{"id":39513,"date":"2025-03-19T08:02:25","date_gmt":"2025-03-19T00:02:25","guid":{"rendered":"https:\/\/17aitech.com\/?p=39513"},"modified":"2025-03-19T08:02:25","modified_gmt":"2025-03-19T00:02:25","slug":"%e5%8e%9f%e5%ad%90%e7%ba%a7%e7%b2%be%e7%a1%ae%ef%bc%8cdavid-baker%e5%9b%a2%e9%98%9f%e5%bc%80%e5%8f%91rfdiffusion%e5%8f%98%e4%bd%93%e5%af%b9%e6%8a%97%e4%bd%93%e8%bf%9b%e8%a1%8c%e4%bb%8e%e5%a4%b4","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=39513","title":{"rendered":"\u539f\u5b50\u7ea7\u7cbe\u786e\uff0cDavid Baker\u56e2\u961f\u5f00\u53d1RFdiffusion\u53d8\u4f53\u5bf9\u6297\u4f53\u8fdb\u884c\u4ece\u5934\u8bbe\u8ba1"},"content":{"rendered":"<p>\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:<a href=\"https:\/\/www.jiqizhixin.com\/articles\/2025-03-18-5\" target=\"_blank\">\u539f\u5b50\u7ea7\u7cbe\u786e\uff0cDavid Baker\u56e2\u961f\u5f00\u53d1RFdiffusion\u53d8\u4f53\u5bf9\u6297\u4f53\u8fdb\u884c\u4ece\u5934\u8bbe\u8ba1<\/a><\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-4e40330c5f6b9a7d94a581e1c3be0d54.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-4e40330c5f6b9a7d94a581e1c3be0d54.png\"><\/a><\/p>\n<p>\u7f16\u8f91 | \u841d\u535c\u76ae<\/p>\n<p>\u6297\u4f53\u5728\u73b0\u4ee3\u533b\u5b66\u4e2d\u53d1\u6325\u7740\u6838\u5fc3\u4f5c\u7528\uff0c\u4f46\u76ee\u524d\u8fd8\u6ca1\u6709\u5b8c\u5168\u5728\u8ba1\u7b97\u673a\u4e2d\u8bbe\u8ba1\u4e0e\u7279\u5b9a\u8868\u4f4d\u7ed3\u5408\u7684\u65b0\u578b\u6297\u4f53\u7684\u65b9\u6cd5\u3002\u76f8\u53cd\uff0c\u6297\u4f53\u53d1\u73b0\u76ee\u524d\u4f9d\u8d56\u4e8e\u52a8\u7269\u514d\u75ab\u6216\u968f\u673a\u6587\u5e93\u7b5b\u9009\u65b9\u6cd5\u3002<\/p>\n<p>\u534e\u76db\u987f\u5927\u5b66 David Baker \u56e2\u961f\u8bc1\u660e\uff0c\u7ed3\u5408\u4f7f\u7528\u5fae\u8c03 RFdiffusion \u7f51\u7edc\u7684\u8ba1\u7b97\u86cb\u767d\u8d28\u8bbe\u8ba1\u4e0e\u9175\u6bcd\u5c55\u793a\u7b5b\u9009\uff0c\u53ef\u4ee5\u751f\u6210\u6297\u4f53\u53ef\u53d8\u91cd\u94fe\uff08VHH\uff09\u548c\u5355\u94fe\u53ef\u53d8\u7247\u6bb5\uff08scFv\uff09\uff0c\u4ee5\u539f\u5b50\u7ea7\u7cbe\u5ea6\u7ed3\u5408\u7528\u6237\u6307\u5b9a\u7684\u8868\u4f4d\u3002<\/p>\n<p>\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e00\u70b9\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u591a\u79cd\u6b63\u4ea4\u751f\u7269\u7269\u7406\u65b9\u6cd5\uff08\u5305\u62ec\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\uff09\u5bf9\u56db\u79cd\u75be\u75c5\u76f8\u5173\u8868\u4f4d\u7684 