{"id":39186,"date":"2025-03-04T07:01:37","date_gmt":"2025-03-03T23:01:37","guid":{"rendered":"https:\/\/17aitech.com\/?p=39186"},"modified":"2025-03-04T07:01:37","modified_gmt":"2025-03-03T23:01:37","slug":"%e9%80%9f%e5%ba%a6%e6%8f%90%e5%8d%873200%e5%80%8d%ef%bc%8c%e5%87%86%e7%a1%ae%e7%8e%87%e6%8f%90%e9%ab%9840%ef%bc%81%e6%b7%b1%e5%ba%a6%e7%a5%9e%e7%bb%8f%e7%bd%91%e7%bb%9c%e7%ba%a0%e9%94%99%e7%a0%81","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=39186","title":{"rendered":"\u901f\u5ea6\u63d0\u53473200\u500d\uff0c\u51c6\u786e\u7387\u63d0\u9ad840%\uff01\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc+\u7ea0\u9519\u7801\u9769\u65b0DNA\u5b58\u50a8\u6280\u672f"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u901f\u5ea6\u63d0\u53473200\u500d\uff0c\u51c6\u786e\u7387\u63d0\u9ad840%\uff01\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc+\u7ea0\u9519\u7801\u9769\u65b0DNA\u5b58\u50a8\u6280\u672f<\/a><\/p>\n

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\u7f16\u8f91 | 2049<\/strong><\/strong><\/strong><\/p>\n

\u5728\u5168\u7403\u6570\u636e\u91cf\u5448\u6307\u6570\u7ea7\u589e\u957f\u7684\u4eca\u5929\uff0c\u4f20\u7edf\u5b58\u50a8\u6280\u672f\u7684\u6269\u5c55\u901f\u5ea6\u5df2\u96be\u4ee5\u8ddf\u4e0a\u3002<\/p>\n

\u8131\u6c27\u6838\u7cd6\u6838\u9178\uff08DNA\uff09\u5206\u5b50\u4f5c\u4e3a\u4e00\u79cd\u4fe1\u606f\u5b58\u50a8\u4ecb\u8d28\uff0c\u4ee5\u5176\u5353\u8d8a\u7684\u4fe1\u606f\u5bc6\u5ea6\u3001\u589e\u5f3a\u7684\u6570\u636e\u8010\u4e45\u6027\u548c\u51e0\u4e4e\u53ef\u5ffd\u7565\u7684\u7ef4\u62a4\u80fd\u8017\uff0c\u6b63\u9010\u6e10\u6210\u4e3a\u89e3\u51b3\u5b58\u50a8\u5371\u673a\u7684\u5173\u952e\u65b9\u6848\u3002<\/p>\n

\u7136\u800c\uff0cDNA \u5b58\u50a8\u6280\u672f\u9762\u4e34\u53ef\u6269\u5c55\u6027\u548c\u51c6\u786e\u6027\u4e4b\u95f4\u7684\u6743\u8861\u56f0\u5883\uff0c\u6210\u4e3a\u5546\u4e1a\u5316\u843d\u5730\u7684\u4e3b\u8981\u969c\u788d\u3002<\/p>\n

\u6765\u81ea\u4ee5\u8272\u5217\u7406\u5de5\u5b66\u9662\uff08Technion\uff09\u8ba1\u7b97\u673a\u79d1\u5b66\u5b66\u9662\u7684\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u521b\u65b0\u65b9\u6cd5\uff0c\u901a\u8fc7\u5c06\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc<\/mark><\/mark>\uff08DNN\uff09\u3001\u57fa\u4e8e\u5f20\u91cf<\/mark>\u79ef\u7684\u7ea0\u9519\u7801\uff08Error-Correcting Codes\uff0cECC\uff09\u548c\u5b89\u5168\u8fb9\u9645\u673a\u5236\u6574\u5408\u5230\u4e00\u4e2a\u7edf\u4e00\u7684\u6d41\u7a0b\u4e2d\uff0c\u5b9e\u73b0\u4e86 DNA \u5b58\u50a8\u7cfb\u7edf\u5728\u9ad8\u566a\u58f0\u73af\u5883\u4e0b\u7684\u9ad8\u6548\u53ef\u9760\u8fd0\u884c\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cScalable and robust DNA-based storage via coding theory and deep learning<\/em>\u300d\u4e3a\u9898\uff0c\u53d1\u8868\u4e8e 2025 \u5e74 2 \u6708 21 \u65e5\u7684\u300aNature Machine Intelligence<\/em>\u300b\u3002<\/p>\n

