{"id":39334,"date":"2025-03-11T04:02:23","date_gmt":"2025-03-10T20:02:23","guid":{"rendered":"https:\/\/17aitech.com\/?p=39334"},"modified":"2025-03-11T04:02:23","modified_gmt":"2025-03-10T20:02:23","slug":"%e6%89%a9%e6%95%a3%e6%a8%a1%e5%9e%8b%e6%b7%b1%e5%ba%a6%e5%ad%a6%e4%b9%a0%e5%8f%8c%e5%89%91%e5%90%88%e7%92%a7%ef%bc%8c%e7%94%9f%e6%88%90%e5%bc%8fai%e7%a0%b4%e8%a7%a3%e6%9f%93%e8%89%b2%e8%b4%a8","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=39334","title":{"rendered":"\u6269\u6563\u6a21\u578b+\u6df1\u5ea6\u5b66\u4e60\u53cc\u5251\u5408\u74a7\uff0c\u751f\u6210\u5f0fAI\u7834\u89e3\u67d3\u8272\u8d28\u6784\u8c61"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u6269\u6563\u6a21\u578b+\u6df1\u5ea6\u5b66\u4e60\u53cc\u5251\u5408\u74a7\uff0c\u751f\u6210\u5f0fAI\u7834\u89e3\u67d3\u8272\u8d28\u6784\u8c61<\/a><\/p>\n

<\/a><\/section>\n

\u7f16\u8f91\u4e28&<\/p>\n

\u4eba\u4f53\u5185\u7684\u6bcf\u4e00\u4e2a\u7ec6\u80de\u90fd\u5305\u542b\u76f8\u540c\u7684\u57fa\u56e0\u5e8f\u5217\uff0c\u4f46\u6bcf\u4e2a\u7ec6\u80de\u53ea\u8868\u8fbe\u8fd9\u4e9b\u57fa\u56e0\u7684\u4e00\u4e2a\u65b9\u9762\u3002\u8fd9\u4e9b\u7ec6\u80de\u7279\u5f02\u6027\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u786e\u4fdd\u8111\u7ec6\u80de\u4e0e\u76ae\u80a4\u7ec6\u80de\u4e0d\u540c\uff0c\u90e8\u5206\u7531\u67d3\u8272\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\u51b3\u5b9a\uff0c\u9057\u4f20\u7269\u8d28\u63a7\u5236\u7740\u6bcf\u4e2a\u57fa\u56e0\u7684\u53ef\u53ca\u6027\u3002<\/p>\n

\u9ad8\u901a\u91cf\u6d4b\u5e8f\u548c\u6210\u50cf\u6280\u672f\u7684\u6700\u65b0\u8fdb\u5c55\u5927\u5927\u63d0\u9ad8\u4e86\u5982\u4eca\u7814\u7a76\u5355\u4e2a\u7ec6\u80de\u57fa\u56e0\u7ec4\u7ec4\u7ec7\u7684\u80fd\u529b\u3002\u7136\u800c\uff0c\u73b0\u6709\u65b9\u6cd5\u901a\u5e38\u8d39\u529b\u4e14\u8017\u65f6\uff0c\u963b\u788d\u4e86\u5bf9\u4e0d\u540c\u7ec6\u80de\u73af\u5883\u4e2d\u67d3\u8272\u8d28\u6784\u8c61\u53d8\u5f02\u6027\u7684\u5168\u9762\u5206\u6790\u3002<\/p>\n

\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u7684\u5316\u5b66\u5bb6\u4eec\u73b0\u5728\u60f3\u51fa\u4e86\u4e00\u79cd\u4f7f\u7528\u751f\u6210\u5f0f\u4eba\u5de5\u667a\u80fd<\/mark>\u6765\u786e\u5b9a\u8fd9\u4e9b 3D \u57fa\u56e0\u7ec4\u7ed3\u6784\u7684\u65b0\u65b9\u6cd5\u3002\u4ed6\u4eec\u7684\u6280\u672f\u53ef\u4ee5\u5728\u51e0\u5206\u949f\u5185\u9884\u6d4b\u6570\u5343\u4e2a\u7ed3\u6784\uff0c\u8fd9\u6bd4\u73b0\u6709\u7684\u7ed3\u6784\u5206\u6790\u5b9e\u9a8c\u65b9\u6cd5\u8981\u5feb\u5f97\u591a\u3002<\/p>\n