VHH \u7ed3\u5408\u7269\u8fdb\u884c\u4e86\u5b9e\u9a8c\u8868\u5f81\uff0c\u8bc1\u5b9e\u4e86\u9488\u5bf9\u6d41\u611f\u8840\u51dd\u7d20\u548c\u8270\u96be\u68ad\u83cc\u6bd2\u7d20 B (TcdB) \u8bbe\u8ba1\u7684 VHH \u5177\u6709\u6b63\u786e\u7684\u514d\u75ab\u7403\u86cb\u767d\u6298\u53e0\u548c\u7ed3\u5408\u59ff\u52bf\u3002\u5bf9\u4e8e\u9488\u5bf9\u6d41\u611f\u7684 VHH\uff0c\u9ad8\u5206\u8fa8\u7387\u7ed3\u6784\u6570\u636e\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86 CDR \u73af\u6784\u8c61\u7684\u51c6\u786e\u6027\u3002<\/p>\n<p>\u867d\u7136\u521d\u59cb\u8ba1\u7b97\u8bbe\u8ba1\u8868\u73b0\u51fa\u9002\u5ea6\u7684\u4eb2\u548c\u529b\uff0c\u4f46\u4f7f\u7528 OrthoRep \u8fdb\u884c\u4eb2\u548c\u529b\u6210\u719f\u53ef\u4ee5\u4ea7\u751f\u4fdd\u6301\u9884\u671f\u8868\u4f4d\u9009\u62e9\u6027\u7684\u4e2a\u4f4d\u6570\u7eb3\u6469\u5c14\u7ed3\u5408\u7269\u3002<\/p>\n<p>\u56e2\u961f\u8fdb\u4e00\u6b65\u5c55\u793a\u4e86\u5355\u94fe\u53ef\u53d8\u7247\u6bb5\uff08scFvs\uff09\u7684\u4ece\u5934\u8bbe\u8ba1\uff0c\u901a\u8fc7\u7ed3\u5408\u8bbe\u8ba1\u7684\u91cd\u94fe\u548c\u8f7b\u94fe CDR \u521b\u5efa TcdB \u548c Phox2b \u80bd-MHC \u590d\u5408\u7269\u7684\u7ed3\u5408\u7269\u3002\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\u7ed3\u6784\u6570\u636e\u8bc1\u5b9e\u4e86\u4e24\u79cd\u4e0d\u540c\u7684 TcdB scFv \u7684\u6b63\u786e\u514d\u75ab\u7403\u86cb\u767d\u6298\u53e0\u548c\u7ed3\u5408\u59ff\u52bf\uff0c\u5176\u4e2d\u4e00\u79cd\u8bbe\u8ba1\u7684\u9ad8\u5206\u8fa8\u7387\u6570\u636e\u8fd8\u9a8c\u8bc1\u4e86\u6240\u6709\u516d\u4e2a CDR \u73af\u7684\u539f\u5b50\u7ea7\u7cbe\u786e\u6784\u8c61\u3002<\/p>\n<p>\u8fd9\u79cd\u65b9\u6cd5\u5efa\u7acb\u4e86\u4e00\u4e2a\u6846\u67b6\uff0c\u7528\u4e8e\u5408\u7406\u8ba1\u7b97\u8bbe\u8ba1\u3001\u7b5b\u9009\u3001\u5206\u79bb\u548c\u8868\u5f81\u5b8c\u5168\u65b0\u751f\u6297\u4f53\uff0c\u5728\u7ed3\u6784\u548c\u8868\u4f4d\u9776\u5411\u65b9\u9762\u90fd\u5177\u6709\u539f\u5b50\u7ea7\u7cbe\u5ea6\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u4ee5\u300c<em>Atomically accurate de novo design of antibodies with RFdiffusion<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 2 \u6708 28 \u65e5\u53d1\u5e03\u5728\u00a0<em>bioRxiv<\/em> \u9884\u5370\u5e73\u53f0\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-92c43acb8a0bec49b82762219b82706b.