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\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s42256-025-01003-z<\/em><\/p>\n

\u6570\u636e\u94fe\u63a5\uff1ahttps:\/\/zenodo.org\/records\/13896773<\/em><\/p>\n

\u4ee3\u7801\u5730\u5740\uff1ahttps:\/\/github.com\/itaiorr\/Deep-DNA-based-storage.git\u00a0<\/em><\/p>\n

\u7814\u7a76\u80cc\u666f\uff1aDNA \u5b58\u50a8\u7cfb\u7edf\u7684\u6311\u6218<\/p>\n

DNA \u5b58\u50a8\u901a\u8fc7\u5c06\u6570\u5b57\u4fe1\u606f\u7f16\u7801\u6210 DNA \u5e8f\u5217\u5e76\u5408\u6210\u5bf9\u5e94\u7684 DNA \u94fe\uff0c\u5177\u5907\u7406\u8bba\u4e0a\u51e0\u4e4e\u65e0\u9650\u7684\u5b58\u50a8\u5bb9\u91cf\u3002<\/p>\n

\u7136\u800c\uff0c\u6b64\u8fc7\u7a0b\u4e2d\u7684\u5173\u952e\u6311\u6218\u5728\u4e8e\u4fe1\u606f\u68c0\u7d22<\/mark>\u7cfb\u7edf\uff0c\u5176\u9700\u8981\u514b\u670d DNA \u5408\u6210\u548c\u6d4b\u5e8f\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u5404\u7c7b\u9519\u8bef\uff0c\u5305\u62ec\u78b1\u57fa\u66ff\u6362\u3001\u63d2\u5165\u548c\u5220\u9664\u3002<\/p>\n

\u4f20\u7edf\u7684 DNA \u4fe1\u606f\u68c0\u7d22<\/mark>\u6d41\u7a0b\u5305\u62ec\u805a\u7c7b<\/mark>\u3001\u91cd\u5efa\u548c\u89e3\u7801\u4e09\u4e2a\u5173\u952e\u73af\u8282\uff0c\u5176\u4e2d\u6bcf\u4e00\u6b65\u90fd\u9762\u4e34\u7740\u7b97\u6cd5\u590d\u6742\u5ea6\u548c\u51c6\u786e\u6027\u4e4b\u95f4\u7684\u5e73\u8861\u95ee\u9898\u3002<\/p>\n

\u6b64\u524d\u7684\u89e3\u51b3\u65b9\u6848\u5f80\u5f80\u91c7\u7528\u5185\u90e8\u7f16\u7801\u6216\u5916\u90e8\u7f16\u7801\u6280\u672f\uff0c\u901a\u8fc7\u6dfb\u52a0\u5197\u4f59\u7b26\u53f7\u6765\u68c0\u6d4b\u548c\u7ea0\u6b63\u9519\u8bef\u3002\u8fd9\u7c7b\u65b9\u6cd5\u672a\u80fd\u5145\u5206\u5229\u7528 DNA \u5408\u6210\u548c\u6d4b\u5e8f\u8fc7\u7a0b\u4e2d\u7684\u56fa\u6709\u5197\u4f59\uff0c\u5bfc\u81f4\u7f16\u7801\u65b9\u6848\u5197\u4f59\u5ea6\u8f83\u9ad8\uff0c\u540c\u65f6\u9700\u8981\u5904\u7406\u66f4\u591a\u7684 DNA \u94fe\u548c\u8bfb\u53d6\u5e8f\u5217\uff0c\u7cfb\u7edf\u6548\u7387\u8f83\u4f4e\u3002<\/p>\n

