{"id":39084,"date":"2025-03-01T06:01:49","date_gmt":"2025-02-28T22:01:49","guid":{"rendered":"https:\/\/17aitech.com\/?p=39084"},"modified":"2025-03-01T06:01:49","modified_gmt":"2025-02-28T22:01:49","slug":"%e6%97%a0%e9%9c%80%e4%be%b5%e5%85%a5%ef%bc%8c%e4%b8%80%e9%94%ae%e9%87%8d%e6%9e%84%e7%bb%86%e8%83%9e%e3%80%8c%e7%94%b5%e6%b4%bb%e5%8a%a8%e3%80%8d%ef%bc%8cai%e9%9d%a9%e6%96%b0%e8%8d%af%e7%89%a9%e5%bf%83","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=39084","title":{"rendered":"\u65e0\u9700\u4fb5\u5165\uff0c\u4e00\u952e\u91cd\u6784\u7ec6\u80de\u300c\u7535\u6d3b\u52a8\u300d\uff0cAI\u9769\u65b0\u836f\u7269\u5fc3\u810f\u6bd2\u6027\u8bc4\u4f30"},"content":{"rendered":"

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\u7f16\u8f91\u4e28&<\/p>\n

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\u867d\u7136\uff0c\u4f7f\u7528 NEA \u83b7\u53d6\u7ec6\u80de\u5185\u7535\u4f4d\u4ecd\u9887\u5177\u5177\u6709\u6311\u6218\u6027\uff0c\u4f46\u7f8e\u56fd\u65af\u5766\u798f\u5927\u5b66\u4e0e\u52a0\u5dde\u5927\u5b66\u7684\u8054\u5408\u7814\u7a76\u56e2\u961f\u63d0\u51fa\u4e86\u4e00\u79cd AI \u652f\u6301\u7684\u6280\u672f\uff0c\u8be5\u6280\u672f\u5229\u7528\u6765\u81ea NEA \u4e0a\u5e72\u7ec6\u80de\u884d\u751f\u5fc3\u808c\u7ec6\u80de\u7684\u6570\u5343\u4e2a\u540c\u6b65 eAP \u548c iAP \u5bf9\u3002<\/p>\n

\u8fd9\u79cd\u57fa\u4e8e\u7269\u7406\u5b66\u7684\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u5c55\u793a\u4e86\u5176\u7528\u4e8e\u975e\u4fb5\u5165\u6027\u3001\u957f\u671f\u3001\u9ad8\u901a\u91cf\u836f\u7269\u5fc3\u810f\u6bd2\u6027\u8bc4\u4f30\u7684\u6f5c\u529b\uff0c\u4e3a\u672a\u6765\u5404\u79cd\u7ec6\u80de\u7c7b\u578b\u548c\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u7535\u751f\u7406\u5b66\u7814\u7a76\u94fa\u5e73\u4e86\u9053\u8def\u3002<\/p>\n

\u4ed6\u4eec\u7684\u7814\u7a76\u4ee5\u300cIntelligent in-cell electrophysiology: Reconstructing intracellular action potentials using a physics-informed deep learning model trained on nanoelectrode array recordings<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 1 \u6708 14 \u65e5\u520a\u767b\u4e8e\u300aNature Communications<\/em>\u300b\u3002<\/p>\n

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\u73b0\u9636\u6bb5\u533b\u5b66\u65b9\u6cd5<\/strong><\/p>\n

