8bf4\u5f88\u5dee\u3002<\/p>\n<p><strong>\u6768\u5efa\u76ca\uff1a<\/strong>\u6211\u518d\u8865\u5145\u4e00\u4e0b\uff0c\u4e0a\u4e00\u5c4a CASP \u624d\u5f15\u5165 RNA\uff0c\u4f46\u90a3\u65f6\u53ea\u6709 12 \u4e2a RNA\uff0c\u5176\u4e2d 8 \u4e2a\u5929\u7136\uff0c4 \u4e2a\u4eba\u5de5\u8bbe\u8ba1\uff0c\u4eba\u5de5\u8bbe\u8ba1\u6700\u957f\u6709 700 \u591a\u4e2a\u6838\u9178\uff0c\u5929\u7136\u7684RNA\u90fd\u6bd4\u8f83\u77ed\uff0c\u5927\u6982\u5728\u51e0\u5341\u5230\u4e00\u767e\u5de6\u53f3\u3002<\/p>\n<p>\u8fd9\u4e00\u5c4a\u7c7b\u522b\u660e\u663e\u66f4\u591a\uff0c\u5305\u62ec\u590d\u5408\u7269\u3001\u5c0f\u5206\u5b50\uff0c\u751a\u81f3\u6709 RNA \u8ddf\u6c34\u5206\u5b50\u7684\u4e92\u4f5c\uff0c\u6574\u4f53\u4e0a\u9884\u6d4b\u8d77\u6765\u975e\u5e38\u56f0\u96be\uff0c\u5c24\u5176\u662f\u590d\u5408\u7269\u7c7b\u578b\u3002\u6211\u4eec\u8bfe\u9898\u7ec4\u505a\u7684 trRosettaRNA \u4e3b\u8981\u9488\u5bf9 RNA \u5355\u4f53\u800c\u8a00\uff0c\u5f53\u524d\u53ef\u7528 AlphaFold3 \u4e0e RoseTTAFold NA \u9884\u6d4b\u86cb\u767d-RNA \u7ed3\u6784\uff0c\u4f46\u5176\u6027\u80fd\u4f9d\u7136\u4e0d\u7406\u60f3\u3002<\/p>\n<p>\u5c31 RNA \u5355\u4f53\u800c\u8a00\uff0c\u9884\u6d4b\u8ddf\u4e0a\u5c4a\u6bd4\u4e0d\u89c1\u5f97\u66f4\u96be\uff0c\u4e0a\u5c4a\u96be\u5728\u4eba\u5de5\u8bbe\u8ba1\uff0c\u8fd9\u90e8\u5206\u65e0\u8bba AI \u8fd8\u662f\u4f20\u7edf\u7269\u7406\u65b9\u6cd5\u90fd\u505a\u4e0d\u597d\u81ea\u52a8\u9884\u6d4b\uff0c\u4f46\u4e0a\u4e00\u5c4a\u6bd4\u8d5b\u4e2d\u718a\u9e4f\u56e2\u961f\u628a\u4eba\u5de5\u8bbe\u8ba1\u7684 RNA \u505a\u7684\u5f88\u597d\u3002\u8fd9\u5c4a RNA \u7684\u7cbe\u5ea6\u4e0d\u6bd4\u4e0a\u6b21\u4f4e\uff0c\u6211\u4eec\u81ea\u5df1\u65b9\u6cd5\u7684\u5728 RNA \u5355\u4f53\u7684\u5e73\u5747 RMSD \u5927\u6982 15 \u57c3\uff0c\u4e0a\u4e00\u5c4a\u662f 20 \u57c3\u4ee5\u4e0a\uff0c\u4e3b\u8981\u662f\u4eba\u5de5\u8bbe\u8ba1\u7684 RNA \u505a\u5f97\u4e0d\u597d\uff0cRMSD \u90fd\u662f\u4e09\u56db\u5341\u57c3\u5de6\u53f3\u3002<\/p>\n<p>CASP16 \u7684 RNA \u901a\u8fc7 AI \u9884\u6d4b\u7684\u7cbe\u5ea6\u8fd8\u662f\u53ef\u63a5\u53d7\u7684\uff0c\u4f46\u8fd8\u6ca1\u90a3\u4e48\u7cbe\u51c6\uff0c\u4eba\u5de5\u7ecf\u9a8c\u8fd8\u662f\u6bd4\u8f83\u91cd\u8981\uff0c\u8fd9\u65b9\u9762\u548c\u86cb\u767d\u533a\u522b\u7279\u522b\u5927\uff0c\u5728\u86cb\u767d\u7ed3\u6784\u9884\u6d4b\u4e2d\uff0c\u4eba\u5de5\u5e72\u9884\u4e0d\u4e00\u5b9a\u6709\u7279\u522b\u5927\u5e2e\u52a9\uff0c\u4f46 RNA \u4e2d\u4eba\u5de5\u5e72\u9884\u633a\u5173\u952e\u7684\uff0c\u6392\u540d\u524d\u4e09\u7684\u56e2\u961f\u90fd\u662f\u4eba\u5de5\u5e72\u9884\u505a\u4e86\u5f88\u591a\u4fee\u6b63\uff0c\u5305\u62ec\u4eba\u5de5\u6784\u5efa\u4e8c\u7ea7\u7ed3\u6784\u3001\u6a21\u62df\u4ea7\u751f\u6570\u636e\u540e\u4eba\u5de5\u7b5b\u9009\u3001\u57fa\u4e8e MSA \u8c03\u6574\u7ed3\u6784\u7b49\uff0c\u8fc7\u7a0b\u975e\u5e38\u7e41\u7410\uff0cAI \u5f88\u96be\u628a\u6240\u6709\u65b9\u9762\u90fd\u8003\u8651\u5230\u3002<\/p>\n<p>\u81ea\u52a8\u9884\u6d4b\u597d\u5904\u5728\u4e8e\u4f1a\u6709\u8bb8\u591a\u4eba\u53d7\u76ca\uff0c\u6211\u4eec\u63d0\u4f9b\u4e86 trRosettaRNA \u670d\u52a1\u5668\uff0c\u5f53\u7528\u6237\u8f93\u5165\u7684\u5e8f\u5217\u5728\u8bad\u7ec3\u96c6\u4e2d\u5b58\u5728\u76f8\u4f3c\u6570\u636e\u65f6\uff0c\u81ea\u52a8\u9884\u6d4b\u7684\u7ed3\u6784\u5927\u6982\u7387\u4f1a\u6bd4\u8f83\u51c6\u786e\u3002\u81ea\u52a8\u9884\u6d4b\u7684\u4f18\u70b9\u5728\u4e8e\u53ef\u4ee5\u670d\u52a1\u66f4\u591a\u7528\u6237\uff0c\u6211\u4eec\u670d\u52a1\u5668\u6bcf\u5929\u90fd\u4f1a\u6536\u5230\u4e0d\u5c11\u65b0\u4efb\u52a1\u3002<\/p>\n<p>\u81ea\u52a8\u9884\u6d4b\u662f\u672a\u6765\u53d1\u5c55\u65b9\u5411\uff0c\u867d\u7136\u73b0\u5728 AlphaFold3 \u4f18\u52bf\u4e0d\u660e\u663e\uff0c\u4f46\u540e\u9762\u5e94\u8be5\u4f1a\u8d8a\u6765\u8d8a\u597d\uff0c\u5b83\u7cbe\u5ea6\u4e0d\u9ad8\u7684\u539f\u56e0\u8fd8\u662f\u5df2\u6709\u5b9e\u9a8c\u6570\u636e\u6709\u9650\uff0c\u521a\u624d\u90d1\u4f1f\u63d0\u5230\u5927\u6982\u6709\u51e0\u5343\u4e2a\u6570\u636e\uff0c\u4f46\u8fd9\u4e9b\u6570\u636e\u5f88\u591a\u90fd\u6765\u81ea\u540c\u4e00\u7c7b RNA \u6216\u590d\u5408\u7269\uff0c\u5176\u4e2d\u7279\u522b\u591a tRNA\uff0c\u6211\u4eec\u670d\u52a1\u5668\u4e5f\u7ecf\u5e38\u6536\u5230\u8fd9\u7c7b\u5e8f\u5217\uff0c\u9884\u6d4b\u7ed3\u6784\u90fd\u633a\u53ef\u9760\uff0c\u4f46\u6bd4\u8f83\u65b0\u7684 RNA \u505a\u5f97\u5e76\u4e0d\u597d\u3002\u86cb\u767d\u7ed3\u6784\u9884\u6d4b\u516d\u4e03\u5341\u5e74\u79ef\u7d2f\u4e0b\u6765\u6570\u636e\u5e93\u5f88\u5927\uff0c\u6709 20 \u591a\u4e07\u4e2a\u7ed3\u6784\u4f9b AI \u5b66\u4e60\uff0c\u4f46 RNA \u6570\u636e\u8fd8\u592a\u5c11\uff0c\u975e\u5197\u4f59\u7684\u6570\u636e\u5c31\u51e0\u767e\u4e2a\uff0c\u5b66\u4e0d\u597d\u53ef\u4ee5\u7406\u89e3\u3002<\/p>\n<p>\u4e0a\u5c4a\u6bd4\u8d5b\u524d\u51e0\u540d\u90fd\u6ca1\u6709\u7528\u5230 AI \u9884\u6d4b\uff0c\u4f46\u8fd9\u5c4a\u524d\u51e0\u540d\u90fd\u7528 AlphaFold3 \u6216 trRosettaRNA \u8f85\u52a9\u7b5b\u9009\u6216\u6a21\u62df\uff0cAI \u7684\u4ef7\u503c\u5c06\u4f1a\u8d8a\u6765\u8d8a\u5927\u3002\u6211\u76f8\u4fe1 RNA \u6570\u636e\u79ef\u7d2f\u662f\u4e2a\u8fc7\u7a0b\uff0c\u86cb\u767d\u7ed3\u6784\u9884\u6d4b\u65e9\u671f\u5176\u5b9e\u7ed3\u6784\u4e5f\u4e0d\u51c6\u786e\uff0c\u73b0\u5728\u7684\u8fdb\u6b65\u901f\u5ea6\u5e94\u8be5\u6bd4\u4e4b\u524d\u8981\u5feb\uff0c\u4e0b\u4e00\u5c4a\u5e94\u8be5\u4f1a\u6709\u66f4\u591a\u7684 RNA \u53c2\u8d5b\u56e2\u961f\uff0c\u7ed3\u6784\u9884\u6d4b\u7cbe\u5ea6\u5e94\u8be5\u4f1a\u8d8a\u6765\u8d8a\u9ad8\u3002<\/p>\n<p><strong>\u5e38\u73ca\uff1a<\/strong>\u81ea\u52a8\u5316\u7684 RNA \u7ed3\u6784\u9884\u6d4b\u975e\u5e38\u91cd\u8981\uff0c\u5728 AlphaFold3 \u7684\u6587\u7ae0\u91cc\uff0c\u5176\u5b9e\u5728 CASP15 \u6bd4\u8f83 RNA \u7ed3\u6784\u9884\u6d4b\u7684\u65f6\u5019\uff0c\u7ed3\u679c\u5176\u5b9e\u5dee\u8ddd\u4e0d\u5927\uff0c\u4eba\u5de5\u7ec4\u8fd8\u66f4\u5360\u4f18\u4e00\u4e9b\uff0c\u5728\u5c0f\u5206\u5b50\u9884\u6d4b\u65b9\u9762\u5219\u663e\u793a\u51fa\u6709\u6bd4\u8f83\u5927\u7684\u63d0\u5347\uff0c\u5c31\u50cf\u7a0b\u5efa\u6797\u8001\u5e08\u8bf4\u7684\uff0c\u786e\u5b9e\u8fd9\u4e00\u5c4a\u7684\u8bc4\u4f30\u4e5f\u5c55\u793a\u4e86\u914d\u4f53\u9884\u6d4b\u4e2d AlphaFold3 \u4f5c\u4e3a Baseline \u7684\u7ed3\u679c\uff0c\u4eba\u5de5\u7ec4\u6ca1\u6709\u8d85\u8fc7 AlphaFold3\uff0c\u8fd9\u4e5f\u662f\u6709\u6311\u6218\u7684\u95ee\u9898\uff0c\u8bf7\u5b54\u97e7\u8001\u5e08\u548c\u7a0b\u5efa\u6797\u8001\u5e08\u7b80\u5355\u4ecb\u7ecd\u4e00\u4e0b\u3002<\/p>\n<p><strong>\u5b54\u97e7\uff1a<\/strong>\u4e0a\u4e00\u5c4a\u6bd4\u8d5b\u4e2d\u66f4\u591a\u662f\u4e00\u4e2a\u86cb\u767d\u7ed3\u5408\u4e00\u4e2a\u5c0f\u5206\u5b50\uff0c\u6216\u8005\u4e00\u4e2a\u86cb\u767d\u540c\u65f6\u7ed3\u5408\u591a\u4e2a\u5c0f\u5206\u5b50\uff0c\u8fd9\u6837\u7684\u95ee\u9898\u66f4\u50cf\u662f\u8fd9\u4e2a\u751f\u7269\u4f53\u7cfb\u4e2d\u86cb\u767d\u8d28\u8ddf\u8f85\u56e0\u5b50\u7ed3\u5408\u7684\u9884\u6d4b\u95ee\u9898\uff0c\u6211\u4eec\u6bd4\u8d5b\u7ed3\u679c\u975e\u5e38\u597d\uff0c\u56e0\u4e3a\u7528\u7684\u662f\u00a0template based docking\u7684\u65b9\u6cd5\uff0c\u90a3\u65f6 AlphaFold \u8fd8\u4e0d\u80fd\u9884\u6d4b\u86cb\u767d\u5c0f\u5206\u5b50\u4f53\u7cfb\uff0c\u5728\u8fd9\u79cd\u86cb\u767d\u4e0e\u8f85\u56e0\u5b50\u7ed3\u5408\u7684\u95ee\u9898\u4e2d\uff0c\u6709\u5f88\u591a\u9ad8\u5ea6\u7c7b\u4f3c template \u80fd\u88ab\u627e\u5230\u3002<\/p>\n<p>\u8fd9\u5c4a\u6bd4\u8d5b\u5176\u5b9e\u5f15\u5165\u4e86\u66f4\u52a0\u73b0\u5b9e\u7684\u95ee\u9898\uff0c\u5c31\u662f\u4e00\u4e2a\u86cb\u767d\u4f5c\u4e3a\u4e00\u4e2a\u836f\u7269\u9776\u70b9\uff0c\u6211\u4eec\u901a\u5e38\u5728\u836f\u7269\u53d1\u73b0\u7684\u8fc7\u7a0b\u4e2d\u9700\u8981\u53bb\u8bc4\u4f30\u5b83\u8ddf\u591a\u4e2a\u4e0d\u540c\u5316\u5b66\u7ed3\u6784\u5c0f\u5206\u5b50\u7ed3\u5408\u7684\u6a21\u5f0f\u95ee\u9898\uff0c\u4ee5\u53ca\u7ed3\u5408\u7684\u5f3a\u5ea6\u95ee\u9898\u3002\u8fd9\u5176\u5b9e\u66f4\u63a5\u8fd1\u4e8e\u6211\u4eec\u5728\u5c0f\u5206\u5b50\u5f00\u53d1\u4e2d\u4f1a\u78b0\u5230\u7684\u95ee\u9898\uff0c\u8fd9\u6b21 AlphaFold3 \u6ca1\u6709\u4f5c\u4e3a\u53c2\u8d5b\u8005\u53c2\u8d5b\uff0c\u4f46\u5728\u8bc4\u4f30\u5b9e\u9a8c\u4e2d\u8868\u73b0\u975e\u5e38\u4e0d\u9519\u3002<\/p>\n<p>\u8fd9\u6b21\u4e00\u5171\u6709 L1000 \u5230 L4000 \u56db\u4e2a target\uff0c\u5206\u522b\u662f\u56db\u4e2a\u836f\u9776\u5bf9\u5e94\u51e0\u5341\u4e2a\u5230\u4e0a\u767e\u4e2a\u5c0f\u5206\u5b50\uff0cAlphaFold3 \u5728 L3000 \u4e2d\u8868\u73b0\u8d85\u8fc7\u6240\u6709\u53c2\u8d5b\u7ec4\uff0c\u5728 L4000 \u4e0a\u8868\u73b0\u6ca1\u90a3\u4e48\u597d\uff0c\u5728 L2000 \u548c L1000 \u8fd9\u4e24\u4e2a\u540c\u6e90\u86cb\u767d\u4e2d\uff0c\u5b83\u5728 L2000 \u4e0a\u7684\u8868\u73b0\u7a0d\u5fae\u597d\u4e00\u70b9\u3002\u6574\u4f53\u6765\u770b\uff0cAlphaFold3 \u5df2\u7ecf\u8868\u73b0\u51fa\u4f18\u52bf\uff0c\u5728\u67d0\u4e9b\u9776\u70b9\u4e0a\u6bd4\u4f20\u7edf\u5bf9\u63a5\u65b9\u6cd5\u8981\u5f3a\uff0c\u5c06\u6765\u6211\u4eec\u771f\u6b63\u505a\u836f\u7269\u7814\u53d1\u65f6\uff0c\u53ef\u4ee5\u628a\u4f20\u7edf\u7684\u5bf9\u63a5\u65b9\u6cd5\u548c AlphaFold \u7684\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u7ed3\u5408\u8d77\u6765\u505a\u7efc\u5408\u8003\u8651\u548c\u4f7f\u7528\uff0c\u4ea7\u751f\u66f4\u591a\u6709\u53ef\u80fd\u6b63\u786e\u7684\u00a0pose\u3002<\/p>\n<p>\u800c\u8fd9\u53c8\u5e26\u6765\u8fd9\u4e48\u591a\u6b63\u786e pose \u5982\u4f55\u6311\u9009\u7684\u65b0\u95ee\u9898\uff0c\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u4e2d\u4e5f\u4f1a\u78b0\u5230\u7c7b\u4f3c\u95ee\u9898\uff0c\u901a\u5e38\u5982\u679c\u7528 template base \u65b9\u6cd5\u5f88\u7b80\u5355\uff0c\u5c31\u662f\u5982\u679c\u80fd\u591f\u5728 PDB \u5e93\u4e2d\u627e\u5230\u7c7b\u4f3c\u7684\u5c0f\u5206\u5b50\u3001\u5316\u5b66\u00a0atom type\uff0c\u6216\u8005\u7c7b\u4f3c\u7684\u5468\u56f4\u7684\u00a0residue type\u00a0\u7684\u8bdd\uff0c\u6839\u636e\u76f8\u4f3c\u6027\u6253\u5206\u53bb\u8bc4\u4f30\uff0c\u7c7b\u4f3c\u5ea6\u8f83\u9ad8\u7684 pose \u6b63\u786e\u7684\u53ef\u80fd\u6027\u8f83\u5927\u3002<\/p>\n<p>\u6b63\u786e\u7ed3\u6784\u6311\u51fa\u4e4b\u540e\uff0c\u5176\u5b9e\u6bd4\u8d5b\u4e5f\u5206\u4e86\u4e24\u4e2a\u9636\u6bb5\uff0c\u7b2c\u4e00\u9636\u6bb5\u662f\u9884\u6d4b\u5c0f\u5206\u5b50\u7684\u7ed3\u5408\u6a21\u5f0f\u4ee5\u53ca\u7ed3\u5408\u4eb2\u548c\u529b\uff0c\u7b2c\u4e8c\u9636\u6bb5\u662f\u544a\u77e5\u5168\u90e8\u6676\u4f53\u7ed3\u6784\u548c\u7ed3\u5408\u6a21\u5f0f\uff0c\u76f4\u63a5\u9884\u6d4b\u4eb2\u548c\u529b\u5c31\u884c\u3002\u4f46\u76ee\u524d\u8fd8\u6ca1\u6709\u7279\u522b\u597d\u7684\u65b9\u6cd5\u80fd\u8bc4\u4f30\u5c0f\u5206\u5b50\uff0c\u6216\u8005\u591a\u4e2a\u5c0f\u5206\u5b50\u5bf9\u540c\u4e00\u9776\u70b9\u7684\u7ed3\u5408\u4eb2\u548c\u529b\uff0c\u5c06\u6765\u6211\u4eec\u4e5f\u60f3\u5f80\u8fd9\u4e2a\u65b9\u5411\u505a\u3002<\/p>\n<p><strong>\u7a0b\u5efa\u6797\uff1a<\/strong>\u5b54\u8001\u5e08\u63d0\u5230 AlphaFold3 \u73b0\u5728\u53ef\u80fd\u8d85\u8fc7\u4e86\u5176\u4ed6\u65b9\u6cd5\uff0c\u4f46\u5176\u5b9e\u8fd8\u662f\u6709\u5f88\u591a\u5730\u65b9\u53ef\u4ee5\u63d0\u9ad8\uff0c\u6bd4\u5982\u600e\u4e48\u7528\u6a21\u677f\u3001\u600e\u4e48\u9009\u62e9\u6a21\u578b\u4e4b\u7c7b\u7684\uff0c\u540c\u65f6\u4e5f\u4f1a\u6709\u5176\u4ed6\u7ade\u4e89\u65b9\u6cd5\u51fa\u73b0\uff0c\u6700\u8fd1\u6709\u65b9\u6cd5\u81ea\u79f0\u8d85\u8fc7\u4e86 AlphaFold3\uff0c\u4f46\u4e5f\u8fd8\u9700\u8981\u5ba2\u89c2\u8bc4\u4f30\uff0c\u53e6\u5916\u8fd9\u4e9b\u65b9\u6cd5\u5404\u6709\u6240\u957f\uff0c\u6709\u6ca1\u6709\u53ef\u80fd\u7ed3\u5408\u5728\u4e00\u8d77\u5f97\u5230\u66f4\u597d\u7684\u65b9\u6cd5\u4e5f\u662f\u53ef\u4ee5\u7814\u7a76\u7684\u95ee\u9898\u3002<\/p>\n<p>\u53e6\u5916\u6211\u7684\u5b66\u751f\u5728\u8bc4\u4f30\u4e3b\u8981\u7684\u86cb\u767d\u8d28\u5c0f\u5206\u5b50\u590d\u5408\u4f53\u9884\u6d4b\u7684\u65b9\u6cd5\u65f6\uff0c\u53d1\u73b0\u4e86\u4e00\u4e2a\u95ee\u9898\u662f\u5f88\u591a\u65b9\u6cd5\u5728\u8bad\u7ec3\u4e4b\u540e\u7684\u6d4b\u8bd5\u8fc7\u7a0b\u4e2d\uff0c\u5982\u679c\u5c0f\u5206\u5b50\u8ddf\u4ee5\u524d\u8bad\u7ec3\u6570\u636e\u4e2d\u6709\u4e00\u5b9a\u76f8\u4f3c\u6027\u7684\u8bdd\uff0c\u53ef\u80fd\u6548\u679c\u6bd4\u8f83\u597d\uff0c\u5982\u679c\u4e0d\u4e00\u6837\uff0c\u6027\u80fd\u5c31\u4e0d\u53ef\u9884\u6d4b\uff0c\u90a3\u4e48\u8981\u600e\u6837\u63d0\u9ad8\u8fd9\u4e9b\u4eba\u5de5\u667a\u80fd\u65b9\u6cd5\u7684\u901a\u7528\u6027\uff0c\u8fd9\u662f\u4e00\u4e2a\u9700\u8981\u89e3\u51b3\u7684\u95ee\u9898\u3002<\/p>\n<p>\u86cb\u767d\u8d28\u5c0f\u5206\u5b50\u7ed3\u5408\u4eb2\u548c\u529b\u7684\u9884\u6d4b\u5bf9\u7b5b\u9009\u836f\u7269\u800c\u8a00\u4e5f\u975e\u5e38\u91cd\u8981\uff0c\u63d0\u4f9b\u4e00\u4e2a\u836f\u7269\u9776\u70b9\uff0c\u600e\u6837\u7b5b\u9009\u5404\u79cd\u548c\u86cb\u767d\u53ef\u80fd\u6709\u76f8\u4e92\u4f5c\u7528\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u54ea\u6015\u4e0d\u80fd\u9884\u6d4b\u7ed3\u6784\uff0c\u53ea\u8981\u77e5\u9053\u4eb2\u548c\u529b\u4e5f\u591f\u4e86\u3002\u4f46\u8fd9\u4e2a\u9886\u57df\u8fd8\u5904\u4e8e\u975e\u5e38\u521d\u7ea7\u7684\u9636\u6bb5\uff0c\u5176\u5b9e\u8ddf\u6392\u5e8f\u3001\u8d28\u91cf\u8bc4\u4f30\u90fd\u662f\u76f8\u5173\u7684\uff0c\u662f\u4e2a\u975e\u5e38\u56f0\u96be\u7684\u95ee\u9898\uff0c\u5c31\u50cf\u5728\u6240\u4ea7\u751f\u7684\u4e0a\u4e07\u4e2a\u6a21\u578b\u4e2d\u968f\u673a\u6311\u9009\u6700\u4f18\uff0c\u8fd9\u6837\u6982\u7387\u4f1a\u975e\u5e38\u4f4e\u3002<\/p>\n<p><\/p>\n<p style=\"text-align: center\"><span style=\"font-size: 20px\"><strong>\u7ed3\u6784\u9884\u6d4b\u7684\u84dd\u6d77\u65b9\u5411<\/strong><\/span><\/p>\n<p><strong>\u5b54\u97e7\uff1a<\/strong>\u6211\u7684\u9886\u57df\u5c5e\u4e8e CADD\uff08\u836f\u7269\u8f85\u52a9\u8bbe\u8ba1\uff09\uff0c\u540e\u6765\u56e0\u4e3a CASP \u6709\u4e86\u5c0f\u5206\u5b50\u8d5b\u9053\uff0c\u6211\u624d\u66f4\u591a\u53c2\u4e0e\u5230 CASP \u7684\u5c0f\u5206\u5b50\u7ed3\u6784\u9884\u6d4b\u4e2d\u3002CADD \u9886\u57df\u4e5f\u6709\u5f88\u591a\u4f20\u7edf\u00a0 docking\u3001binding affinity \u4ee5\u53ca\u7ed3\u5408\u81ea\u7531\u8ba1\u7b97\u65b9\u5411\u7684\u4e13\u5bb6\u548c\u56e2\u961f\uff0c\u5927\u5bb6\u53ef\u4ee5\u66f4\u591a\u53c2\u4e0e\u5230 CASP \u6bd4\u8d5b\u4e2d\uff0c\u56e0\u4e3a CASP \u7684\u6570\u636e\u96c6\u516c\u5e03\u4e86\u7ed3\u6784\u3001\u4eb2\u548c\u529b\uff0c\u53ef\u4ee5\u7528\u5176\u6570\u636e\u96c6\u6d4b\u8bd5\u81ea\u5df1\u516c\u53f8\u3001\u8bfe\u9898\u7ec4\u7684 pipeline \u662f\u4e0d\u662f\u80fd\u5f88\u597d\u5730\u9884\u6d4b\u00a0binding affinity\uff0c\u6211\u975e\u5e38\u60f3\u770b\u5230\u8fd9\u4e2a\u65b9\u5411\u6709\u6ca1\u6709\u6bd4\u8f83\u597d\u7684\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n<p><strong>\u5e38\u73ca\uff1a<\/strong>\u5b54\u8001\u5e08\u7684\u89c2\u70b9\u6b63\u597d\u548c\u4e0b\u4e2a\u95ee\u9898\u76f8\u5173\uff0c\u5c31\u662f CASP \u8bc4\u4f30\u8d5b\u5bf9\u4ea7\u4e1a\u7684\u5b9e\u9645\u5e94\u7528\uff0c\u6bd4\u5982\u5bf9\u5408\u6210\u751f\u7269\u4ea7\u4e1a\u6216\u751f\u7269\u533b\u836f\u7684\u4ea7\u4e1a\u5f71\u54cd\u662f\u4ec0\u4e48\uff1f\u53ef\u4ee5\u8bf7\u5f20\u8d35\u519b\u8001\u5e08\u548c\u5b54\u8001\u5e08\u518d\u7ed9\u6211\u4eec\u5206\u4eab\u4e00\u4e0b\u3002<\/p>\n<p><strong>\u5f20\u8d35\u519b\uff1a<\/strong>\u53ea\u8981\u8ddf\u751f\u7269\u6709\u5173\u7684\u90fd\u548c\u7ed3\u6784\u5bc6\u4e0d\u53ef\u5206\uff0c\u8fd9\u51e0\u5e74\u6765\u533b\u5b66\u3001\u836f\u5b66\u3001\u519c\u5b66\u9886\u57df\u7684\u4e13\u5bb6\u5bf9\u7ed3\u6784\u90fd\u975e\u5e38\u5173\u6ce8\uff0c\u56e0\u4e3a\u5b83\u80fd\u63ed\u793a\u91cd\u8981\u7684\u751f\u7269\u5b66\u529f\u80fd\u673a\u5236\u3002<\/p>\n<p>\u5bf9\u4e8e\u836f\u5b66\u800c\u8a00\uff0c\u836f\u7269\u9776\u6807\u53d1\u73b0\u662f\u6bd4\u8f83\u91cd\u8981\u7684\u5e94\u7528\uff0c\u968f\u7740\u76ee\u524d\u7126\u70b9\u4ece\u7684\u9759\u6001\u6784\u8c61\u8f6c\u5411\u591a\u6784\u8c61\u7814\u7a76\uff0c\u90a3\u4e48\u591a\u6784\u8c61\u4e4b\u4e2d\u7684\u67d0\u4e00\u4e2a\u53ef\u80fd\u662f\u6f5c\u5728\u7684\u9776\u70b9\u3002\u533b\u5b66\u4e0a\u6297\u4f53\u7684\u8fdb\u5c55\u4e5f\u975e\u5e38\u8fc5\u731b\uff0c\u8fd9\u610f\u5473\u7740\u5728\u75ab\u82d7\u7684\u8bbe\u8ba1\u4e2d\uff0c\u5305\u62ec\u68c0\u6d4b\u3001\u8bca\u65ad\u3001\u6297\u4f53\u6cbb\u7597\u4e0a\uff0c\u90fd\u6709\u5f88\u591a\u4e1c\u897f\u80fd\u63a2\u7d22\u3002<\/p>\n<p>\u5408\u6210\u751f\u7269\u5b66\u65b9\u9762\uff0c\u7ed3\u6784\u7684\u7814\u7a76\u76f4\u63a5\u5f15\u8d77\u4e86\u4ea7\u4e1a\u7684\u98de\u901f\u53d1\u5c55\uff0c\u5305\u62ec\u5728\u53ef\u964d\u89e3\u6750\u6599\u3001\u7eff\u8272\u5236\u9020\u7b49\u9886\u57df\uff0c\u5c06\u6210\u4e3a\u6709\u6548\u5e94\u5bf9\u5168\u7403\u53d8\u6696\u95ee\u9898\u7684\u6709\u6548\u624b\u6bb5\u3002\u4eca\u5e74\u90fd\u5feb\u653e\u5bd2\u5047\u4e86\uff0c\u4f46\u662f\u676d\u5dde\u5929\u6c14\u8fd8\u6ca1\u6709\u53bb\u5e74\u90a3\u4e48\u51b7\uff0c\u73af\u4fdd\u95ee\u9898\u662f\u4e8b\u5173\u4eba\u7c7b\u751f\u5b58\u7684\u91cd\u5927\u6311\u6218\u6027\u95ee\u9898\u3002<\/p>\n<p><strong>\u5b54\u97e7\uff1a<\/strong>\u7ed3\u6784\u5bf9\u751f\u547d\u79d1\u5b66\u76f8\u5173\u4ea7\u4e1a\u90fd\u4f1a\u5e26\u6765\u4e00\u5b9a\u5f71\u54cd\uff0c\u73b0\u5728\u53ea\u662f\u5f00\u59cb\uff0c\u968f\u7740\u5de5\u5177\u5e94\u7528\u53d8\u5e7f\uff0c\u5e94\u7528\u5728\u5177\u4f53\u95ee\u9898\u4e0a\u53d8\u591a\uff0c\u5f71\u54cd\u4f1a\u66f4\u6df1\u523b\u3002<\/p>\n<p>\u6211\u4eec\u4e4b\u524d\u8ddf\u505a\u57fa\u7840\u533b\u5b66\u7684\u8001\u5e08\u6709\u5408\u4f5c\u4ea4\u6d41\uff0c\u4ed6\u4eec\u5728\u89e3\u91ca\u5f88\u591a\u86cb\u767d\u529f\u80fd\u91cd\u8981\u6027\u95ee\u9898\u65f6\uff0c\u901a\u5e38\u4f1a\u7528 coIP \u6216\u8005 WB \u6765\u505a\uff0c\u770b\u4e24\u4e2a\u86cb\u767d\u662f\u5426\u7ed3\u5408\u3001\u8c01\u8ddf\u8c01\u7ed3\u5408\uff0c\u6211\u4eec\u5efa\u8bae\u53ef\u4ee5\u7528\u7ed3\u6784\u9884\u6d4b\u7684\u65b9\u6cd5\u4ece\u4e09\u7ef4\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u89d2\u5ea6\uff0c\u770b\u86cb\u767d\u8d28\u7ed3\u6784\u8ddf\u529f\u80fd\u95f4\u7684\u5173\u7cfb\u3001\u7ed3\u6784\uff0c\u4ee5\u53ca\u5982\u4f55\u7ed3\u5408\u53e6\u4e00\u4e2a\u86cb\u767d\uff0c\u54ea\u4e2a\u7ed3\u6784\u53d1\u6325\u4e86\u4f5c\u7528\uff0c\u54ea\u4e2a\u754c\u9762\u6b8b\u57fa\u91cd\u8981\uff0c\u7528\u8fd9\u4e9b\u4fe1\u606f\u5e2e\u52a9\u4ed6\u4eec\u505a\u4e0b\u4e00\u6b65\u5b9e\u9a8c\u8bbe\u8ba1\u3002\u5982\u679c\u8fd9\u6837\u7684\u7ed3\u5408\u5bf9\u7ec6\u80de\u8868\u578b\u3001\u75be\u75c5\u8868\u578b\u6709\u91cd\u8981\u5f71\u54cd\u7684\u8bdd\uff0c\u8fd8\u53ef\u4ee5\u6d89\u53ca\u591a\u80bd\u3001\u86cb\u767d\u3001\u6297\u4f53\u3001\u5c0f\u5206\u5b50\u53bb\u5f71\u54cd\u8fd9\u4e2a\u8fc7\u7a0b\uff0c\u6700\u7ec8\u5173\u8054\u5230\u836f\u7269\u7814\u53d1\u4e0a\u3002<\/p>\n<p>\u5408\u6210\u751f\u7269\u5b66\u9886\u57df\u73b0\u5728\u4e5f\u975e\u5e38\u70ed\uff0c\u5f53\u4e2d\u5c31\u662f\u7528\u7ec6\u80de\u5de5\u5382\u6765\u5408\u6210\u60f3\u8981\u7684\u4e1c\u897f\uff0c\u7ec6\u80de\u5de5\u5382\u91cc\u5177\u4f53\u7684\u6267\u884c\u8005\u662f\u86cb\u767d\u8d28\u3001\u4ee3\u8c22\u7f51\u7edc\u3001\u4ee3\u8c22\u9176\uff0c\u5176\u4e2d\u9650\u901f\u9176\u662f\u8c01\uff1f\u9650\u901f\u9176\u662f\u5982\u4f55\u9650\u901f\u7684\uff1f\u600e\u6837\u6539\u8fdb\u9650\u901f\u9176\u7684\u50ac\u5316\u6548\u7387\uff1f\u9650\u901f\u9176\u8ddf\u5b83\u7684\u4ea7\u7269\u5982\u4f55\u7ed3\u5408\uff1f\u5982\u679c\u80fd\u77e5\u9053\u5e95\u7269\u7ed3\u5408\u4e0e\u4ea7\u7269\u91ca\u653e\u7684\u52a8\u6001\u8fc7\u7a0b\uff0c\u5c31\u53ef\u4ee5\u627e\u51fa\u5176\u4e2d\u7684\u5173\u952e\u6b8b\u57fa\uff0c\u5bf9\u9176\u6539\u9020\u8fdb\u884c\u5408\u7406\u8bbe\u8ba1\uff0c\u8fd9\u4e5f\u662f\u53ef\u4ee5\u60f3\u8c61\u7684\u65b9\u5411\u3002<\/p>\n<p><strong>\u5e38\u73ca\uff1a<\/strong>\u6211\u6700\u8fd1\u770b\u5230 Baker \u5728\u91c7\u8bbf\u4e2d\u6307\u51fa\u4e86\u5927\u6982\u5341\u51e0\u4e2a\u6709\u53ef\u80fd\u4f7f\u7528\u7ed3\u6784\u9884\u6d4b\u6216\u8005\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u84dd\u6d77\u9886\u57df\uff0c\u662f\u5927\u5bb6\u53ef\u4ee5\u53bb\u5173\u6ce8\u7684\u65b9\u5411\u3002\u8fd8\u6709\u54ea\u4e9b\u65b9\u5411\u662f\u8bfa\u5956\u4e4b\u540e\uff0c\u7ed3\u6784\u9884\u6d4b\u66f4\u597d\u7684\u53d1\u5c55\u65b9\u5411\uff0c\u8bf7\u7a0b\u5efa\u6797\u8001\u5e08\u548c\u6768\u5efa\u76ca\u8001\u5e08\u5206\u4eab\u4e00\u4e0b\u3002<\/p>\n<p><strong>\u6768\u5efa\u76ca\uff1a<\/strong>\u6211\u89c9\u5f97\u5355\u5e8f\u5217\u9884\u6d4b\u5982\u679c\u628a\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u89e3\u51b3\u4e86\uff0c\u5c06\u662f\u8bfa\u5956\u7ea7\u7684\u5de5\u4f5c\u3002\u8981\u4ece\u5355\u5e8f\u5217\u53bb\u9884\u6d4b\u7ed3\u6784\uff0c\u6df1\u5165\u63a2\u7d22\u86cb\u767d\u8d28\u6298\u53e0\u673a\u7406\u548c\u95ee\u9898\u8fd8\u6709\u5f88\u957f\u7684\u8def\u8981\u8d70\u3002\u4ee5\u540e\u80af\u5b9a\u4f1a\u662f