\u4ed6\u4eec\u7684\u7814\u7a76\u4ee5\u300cChromoGen: Diffusion model predicts single-cell chromatin conformations<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 1 \u6708 31 \u65e5\u53d1\u5e03\u5728\u300aScience Advances<\/em>\u300b\u3002<\/p>\n

<\/a><\/section>\n

\u300c\u6211\u4eec\u7684\u76ee\u6807\u662f\u5c1d\u8bd5\u4ece\u6f5c\u5728\u7684 DNA \u5e8f\u5217\u4e2d\u9884\u6d4b\u4e09\u7ef4\u57fa\u56e0\u7ec4\u7ed3\u6784\uff0c\u300d\u5316\u5b66\u526f\u6559\u6388\u3001\u8be5\u7814\u7a76\u7684\u8d44\u6df1\u4f5c\u8005\u00a0Bin Zhang\u00a0\u8bf4\u3002\u300c\u73b0\u5728\u6211\u4eec\u53ef\u4ee5\u505a\u5230\u8fd9\u4e9b\uff0c\u8fd9\u4f7f\u5f97\u5b83\u53ef\u4ee5\u4e0e\u5c16\u7aef\u7684\u5b9e\u9a8c\u6280\u672f\u76f8\u63d0\u5e76\u8bba\uff0c\u5e76\u5f00\u8f9f\u5f88\u591a\u6709\u8da3\u7684\u673a\u4f1a\u3002\u300d<\/p>\n

ChromoGen<\/strong><\/p>\n

\u4e86\u89e3\u57fa\u56e0\u7ec4\u7684\u4e09\u7ef4 \uff083D\uff09 \u7ec4\u7ec7\u5bf9\u4e8e\u63ed\u793a\u5176\u529f\u80fd\u590d\u6742\u6027\u548c\u5728\u57fa\u56e0\u8c03\u63a7\u4e2d\u7684\u4f5c\u7528\u81f3\u5173\u91cd\u8981\u3002\u591a\u5e74\u6765\uff0c\u5206\u5b50\u751f\u7269\u5b66\u6280\u672f\u7684\u8fdb\u6b65\u4e3a\u57fa\u56e0\u7ec4\u6784\u8c61\u63d0\u4f9b\u4e86\u5b9d\u8d35\u7684\u89c1\u89e3\u3002\u8fd9\u4e9b\u89c1\u89e3\u63ed\u793a\u4e86\u67d3\u8272\u8d28\u7ed3\u6784\u5982\u4f55\u4fc3\u8fdb\u57fa\u56e0\u5468\u56f4\u7a7a\u95f4\u73af\u5883\u7684\u5efa\u7acb\uff0c\u6709\u52a9\u4e8e\u5728\u9002\u5f53\u7684\u65f6\u95f4\u52df\u96c6\u9002\u5f53\u7684\u5206\u5b50\u6765\u534f\u8c03\u8f6c\u5f55\u3002<\/p>\n

\u6700\u8fd1\uff0c\u6df1\u5ea6\u5b66\u4e60<\/mark>\u6280\u672f\u4e3a\u76f4\u63a5\u4ece\u6d4b\u5e8f\u6570\u636e\u9884\u6d4b\u5355\u7ec6\u80de\u67d3\u8272\u8d28\u6784\u8c61\u63d0\u4f9b\u4e86\u6709\u6f5c\u529b\u7684\u7814\u7a76\u65b9\u5411\u3002\u4e0e\u5e8f\u5217\u7279\u5f81\u548c\u7fa4\u4f53\u5e73\u5747\u503c\u4e4b\u95f4\u76f8\u5bf9\u7b80\u5355\u7684\u6620\u5c04<\/mark>\u4e0d\u540c\uff0c\u5e8f\u5217\u7279\u5f81\u6620\u5c04<\/mark>\u5230\u5355\u4e2a 3D \u7ed3\u6784\u672c\u8d28\u4e0a\u662f\u968f\u673a\u7684\u3002\u56e0\u6b64\uff0c\u9884\u6d4b\u5355\u4e2a\u67d3\u8272\u8d28\u7ed3\u6784\u9700\u8981\u4e00\u4e2a\u56fa\u6709\u7684\u968f\u673a\u6a21\u578b\u6765\u7406\u89e3\u548c\u518d\u73b0\u8fd9\u79cd\u5f02\u8d28\u6027\u3002<\/p>\n

