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\u7f16\u8f91 | 2049<\/p>\n

\u795e\u7ecf\u5143<\/mark>\u5bf9\u76f8\u540c\u523a\u6fc0\u7684\u53cd\u5e94\u4e3a\u4ec0\u4e48\u4f1a\u8868\u73b0\u51fa\u663e\u8457\u5dee\u5f02\uff1f\u8fd9\u79cd\u53d8\u5f02\u6027\u662f\u5426\u4ec5\u4ec5\u662f\u300c\u566a\u58f0\u300d\uff1f<\/p>\n

\u4f20\u7edf\u7814\u7a76\u5f80\u5f80\u5047\u8bbe\u795e\u7ecf\u6d3b\u52a8\u53d8\u5f02\u6027\u662f\u9759\u6001\u7684\uff0c\u4f46\u771f\u5b9e\u5927\u8111\u72b6\u6001\u5728\u79d2\u7ea7\u5c3a\u5ea6\u5185\u5feb\u901f\u5207\u6362\uff0c\u5bfc\u81f4\u7f16\u7801\u6548\u7387\u7684\u52a8\u6001\u6ce2\u52a8\u3002<\/p>\n

\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u827e\u4f26\u7814\u7a76\u6240\uff08Allen Institute\uff09\u548c\u6e05\u534e\u5927\u5b66<\/mark>\u7684\u8054\u5408\u7814\u7a76\u56e2\u961f\u63ed\u793a\u4e86\u795e\u7ecf\u5143<\/mark>\u53cd\u5e94\u53d8\u5f02\u6027\u80cc\u540e\u7684\u52a8\u6001\u673a\u5236\u3002<\/p>\n

\u4ed6\u4eec\u53d1\u73b0\uff0c\u5927\u8111\u5185\u90e8\u72b6\u6001\u7684\u6ce2\u52a8\u4f1a\u663e\u8457\u5f71\u54cd\u795e\u7ecf\u7f16\u7801\u7684\u6548\u7387\uff0c\u4e0d\u540c\u8111\u533a\u7684\u795e\u7ecf\u5143<\/mark>\u6839\u636e\u5176\u5728\u89e3\u5256\u5c42\u7ea7\u4e2d\u7684\u4f4d\u7f6e\uff0c\u5bf9\u611f\u77e5<\/mark>\u523a\u6fc0\u548c\u884c\u4e3a\u8868\u73b0\u51fa\u72ec\u7279\u7684\u7f16\u7801\u6a21\u5f0f\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cDeciphering neuronal variability across states reveals dynamic sensory encoding<\/em>\u300d\u4e3a\u9898\uff0c\u53d1\u8868\u4e8e 2025 \u5e74 2 \u6708 19 \u65e5\u7684\u300aNature Communications<\/em>\u300b\u3002<\/p>\n

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\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41467-025-56733-w<\/em><\/p>\n

\u6570\u636e\u94fe\u63a5\uff1ahttps:\/\/portal.brain-map.org\/circuits-behavior\/visual-coding-neuropixels<\/em><\/p>\n

\u4ee3\u7801\u5730\u5740\uff1ahttps:\/\/github.com\/shailajaAkella\/Deciphering-neuronal-variability<\/em>
<\/em><\/p>\n

\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n

\u795e\u7ecf\u5143<\/mark>\u6d3b\u52a8\u53d8\u5f02\u6027\u6e90\u4e8e\u611f\u5b98\u8f93\u5165\u3001\u884c\u4e3a\u72b6\u6001\u4e0e\u5185\u90e8\u8111\u52a8\u6001\u7684\u590d\u6742\u4ea4\u4e92\u3002\u65e9\u671f\u7814\u7a76\u901a\u8fc7\u56fa\u5b9a\u5b9e\u9a8c\u6761\u4ef6\u6216\u9ebb\u9189\u52a8\u7269\u7b80\u5316\u95ee\u9898\uff0c\u4f46\u727a\u7272\u4e86\u81ea\u7136\u72b6\u6001\u4e0b\u7684\u52a8\u6001\u7279\u5f81\u3002<\/p>\n

\u8fd1\u5e74\u5927\u89c4\u6a21\u795e\u7ecf\u8bb0\u5f55\u6280\u672f\u867d\u80fd\u6355\u6349\u884c\u4e3a\u76f8\u5173\u7684\u6d3b\u52a8\u53d8\u5316\uff0c\u5374\u96be\u4ee5\u533a\u5206\u81ea\u53d1\u8fd0\u52a8\u4e0e\u5185\u90e8\u72b6\u6001\u7684\u5f71\u54cd\u3002<\/p>\n