AI \u4e3b\u5bfc\u7684\uff0c\u901a\u8fc7 AI \u4e0d\u65ad\u8fed\u4ee3\u3001\u66f4\u65b0\uff0c\u7cbe\u5ea6\u63d0\u9ad8\u7684\u540c\u65f6\uff0c\u4e0d\u65ad\u52a0\u6df1\u5bf9\u6298\u53e0\u673a\u7406\u7684\u7406\u89e3\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u73b0\u5728 AlphaFold \u89e3\u51b3\u7684\u662f\u9759\u6001\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\uff0c\u73b0\u5728\u5927\u5bb6\u5173\u6ce8\u7684\u91cd\u70b9\u9010\u6b65\u4ece\u9759\u6001\u8f6c\u4e3a\u52a8\u6001\u3002\u56e0\u4e3a\u86cb\u767d\u8d28\u8981\u6267\u884c\u751f\u7269\u5b66\u529f\u80fd\uff0c\u4e3b\u8981\u662f\u56e0\u4e3a\u5b83\u5728\u52a8\uff0c\u867d\u7136\u6211\u4e00\u76f4\u89c9\u5f97\u53ea\u7814\u7a76\u4e00\u6761\u86cb\u767d\u8d28\u7684\u52a8\u6001\u6ca1\u6709\u592a\u5927\u7684\u610f\u4e49\uff0c\u91cd\u70b9\u8fd8\u662f\u5728\u590d\u5408\u7269\uff0c\u56e0\u4e3a\u52a8\u662f\u6709\u539f\u56e0\u7684\uff0c\u6bd4\u5982\u8bf4\u8ddf\u5c0f\u5206\u5b50\u3001\u86cb\u767d\u3001\u6838\u9178\u4e92\u4f5c\u3002\u6240\u4ee5\u5728\u590d\u5408\u7269\u80cc\u666f\u4e0b\u7814\u7a76\u52a8\u6001\u6784\u9879\u53d8\u5316\u662f\u91cd\u8981\u65b9\u5411\uff0c\u4f46\u5bf9\u4e8e\u9884\u6d4b\u8005\u3001\u8bc4\u4f30\u8005\u6765\u8bb2\u90fd\u5f88\u56f0\u96be\u3002<\/p>\n<p><strong>\u7a0b\u5efa\u6797\uff1a<\/strong>\u83b7\u5f97\u8bfa\u5956\u662f\u5bf9\u6211\u4eec\u6574\u4e2a\u9886\u57df\u7684\u627f\u8ba4\uff0c\u4f1a\u4ea7\u751f\u5f88\u5927\u5f71\u54cd\uff0c\u5438\u5f15\u5f88\u591a\u4eba\u6765\u5b66\u4e60\u7ed3\u6784\u9884\u6d4b\u3002\u6211\u89c9\u5f97\u8fd8\u6709\u51e0\u4e2a\u53ef\u80fd\u8fbe\u5230\u8bfa\u5956\u7ea7\u522b\u7684\u5de5\u4f5c\uff0c\u6bd4\u5982\u5355\u5e8f\u5217\u7ed3\u6784\u9884\u6d4b\uff0c\u7136\u540e RNA \u5982\u679c\u80fd\u505a\u5230 AlphaFold2 \u5f53\u5e74\u5bf9\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u6c34\u5e73\u5c31\u5df2\u7ecf\u8fbe\u5230\u5f88\u9ad8\u7684\u7cbe\u5ea6\u4e86\uff0c\u8fd9\u4e5f\u662f\u8bfa\u5956\u7ea7\u522b\u7684\u5de5\u4f5c\u3002<\/p>\n<p>\u86cb\u767d\u5c0f\u5206\u5b50\u590d\u5408\u4f53\u7ed3\u6784\u9884\u6d4b\uff0c\u867d\u7136\u73b0\u5728 AlphaFold3 \u5c5e\u4e8e\u9886\u5148\u72b6\u6001\uff0c\u4f46\u5b83\u7684\u7cbe\u5ea6\u8fd8\u8fdc\u8fdc\u6ca1\u6709\u8fbe\u5230\u89e3\u51b3\u5927\u90e8\u5206\u95ee\u9898\uff0c\u4e0d\u50cf\u5b83 90% \u89e3\u51b3\u4e86\u86cb\u767d\u5355\u94fe\u7684\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\u3002\u86cb\u767d\u8d28\u5c0f\u5206\u5b50\u5176\u5b9e\u8fd8\u6709\u5f88\u591a\u5de5\u4f5c\u8981\u505a\uff0c\u8fd9\u4e2a\u95ee\u9898\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u4e3a\u73b0\u5b9e\u610f\u4e49\u662f\u5de8\u5927\u7684\uff0c\u5bf9\u5236\u836f\u3001\u75be\u75c5\u7684\u7406\u89e3\u662f\u975e\u5e38\u91cd\u8981\u7684\uff0c\u5982\u679c\u80fd\u591f\u53d6\u5f97\u7a81\u7834\u6027\u7684\u8fdb\u5c55\uff0c\u4e5f\u662f\u8fbe\u5230\u8bfa\u5956\u7ea7\u522b\u7684\u3002<\/p>\n<p>\u5f97\u5230\u8bfa\u8d1d\u5956\u6700\u91cd\u8981\u7684\u56e0\u7d20\u5728\u4e8e\u8981\u6709\u5de8\u5927\u7684\u3001\u7a81\u7136\u6027\u7684\uff0c\u98a0\u8986\u6027\u7684\u7a81\u7834\uff0c\u8fd8\u6709\u5176\u5b9e\u8fd9\u662f\u4eba\u5de5\u667a\u80fd\u5728\u79d1\u5b66\u9886\u57df\u91cc\u83b7\u5f97\u7684\u8fc4\u4eca\u4e3a\u6b62\u7b2c\u4e00\u4e2a\u6700\u91cd\u8981\u7684\u7a81\u7834\uff0cAlphaGo\u3001ChatGPT \u90fd\u662f\u65b0\u7684\u4ee3\u8868\u6027\u65f6\u523b\uff0c\u800c\u5728\u79d1\u5b66\u9886\u57df\u91cc\u7684\u65f6\u523b\u5176\u5b9e\u5c31\u662f\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\uff0c\u5df2\u7ecf\u6210\u4e3a\u79d1\u5b66\u4e2d\u7684\u6837\u677f\u3002<\/p>\n<p>\u5f88\u591a\u4eba\u4ee5\u524d\u90fd\u4e0d\u5173\u5fc3\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\uff0c\u73b0\u5728\u4ed6\u4eec\u90fd\u8981\u5728\u81ea\u5df1\u7814\u7a76\u7684\u75be\u75c5\u6216\u751f\u7269\u7cfb\u7edf\u91cc\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u6bd4\u5982\u519c\u4e1a\u91cc\u8bbe\u8ba1\u80b2\u79cd\uff0c\u4f7f\u5176\u66f4\u6709\u6297\u65f1\u6027\uff0c\u80fd\u6e90\u9886\u57df\u8bbe\u8ba1\u9176\uff0c\u628a\u751f\u7269\u5e9f\u6599\u8f6c\u6210\u80fd\u91cf\u3002\u53e6\u5916\uff0c\u5f88\u591a\u751f\u7269\u79d1\u6280\u516c\u53f8\u751a\u81f3\u5927\u516c\u53f8\u4e5f\u5728\u6295\u5165\u5176\u4e2d\uff0c\u4ed6\u4eec\u4f1a\u4f7f\u7528\u3001\u7ee7\u7eed\u5f00\u53d1\u8fd9\u4e9b\u5de5\u5177\uff0c\u6216\u8005\u5e94\u7528\u5230\u5404\u4e2a\u4e0d\u540c\u7684\u9886\u57df\u91cc\uff0c\u6240\u4ee5\u5b83\u5df2\u7ecf\u6210\u4e3a\u975e\u5e38\u6709\u6f5c\u529b\u7684\u9886\u57df\uff0c\u4f46\u4ece\u5b66\u672f\u754c\u7684\u89d2\u5ea6\u6765\u8bb2\u8fd8\u5b58\u5728\u8bb8\u591a\u6709\u6311\u6218\u6027\u7684\u7814\u7a76\u95ee\u9898\u5f85\u89e3\u3002<\/p>\n<p><strong>\u5e38\u73ca\uff1a<\/strong>\u8bfa\u5956\u786e\u5b9e\u662f\u5bf9\u6211\u4eec\u7ed3\u6784\u9884\u6d4b\u9886\u57df\u7684\u4e00\u4e2a\u5f88\u91cd\u8981\u7684\u80af\u5b9a\uff0c\u4e4b\u524d\u5f88\u5c11\u4eba\u4f1a\u5173\u6ce8\u8fd9\u4e2a\u9886\u57df\uff0c\u6216\u8005\u5927\u5bb6\u4e0d\u662f\u7279\u522b\u4e86\u89e3\uff0c\u8fd9\u4e5f\u662f\u6211\u4eec\u4e3e\u529e\u8fd9\u6b21\u5706\u684c\u4f1a\u8bae\u7684\u91cd\u8981\u539f\u56e0\uff0c\u7ed3\u6784\u9884\u6d4b\u83b7\u5f97\u8bfa\u5956\u80af\u5b9a\u4ee5\u540e\uff0c\u6211\u4eec\u9700\u8981\u8ba9\u5927\u5bb6\u77e5\u9053\u8bfa\u5956\u5230\u5e95\u4e3a\u4ec0\u4e48\u9881\u7ed9\u7ed3\u6784\u9884\u6d4b\uff0c\u7ed3\u6784\u9884\u6d4b\u53ef\u4ee5\u5e2e\u52a9\u5b66\u672f\u7814\u7a76\u3001\u4ea7\u4e1a\u754c\u505a\u4ec0\u4e48\u4e8b\u3002<\/p>\n<p>\u76ee\u524d\u4e2d\u56fd\u56e2\u961f\u53c2\u52a0 