\u4e3a\u4e86\u5728\u6355\u83b7\u5176\u5f02\u8d28\u6027\u7684\u540c\u65f6\u9884\u6d4b\u5355\u7ec6\u80de\u67d3\u8272\u8d28\u7ed3\u6784\uff0c\u56e2\u961f\u5f15\u5165\u4e86 ChromoGen\uff0c\u5b83\u662f\u4e00\u79cd\u6269\u6563\u6a21\u578b\uff0c\u5df2\u88ab\u8bc1\u660e\u5728\u6587\u672c\u5230\u56fe\u50cf\u5e94\u7528\u4ee5\u53ca\u9884\u6d4b\u914d\u4f53\u548c\u86cb\u767d\u8d28\u5206\u5b50\u7684 3D \u5750\u6807\u65b9\u9762\u5177\u6709\u5f88\u5f3a\u7684\u80fd\u529b\u3002<\/p>\n

<\/a><\/section>\n
\u56fe 1\uff1aChromoGen \u5728\u4f7f\u7528\u5e8f\u5217\u6570\u636e\u5bf9\u67d3\u8272\u8d28\u7ec4\u7ec7\u8fdb\u884c\u4ece\u5934\u9884\u6d4b\u65f6\u9075\u5faa\u7684\u7a0b\u5e8f\u56fe\u793a\u3002\uff08\u56fe\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u5fae\u8c03\u7684 EPCOT \u6a21\u578b\u5c06 DNA \u5e8f\u5217\u548c\u8131\u6c27\u6838\u7cd6\u6838\u9178\u9176\u5e8f\u5217\uff08DNase-seq\uff09\u6570\u636e\u8f6c\u6362\u4e3a\u4fe1\u606f\u4e30\u5bcc\u7684\u4f4e\u7ef4\u6570\u5b57\u5d4c\u5165\u3002\u63a5\u4e0b\u6765\uff0c\u7531\u5fae\u8c03\u6a21\u578b\u521b\u5efa\u7684\u5d4c\u5165\u4f7f\u7528\u65e0\u5206\u7c7b\u5668\u6307\u5bfc\u7684\u53bb\u566a\u6269\u6563\u6982\u7387\u6a21\u578b\uff08DDPM\uff09\u5bf9\u91c7\u6837\u7684\u5206\u5e03\u8fdb\u884c\u6761\u4ef6\u5904\u7406\u3002<\/p>\n

\u6b64\u5916\uff0c\u8ddd\u79bb\u56fe\u81ea\u7136\u4e0d\u53d7 3D \u6784\u8c61\u7684\u65cb\u8f6c\u548c\u5e73\u79fb\u7684\u5f71\u54cd\uff0c\u8bb8\u591a\u795e\u7ecf\u7f51\u7edc<\/mark>\u67b6\u6784\u90fd\u96be\u4ee5\u7406\u89e3\uff0c\u5e76\u4e14\u8ddd\u79bb\u56fe\u53ef\u4ee5\u6309\u7167\u6750\u6599\u548c\u65b9\u6cd5\u4e2d\u6982\u8ff0\u7684\u8fc7\u7a0b\u8f7b\u677e\u8f6c\u6362\u4e3a\u7b1b\u5361\u5c14\u5750\u6807\u3002<\/p>\n