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-92c43acb8a0bec49b82762219b82706b.png\"><\/a><\/p>\n<p><strong>\u80cc\u666f<\/strong><\/p>\n<p>\u6297\u4f53\u662f\u86cb\u767d\u8d28\u6cbb\u7597\u836f\u7269\u4e2d\u5360\u4e3b\u5bfc\u5730\u4f4d\u7684\u4e00\u7c7b\uff0c\u76ee\u524d\u5168\u7403\u5df2\u83b7\u8bb8\u53ef\u7684\u6297\u4f53\u6cbb\u7597\u836f\u7269\u8d85\u8fc7 160 \u79cd\uff0c\u9884\u8ba1\u672a\u6765\u4e94\u5e74\u5e02\u573a\u4ef7\u503c\u5c06\u8fbe\u5230 4450 \u4ebf\u7f8e\u5143\u3002\u867d\u7136\u5236\u836f\u754c\u5bf9\u6297\u4f53\u6cbb\u7597\u836f\u7269\u5174\u8da3\u6d53\u539a\uff0c\u4f46\u6297\u4f53\u6cbb\u7597\u836f\u7269\u7684\u5f00\u53d1\u4ecd\u7136\u4f9d\u8d56\u4e8e\u52a8\u7269\u514d\u75ab\u6216\u6297\u4f53\u5e93\u7b5b\u9009\uff0c\u4ee5\u786e\u5b9a\u4e0e\u76ee\u6807\u9776\u6807\u7ed3\u5408\u7684\u5019\u9009\u5206\u5b50\u3002\u8fd9\u4e9b\u65b9\u6cd5\u8d39\u529b\u3001\u8d39\u65f6\uff0c\u800c\u4e14\u53ef\u80fd\u65e0\u6cd5\u4ea7\u751f\u4e0e\u6cbb\u7597\u76f8\u5173\u8868\u4f4d\u76f8\u4e92\u4f5c\u7528\u7684\u6297\u4f53\u3002<\/p>\n<p>\u6297\u4f53\u7684\u8ba1\u7b97\u673a\u8bbe\u8ba1\u5de5\u4f5c\u5df2\u5c06\u6b8b\u57fa\u79fb\u690d\u5230\u73b0\u6709\u6297\u4f53\u7ed3\u6784\u4e2d\uff0c\u91c7\u6837\u66ff\u4ee3\u5929\u7136 CDR \u73af\u4ee5\u63d0\u9ad8\u4eb2\u548c\u529b\uff0c\u5e76\u4f7f\u7528 Rosetta \u5e8f\u5217\u8bbe\u8ba1\u6765\u6539\u5584\u76f8\u4e92\u4f5c\u7528\u533a\u57df\u3002\u57fa\u4e8e\u7ed3\u6784\u548c\u57fa\u4e8e\u5e8f\u5217\u7684<mark data-type=\"tech_methods\" data-id=\"01946acc-d031-4c0e-909c-f062643b7273\">\u6df1\u5ea6\u5b66\u4e60<\/mark>\u7f51\u7edc\u5df2\u88ab\u8bad\u7ec3\u6765\u8bbe\u8ba1\u65b0\u7684\u6297\u4f53\u5e8f\u5217\uff0c\u4f46\u4ece\u5934\uff08\u4e0e\u9488\u5bf9\u8be5\u8868\u4f4d\u7684\u73b0\u6709\u6297\u4f53\u65e0\u540c\u6e90\u6027\uff09\u8bbe\u8ba1\u7ed3\u6784\u51c6\u786e\u7684\u6297\u4f53\u4ecd\u7136\u96be\u4ee5\u5b9e\u73b0\u3002<\/p>\n<p>\u6700\u8fd1\u5728\u4f7f\u7528 RFdiffusion \u8bbe\u8ba1\u7ed3\u5408\u86cb\u767d\uff08\u4e0d\u662f\u6297\u4f53\uff09\u65b9\u9762\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u4e0e\u4e4b\u524d\u7684\u65b9\u6cd5\u4e0d\u540c\uff0c\u5b83\u4e0d\u9700\u8981\u9884\u5148\u6307\u5b9a\u86cb\u767d\u8d28\u7ed3\u5408\u7269\u9aa8\u67b6\uff0c\u4ece\u800c\u5141\u8bb8\u8bbe\u8ba1\u5177\u6709\u4e0e\u7528\u6237\u6307\u5b9a\u7684\u8868\u4f4d\u56fa\u6709\u5f62