\u66f4\u6df1\u5c42\u7684\u6311\u6218\u5728\u4e8e\uff1a\u4e0d\u540c\u6765\u6e90\u7684\u53d8\u5f02\u6027\u4ee5\u975e\u7ebf\u6027\u65b9\u5f0f\u8026\u5408\uff0c\u4e14\u8d21\u732e\u6743\u91cd<\/mark>\u968f\u65f6\u95f4\u5feb\u901f\u53d8\u5316\u3002\u4f8b\u5982\uff0c\u5728\u4e3b\u52a8\u63a2\u7d22\u65f6\uff0c\u5c0f\u9f20\u89c6\u89c9\u76ae\u5c42\u901a\u8fc7\u53bb\u540c\u6b65\u5316\u63d0\u5347\u523a\u6fc0\u54cd\u5e94\uff0c\u800c\u5728\u9759\u606f\u72b6\u6001\u5219\u5448\u73b0\u540c\u6b65\u5316\u4f4e\u654f\u611f\u6a21\u5f0f\u3002<\/p>\n

\u7814\u7a76\u56e2\u961f\u521b\u65b0\u6027\u5730\u4ee5\u5c40\u90e8\u573a\u7535\u4f4d\uff08LFP\uff09\u9891\u8c31\u7279\u5f81\u4e3a\u951a\u70b9\uff0c\u6784\u5efa\u5168\u5c40\u8111\u72b6\u6001\u65f6\u5e8f\u6846\u67b6\uff0c\u4e3a\u52a8\u6001\u53d8\u5f02\u6027\u5206\u6790\u5efa\u7acb\u4e86\u7edf\u4e00\u5750\u6807\u7cfb\u3002<\/p>\n

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\u56fe\u793a\uff1a \u8de8\u65f6\u95f4\u548c\u5c42\u6b21\u89e3\u6790\u53d8\u5f02\u6027\u7684\u793a\u610f\u56fe\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u5927\u8111\u632f\u8361\u72b6\u6001\u7684\u52a8\u6001\u7279<\/strong>\u5f81<\/strong><\/p>\n

\u7814\u7a76\u56e2\u961f\u5206\u6790\u4e86\u827e\u4f26\u7814\u7a76\u6240\u4e4b\u524d\u53d1\u5e03\u7684\u516c\u5f00\u53ef\u7528\u7684 Allen Brain Observatory Neuropixels \u6570\u636e\u96c6\uff0c\u8be5\u6570\u636e\u96c6\u5305\u62ec\u6765\u81ea\u5c0f\u9f20\u89c6\u89c9\u76ae\u5c42\u516d\u4e2a\u5206\u533a\u7684 LFP \u4e0e\u950b\u7535\u4f4d\u3002\u00a0<\/p>\n

\u76f8\u5173\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41586-020-03171-x<\/p>\n

\u901a\u8fc7\u5bf9LFP\u7684\u5206\u6790,\u53d1\u73b0\u6240\u6709\u88ab\u8bd5\u5c0f\u9f20\u7684 LFP \u52a8\u6001\u5747\u5448\u73b0\u4e09\u79cd\u7a33\u5b9a\u632f\u8361\u72b6\u6001\uff1a\u9ad8\u9891\u6001\uff08SH\uff0c30-80Hz\u4f3d\u9a6c\u9891\u6bb5\u529f\u7387\u589e\u5f3a\uff09\u3001\u4f4e\u9891\u6001\uff08SL\uff0c3-8Hz theta\u529f\u7387\u4e3b\u5bfc\uff09\u548c\u4e2d\u95f4\u6001\uff08SI\uff0c\u529f\u7387\u8c31\u5747\u5300\u5206\u5e03\uff09\u3002<\/p>\n