CASP \u7684\u70ed\u60c5\u4e5f\u5f88\u9ad8\uff0c\u6240\u4ee5\u6211\u4eec\u4e5f\u5728\u8ba8\u8bba\u6709\u6ca1\u6709\u53ef\u80fd\u8ba9\u4e2d\u56fd\u6765\u627f\u529e\u4e00\u6b21\uff0c\u5728\u4e2d\u56fd\u627f\u529e\u7684\u8bdd\uff0c\u4f1a\u66f4\u5927\u5730\u6269\u5927\u7ed3\u6784\u9884\u6d4b\u7684\u5f71\u54cd\u529b\uff0c\u8fd9\u65b9\u9762\u60f3\u8bf7\u6768\u5efa\u76ca\u8001\u5e08\u548c\u90d1\u4f1f\u8001\u5e08\u6765\u8c08\u4e00\u4e0b\u5efa\u8bae\u3002<\/p>\n<p><strong>\u6768\u5efa\u76ca\uff1a<\/strong>CASP \u53d1\u9080\u8bf7\u4fe1\u7684\u65f6\u5019\u6211\u5c31\u95ee\u8fc7\u4e0b\u4e00\u5c4a\u80fd\u4e0d\u80fd\u5728\u4e2d\u56fd\u529e\uff0c\u4ed6\u4eec\u56de\u590d\u5f88\u611f\u5174\u8da3\uff0c\u8fd9\u6b21\u4f1a\u8bae\u6700\u540e\u4e00\u5929\u7684\u9884\u6d4b\u4f1a\u8bae\u4e2d\uff0c\u4e5f\u6709\u4eba\u5efa\u8bae\u5728\u4e9a\u6d32\u4e3e\u529e CASP17\u3002Joun Moult \u56de\u590d\u90ae\u4ef6\u8bf4\u8fd9\u4e00\u5c4a\u6bd4\u8d5b\u7684\u4e2d\u56fd\u53c2\u8d5b\u8005\u4ec5\u6b21\u4e8e\u7f8e\u56fd\uff0c\u65e5\u97e9\u56e2\u961f\u4e5f\u5f88\u591a\uff0c\u4ed6\u5f88\u611f\u5174\u8da3\uff0c\u4e0d\u8fc7\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u8ba8\u8bba\u3002<\/p>\n<p><strong>\u90d1\u4f1f\uff1a<\/strong>\u4e0b\u4e00\u5c4a\u611f\u89c9\u56e0\u4e3a\u4f1a\u8bae\u7ec4\u7ec7\u53d7\u56fd\u9645\u653f\u6cbb\u7684\u56e0\u7d20\u5f71\u54cd\u6bd4\u8f83\u5927\uff0c\u4f1a\u4e0d\u4f1a\u9009\u5728\u4e2d\u56fd\u5176\u5b9e\u4e0d\u592a\u597d\u8bf4\uff0c\u4f30\u8ba1\u65e5\u97e9\u6982\u7387\u4f1a\u6bd4\u8f83\u5927\uff0c\u4f46\u662f\u4e5f\u4e0d\u662f\u8bf4\u6ca1\u5e0c\u671b\uff0c\u8981\u96c6\u4f53\u8ddf\u7ec4\u59d4\u4f1a\u53cd\u6620\uff0c\u6700\u5927\u52aa\u529b\u4e89\u53d6\u3002<\/p>\n<p><strong>\u5e38\u73ca\uff1a<\/strong>\u8bc4\u8bba\u533a\u4e5f\u8fd8\u6709\u4e00\u4e9b\u95ee\u9898\u9700\u8981\u8ba8\u8bba\u4e00\u4e0b\uff0c\u5927\u5bb6\u6bd4\u8f83\u5173\u5fc3\u7ed3\u6784\u9884\u6d4b\u5bf9\u4e8e\u7a81\u53d8\u540e\u86cb\u767d\u8d28\u7684\u9884\u6d4b\u6548\u679c\u5982\u4f55\uff1f\u6216\u8005\u5bf9\u4e8e\u86cb\u767d\u8d28\u7a81\u53d8\u4e2d\u6bd4\u8f83\u5c0f\u7684\u7ec6\u5fae\u7684\u5e8f\u5217\u53d8\u5316\uff0c\u4f1a\u4e0d\u4f1a\u6709\u6bd4\u8f83\u597d\u7684\u9884\u6d4b\u7ed3\u679c\u5417\uff1f\u8fd8\u6709\u5bf9\u4e8e Loop \u533a\u7684\u9884\u6d4b\u6709\u6ca1\u6709\u4e00\u4e9b\u6bd4\u8f83\u597d\u7684\u5efa\u8bae\uff1f\u6709\u6ca1\u6709\u8001\u5e08\u53ef\u4ee5\u89e3\u7b54\u4e00\u4e0b\u3002<\/p>\n<p><strong>\u7a0b\u5efa\u6797\uff1a<\/strong>\u6211\u56de\u7b54\u7b2c\u4e00\u4e2a\u95ee\u9898\u3002\u76ee\u524d\u5bf9\u7a81\u53d8\u7684\u7ed3\u6784\u9884\u6d4b\u8fd8\u4e0d\u662f\u7279\u522b\u6210\u529f\uff0c\u56e0\u4e3a AlphaFold2\u3001AlphaFold3 \u4e3b\u8981\u662f\u7528\u5bf9\u9f50\u7684\u591a\u5e8f\u5217\u4f5c\u4e3a\u8f93\u5165\uff0c\u6240\u4ee5\u5982\u679c\u53ea\u6709\u51e0\u4e2a\u6c28\u57fa\u9178\u53d1\u751f\u53d8\u5f02\u4e4b\u540e\uff0c\u5176\u5b9e\u5b83\u4e0d\u80fd\u654f\u611f\u5bdf\u89c9\u53d8\u5316\uff0c\u4ea7\u751f\u7684\u7ed3\u679c\u548c\u7528\u539f\u59cb\u5e8f\u5217\u662f\u5dee\u4e0d\u591a\u7684\uff0c\u6211\u4eec\u4eca\u5929\u6ca1\u6709\u8ba8\u8bba\u5230\uff0c\u4f46\u8fd9\u662f\u4e4b\u540e\u7ed3\u6784\u9884\u6d4b\u8981\u89e3\u51b3\u7684\u91cd\u8981\u95ee\u9898\u3002<\/p>\n<p><strong>\u90d1\u4f1f\uff1a<\/strong>\u6211\u89c9\u5f97\u70b9\u7a81\u53d8\u5206\u4e24\u4e2a\u65b9\u5411\uff0c\u4e00\u662f\u70b9\u7a81\u53d8\u5bf9\u7ed3\u6784\u5f71\u54cd\u6bd4\u8f83\u5927\u7684\uff0c\u4e8c\u662f\u70b9\u7a81\u53d8\u5bf9\u7ed3\u6784\u5f71\u54cd\u5e76\u4e0d\u90a3\u4e48\u5927\u7684\u3002\u70b9\u7a81\u53d8\u5bf9\u7ed3\u6784\u6539\u53d8\u6bd4\u8f83\u5927\u7684\u65b9\u5411\uff0c\u6211\u4eec\u662f\u6709\u4e00\u4e9b case \u80fd\u505a\u7684\uff0cCASP15 \u4e5f\u6709\u4e00\u4e2a\u70b9\u7a81\u53d8\u590d\u5408\u7269\uff0c\u5f88\u591a\u56e2\u961f\u90fd\u9884\u6d4b\u5f97\u8fd8\u4e0d\u9519\uff0c\u4f46\u70b9\u7a81\u53d8\u5bf9\u7ed3\u6784\u6539\u53d8\u6bd4\u8f83\u5927\u7684 case \u73b0\u5728\u4e0d\u662f\u592a\u591a\u3002\u800c\u70b9\u7a81\u53d8\u5bf9\u5c0f\u6784\u9879\u7684\u5f71\u54cd\uff0c\u5982\u679c\u4ece\u7ed3\u6784\u9884\u6d4b\u770b\u7684\u8bdd\uff0c\u5176\u5b9e\u5728\u4fa7\u94fe\u662f\u80fd\u53cd\u6620\u51fa\u6765\u7684\uff0c\u4f46\u8fd9\u79cd\u53d8\u5316\u80fd\u6709\u591a\u5c11\u88ab\u771f\u5b9e\u53cd\u5e94\u5f88\u96be\u8bf4\uff0c\u70b9\u7a81\u53d8\u95ee\u9898\u9700\u8981\u4ee5\u7ed3\u6784\u9884\u6d4b\u52a0\u751f\u7269\u5b66\u9a8c\u8bc1\u7684\u7ed3\u5408\u624b\u6bb5\u4e3a\u4e3b\uff0c\u8fd9\u662f\u6bd4\u8f83\u6b63\u786e\u7684\u65b9\u5411\uff0c\u73b0\u9636\u6bb5\u60f3\u4f9d\u8d56 