DNAformer\uff1a\u7aef\u5230\u7aef\u4fe1\u606f\u68c0\u7d22<\/mark>\u89e3\u51b3\u65b9\u6848<\/strong><\/p>\n

\u7814\u7a76\u56e2\u961f\u63d0\u51fa\u7684 DNAformer \u89e3\u51b3\u65b9\u6848\u91c7\u7528\u6a21\u5757\u5316\u7f16\u7801\u65b9\u6848\uff0c\u5c06 ECC \u548c\u7ea6\u675f\u7801\u7ed3\u5408\u5728 DNA \u5408\u6210\u548c\u5b58\u50a8\u4e4b\u524d\u3002\u8fd9\u79cd\u8bbe\u8ba1\u5141\u8bb8\u5c06\u5927\u578b\u6570\u636e\u96c6\u5212\u5206\u4e3a\u66f4\u5c0f\u7684\u5757\uff0c\u5b9e\u73b0\u5feb\u901f\u3001\u7b80\u4fbf\u7684\u6570\u636e\u8bbf\u95ee\u3002<\/p>\n

DNAformer \u7684\u521b\u65b0\u5728\u4e8e\u4fe1\u606f\u68c0\u7d22<\/mark>\u6d41\u7a0b\u3002\u9996\u5148\uff0c\u7cfb\u7edf\u91c7\u7528\u57fa\u4e8e\u7d22\u5f15\u7684\u7b80\u5355\u5206\u7bb1\u7b97\u6cd5\u8fdb\u884c\u805a\u7c7b<\/mark>\uff0c\u8fd9\u79cd\u65b9\u6cd5\u867d\u7136\u4f1a\u5f15\u5165\u566a\u58f0\uff0c\u4f46\u6781\u5927\u63d0\u5347\u4e86\u5904\u7406\u901f\u5ea6\u3002\u63a5\u7740\uff0c\u7cfb\u7edf\u4f7f\u7528 DNN \u4ece\u8bfb\u53d6\u5e8f\u5217\u91cd\u5efa\u539f\u59cb\u7f16\u7801\u5e8f\u5217\u3002<\/p>\n

\u8be5\u7f51\u7edc\u91c7\u7528\u5377\u79ef\u548c Transformer \u7684\u7ec4\u5408\u67b6\u6784\uff0c\u540e\u63a5\u7f6e\u4fe1\u5ea6\u8fc7\u6ee4\u5668\uff0c\u7528\u4e8e\u7b5b\u9009\u51c6\u786e\u9884\u6d4b\u548c\u4e0d\u51c6\u786e\u9884\u6d4b\u3002\u5bf9\u4e8e\u53ef\u80fd\u4e0d\u51c6\u786e\u7684\u9884\u6d4b\uff0c\u7cfb\u7edf\u4f1a\u5e94\u7528\u57fa\u4e8e\u52a8\u6001\u89c4\u5212<\/mark>\u7684\u6761\u4ef6\u6982\u7387\u903b\u8f91<\/mark>\uff08Conditional Probability Logic\uff0cCPL\uff09\u7b97\u6cd5\u8fdb\u884c\u4e8c\u6b21\u91cd\u5efa\uff0c\u8be5\u7b97\u6cd5\u65e0\u9700\u5148\u9a8c\u77e5\u8bc6<\/mark>\u5373\u53ef\u4f30\u8ba1\u805a\u7c7b<\/mark>\u4e2d\u7684\u9519\u8bef\u6982\u7387\uff0c\u6709\u6548\u5e73\u8861\u4e86\u51c6\u786e\u6027\u548c\u901f\u5ea6\u7684\u6743\u8861\u3002<\/p>\n