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\u7535\u751f\u7406\u5b66\u7814\u7a76\u751f\u7269\u7ec6\u80de\u548c\u7ec4\u7ec7\u7684\u7535\u7279\u6027\uff0c\u5bf9\u4e8e\u4e86\u89e3\u836f\u7269\u673a\u5236\u3001\u5f00\u53d1\u5fc3\u810f\u548c\u795e\u7ecf\u7597\u6cd5\u4ee5\u53ca\u8bc4\u4f30\u5404\u79cd\u836f\u7269\u7684\u5fc3\u810f\u6bd2\u6027\u81f3\u5173\u91cd\u8981\u3002\u76ee\u524d\u533b\u5b66\u79d1\u5b66\u6240\u6709\u9886\u57df\u4f7f\u7528\u7684\u7ec6\u80de\u5185\u7535\u751f\u7406\u5b66\u6280\u672f\u7684\u91d1\u6807\u51c6\u662f\u819c\u7247\u94b3\u6280\u672f\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4ee5\u9ad8\u7cbe\u5ea6\u5730\u6d4b\u91cf\u7ec6\u80de\u5185\u7535\u4f4d\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u6280\u672f\u901a\u91cf\u4f4e\uff0c\u9700\u8981\u624b\u64cd\uff0c\u5e76\u4e14\u5bf9\u8bb0\u5f55\u7684\u7ec6\u80de\u4ecd\u7136\u5177\u6709\u4fb5\u5165\u6027\u3002<\/p>\n

\u7ec6\u80de\u5916\u7535\u751f\u7406\u5b66\u6280\u672f\uff0c\u5982\u5fae\u7535\u6781\u9635\u5217 \uff08MEA\uff09\uff0c\u514b\u670d\u4e86\u819c\u7247\u94b3\u7684\u4fb5\u5165\u6027\u548c\u901a\u91cf\u9650\u5236\u3002\u7136\u800c\uff0c\u7531\u4e8e\u8bb0\u5f55\u7535\u6781\u4fdd\u6301\u5728\u7ec6\u80de\u5916\uff0c\u8be5\u6280\u672f\u63d0\u4f9b\u7684\u7535\u4fe1\u53f7\u5f62\u72b6\u4fe1\u606f\u6709\u9650\uff0c\u65e0\u6cd5\u89e3\u51b3\u5fc3\u810f\u6bd2\u6027\u8bc4\u4f30\u6240\u9700\u7684\u7ec6\u80de\u5185\u7535\u4f4d\u7684\u7ec6\u5fae\u53d8\u5316\u3002<\/p>\n

<\/a><\/section>\n
\u56fe\u793a\uff1a\u7eb3\u7c73\u7535\u6781\u7684\u6570\u636e\u6536\u96c6\u4e0e\u9884\u5904\u7406\u3002\uff08\u56fe\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u7eb3\u7c73\u7535\u6781\u9635\u5217 \uff08NEA\uff09\uff0c\u7531\u6bd4\u7ec6\u80de\u5927\u5c0f\u5c0f 200 \u500d\u7684\u72ec\u7acb\u7eb3\u7c73\u7ea7\u7535\u6781\u7ec4\u6210\uff0c\u5df2\u6210\u4e3a\u4e00\u79cd\u5f88\u6709\u524d\u9014\u7684\u65b9\u6cd5\uff0c\u5b83\u7ed3\u5408\u4e86\u7ec6\u80de\u5185\u548c\u7ec6\u80de\u5916\u7535\u751f\u7406\u5b66\u6280\u672f\u7684\u4f18\u52bf\uff0c\u5e76\u4e14\u80fd\u591f\u540c\u65f6\u8bb0\u5f55\u6765\u81ea\u5404\u79cd\u7ec6\u80de\u7c7b\u578b\u4e2d\u5355\u4e2a\u7ec6\u80de\u7684\u9ad8\u901a\u91cf\u7ec6\u80de\u5916\u4fe1\u53f7\u548c\u6309\u9700\u7ec6\u80de\u5185\u4fe1\u53f7\u3002<\/p>\n

\u5728\u8fd9\u91cc\uff0c\u56e2\u961f\u4eec\u7684\u76ee\u6807\u662f\u6784\u5efa\u4e00\u4e2a\u6a21\u578b\uff0c\u4f7f\u7528 eAP \u8bb0\u5f55\u91cd\u5efa iAP \u6ce2\u5f62\u3002\u7814\u7a76\u4ecb\u7ecd\u4e86\u7269\u7406\u77e5\u60c5\u6ce8\u610f\u529b UNET \uff08PIA-UNET\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u4ece eAP \u6ce2\u5f62\u91cd\u5efa iAP \u6ce2\u5f62\u7684\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u3002<\/p>\n