\u4e3a\u4e86\u7814\u7a76\u901a\u7528\u533a\u57df\u975e\u7279\u5f02\u6027\u7cfb\u7efc\u7684\u7279\u6027\uff0c\u56e2\u961f\u901a\u8fc7\u7ec4\u5408\u6765\u81ea\u66f4\u5e7f\u6cdb\u6570\u636e\u96c6\u4e2d\u6bcf\u4e2a\u533a\u57df\u7684 200 \u4e2a\u751f\u6210\u7684\u7ed3\u6784\u6765\u8fd1\u4f3c\u4e00\u4e2a\u901a\u7528\u96c6\u6210\uff0c\u5e76\u8ba1\u7b97\u4e86\u7531\u5404\u79cd\u5e8f\u5217\u957f\u5ea6\u5206\u9694\u7684\u57fa\u56e0\u5ea7\u4e4b\u95f4\u7a7a\u95f4\u8ddd\u79bb\u7684\u6982\u7387\u5206\u5e03<\/mark>\u3002<\/p>\n

<\/a><\/section>\n
\u56fe 2\uff1aChromoGen \u53ef\u51c6\u786e\u6355\u83b7\u5728\u5355\u7ec6\u80de\u67d3\u8272\u8d28\u7ed3\u6784\u4e2d\u89c2\u5bdf\u5230\u7684\u6784\u8c61\u5206\u5e03\u3002\uff08\u56fe\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u4e0e\u5148\u524d\u5bf9\u5355\u4e2a\u63a5\u89e6\u5bf9\u7684\u5206\u6790\u76f8\u6bd4\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5141\u8bb8\u5bf9\u67d3\u8272\u8d28\u6784\u8c61\u8fdb\u884c\u66f4\u5168\u9762\u7684\u6bd4\u8f83\u3002\u4f7f\u7528\u751f\u6210\u7684\u6784\u8c61\u652f\u6301 ChromoGen \u4ea7\u751f\u9ad8\u5ea6\u590d\u6742\u7ed3\u6784\u7684\u80fd\u529b\uff0c\u8fd9\u4e9b\u7ed3\u6784\u6db5\u76d6\u5e7f\u6cdb\u7684\u6784\u8c61\u548c\u7ed3\u6784\u57fa\u5e8f\u3002<\/p>\n

\u66f4\u591a\u66f4\u51c6\u786e\u7684\u5e94\u7528\u6d4b\u8bd5<\/strong><\/p>\n

\u9a8c\u8bc1\u4e86\u751f\u6210\u7684\u6784\u8c61\u7684\u901a\u7528\u7269\u7406\u7279\u6027\u540e\uff0c\u4ed6\u4eec\u63a5\u4e0b\u6765\u7814\u7a76\u4e86 ChromoGen \u6355\u83b7\u5177\u6709\u751f\u7269\u5b66\u610f\u4e49\u7684\u7ed3\u6784\u7279\u5f81\u7684\u80fd\u529b\u3002\u5728\u6240\u6709\u60c5\u51b5\u4e0b\uff0c\u751f\u6210\u7684\u4e2d\u4f4d\u8ddd\u79bb\u56fe\u6355\u83b7\u4e86\u7fa4\u4f53\u4e2d\u53ef\u89c1\u7684\u5173\u952e\u7ed3\u6784\u7279\u5f81\u3002\u540c\u6837\uff0c\u751f\u6210\u7684\u5355\u4e2a\u7ed3\u6784\u4e0e\u5b83\u4eec\u4ece Dip-C \u884d\u751f\u7684\u5bf9\u5e94\u7ed3\u6784\u975e\u5e38\u76f8\u4f3c\u3002<\/p>\n

\u4e3a\u4e86\u5b9a\u91cf\u8bc4\u4f30\u751f\u6210\u7ed3\u6784\u548c\u5b9e\u9a8c\u7ed3\u6784\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\uff0c\u56e2\u961f\u5bf9\u9884\u6d4b\u6570\u636e\u96c6\u6240\u5305\u542b\u7684\u6574\u4e2a\u57fa\u56e0\u7ec4\u533a\u57df\u8fdb\u884c\u4e86\u591a\u6b21\u5206\u6790\u3002\u7ed3\u679c\u663e\u793a\u4f7f\u7528\u751f\u6210\u7684\u548c Dip-C \u6784\u8c61\u8ba1\u7b97\u7684\u4e2d\u4f4d\u8ddd\u79bb\u56fe\u59cb\u7ec8\u5177\u6709\u5f3a\u76f8\u5173\u6027\u3002<\/p>\n