AI \u53bb\u89e3\u51b3\u6bd4\u8f83\u96be\u3002<\/p>\n<p>Loop \u533a\u6211\u89c9\u5f97\u672c\u6765\u5c31\u662f\u6bd4\u8f83\u7075\u6d3b\u7684\u533a\u57df\uff0c\u76f8\u5bf9\u6765\u8bf4\u6bd4\u8f83\u96be\u9884\u6d4b\uff0c\u5efa\u8bae\u53ef\u4ee5\u591a\u9884\u6d4b\u4e00\u4e9b\u6a21\u578b\uff0c\u7136\u540e\u628a Loop \u533a\u6574\u4f53\u5bf9\u9f50\u518d\u770b\u4e00\u4e0b\uff0c\u7136\u540e\u8fd8\u662f\u9700\u8981\u7ed3\u5408\u751f\u7269\u5b66\u7684\u9a8c\u8bc1\u7ecf\u9a8c\u7b5b\u9009\u6a21\u578b\uff0c\u5b8c\u5168\u4f9d\u8d56\u4e8e AI \u53bb\u9884\u6d4b\u4e5f\u662f\u5f88\u96be\u7684\u3002<\/p>\n<p><strong>\u5e38\u73ca\uff1a<\/strong>Loop \u533a\u7684\u6784\u9879\u672c\u8eab\u4e5f\u5f88\u591a\uff0c\u6709\u70b9\u7c7b\u4f3c\u4e8e\u86cb\u767d\u8d28\u591a\u6784\u8c61\u7684\u9884\u6d4b\u95ee\u9898\uff0c\u6240\u4ee5\u5f88\u96be\u8bf4\u6709\u54ea\u4e2a\u6784\u9879\u662f\u5360\u4f18\u7684\uff0c\u672c\u8eab\u8fd8\u662f\u6709\u4e00\u5b9a\u4e0d\u786e\u5b9a\u6027\u7684\u3002<\/p>\n<p><strong>\u6768\u5efa\u76ca\uff1a<\/strong>\u540c\u610f\u3002Loop \u7684\u8bdd\u8ddf\u6267\u884c\u529f\u80fd\u662f\u6709\u5173\u7684\uff0c\u5355\u7eaf\u8003\u8651\u4e00\u4e2a\u86cb\u767d\u8bf4Loop \u51c6\u4e0d\u51c6\u610f\u4e49\u4e0d\u592a\u5927\uff0c\u8fd9\u4e9b\u533a\u57df\u9884\u6d4b\u7cbe\u5ea6\u4f4e\u975e\u5e38\u6b63\u5e38\uff0c\u5373\u4f7f\u505a\u5b9e\u9a8c\u4e5f\u65e0\u6cd5\u83b7\u53d6\u53ef\u9760\u7684\u7ed3\u6784\u3002\u5e94\u8be5\u8981\u8003\u8651\u5b83\u4e0e\u7ed3\u5408\u5bf9\u8c61\u7684\u4e92\u4f5c\u7528\uff0c\u770b\u901a\u8fc7\u7ed3\u5408\u5176\u4ed6\u5bf9\u8c61\u80fd\u5426\u7a33\u56fa Loop \u533a\u7684\u7ed3\u6784\u3002<span style=\"color: #FFFFFF\">\u96f7\u5cf0\u7f51<span style=\"color:#FD5D3C\">(\u516c\u4f17\u53f7\uff1a\u96f7\u5cf0\u7f51)<\/span>\u96f7\u5cf0\u7f51<\/span><\/p>\n<p>\u96f7\u5cf0\u7f51\u539f\u521b\u6587\u7ae0\uff0c\u672a\u7ecf\u6388\u6743\u7981\u6b62\u8f6c\u8f7d\u3002\u8be6\u60c5\u89c1<a href=\"https:\/\/r.xiumi.us\/board\/v5\/3qhbI\/392977584\" rel=\"nofollow\" target=\"_blank\">\u8f6c\u8f7d\u987b\u77e5<\/a>\u3002<\/p>\n<p>\n                        <a href=\"https:\/\/vip.yanxishe.com\/?from=leiphonearticle\" target=\"_blank\"><br \/>\n                            <a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/01\/frc-ef1b38dfb738ad25d47c69ef4a8cea34.jpeg\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/01\/frc-ef1b38dfb738ad25d47c69ef4a8cea34.jpeg\"><\/a><br \/>\n                        <\/a>\n                    <\/p>\n<p>                                            \u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:<a href=\"https:\/\/www.leiphone.com\/category\/ai\/0nuPls59UixWoHrD.html\" target=\"_blank\">AI \u79d1\u5b66\u5bb6\u83b7\u8bfa\u5956\u540e\uff1a\u4ece CASP \u770b\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u673a\u9047\u4e0e\u6311\u6218\u4e28GAIR Live<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4f5c\u8005\u4e28\u6731\u53ef\u8f69 \u7f16\u8f91\u4e28\u9648\u5f69\u5a34 \u201cAlpha [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[27],"tags":[68,65],"class_list":["post-39050","post","type-post","status-publish","format-standard","hentry","category-news","tag-68","tag-65"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>AI \u79d1\u5b66\u5bb6\u83b7\u8bfa\u5956\u540e\uff1a\u4ece CASP \u770b\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u673a\u9047\u4e0e\u6311\u6218\u4e28GAIR Live - \u4e00\u8d77AI\u6280\u672f<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/17aitech.com\/?p=39050\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/17aitech.com\/?p=39050\",\"url\":\"https:\/\/17aitech.com\/?p=39050\",\"name\":\"AI \u79d1\u5b66\u5bb6\u83b7\u8bfa\u5956\u540e\uff1a\u4ece CASP \u770b\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u673a\u9047\u4e0e\u6311\u6218\u4e28GAIR Live - \u4e00\u8d77AI\u6280\u672f\",\"isPartOf\":{\"@id\":\"https:\/\/17aitech.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/17aitech.com\/?p=39050#primaryimage\"},\"image\":{\"@id\":\"https:\/\/17aitech.com\/?p=39050#primaryimage\"},\"thumbnailUrl\":\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/01\/frc-df885730bf152495443431244d4da421.jpeg\",\"datePublished\":\"2025-02-28T05:01:37+00:00\",\"author\":{\"@id\":\"https:\/\/17aitech.com\/#\/schema\/person\/60225458499e817ae0af73e67e440b9d\"},\"breadcrumb\":{\"@id\":\"https:\/\/17aitech.com\/?p=39050#breadcrumb\"},\"inLanguage\":\"zh-Hans\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/17aitech.com\/?p=39050\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-Hans\",\"@id\":\"https:\/\/17aitech.com\/?p=39050#primaryimage\",\"url\":\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/01\/frc-df885730bf152495443431244d4da421.jpeg\",\"contentUrl\":\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/01\/frc-df885730bf152495443431244d4da421.jpeg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/17aitech.com\/?p=39050#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/17aitech.