\u4e0e\u4f9d\u8d56\u5927\u91cf\u53c2\u6570\u4f30\u8ba1\u7684\u4f20\u7edf\u6a21\u578b\u4e0d\u540c\uff0cPIA-UNET \u901a\u8fc7\u5173\u6ce8\u5185\u5728\u6a21\u5f0f\u6765\u76f4\u89c2\u5730\u8f6c\u6362 eAP \u548c iAP \u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u4ece\u800c\u7ed5\u8fc7\u4e86\u590d\u6742\u7684\u53c2\u6570\u4f30\u8ba1\u6b65\u9aa4\u3002<\/p>\n

\u901a\u8fc7\u5bf9 eAP \u548c iAP \u5bf9\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u8fdb\u884c\u5b9a\u91cf\u5206\u6790\uff0c\u7814\u7a76\u5047\u8bbe eAP \u4e2d\u6709\u8db3\u591f\u7684\u4fe1\u606f\u6765\u91cd\u5efa iAP\u3002\u7136\u540e\uff0c\u901a\u8fc7\u5b9e\u9a8c\u8bc1\u660e\uff0c\u4f7f\u7528\u7269\u7406\u4fe1\u606f\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u53ef\u4ee5\u4ece eAP \u8bb0\u5f55\u4e2d\u5b8c\u5168\u51c6\u786e\u5730\u91cd\u5efa iAP\u3002<\/p>\n

eAP \u548c iAP \u5bf9<\/strong><\/p>\n

\u8fd9\u9879\u5de5\u4f5c\u7684\u76ee\u6807\u662f\u901a\u8fc7\u4f7f\u7528\u5e26\u6709\u7eb3\u7c73\u7535\u6781\u7684\u65f6\u95f4\u540c\u6b65\u5bf9 eAP \u548c iAP \u8bb0\u5f55\u6765\u8bad\u7ec3\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff0c\u4ece eAP \u8bb0\u5f55\u4e2d\u91cd\u5efa iAP \u6ce2\u5f62\u3002<\/p>\n

\u8bad\u7ec3\u6570\u636e\u96c6\u7684\u8d28\u91cf\u5bf9\u4e8e\u4efb\u4f55\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u7684\u6709\u6548\u6027\u90fd\u81f3\u5173\u91cd\u8981\u3002\u56e0\u6b64\uff0c\u867d\u7136\u4ee5\u524d\u7684\u7814\u7a76\u5df2\u7ecf\u8bc1\u660e\u4e86 NEA \u8bb0\u5f55\u7684\u5f52\u4e00\u5316 iAP \u6ce2\u5f62\u4e0e\u91d1\u6807\u51c6\u819c\u7247\u94b3\u6280\u672f\u4e4b\u95f4\u7684\u76f8\u4f3c\u6027\uff0c\u4f46\u56e2\u961f\u8fd8\u662f\u5c31\u6b64\u8fdb\u884c\u4e86\u66f4\u5168\u9762\u7684\u5206\u6790\u3002<\/p>\n

eAP \u548c iAP \u7279\u5f81\u4e4b\u95f4\u63ed\u793a\u7684\u8fd9\u4e9b\u65b0\u5173\u7cfb\u4e4b\u6240\u4ee5\u80fd\u591f\u8bc6\u522b\uff0c\u53ea\u662f\u56e0\u4e3a\u91c7\u7528\u4e86\u72ec\u7279\u7684\u6570\u636e\u96c6\uff0c\u8be5\u6570\u636e\u96c6\u7531\u591a\u4e2a eAP \u548c iAP \u5bf9\u7ec4\u6210\u3002\u5728\u786e\u5b9a eAP \u7279\u5f81\u662f iAP \u7279\u5f81\u7684\u51c6\u786e\u9884\u6d4b\u56e0\u5b50\u540e\uff0c\u56e2\u961f\u63a2\u7a76\u662f\u5426\u53ef\u4ee5\u4f7f\u7528\u6df1\u5ea6\u5b66\u4e60\u4ece eAP \u91cd\u5efa\u6574\u4e2a iAP \u6ce2\u5f62\u3002<\/p>\n

