{"id":39277,"date":"2025-03-08T01:02:26","date_gmt":"2025-03-07T17:02:26","guid":{"rendered":"https:\/\/17aitech.com\/?p=39277"},"modified":"2025-03-08T01:02:26","modified_gmt":"2025-03-07T17:02:26","slug":"11%e5%a4%a9%e5%ae%9e%e7%8e%b018%e7%a7%8d%e5%b9%bf%e8%b0%b1%e6%8a%97%e8%8f%8c%e7%b4%a0%e8%ae%be%e8%ae%a1%ef%bc%8c%e4%bd%93%e5%a4%96%e9%aa%8c%e8%af%81%e6%88%90%e5%8a%9f%e7%8e%8794-4%ef%bc%8c%e6%b5%99","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=39277","title":{"rendered":"11\u5929\u5b9e\u73b018\u79cd\u5e7f\u8c31\u6297\u83cc\u7d20\u8bbe\u8ba1\uff0c\u4f53\u5916\u9a8c\u8bc1\u6210\u529f\u738794.4%\uff0c\u6d59\u5927\u4faf\u5ef7\u519b\u7b49\u7528LLM\u65b9\u6cd5\u4ece\u5934\u8bbe\u8ba1AMP"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:11\u5929\u5b9e\u73b018\u79cd\u5e7f\u8c31\u6297\u83cc\u7d20\u8bbe\u8ba1\uff0c\u4f53\u5916\u9a8c\u8bc1\u6210\u529f\u738794.4%\uff0c\u6d59\u5927\u4faf\u5ef7\u519b\u7b49\u7528LLM\u65b9\u6cd5\u4ece\u5934\u8bbe\u8ba1AMP<\/a><\/p>\n

<\/a><\/section>\n

\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n

\u5927\u578b\u8bed\u8a00\u6a21\u578b (LLM) \u5728\u5316\u5b66\u548c\u751f\u7269\u533b\u5b66\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u53ef\u4f5c\u4e3a\u5404\u79cd\u4efb\u52a1\u7684\u591a\u529f\u80fd\u57fa\u7840\u6a21\u578b\u3002<\/p>\n

\u6d59\u6c5f\u5927\u5b66\u4faf\u5ef7\u519b\u3001\u8c22\u660c\u8c15\u4ee5\u53ca\u5357\u65b9\u533b\u79d1\u5927\u5b66\u59dc\u5fd7\u8f89\u7b49\u8bfe\u9898\u7ec4\u7ec4\u6210\u7684\u8054\u5408\u56e2\u961f\u63d0\u51fa\u4e86 AMP-Designer\uff0c\u8fd9\u662f\u4e00\u79cd\u57fa\u4e8e LLM \u7684\u65b9\u6cd5\uff0c\u7528\u4e8e\u5feb\u901f\u8bbe\u8ba1\u5177\u6709\u6240\u9700\u7279\u6027\u7684\u6297\u83cc\u80bd (AMP)\u3002<\/p>\n

\u5728 11 \u5929\u5185\uff0cAMP-Designer \u5b9e\u73b0\u4e86 18 \u79cd\u5177\u6709\u5e7f\u8c31\u6297\u9769\u5170\u6c0f\u9634\u6027\u7ec6\u83cc\u6d3b\u6027\u7684 AMP \u7684\u4ece\u5934\u8bbe\u8ba1\u3002<\/p>\n