\u8fd9\u4e9b\u72b6\u6001\u4e0e\u52a8\u7269\u7684\u884c\u4e3a\u8868\u73b0\u51fa\u663e\u8457\u5173\u8054\uff1a\u9ad8\u9891\u6001\u4f34\u968f\u77b3\u5b54\u6269\u5f20\u548c\u8fd0\u52a8\u589e\u52a0\uff0c\u8868\u5f81\u9ad8\u5ea6\u8b66\u9192\u72b6\u6001\uff1b\u4f4e\u9891\u6001\u5bf9\u5e94\u9759\u606f\u72b6\u6001\uff1b\u800c\u4e2d\u95f4\u6001\u5219\u4f5c\u4e3a\u72b6\u6001\u8f6c\u6362\u7684\u5fc5\u7ecf\u6865\u6881\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u72b6\u6001\u8f6c\u6362\u5448\u73b0\u51fa\u4e25\u683c\u7684\u52a8\u529b\u5b66\u7ea6\u675f\u2014\u2014\u9ad8\u9891\u6001\u4e0e\u4f4e\u9891\u6001\u4e4b\u95f4\u7684\u5207\u6362\u5927\u90e8\u5206\u5fc5\u987b\u901a\u8fc7\u4e2d\u95f4\u6001\u5b8c\u6210\uff0c\u4e14\u6bcf\u4e2a\u72b6\u6001\u7684\u5e73\u5747\u9a7b\u7559\u65f6\u95f4\u4ec5 1.5 \u79d2\uff0c\u63ed\u793a\u4e86\u5927\u8111\u72b6\u6001\u7684\u5feb\u901f\u52a8\u6001\u7279\u6027\u3002<\/p>\n

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\u56fe\u793a\uff1a\u4ece\u5c40\u90e8\u573a\u7535\u4f4d\u8bc6\u522b\u7684\u5185\u90e8\u632f\u8361\u72b6\u6001\u7279\u6027\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u89c6\u89c9\u7cfb\u7edf\u7684\u53d8\u5f02\u6027\u5206\u5e03<\/strong><\/p>\n

\u901a\u8fc7\u56e0\u5b50\u5206\u6790<\/mark>\uff08FA\uff09\u3001Fano \u56e0\u5b50\uff08FF\uff09\u548c\u53d8\u5f02\u7cfb\u6570\uff08CV\uff09\u7b49\u591a\u7ef4\u5ea6\u6307\u6807\uff0c\u7814\u7a76\u53d1\u73b0\u4e0d\u540c\u72b6\u6001\u4e0b\u7684\u53d8\u5f02\u6027\u5448\u73b0\u663e\u8457\u5c42\u7ea7\u5dee\u5f02\u3002<\/p>\n

\u5728\u9ad8\u9891\u6001\u4e2d\uff0c\u7fa4\u4f53\u5171\u4eab\u65b9\u5dee\u964d\u4f4e\u4e86 36.6\u00b13.4%\uff0c\u867d\u7136\u795e\u7ecf\u5143<\/mark>\u7684\u65f6\u95f4\u53d1\u653e\u53d8\u5f02\u6027\u589e\u52a0\uff0c\u4f46\u8bd5\u6b21\u95f4\u53d8\u5f02\u6027\u8fbe\u5230\u6700\u5c0f\uff0c\u8fd9\u79cd\u53d8\u5f02\u6027\u7ec4\u5408\u5bf9\u5e94\u7740\u8f83\u9ad8\u7684\u523a\u6fc0\u7f16\u7801\u8868\u73b0\u3002<\/p>\n

\u7814\u7a76\u53d1\u73b0\u521d\u7ea7\u89c6\u89c9\u533a\uff08V1\uff09\u795e\u7ecf\u5143<\/mark>\u5728\u9ad8\u9891\u6001\u4e0b\u5bf9\u81ea\u7136\u7535\u5f71\u50cf\u7d20\u4fe1\u606f\u7684\u7f16\u7801\u80fd\u529b\u663e\u8457\u9ad8\u4e8e\u4f4e\u9891\u6001\uff0c\u4e14\u8fd9\u79cd\u7f16\u7801\u4f18\u52bf\u6cbf\u7740\u89c6\u89c9\u5904\u7406\u5c42\u7ea7\u9010\u6e10\u51cf\u5f31\u3002<\/p>\n

\u7279\u522b\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4f4d\u4e8e\u89c6\u89c9-\u4f53\u611f\u4ea4\u754c\u5904\u7684RL\u533a\uff08\u89e3\u5256\u5b66\u90bb\u8fd1\u521d\u7ea7\u4f53\u611f\u76ae\u5c42S1\uff09\u8868\u73b0\u51fa\u72ec\u7279\u7684\u4f4e\u7f16\u7801\u6548\u7387\u548c\u8f83\u9ad8\u7684\u8bd5\u6b21\u95f4\u53d8\u5f02\u6027\uff0c\u8fd9\u79cd\u5f02\u5e38\u6a21\u5f0f\u53ef\u80fd\u53cd\u6620\u4e86\u5176\u4f5c\u4e3a\u591a\u611f\u89c9\u6574\u5408\u533a\u57df\u7684\u7279\u6b8a\u529f\u80fd\u5c5e\u6027\u3002<\/p>\n