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"AI \u79d1\u5b66\u5bb6\u83b7\u8bfa\u5956\u540e\uff1a\u4ece CASP \u770b\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u673a\u9047\u4e0e\u6311\u6218\u4e28GAIR Live\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/17aitech.com\/#website\",\"url\":\"https:\/\/17aitech.com\/\",\"name\":\"\u4e00\u8d77AI\u6280\u672f\",\"description\":\"\u8ba9AI\u77e5\u8bc6\u89e6\u624b\u53ef\u53ca\",\"alternateName\":\"\u4e00\u8d77AI\u6280\u672f\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/17aitech.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-Hans\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/17aitech.com\/#\/schema\/person\/60225458499e817ae0af73e67e440b9d\",\"name\":\"AI\u5c0f\u52a9\u624b\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-Hans\",\"@id\":\"https:\/\/17aitech.com\/#\/schema\/person\/image\/\",\"url\":\"\/\/17aitech.com\/wp-content\/uploads\/2024\/04\/robot_3.png\",\"contentUrl\":\"\/\/17aitech.com\/wp-content\/uploads\/2024\/04\/robot_3.png\",\"caption\":\"AI\u5c0f\u52a9\u624b\"},\"description\":\"\u8fd9\u4e2a\u4eba\u5f88\u61d2\uff0c\u4ec0\u4e48\u90fd\u6ca1\u6709\u7559\u4e0b\uff5e\",\"url\":\"https:\/\/17aitech.com\/?page_id=33738&user=3\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"AI \u79d1\u5b66\u5bb6\u83b7\u8bfa\u5956\u540e\uff1a\u4ece CASP \u770b\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u673a\u9047\u4e0e\u6311\u6218\u4e28GAIR Live - \u4e00\u8d77AI\u6280\u672f","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/17aitech.com\/?p=39050","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/17aitech.com\/?p=39050","url":"https:\/\/17aitech.com\/?p=39050","name":"AI \u79d1\u5b66\u5bb6\u83b7\u8bfa\u5956\u540e\uff1a\u4ece CASP \u770b\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u673a\u9047\u4e0e\u6311\u6218\u4e28GAIR Live - \u4e00\u8d77AI\u6280\u672f","isPartOf":{"@id":"https:\/\/17aitech.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/17aitech.com\/?p=39050#primaryimage"},"image":{"@id":"https:\/\/17aitech.com\/?p=39050#primaryimage"},"thumbnailUrl":"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/01\/frc-df885730bf152495443431244d4da421.jpeg","datePublished":"2025-02-28T05:01:37+00:00","author":{"@id":"https:\/\/17aitech.com\/#\/schema\/person\/60225458499e817ae0af73e67e440b9d"},"breadcrumb":{"@id":"https:\/\/17aitech.com\/?p=39050#breadcrumb"},"inLanguage":"zh-Hans","potentialAction":[{"@type":"ReadAction","target":["https:\/\/17aitech.com\/?p=39050"]}]},{"@type":"ImageObject","inLanguage":"zh-Hans","@id":"https:\/\/17aitech.com\/?p=39050#primaryimage","url":"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/01\/frc-df885730bf152495443431244d4da421.jpeg","contentUrl":"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/01\/frc-df885730bf152495443431244d4da421.jpeg"},{"@type":"BreadcrumbList","@id":"https:\/\/17aitech.com\/?p=39050#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/17aitech.com\/"},{"@type":"ListItem","position":2,"name":"AI \u79d1\u5b66\u5bb6\u83b7\u8bfa\u5956\u540e\uff1a\u4ece CASP \u770b\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u673a\u9047\u4e0e\u6311\u6218\u4e28GAIR Live"}]},{"@type":"WebSite","@id":"https:\/\/17aitech.com\/#website","url":"https:\/\/17aitech.com\/","name":"\u4e00\u8d77AI\u6280\u672f","description":"\u8ba9AI\u77e5\u8bc6\u89e6\u624b\u53ef\u53ca","alternateName":"\u4e00\u8d77AI\u6280\u672f","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/17aitech.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-Hans"},{"@type":"Person","@id":"https:\/\/17aitech.com\/#\/schema\/person\/60225458499e817ae0af73e67e440b9d","name":"AI\u5c0f\u52a9\u624b","image":{"@type":"ImageObject","inLanguage":"zh-Hans","@id":"https:\/\/17aitech.com\/#\/schema\/person\/image\/","url":"\/\/17aitech.com\/wp-content\/uploads\/2024\/04\/robot_3.png","contentUrl":"\/\/17aitech.com\/wp-content\/uploads\/2024\/04\/robot_3.png","caption":"AI\u5c0f\u52a9\u624b"},"description":"\u8fd9\u4e2a\u4eba\u5f88\u61d2\uff0c\u4ec0\u4e48\u90fd\u6ca1\u6709\u7559\u4e0b\uff5e","url":"https:\/\/17aitech.com\/?page_id=33738&user=3"}]}},"_links":{"self":[{"href":"https:\/\/17aitech.com\/index.php?rest_route=\/wp\/v2\/posts\/39050","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/17aitech.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/17aitech.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/17aitech.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/17aitech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=39050"}],"version-history":[{"count":0,"href":"https:\/\/17aitech.com\/index.php?rest_route=\/wp\/v2\/posts\/39050\/revisions"}],"wp:attachment":[{"href":"https:\/\/17aitech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=39050"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/17aitech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=39050"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/17aitech.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=39050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}