\u4f53\u5916\u9a8c\u8bc1\u663e\u793a\u6210\u529f\u7387\u4e3a 94.4%\uff0c\u4e24\u79cd\u5019\u9009\u836f\u7269\u8868\u73b0\u51fa\u5353\u8d8a\u7684\u6297\u83cc\u529f\u6548\u3001\u6700\u5c0f\u7684\u8840\u6db2\u6bd2\u6027\u3001\u5728\u4eba\u8840\u6d46\u4e2d\u7684\u7a33\u5b9a\u6027\u4ee5\u53ca\u8f83\u4f4e\u7684\u8bf1\u53d1\u8010\u836f\u6027\u53ef\u80fd\u6027\uff0c\u5c0f\u9f20\u80ba\u90e8\u611f\u67d3\u5b9e\u9a8c\u4e2d\u7ec6\u83cc\u8d1f\u8377\u663e\u8457\u51cf\u5c11\u5c31\u662f\u660e\u8bc1\u3002\u4ece\u8bbe\u8ba1\u5230\u9a8c\u8bc1\u7684\u6574\u4e2a\u8fc7\u7a0b\u5728 48 \u5929\u5185\u5b8c\u6210\u3002<\/p>\n

\u5c3d\u7ba1\u6570\u636e\u6709\u9650\uff0cAMP-Designer \u4ecd\u64c5\u957f\u521b\u5efa\u9488\u5bf9\u7279\u5b9a\u83cc\u682a\u7684 AMP\uff0c\u5176\u4e2d\u6700\u4f73\u5019\u9009\u7269\u5bf9\u75e4\u75ae\u4e19\u9178\u6746\u83cc\u7684\u6700\u4f4e\u6291\u5236\u6d53\u5ea6\u4e3a\u6bcf\u6beb\u5347 2.0 \u5fae\u514b\u3002AMP-Designer \u96c6\u6210\u4e86\u5148\u8fdb\u7684\u673a\u5668\u5b66\u4e60\u6280\u672f\uff0c\u8868\u73b0\u51fa\u5353\u8d8a\u7684\u6548\u7387\uff0c\u4e3a\u6297\u751f\u7d20\u8010\u836f\u6027\u7684\u521b\u65b0\u89e3\u51b3\u65b9\u6848\u94fa\u5e73\u4e86\u9053\u8def\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cDiscovery of antimicrobial peptides with notable antibacterial potency by an LLM-based foundation model<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 3 \u6708 5 \u65e5\u53d1\u5e03\u5728\u300aScience Advance<\/em>\u300b\u3002<\/p>\n

<\/a><\/section>\n

\u80cc\u666f<\/p>\n

\u7ec6\u83cc\u6297\u83cc\u7d20\u8010\u836f\u6027\uff08AMR\uff09\u5bf9\u5168\u7403\u4eba\u7c7b\u5065\u5eb7\u6784\u6210\u91cd\u5927\u5a01\u80c1\uff0c2019 \u5e74\u5168\u7403\u7ea6 495 \u4e07\u6b7b\u4ea1\u4e0e\u7ec6\u83ccAMR\u76f8\u5173\uff0c\u5176\u4e2d 127 \u4e07\u6b7b\u4ea1\u76f4\u63a5\u5f52\u56e0\u4e8e AMR\uff0c\u9884\u8ba1\u5230 2050 \u5e74\u6bcf\u5e74\u6b7b\u4ea1\u4eba\u6570\u5c06\u8fbe 1000 \u4e07\u3002\u9769\u5170\u6c0f\u9634\u6027\u83cc\u5bf9\u5e38\u7528\u6297\u751f\u7d20\u8010\u836f\u6027\u5c24\u4e3a\u4e25\u91cd\uff0c\u4e14\u81ea 1968 \u5e74\u55b9\u8bfa\u916e\u7c7b\u6297\u751f\u7d20\u95ee\u4e16\u4ee5\u6765\uff0c\u5c1a\u65e0\u6709\u6548\u65b0\u836f\u901a\u8fc7\u4e34\u5e8a\u9636\u6bb5\u3002<\/p>\n

