{"id":39858,"date":"2025-04-03T02:02:23","date_gmt":"2025-04-02T18:02:23","guid":{"rendered":"https:\/\/17aitech.com\/?p=39858"},"modified":"2025-04-03T02:02:23","modified_gmt":"2025-04-02T18:02:23","slug":"%e5%87%86%e7%a1%ae%e7%8e%87%e8%be%be85%ef%bc%8c%e8%8b%8f%e5%a4%a7%e3%80%81%e5%a4%a7%e8%bf%9e%e7%90%86%e5%b7%a5%e5%bc%80%e5%8f%91%e5%a4%9a%e6%a8%a1%e6%80%81%e7%89%b9%e5%be%81%e8%9e%8d%e5%90%88ml","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=39858","title":{"rendered":"\u51c6\u786e\u7387\u8fbe85%\uff0c\u82cf\u5927\u3001\u5927\u8fde\u7406\u5de5\u5f00\u53d1\u591a\u6a21\u6001\u7279\u5f81\u878d\u5408ML\uff0c\u9884\u6d4b\u5de5\u7a0b\u7eb3\u7c73\u6750\u6599\u8bf1\u5bfc\u7684\u6162\u6027\u635f\u4f24"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u51c6\u786e\u7387\u8fbe85%\uff0c\u82cf\u5927\u3001\u5927\u8fde\u7406\u5de5\u5f00\u53d1\u591a\u6a21\u6001\u7279\u5f81\u878d\u5408ML\uff0c\u9884\u6d4b\u5de5\u7a0b\u7eb3\u7c73\u6750\u6599\u8bf1\u5bfc\u7684\u6162\u6027\u635f\u4f24<\/a><\/p>\n

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\u7f16\u8f91 | \u767d\u83dc\u53f6<\/p>\n

\u7eb3\u7c73\u9897\u7c92\u5f15\u8d77\u7684\u6162\u6027\u635f\u4f24\uff08\u4f8b\u5982\u7ea4\u7ef4\u5316\u548c\u81f4\u764c\u4f5c\u7528\uff09\u5f15\u8d77\u4e86\u516c\u4f17\u5065\u5eb7\u62c5\u5fe7\uff0c\u9700\u8981\u5728\u5371\u5bb3\u8bc6\u522b\u4e2d\u8fc5\u901f\u8bc4\u4f30\u3002\u5c3d\u7ba1\u8ba1\u7b97\u673a\u5206\u6790\u901a\u5e38\u7528\u4e8e\u5316\u5b66\u54c1\u98ce\u9669\u8bc4\u4f30\uff0c\u4f46\u7531\u4e8e\u7eb3\u7c73\u751f\u7269\u6d41\u4f53\u548c\u7eb3\u7c73\u4e9a\u7ec6\u80de\u5668\u7b49\u591a\u4e2a\u754c\u9762\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\uff0c\u9884\u6d4b\u4f53\u5185\u6162\u6027\u7eb3\u7c73\u6bd2\u6027\u4ecd\u7136\u5177\u6709\u6311\u6218\u6027\u3002<\/p>\n

\u82cf\u5dde\u5927\u5b66\u3001\u5927\u8fde\u7406\u5de5\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u4e2a\u591a\u6a21\u6001\u7279\u5f81\u878d\u5408\u5206\u6790\u6846\u67b6\u6765\u9884\u6d4b\u91d1\u5c5e\u6c27\u5316\u7269\u7eb3\u7c73\u9897\u7c92\uff08MeONP\uff09\u5728\u96cc\u6027\u5c0f\u9f20\u4e2d\u7684\u7ea4\u7ef4\u5316\u6f5c\u529b\u3002\u5c06\u6bcf\u4e2a\u7eb3\u7c73\u751f\u7269\u754c\u9762\u89c6\u4e3a\u4e00\u4e2a\u72ec\u7acb\u5b9e\u4f53\uff0c\u5229\u7528 MeONP-\u80ba\u76f8\u4e92\u4f5c\u7528\u5f97\u51fa\u7684 87 \u4e2a\u7279\u5f81\u6765\u5f00\u53d1\u57fa\u4e8e\u673a\u5668\u5b66\u4e60\u7684\u80ba\u7ea4\u7ef4\u5316\u9884\u6d4b\u6846\u67b6\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u5c06\u5de8\u566c\u7ec6\u80de\u548c\u4e0a\u76ae\u7ec6\u80de\u4e2d\u7684\u7ec6\u80de\u635f\u4f24\u548c\u7ec6\u80de\u56e0\u5b50\uff08IL-1\u03b2 \u548c TGF-\u03b21\uff09\u4ea7\u751f\u786e\u5b9a\u4e3a\u4e0e\u9897\u7c92\u5927\u5c0f\u3001\u8868\u9762\u7535\u8377\u548c\u6eb6\u9176\u4f53\u76f8\u4e92\u4f5c\u7528\u5bc6\u5207\u76f8\u5173\u7684\u5173\u952e\u4e8b\u4ef6\u3002\u5b9e\u9a8c\u8868\u660e\uff0c\u8be5\u8ba1\u7b97\u673a\u6a21\u578b\u51c6\u786e\u7387\u4e3a 85%\u3002<\/p>\n