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\u56fe\u793a\uff1a\u8de8\u72b6\u6001\u548c\u89c6\u89c9\u5c42\u6b21\u7684\u795e\u7ecf\u5143<\/mark>\u53d8\u5f02\u6027\u548c\u4fe1\u606f\u7f16\u7801\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u53d8\u5f02\u6027\u6765\u6e90\u7684\u72b6\u6001\u4f9d\u8d56\u6027<\/strong>\u6a21\u578b<\/strong><\/p>\n

\u4e3a\u4e86\u5b9a\u91cf\u89e3\u6790\u5f71\u54cd\u795e\u7ecf\u53d8\u5f02\u6027\u7684\u4e0d\u540c\u6765\u6e90\uff0c\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u4e2a\u521b\u65b0\u7684\u72b6\u6001\u6761\u4ef6\u7f16\u7801\u6a21\u578b\u3002\u5728\u7fa4\u4f53\u6d3b\u52a8\u6c34\u5e73\u4e0a\uff0c\u5185\u90e8\u8111\u52a8\u6001\u80fd\u89e3\u91ca 41.0 \u00b1 7.6% \u7684\u65b9\u5dee\uff0c\u663e\u8457\u8d85\u8fc7\u884c\u4e3a\uff0818.9 \u00b1 7.0%\uff09\u548c\u89c6\u89c9\u523a\u6fc0\u7279\u5f81\uff0822.8 \u00b1 8.8%\uff09\u7684\u8d21\u732e\u3002<\/p>\n

\u7136\u800c\u5728\u5355\u4e2a\u795e\u7ecf\u5143<\/mark>\u5c42\u9762\uff0c\u8fd9\u79cd\u8d21\u732e\u683c\u5c40\u53d1\u751f\u663e\u8457\u53cd\u8f6c\uff1a\u89c6\u89c9\u523a\u6fc0\u7279\u5f81\u8d21\u732e\u4e86 19.8% \u7684\u65b9\u5dee\uff0c\u800c\u884c\u4e3a\u548c\u5185\u90e8\u52a8\u6001\u5206\u522b\u4ec5\u5360 11.6% \u548c 11.1%\u3002<\/p>\n

\u901a\u8fc7\u65e0\u76d1\u7763\u805a\u7c7b<\/mark>\u5206\u6790\uff0c\u7814\u7a76\u53d1\u73b0\u89c6\u89c9\u7cfb\u7edf\u4e2d\u5b58\u5728\u529f\u80fd\u5206\u5de5\u660e\u786e\u7684\u795e\u7ecf\u5143<\/mark>\u4e9a\u7fa4\uff1a\u7ea6 29.5% \u7684\u795e\u7ecf\u5143<\/mark>\u4e13\u95e8\u8d1f\u8d23\u523a\u6fc0\u7f16\u7801\uff0c30.2% \u53d7\u5230\u591a\u79cd\u56e0\u7d20\u7684\u5171\u540c\u8c03\u63a7\u3002\u968f\u7740\u89c6\u89c9\u5904\u7406\u5c42\u7ea7\u4e0a\u5347\uff0c\u591a\u6a21\u6001\u6574\u5408\u529f\u80fd\u7684\u795e\u7ecf\u5143<\/mark>\u6bd4\u4f8b\u9010\u6e10\u589e\u52a0\u3002<\/p>\n

\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5f53\u5927\u8111\u72b6\u6001\u53d1\u751f\u8f6c\u6362\u65f6\uff0c\u8d85\u8fc7\u534a\u6570\uff0853%\uff09\u7684\u795e\u7ecf\u5143<\/mark>\u4f1a\u91cd\u6784<\/mark>\u5176\u4e3b\u5bfc\u8f93\u5165\u6765\u6e90\u3002\u4f8b\u5982\uff0c\u5728\u4f4e\u9891\u6001\u4e2d\u7f3a\u4e4f\u660e\u786e\u7f16\u7801\u7279\u5f81\u7684\u795e\u7ecf\u5143<\/mark>\u53ef\u80fd\u5728\u8f6c\u5165\u9ad8\u9891\u6001\u540e\u53d8\u4e3a\u5bf9\u89c6\u89c9\u523a\u6fc0\u9ad8\u5ea6\u654f\u611f\u3002<\/p>\n

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