\u6297\u83cc\u80bd\uff08AMPs\uff09\u56e0\u5176\u7ed3\u6784\u529f\u80fd\u591a\u6837\u3001\u7597\u6548\u597d\u4e14\u4e0d\u6613\u4ea7\u751f\u8010\u836f\u6027\uff0c\u88ab\u89c6\u4e3a\u6f5c\u5728\u66ff\u4ee3\u4f20\u7edf\u5c0f\u5206\u5b50\u6297\u751f\u7d20\u7684\u5019\u9009\uff0c\u4f46\u5176\u6297\u83cc\u6d3b\u6027\u8f83\u4f4e\u3001\u6bd2\u6027\u4e0d\u786e\u5b9a\u3001\u6613\u5931\u6d3b\u7b49\u95ee\u9898\u9650\u5236\u4e86\u5e7f\u6cdb\u5e94\u7528\u3002\u5f53\u524d\u7814\u7a76\u81f4\u529b\u4e8e\u63d0\u5347 AMP \u6d3b\u6027\u3001\u964d\u4f4e\u6bd2\u6027\u3001\u589e\u5f3a\u6297\u6c34\u89e3\u80fd\u529b\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u8ba1\u7b97\u673a\u8f85\u52a9\u65b9\u6cd5\u52a0\u901f\u4e86 AMP \u8bbe\u8ba1\uff0c\u4f46\u80bd\u5e8f\u5217\u7a7a\u95f4\u5e9e\u5927\uff08\u7ea6 4.5\u00d710^41 \u79cd\u5e8f\u5217\uff09\uff0c\u4e14\u4ec5\u6709\u7ea6 10 \u79cd AMP \u83b7\u6279\uff0c\u8868\u660e\u6709\u6548 AMP \u5206\u5e03\u7a00\u758f\uff0c\u4e9f\u9700\u65b0\u65b9\u6cd5\u63d0\u9ad8\u8bbe\u8ba1\u6548\u7387\u3002<\/p>\n

\u8fd1\u671f\uff0cChatGPT\u3001DeepSeek \u7b49\u5927\u8bed\u8a00\u6a21\u578b\u7684\u5174\u8d77\u4e3a AMP \u8bbe\u8ba1\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002AMP \u751f\u6210\u4f5c\u4e3a\u86cb\u767d\u8d28\u8bed\u8a00\u5efa\u6a21\u4efb\u52a1\uff0c\u53d7\u76ca\u4e8e\u81ea\u7136\u8bed\u8a00\u5904\u7406\u5927\u6a21\u578b\uff08LLM\uff09\u7684\u53d1\u5c55\u3002<\/p>\n

\u7c7b\u6bd4 NLP \u548c\u5176\u4ed6\u86cb\u767d\u8d28\u8bbe\u8ba1\u6848\u4f8b\uff0c\u5927\u89c4\u6a21\u5e8f\u5217\u751f\u6210\u6a21\u578b\u6709\u671b\u5728 AMP \u8bbe\u8ba1\u4e2d\u8868\u73b0\u51fa\u8272\u3002\u63d0\u793a\u8c03\u4f18\uff08prompt tuning\uff09\u9010\u6e10\u53d6\u4ee3\u4f20\u7edf\u5fae\u8c03\u65b9\u6cd5\uff0c\u5177\u6709\u66f4\u9ad8\u8ba1\u7b97\u6548\u7387\u548c\u7075\u6d3b\u6027\uff0c\u80fd\u7f13\u89e3\u8fc7\u62df\u5408\u5e76\u6709\u6548\u8fde\u63a5\u9884\u8bad\u7ec3\u4e0e\u4e0b\u6e38\u4efb\u52a1\uff0c\u9002\u7528\u4e8e\u6761\u4ef6\u751f\u6210\u4efb\u52a1\u4e2d\u591a\u6837\u6027\u4e0e\u6210\u529f\u7387\u7684\u5e73\u8861\u3002<\/p>\n