\u4e3a\u907f\u514d\u9ad8\u6602\u7684 DNN \u8bad\u7ec3\u6570\u636e\u83b7\u53d6\u6210\u672c\uff0c\u7814\u7a76\u56e2\u961f\u4f7f\u7528\u5c0f\u89c4\u6a21\u771f\u5b9e\u6570\u636e\u5206\u6790<\/mark>\u5408\u6210\u3001\u805a\u5408\u9176\u94fe\u5f0f\u53cd\u5e94\uff08Polymerase Chain Reaction\uff0cPCR\uff09\u548c\u6d4b\u5e8f\u7684\u9519\u8bef\u7387\uff0c\u6784\u5efa\u4e86 SOLQC \u5de5\u5177\u6a21\u578b\uff0c\u8fdb\u800c\u751f\u6210\u5927\u91cf\u6a21\u62df\u8bad\u7ec3\u6570\u636e\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ea\u9700\u4e3a\u6bcf\u79cd\u5408\u6210\u548c\u6d4b\u5e8f\u6280\u672f\u5efa\u6a21\u4e00\u6b21\uff0c\u4f7f\u89e3\u51b3\u65b9\u6848\u5728\u6210\u672c\u548c\u89c4\u6a21\u4e0a\u66f4\u5177\u4f18\u52bf\u3002<\/p>\n

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\u56fe\u793a\uff1aDNA \u4fe1\u606f\u68c0\u7d22<\/mark>\u7684\u7aef\u5230\u7aef\u89e3\u51b3\u65b9\u6848\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u5b9e\u9a8c\u9a8c\u8bc1\u4e0e\u6027\u80fd\u5206\u6790<\/strong><\/p>\n

\u7814\u7a76\u56e2\u961f\u4f7f\u7528 Illumina miSeq \u548c Oxford Nanopore MinION \u4e24\u79cd\u4e0d\u540c\u7684\u6d4b\u5e8f\u6280\u672f\uff0c\u5bf9\u603b\u8ba1 3.1 MB \u7684\u4fe1\u606f\u8fdb\u884c\u4e86\u5b9e\u9a8c\u9a8c\u8bc1\u3002\u5b9e\u9a8c\u6570\u636e\u5305\u62ec\u538b\u7f29\u6587\u4ef6\u5939\uff08\u5305\u542b\u56fe\u50cf\u300124 \u79d2\u97f3\u9891\u7247\u6bb5\u548c\u6587\u672c\u6587\u4ef6\uff09\u53ca\u968f\u673a\u4fe1\u606f\u4f4d\uff0c\u5171\u5206\u4e3a\u4e24\u4e2a\u6587\u4ef6\uff0c\u6bcf\u4e2a\u7ea6 1.5 MB\u3002<\/p>\n

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\u56fe\u793a\uff1a\u7528\u4e8e DNA \u5b9e\u9a8c\u7684\u6570\u636e\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u4e0e\u5f53\u524d\u9886\u5148\u7684\u89e3\u51b3\u65b9\u6848\u76f8\u6bd4\uff0cDNAformer \u5728\u901f\u5ea6\u4e0a\u5b9e\u73b0\u4e86 3200 \u500d\u7684\u63d0\u5347\uff0c\u51c6\u786e\u7387<\/mark>\u63d0\u9ad8\u4e86 40%\u3002\u5728\u9ad8\u566a\u58f0\u73af\u5883\u4e0b\uff0c\u8be5\u7cfb\u7edf\u63d0\u4f9b\u4e86\u6bcf\u78b1\u57fa 1.6 \u6bd4\u7279\u7684\u7f16\u7801\u7387\uff0c\u8fdc\u8d85\u73b0\u6709\u65b9\u6848\u3002\u5177\u4f53\u6765\u8bf4\uff0c\u5728 Illumina \u6570\u636e\u96c6\u4e0a\uff0cDNAformer \u7684\u5931\u8d25\u7387\u4ec5\u4e3a 0.0055%\uff1b\u5728 Nanopore \u6570\u636e\u96c6\u4e0a\uff0c\u5931\u8d25\u7387\u4e3a 1.65%\u3002<\/p>\n