\u72b6\u4e92\u8865\u6027\u7684\u975e\u5e38\u591a\u6837\u5316\u7684\u7ed3\u5408\u7269\u3002<\/p>\n<p>\u7136\u800c\uff0c\u4e0e\u5176\u4ed6\u4ece\u5934\u754c\u9762\u8bbe\u8ba1\u65b9\u6cd5\u4e00\u6837\uff0c\u8fd9\u4e9b\u7ed3\u5408\u5242\u51e0\u4e4e\u5b8c\u5168\u4f9d\u8d56\u4e8e\u4e0e\u76ee\u6807\u8868\u4f4d\u7684\u89c4\u5219\u4e8c\u7ea7\u7ed3\u6784\uff08\u87ba\u65cb\u6216\u94fe\uff09\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u56e0\u6b64\u539f\u59cb\uff08\u300cvanilla\u300d\uff09RFdiffusion \u7f51\u7edc\u65e0\u6cd5\u4ece\u5934\u8bbe\u8ba1\u6297\u4f53\u3002<\/p>\n<p>\u8bbe\u8ba1\u4ece\u5934\u6297\u4f53\u7684\u7406\u60f3\u65b9\u6cd5\u5c06\u80fd\u591f 1) \u9488\u5bf9\u4efb\u4f55\u611f\u5174\u8da3\u7684\u9776\u6807\u4e0a\u7684\u4efb\u4f55\u7279\u5b9a\u8868\u4f4d\uff1b2) \u91cd\u70b9\u91c7\u6837 CDR \u73af\uff0c\u4f7f\u6846\u67b6\u5e8f\u5217\u548c\u7ed3\u6784\u63a5\u8fd1\u7528\u6237\u6307\u5b9a\u7684\u9ad8\u5ea6\u4f18\u5316\u7684\u6cbb\u7597\u6027\u6297\u4f53\u6846\u67b6\uff1b3) \u91c7\u6837\u8bbe\u8ba1\u6297\u4f53\u76f8\u5bf9\u4e8e\u8868\u4f4d\u7684\u66ff\u4ee3\u521a\u4f53\u4f4d\u7f6e\u3002<\/p>\n<p><strong>\u9488\u5bf9\u6297\u4f53\u5f00\u53d1\u7684RFdiffusion\u53d8\u4f53<\/strong><\/p>\n<p>Baker \u56e2\u961f\u5047\u8bbe\u5e94\u8be5\u53ef\u4ee5\u5f00\u53d1\u4e00\u79cd\u4e13\u95e8\u7684 RFdiffusion \u53d8\u4f53\uff0c\u80fd\u591f\u8bbe\u8ba1\u4ece\u5934 CDR \u4ecb\u5bfc\u7684\u754c\u9762\uff0c\u56e0\u4e3a RFdiffusion \u53ef\u4ee5\u8bbe\u8ba1\u7684\u4ece\u5934\u754c\u9762\u5177\u6709\u591a\u6837\u6027\u548c\u8d28\u91cf\uff0c\u5e76\u4e14\u754c\u9762\u5f62\u6210\u7684\u5e95\u5c42\u70ed\u529b\u5b66\u662f\u76f8\u540c\u7684\u3002<\/p>\n<p>RoseTTAFold2 (RF2) \u548c RFdiffusion \u5728\u6574\u4e2a\u86cb\u767d\u8d28<mark data-type=\"concepts\" data-id=\"700f9c0f-1e8b-4fde-8bae-6de39c13f022\">\u6570\u636e\u5e93<\/mark> (PDB16) \u4e0a\u8fdb\u884c\u8bad\u7ec3\uff0c\u8fd9\u6709\u52a9\u4e8e\u514b\u670d PDB \u5305\u542b\u76f8\u5bf9\u8f83\u5c11\u6297\u4f53\u7ed3\u6784\uff08\u7ea6 8,100 \u4e2a\u6297\u4f53\u7ed3\u6784\uff0c\u800c\u603b\u7ed3\u6784\u8d85\u8fc7 200,000 \u4e2a\uff09\u7684\u95ee\u9898\uff0c\u8fd9\u589e\u52a0\u4e86\u5927\u578b<mark data-type=\"tech_methods\" data-id=\"1a0e9c5e-6502-4cd7-8683-6b5ca6c48be2\">\u673a\u5668\u5b66\u4e60<\/mark>\u6a21\u578b\u7684\u8bad\u7ec3\u96be\u5ea6\u3002<\/p>\n<p>\u8be5\u56e2\u961f\u7740\u624b\u5f00\u53d1 RFdiffusion \u548c RF2 \u7248\u672c\uff0c\u4e13\u95e8\u7528\u4e8e\u6297\u4f53\u7ed3\u6784\u8bbe\u8ba1\u548c\u7ed3\u6784\u9884\u6d4b\uff0c\u65b9\u6cd5\u662f\u5bf9\u5929\u7136\u6297\u4f53\u7ed3\u6784\u8fdb\u884c\u5fae\u8c03\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-cedd4248e4d1f935e9d7d79ac58e45ce.