AMP-Designer<\/p>\n

\u5728\u6700\u65b0\u7684\u5de5\u4f5c\u4e2d\uff0c\u6d59\u5927\u3001\u5357\u533b\u5927\u7684\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86 AMP-Designer\uff0c\u8fd9\u662f\u4e00\u4e2a\u7528\u4e8e AMP \u8bbe\u8ba1\u7684\u7efc\u5408\u6846\u67b6\uff0c\u5b83\u96c6\u6210\u4e86 GPT\u3001\u5feb\u901f\u8c03\u6574\u3001\u5bf9\u6bd4\u5b66\u4e60\u3001\u77e5\u8bc6\u63d0\u70bc\u548c\u5f3a\u5316\u5b66\u4e60 (RL)\uff0c\u7136\u540e\u8fdb\u884c\u4e00\u7cfb\u5217\u6e7f\u5b9e\u9a8c\u5ba4\u5206\u6790\u7528\u6765\u9a8c\u8bc1\u6240\u8bbe\u8ba1\u7684 AMP\u3002<\/p>\n

<\/a><\/section>\n

\u56fe\u793a\uff1aAMP-Designer \u6982\u8ff0\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u8be5\u65b9\u6cd5\u5305\u62ec\u5728\u4ece\u00a0UniProt\u00a0\u4e2d\u63d0\u53d6\u7684\u80bd\u6570\u636e\u96c6\u4e0a\u8bad\u7ec3\u4ee5 AMP \u4e3a\u4e2d\u5fc3\u7684\u8bed\u8a00\u6a21\u578b\u4f5c\u4e3a\u57fa\u7840\u6a21\u578b AMP-GPT\u3002\u4e3a\u4e86\u4fc3\u8fdb\u5728\u6807\u8bb0\u7684 AMP \u6570\u636e\u96c6\u4e0a\u8fdb\u884c\u8fc1\u79fb\u5b66\u4e60\u5e76\u751f\u6210\u5177\u6709\u7406\u60f3\u7279\u5f81\u7684\u80bd\u5e8f\u5217\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86 AMP-Prompt\uff0c\u5373\u5bf9\u6bd4\u63d0\u793a\u5b66\u4e60\uff0c\u540c\u65f6\u4fdd\u6301 AMP-GPT \u7684\u53c2\u6570\u4e0d\u53d8\u3002<\/p>\n

<\/a><\/section>\n

\u56fe\u793a\uff1a\u7269\u7406\u5316\u5b66\u6027\u8d28\u7684\u6bd4\u8f83\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u4e3a\u4e86\u8fdb\u4e00\u6b65\u964d\u4f4e\u8ba1\u7b97\u6210\u672c\uff0c\u8be5\u56e2\u961f\u5bf9 AMP-Prompt \u8fdb\u884c\u4e86\u6a21\u578b\u84b8\u998f\uff0c\u5c06\u5176\u538b\u7f29\u4e3a\u7531\u4e09\u4e2a\u95e8\u63a7\u5faa\u73af\u5355\u5143 (GRU) \u5c42\u7ec4\u6210\u7684 RNN\uff0c\u5373 AMP-Distillation\u3002<\/p>\n

\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u57fa\u4e8e AMP-GPT \u6784\u5efa\u4e86\u4e0d\u540c\u7ec6\u83cc\u7269\u79cd\u7684\u6700\u4f4e\u6291\u83cc\u6d53\u5ea6\uff08MIC\uff09\u9884\u6d4b\u6a21\u578b AMP-MIC\uff0c\u63d0\u4f9b\u53cd\u9988\u5e76\u4fc3\u8fdb\u540e\u7eed\u4f7f\u7528 RL \u8fdb\u884c\u7b5b\u9009\u3002<\/p>\n