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\u56fe\u793a\uff1aDNAformer \u4e0e SOTA DNA \u91cd\u5efa\u65b9\u6cd5\u7684\u6bd4\u8f83\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u6b64\u5916\uff0cDNAformer \u5728\u6570\u636e\u6a21\u6001\u65b9\u9762\u8868\u73b0\u51fa\u8272\uff0c\u4e0d\u4f9d\u8d56\u4e8e\u5e95\u5c42\u8bed\u4e49\u6216\u6570\u636e\u7ed3\u6784\uff0c\u800c\u662f\u4e13\u6ce8\u4e8e\u5408\u6210\u548c\u6d4b\u5e8f\u8fc7\u7a0b\u4e2d\u7684\u566a\u58f0\u7279\u6027\uff0c\u4f7f\u5176\u80fd\u591f\u4ee5\u76f8\u4f3c\u7684\u6027\u80fd\u5904\u7406\u975e\u7ed3\u6784\u5316\u548c\u7ed3\u6784\u5316\u6570\u636e\u3002<\/p>\n

\u7cfb\u7edf\u7684\u53e6\u4e00\u521b\u65b0\u5728\u4e8e\u7f16\u7801\u65b9\u6848\uff0c\u5b83\u4f7f\u7528\u57fa\u4e8e\u5f20\u91cf<\/mark>\u79ef\u7684\u6a21\u5757\u5316\u7f16\u7801\u65b9\u6848\uff0c\u65e2\u5145\u5206\u5229\u7528\u4e0a\u6e38\u6b65\u9aa4\u4e2d\u7684\u56fa\u6709\u5197\u4f59\uff0c\u53c8\u51cf\u5c11\u4e86\u7f16\u7801\u65b9\u6848\u4e2d\u6240\u9700\u7684\u5197\u4f59\u5ea6\u3002\u901a\u8fc7\u5f15\u5165\u5b89\u5168\u8fb9\u9645\u673a\u5236\uff0c\u8be5\u7cfb\u7edf\u80fd\u591f\u91cf\u5316<\/mark>\u5728\u7279\u5b9a\u5de5\u4f5c\u6761\u4ef6\u4e0b\u7684\u7a33\u5065\u6027\uff0c\u8fdb\u4e00\u6b65\u63d0\u5347\u53ef\u9760\u6027\u3002<\/p>\n

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\u56fe\u793a\uff1a\u4fe1\u606f\u68c0\u7d22<\/mark>\u6027\u80fd\u8bc4\u4f30\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u672a\u6765\u5c55\u671b\u4e0e\u610f\u4e49<\/strong><\/p>\n

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\u7136\u800c\uff0c\u8981\u5b9e\u73b0\u89c4\u6a21\u5316\u5e94\u7528\u4ecd\u9700\u89e3\u51b3 DNA \u5408\u6210\u4e0e\u6d4b\u5e8f\u6210\u672c\u3001\u957f\u671f\u7a33\u5b9a\u6027\u4ee5\u53ca\u6cd5\u5f8b\u548c\u6807\u51c6\u5316\u7b49\u95ee\u9898\u3002\u968f\u7740\u76f8\u5173\u6280\u672f\u7684\u8fdb\u6b65\uff0cDNAformer \u8fd9\u7c7b\u7aef\u5230\u7aef\u89e3\u51b3\u65b9\u6848\u5c06\u5728\u5927\u89c4\u6a21\u6570\u636e\u5b58\u50a8\u7cfb\u7edf\u4e2d\u53d1\u6325\u8d8a\u6765\u8d8a\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/p>\n

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