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-cedd4248e4d1f935e9d7d79ac58e45ce.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1aRFdiffusion \u6297\u4f53\u8bbe\u8ba1\u6982\u8ff0\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p>\u5728\u8fd9\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u539f\u59cb RFdiffusion \u7f51\u7edc\u79f0\u4e3a\u300cvanilla RFdiffusion\u300d\uff0c\u5c06\u4ed6\u4eec\u63cf\u8ff0\u7684\u6297\u4f53\u7279\u5b9a\u53d8\u4f53\u7b80\u79f0\u4e3a\u300cRFdiffusion\u300d\u3002<\/p>\n<p><strong>\u6210\u529f\u8bbe\u8ba1\u6297\u4f53<\/strong><\/p>\n<p>\u5b9e\u9a8c\u8868\u660e\uff0c\u4ece\u5934\u8bbe\u8ba1\u9488\u5bf9\u76ee\u6807\u4e0a\u7279\u5b9a\u8868\u4f4d\u7684\u6297\u4f53\u7ed3\u6784\u57df\u662f\u53ef\u80fd\u7684\u3002\u8bbe\u8ba1\u7684 VHH \u9488\u5bf9\u6d41\u611f HA \u548c TcdB \u7684\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\u7ed3\u6784\u6570\u636e\u4e0e\u8ba1\u7b97\u8bbe\u8ba1\u6a21\u578b\u975e\u5e38\u63a5\u8fd1\uff0c\u8868\u660e\u8be5\u65b9\u6cd5\u53ef\u4ee5\u8bbe\u8ba1\u5177\u6709\u539f\u5b50\u7cbe\u5ea6\u7684 VHH \u590d\u5408\u7269\uff08\u5305\u62ec\u9ad8\u5ea6\u53ef\u53d8\u7684 H3 \u73af\u548c\u6574\u4f53\u7ed3\u5408\u65b9\u5411\uff09\uff0c\u8fd9\u4e9b\u590d\u5408\u7269\u4e0e PDB \u4e2d\u4efb\u4f55\u5df2\u77e5\u7ed3\u6784\u90fd\u975e\u5e38\u4e0d\u540c\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-fb9a3626429246793053d2ac4ea7670a.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-fb9a3626429246793053d2ac4ea7670a.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u8bbe\u8ba1\u7684 VHH \u7684\u751f\u5316\u8868\u5f81\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p>\u8bbe\u8ba1\u7684\u4e0e TcdB \u7ed3\u5408\u7684 scFv \u7684\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\u7ed3\u6784\u6570\u636e\u8bc1\u660e\u4e86 RFdiffusion \u80fd\u591f\u51c6\u786e\u8bbe\u8ba1\u53cc\u94fe