<\/a><\/section>\n

\u56fe\u793a\uff1a\u6d3b\u52a8\u6982\u7387\u548c\u6bd4\u8d5b\u5206\u6570\u5206\u5e03\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u4f7f\u7528 AMP-Designer\uff0c\u4ed6\u4eec\u5b9e\u73b0\u4e86\u9488\u5bf9\u7279\u5b9a\u7ec6\u83cc\u7269\u79cd\u7684\u9ad8\u5ea6\u591a\u6837\u5316\u548c\u9ad8\u6548 AMP \u7684\u5feb\u901f\u4ece\u5934\u8bbe\u8ba1\u3002\u6839\u636e AMP-MIC \u63d0\u4f9b\u7684\u5e73\u5747\u9884\u6d4b\u5206\u6570\uff0c\u9009\u62e9\u5e76\u5408\u6210\u524d 20 \u4e2a AMP \u5019\u9009\u7269\uff08\u4e24\u4e2a\u80bd\u5728\u4e09\u8f6e\u5316\u5b66\u5408\u6210\u540e\u5931\u8d25\uff09\uff0c\u4ece\u800c\u5728 48 \u5929\u5185\u53d1\u73b0\u4e86\u4e24\u4e2a\u7ecf\u8fc7\u6e7f\u5b9e\u9a8c\u5ba4\u9a8c\u8bc1\u7684\u5353\u8d8a AMP\uff0c\u5373 KW13 \u548c AI18\u3002<\/p>\n

<\/a><\/section>\n

\u56fe\u793a\uff1a\u6240\u9009\u6297\u83cc\u80bd\uff08AMP\uff09\u7684\u4f53\u5916\u751f\u7269\u5b66\u7279\u6027\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u8fd9\u4e24\u79cd\u591a\u80bd\u5bf9\u591a\u79cd\u9769\u5170\u6c0f\u9634\u6027\u83cc\u548c\u9769\u5170\u6c0f\u9633\u6027\u83cc\u5747\u8868\u73b0\u51fa\u5f88\u5f3a\u7684\u4f53\u5916\u6297\u83cc\u6d3b\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e24\u79cd\u65b0\u8bbe\u8ba1\u7684\u591a\u80bd\u90fd\u8868\u73b0\u51fa\u8f83\u4f4e\u7684\u8131\u9776\u6eb6\u8840\u6bd2\u6027\u3001\u4f18\u5f02\u7684\u8840\u6d46\u7a33\u5b9a\u6027\uff0c\u4ee5\u53ca\u5bf9\u4e00\u7cfb\u5217\u4e34\u5e8a\u6765\u6e90\u7684\u8010\u836f\u9769\u5170\u6c0f\u9634\u6027\u83cc\u7684\u5f3a\u6548\u6297\u83cc\u6d3b\u6027\u3002<\/p>\n

\u4e9a MIC \u6d53\u5ea6\u7684 KW13 \u548c AI18 \u5728\u5927\u80a0\u6746\u83cc\u4e2d\u57f9\u517b 30 \u4ee3\u540e\u672a\u8bf1\u5bfc\u8010\u836f\u6027\u3002\u6b64\u5916\uff0c\u5b83\u4eec\u5728\u7ec6\u83cc\u6027\u80ba\u708e\u5c0f\u9f20\u6a21\u578b\u4e2d\u8868\u73b0\u51fa\u663e\u8457\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

<\/a><\/section>\n

\u56fe\u793a\uff1aKW13 \u548c AI18 \u6cbb\u7597\u5c0f\u9f20\u80ba\u708e\u7684\u4f53\u5185\u7597\u6548\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

AMP-Designer \u662f\u4e00\u4e2a\u5373\u63d2\u5373\u7528\u7684\u6846\u67b6\u3002\u5bf9\u4e8e\u65b0\u7684\u8bbe\u8ba1\u4efb\u52a1\uff0c\u57fa\u4e8e\u8bad\u7ec3\u597d\u7684\u57fa\u7840\u6a21\u578b AMP-GPT\uff0c\u4ec5\u9700 3 \u5929\u5de6\u53f3\u5373\u53ef\u5b8c\u6210\u8bbe\u8ba1\u3002<\/p>\n

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