<\/a><\/section>\n
\u56fe\u793a\uff1a\u7269\u7406\u77e5\u60c5\u6ce8\u610f\u529b Unet \u4ece eAP \u4fe1\u53f7\u91cd\u5efa\u6574\u4e2a iAP \u6ce2\u5f62\u3002\uff08\u56fe\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5\u64c5\u957f\u5904\u7406\u548c\u5206\u6790\u9ad8\u7ef4\u6570\u636e\u3002\u5728\u52aa\u529b\u4ece\u76f8\u5e94\u7684 eAP \u91cd\u5efa\u6574\u4e2a iAP \u6ce2\u5f62\u7684\u8fc7\u7a0b\u4e2d\uff0cAttention-Residual-Block UNET \u6a21\u578b\u88ab\u5f00\u53d1\uff0c\u5e76\u901a\u8fc7\u4f2a\u7269\u7406\u635f\u5931\u51fd\u6570\u5bf9\u5176\u8fdb\u884c\u4e86\u589e\u5f3a\u3002<\/p>\n

\u8be5\u6a21\u578b\u5728\u4e09\u4e2a\u6d4b\u8bd5\u96c6\u4e2d\u5bf9\u819c\u7535\u4f4d\u7684\u9884\u6d4b\u503c\u4e0e\u5b9e\u9645\u503c\u5bc6\u5207\u76f8\u5173\uff0c\u663e\u793a\u51fa\u9ad8\u5ea6\u76f8\u5173\u6027 \u3002\u8bad\u7ec3\u96c6\u4e2d\u4e0d\u540c\u7684\u8bef\u5dee\u6307\u6807\u8bc1\u660e\u4e86\u8be5\u6a21\u578b\u80fd\u591f\u4ece eAP \u8bb0\u5f55\u4e2d\u51c6\u786e\u91cd\u5efa iAP \u6ce2\u5f62\u3002<\/p>\n

\u6a21\u578b\u4ece\u65e0\u521b eAP \u8bb0\u5f55\u4e2d\u51c6\u786e\u91cd\u5efa iAP \u7684\u72ec\u7279\u80fd\u529b\u5728\u7535\u751f\u7406\u5b66\u4e2d\u5177\u6709\u5de8\u5927\u7684\u5e94\u7528\u6f5c\u529b\u3002\u5176\u4e2d\u4e00\u79cd\u5e94\u7528\u662f\u5728 CIPA \u5021\u8bae\u7684\u80cc\u666f\u4e0b\uff0c\u65e8\u5728\u5f00\u53d1\u6539\u8fdb\u7684\u4f53\u5916\u6a21\u578b\uff0c\u4ee5\u4f7f\u7528\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u5fc3\u808c\u7ec6\u80de\u66f4\u51c6\u786e\u5730\u8bc4\u4f30\u5fc3\u810f\u6bd2\u6027\u3002<\/p>\n

\u5b83\u4e5f\u53ef\u4ee5\u53ef\u4ee5\u62a5\u544a\u4efb\u4f55\u6240\u9700 iAP \u7279\u5f81\u7684\u53d8\u5316\uff0c\u5305\u62ec\u6574\u4e2a\u8bb0\u5f55\u4e2d\u7684 APD \u503c\u3002\u7531\u6b64\u53ef\u4ee5\u8be6\u7ec6\u89c2\u5bdf\u5fc3\u808c\u7ec6\u80de\u7fa4\u5185\u7684\u53d8\u5316\uff0c\u6709\u52a9\u4e8e\u5728\u5355\u4e2a\u7ec6\u80de\u548c\u66f4\u5e7f\u6cdb\u7684\u7ec6\u80de\u7fa4\u6c34\u5e73\u4e0a\u8fdb\u884c\u6df1\u5165\u7684\u5fc3\u810f\u7535\u751f\u7406\u5b66\u7814\u7a76\u3002<\/p>\n

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