scFv\u3002\u8fd9\u662f\u9996\u6b21\u901a\u8fc7\u5b9e\u9a8c\u9a8c\u8bc1\u7684\u5177\u6709\u7ed3\u6784\u7cbe\u786e\u7ed3\u5408\u7684\u4ece\u5934\u8bbe\u8ba1\u6297\u4f53\u6848\u4f8b\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u8fd9\u79cd\u65b9\u6cd5\u7684\u6210\u529f\u4e0d\u80fd\u5f52\u56e0\u4e8e\u8bb0\u5fc6\uff0c\u56e0\u4e3a PDB \u4e2d\u4e0d\u5b58\u5728\u9488\u5bf9 TcdB \u8868\u4f4d\u7684\u6297\u4f53\uff0c\u8fd9\u589e\u5f3a\u4e86\u8be5\u6a21\u578b\u8bbe\u8ba1\u771f\u6b63\u4ece\u5934\u7ed3\u5408\u7269\u7684\u80fd\u529b\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-41e0386ea1eab547d456aee9d0c70f44.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-41e0386ea1eab547d456aee9d0c70f44.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u4e24\u79cd\u5168\u65b0\u8bbe\u8ba1\u7684 VHH \u4e0e\u6d41\u611f\u8840\u51dd\u7d20\u548c TcdB \u7ed3\u5408\u7684\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\u7ed3\u6784\u8868\u5f81\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p>\u8be5\u56e2\u961f\u7684\u8ba1\u7b97\u65b9\u6cd5\u4e0e\u4ece\u5927\u578b\u968f\u673a\u5e93\u4e2d\u68c0\u7d22\u6297\u4f53\u7684\u5b9e\u9a8c\u7b5b\u9009\u65b9\u6cd5\u5728\u591a\u4e2a\u65b9\u9762\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002<\/p>\n<p>\u9996\u5148\uff0c\u5e7f\u6cdb\u7528\u4e8e\u6297\u4f53\u5e93\u7b5b\u9009\u7684\u9175\u6bcd\u5c55\u793a\u9009\u62e9\u65b9\u6cd5\u80fd\u591f\u5728\u5927\u91cf\u8bbe\u8ba1\u4e2d\u68c0\u7d22\u51fa\u4eb2\u548c\u529b\u6700\u9ad8\u7684\u7ed3\u5408\u7269\uff0c\u7531\u4e8e\u8bbe\u8ba1\u6210\u529f\u7387\u5f88\u4f4e\uff0c\u8fd9\u4e00\u70b9\u76ee\u524d\u662f\u5fc5\u8981\u7684\u3002<\/p>\n<p>\u5176\u6b21\uff0c\u7b5b\u9009\u7ed3\u5408\u6a21\u5f0f\u76f8\u4f3c\u7684\u8bbe\u8ba1\u4e2d\u6df7\u5408\u91cd\u94fe\u548c\u8f7b\u94fe\u7684\u7ec4\u5408\u5e93\u53ef\u4ee5\u8bc6\u522b\u9488\u5bf9\u7279\u5b9a\u8868\u4f4d\u7684 scFv\uff0c\u6b63\u5982\u6848\u4f8b\u91cc\u7528\u5230\u7684 TcdB \u548c Phox2b \u80bd MHC\u3002\u5728\u6848\u4f8b\u4e2d\uff0c\u8fd9\u79cd\u65b9\u6cd5\u7279\u522b\u6709\u5229\uff0c\u56e0\u4e3a\u5f88\u5927\u4e00\u90e8\u5206\u91cd\u7ec4\u4f53\u53ef\u80fd\u7531\u4e8e\u5176\u7ed3\u6784\u517c\u5bb9\u6027\u800c\u5177\u6709\u529f\u80fd\u6027\u3002<\/p>\n<p>\u7b2c\u4e09\uff0c\u4f7f\u7528 OrthoRep \u8fdb\u884c\u4eb2\u548c\u529b\u6210\u719f\u53ef\u5c06\u521d\u59cb VHH \u8bbe\u8ba1\u7684\u6d4b\u91cf\u4eb2\u548c\u529b\u63d0\u9ad8\u5230\u4e2a\u4f4d\u6570\u7eb3\u6469\u5c14\u6216\u4e9a\u7eb3\u6469\u5c14\u8303\u56f4\uff0c\u540c\u65f6\u4fdd\u7559\u539f\u59cb\u8bbe\u8ba1\u7684\u7ed3\u5408\u6a21\u5f0f\u3002\u4ece\u5b9e\u9645\u89d2\u5ea6\u6765\u770b\uff0c\u8fd9\u9879\u5de5\u4f5c\u7684\u5173\u952e\u8fdb\u5c55\u4e0d\u4ec5\u5728\u4e8e\u80fd\u591f\u9488\u5bf9\u76ee\u6807\u751f\u6210\u7eb3\u7c73\u6297\u4f53\u548c scFv\uff08\u8fd9\u901a\u5e38\u53ef\u4ee5\u901a\u8fc7\u7eaf\u5b9e\u9a8c\u65b9\u6cd5\u5b9e\u73b0\uff09\uff0c\u800c\u4e14\u5728\u4e8e\u80fd\u591f\u51c6\u786e\u9776\u5411\u7279\u5b9a\u7ed3\u5408\u8868\u4f4d\u3002<\/p>\n<p><a href=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-dda38a13972b14299c151bba99cd2a57.png\" data-fancybox=\"images\" data-fancybox=\"gallery\"><img decoding=\"async\" src=\"https:\/\/17aitech.com\/wp-content\/uploads\/2025\/03\/frc-dda38a13972b14299c151bba99cd2a57.png\"><\/a><\/p>\n<p>\u56fe\u793a\uff1a\u4e24\u79cd TcdB \u7ed3\u5408 scFv \u7684\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\u7ed3\u6784\u8868\u5f81\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p>\u4e8b\u5b9e\u4e0a\uff0c\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\u7814\u7a76\u660e\u786e\u8bc1\u5b9e\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u8ba1\u7b97\u8bbe\u8ba1\u7684\u6297\u4f53\u80fd\u591f\u4ee5\u60ca\u4eba\u7684\u7cbe\u5ea6\u4e0e\u76ee\u6807\u8868\u4f4d\u7ed3\u5408\u3002\u8fd9\u79cd\u9ad8\u8bbe\u8ba1\u7cbe\u5ea6\u5bf9\u4e8e\u6cbb\u7597\u5e94\u7528\u81f3\u5173\u91cd\u8981\uff0c\u4f8b\u5982\u963b\u65ad\u53d7\u4f53-\u914d\u4f53\u76f8\u4e92\u4f5c\u7528\u7684\u62ee\u6297\u5242\u3001\u907f\u514d\u4e0e\u5185\u6e90\u6027\u5206\u5b50\u7ade\u4e89\u7684\u6297\u4f53\u3001\u8bf1\u5bfc\u6784\u8c61\u53d8\u5316\u4ee5\u89e6\u53d1\u4fe1\u53f7\u4f20\u5bfc\u7684\u8c03\u8282\u5242\uff0c\u6216\u9776\u5411\u4fdd\u5b88\u6216\u8fdb\u5316\u53d7\u9650\u7684\u75c5\u6bd2\u8868\u4f4d\u7684\u6297\u4f53\u3002<\/p>\n<p><strong>\u5c40\u9650\u6027<\/strong><\/p>\n<p>\u867d\u7136\u8fd9\u91cc\u7684\u7ed3\u679c\u8868\u660e\u6297\u4f53\u4ece\u5934\u8bbe\u8ba1\u662f\u6210\u529f\u7684\uff0c\u4f46\u4ecd\u6709\u5f88\u5927\u7684\u6539\u8fdb\u7a7a\u95f4\u3002<\/p>\n<p>\u5bf9\u4e8e\u4e3b\u94fe\u8bbe\u8ba1\u6b65\u9aa4\uff0c\u7ed3\u5408\u6700\u8fd1\u7684\u67b6\u6784\u6539\u8fdb\u548c\u751f\u6210\u5efa\u6a21\u7684\u65b0\u8fdb\u5c55\u53ef\u80fd\u4f1a\u4ea7\u751f\u5177\u6709\u66f4\u9ad8\u53ef\u8bbe\u8ba1\u6027\u548c\u591a\u6837\u6027\u7684\u8bbe\u8ba1\u6a21\u578b\u3002RoseTTAFold2 \u548c RFdiffusion \u6700\u8fd1\u4e5f\u5df2\u6269\u5c55\u5230\u6a21\u62df\u6240\u6709\u751f\u7269\u5206\u5b50\uff08\u800c\u4e0d\u4ec5\u4ec5\u662f\u86cb\u767d\u8d28\uff09\uff0c\u5c06\u6b64\u529f\u80fd\u6574\u5408\u5230\u6297\u4f53\u8bbe\u8ba1 RFdiffusion \u4e2d\u5e94\u8be5\u53ef\u4ee5\u7cbe\u786e\u8bbe\u8ba1\u9488\u5bf9\u542b\u6709\u975e\u86cb\u767d\u8d28\u539f\u5b50\uff08\u5982\u805a\u7cd6\uff09\u7684\u8868\u4f4d\u7684\u6297\u4f53\u3002<\/p>\n<p>\u4e8b\u5b9e\u4e0a\uff0cVHH_flu_01 \u89c2\u5bdf\u5230\u7684\u4e9a\u5316\u5b66\u8ba1\u91cf\u7ed3\u5408\u53ef\u4ee5\u7528\u9644\u8fd1\u805a\u7cd6 N296 \u7684\u5b58\u5728\u6765\u89e3\u91ca\uff0c\u800c\u8fd9\u5728\u6700\u521d\u8bbe\u8ba1\u6b64 VHH \u65f6\u5e76\u672a\u8003\u8651\u5230\u3002ProteinMPNN \u5728\u672c\u7814\u7a76\u4e2d\u6ca1\u6709\u88ab\u4fee\u6539\uff0c\u4f46\u8bbe\u8ba1\u4e0e\u4eba\u7c7b CDR \u5e8f\u5217\u66f4\u63a5\u8fd1\u7684\u5e8f\u5217\u9884\u8ba1\u4f1a\u964d\u4f4e\u8bbe\u8ba1\u6297\u4f53\u7684\u6f5c\u5728\u514d\u75ab\u539f\u6027\u548c\u53ef\u5f00\u53d1\u6027\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u6297\u4f53\u9884\u6d4b\u65b9\u6cd5\u7684\u8fdb\u4e00\u6b65\u6539\u8fdb\u5e94\u8be5\u80fd\u591f\u66f4\u597d\u5730\u5bf9\u4e0a\u6e38\u8bbe\u8ba1\u65b9\u6cd5\u8fdb\u884c\u8ba1\u7b97\u673a<mark data-type=\"concepts\" data-id=\"308c3a45-0fee-4ec6-858e-85b15f440fc0\">\u57fa\u51c6<\/mark>\u6d4b\u8bd5\uff0c\u5e76\u63d0\u9ad8\u5b9e\u9a8c\u6210\u529f\u7387\u3002<\/p>\n<p>\u5c06 scFv \u8f6c\u6362\u4e3a\u5b8c\u6574\u6297\u4f53\u5e94\u8be5\u5f88\u7b80\u5355\uff0c\u56e0\u4e3a\u53ef\u53d8\u7684 CDR \u5e8f\u5217\u4fdd\u6301\u4e0d\u53d8\u3002\u6216\u8005\uff0c\u8fd9\u91cc\u4f7f\u7528\u7684\u65b9\u6cd5\u53ef\u4ee5\u76f4\u63a5\u5e94\u7528\u4e8e Fab \u8bbe\u8ba1\uff0c\u53ea\u9700\u7701\u7565\u91cd\u94fe\u548c\u8f7b\u94fe\u4e4b\u95f4\u7684\u63a5\u5934\u5373\u53ef\u3002\u968f\u7740\u8fd9\u4e9b\u8fdb\u6b65\uff0c\u8ba1\u7b97\u6297\u4f53\u8bbe\u8ba1\u6709\u671b\u6210\u4e3a\u5e38\u89c4\u65b9\u6cd5\u3002<\/p>\n<p><strong>\u7ed3\u8bed<\/strong><\/p>\n<p>\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u4f7f\u7528 RFdiffusion \u548c\u76f8\u5173\u65b9\u6cd5\u8fdb\u884c\u6297\u4f53\u7684\u8ba1\u7b97\u4ece\u5934\u8bbe\u8ba1\u53ef\u80fd\u4f1a\u5f7b\u5e95\u6539\u53d8\u6297\u4f53\u7684\u53d1\u73b0\u548c\u5f00\u53d1\u3002RFdiffusion 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