\u800c\u5728\u8de8\u7ec6\u80de\u7c7b\u578b\u7684\u9884\u6d4b\u4e0a\uff0c\u4ee5\u524d\u7684\u6a21\u578b\u5df2\u7ecf\u6210\u529f\u5730\u4f7f\u7528\u67d3\u8272\u8d28\u53ef\u53ca\u6027\u6570\u636e\u6765\u9884\u6d4b\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u7fa4\u4f53\u5e73\u5747\u67d3\u8272\u8d28\u7ec4\u7ec7\u6a21\u5f0f\u7684\u5dee\u5f02\u3002\u6240\u4ee5\u9884\u8ba1\u63d0\u4f9b\u7ed9 ChromoGen \u7684\u6570\u636e\u5e94\u8be5\u5141\u8bb8\u5b83\u9884\u6d4b\u5177\u6709\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7684\u6784\u8c61\u96c6\u5408\u3002<\/p>\n

<\/a><\/section>\n
\u56fe 3\uff1aChromoGen \u4ea7\u751f\u51c6\u786e\u7684\u3001\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7684\u67d3\u8272\u8d28\u6784\u8c61\u3002\uff08\u56fe\u6e90\uff1a\u8bba\u6587\uff09<\/section>\n

\u5c3d\u7ba1\u663e\u5fae\u955c\u6210\u50cf\u663e\u793a\uff0c\u53bb\u9664\u9ecf\u8fde\u86cb\u767d\u7684\u7ec6\u80de\u5728\u7fa4\u4f53\u4e2d\u4f4d\u8ddd\u79bb\u56fe\u4e2d\u5e76\u672a\u51fa\u73b0\uff0c\u4f46\u5b83\u4eec\u7684\u786e\u5b58\u5728\u3002\u6b63\u5982\u6210\u50cf\u548c\u7406\u8bba\u7814\u7a76\u6240\u8868\u660e\u7684\u90a3\u6837\uff0c\u5b83\u4eec\u8fd8\u4e0e\u67d3\u8272\u8d28\u7ec4\u7ec7\u5230\u5355\u4e2a\u7ec6\u80de\u5185\u5305\u88c5\u7ed3\u6784\u57df\u7684\u65b0\u5174\u6a21\u578b\u4e00\u81f4\u3002<\/p>\n

\u529f\u80fd\u603b\u7ed3<\/strong><\/p>\n

ChromoGen\uff0c\u4e00\u79cd\u6709\u6548\u751f\u6210\u533a\u57df\u548c\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u67d3\u8272\u8d28\u6784\u8c61\u7684\u667a\u80fd\u6846\u67b6\u3002ChromoGen \u4ea7\u751f\u7684\u6784\u8c61\u518d\u73b0\u4e86\u7fa4\u4f53 Hi-C \u5b9e\u9a8c\u4e2d\u63ed\u793a\u7684\u5404\u79cd\u7ed3\u6784\u7279\u5f81\u4ee5\u53ca\u5728\u5355\u7ec6\u80de\u6570\u636e\u96c6\u4e2d\u89c2\u5bdf\u5230\u7684\u5f02\u8d28\u6027\u3002<\/p>\n

\u7ecf\u8fc7\u8bad\u7ec3\u540e\uff0c\u8be5\u6a21\u578b\u53ef\u4ee5\u5728\u6bd4 Hi-C \u6216\u5176\u4ed6\u5b9e\u9a8c\u6280\u672f\u66f4\u5feb\u7684\u65f6\u95f4\u5c3a\u5ea6\u4e0a\u751f\u6210\u9884\u6d4b\u3002\u5176\u53ef\u4ee5\u5728 20 \u5206\u949f\u5185\u5728\u4e00\u4e2a GPU \u4e0a\u751f\u6210\u7279\u5b9a\u533a\u57df\u7684\u4e00\u5343\u4e2a\u7ed3\u6784\u3002<\/p>\n

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\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.science.org\/doi\/10.1126\/sciadv.adr8265<\/em><\/p>\n

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