\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u9884\u6d4b\u6a21\u578b\u5728\u7eb3\u7c73\u6750\u6599\u98ce\u9669\u8bc4\u4f30\u548c\u534f\u52a9\u76d1\u7ba1\u51b3\u7b56\u65b9\u9762\u5177\u6709\u6f5c\u5728\u7528\u9014\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5\u300cMultimodal feature fusion machine learning for predicting chronic injury induced by engineered nanomaterials<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2025 \u5e74 3 \u6708 20 \u65e5\u53d1\u5e03\u5728\u300aNature Communications<\/em>\u300b\u3002<\/p>\n

<\/a><\/section>\n

\u5168\u7403\u5df2\u6709\u8d85\u8fc7 1 \u4e07\u79cd\u7eb3\u7c73\u4ea7\u54c1\u5e94\u7528\u4e8e\u5404\u884c\u4e1a\uff0c\u90e8\u5206\u7eb3\u7c73\u4ea7\u54c1\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u4f1a\u91ca\u653e\u7eb3\u7c73\u9897\u7c92\u5f62\u6210\u6c14\u6eb6\u80f6\uff0c\u7ecf\u5438\u5165\u540e\u53ef\u80fd\u5f15\u53d1\u54fa\u4e73\u52a8\u7269\u547c\u5438\u9053\u635f\u4f24\u3002<\/p>\n

\u67d0\u4e9b\u5de5\u7a0b\u7eb3\u7c73\u6750\u6599\uff08ENMs\uff09\u5982 ZnO\u3001CuO\u3001Au \u548c Ag \u53ef\u80fd\u901a\u8fc7\u6d3b\u6027\u6c27\u751f\u6210\u3001\u708e\u75c7\u5c0f\u4f53\u6fc0\u6d3b\u6216\u4fc3\u708e\u56e0\u5b50\u91ca\u653e\u5f15\u53d1\u6025\u6027\u80ba\u635f\u4f24\uff0c\u800c\u78b3\u7eb3\u7c73\u7ba1\u548c\u91d1\u5c5e\u6c27\u5316\u7269\u7b49\u5219\u53ef\u80fd\u5bfc\u81f4\u6162\u6027\u547c\u5438\u6bd2\u6027\uff0c\u5982\u80ba\u7ea4\u7ef4\u5316\u548c\u81f4\u764c\uff0c\u8fd9\u4e9b\u635f\u4f24\u901a\u5e38\u662f\u4e0d\u53ef\u9006\u7684\u3002<\/p>\n

\u7531\u4e8e ENMs \u7684\u6f5c\u5728\u6162\u6027\u6bd2\u6027\uff0c\u76f8\u5173\u4ea7\u54c1\u5b89\u5168\u6027\u53d7\u5230\u4e25\u683c\u76d1\u7ba1\uff0c\u4f8b\u5982\u78b3\u7eb3\u7c73\u7ba1\u56e0\u5176\u81f4\u764c\u6027\u88ab\u5217\u5165\u300c\u66ff\u4ee3\u73b0\u5728\u300d\uff08SIN\uff09\u6e05\u5355\u3002\u4e3a\u5e94\u5bf9 ENMs \u98ce\u9669\u8bc4\u4f30\u7684\u9ad8\u6210\u672c\u548c\u65f6\u95f4\u6d88\u8017\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u8ba1\u7b97\u673a\u9884\u6d4b\u6a21\u578b\uff0c\u901a\u8fc7\u7406\u5316\u6027\u8d28\u9884\u6d4b ENMs \u7684\u4f53\u5916\u6bd2\u6027\uff0c\u4f46\u76ee\u524d\u4ecd\u7f3a\u4e4f\u53ef\u9760\u7684\u6a21\u578b\u9884\u6d4b\u5176\u4f53\u5185\u6162\u6027\u547c\u5438\u6bd2\u6027\uff0c\u5982\u80ba\u7ea4\u7ef4\u5316\u3002<\/p>\n

\u80ba\u7ea4\u7ef4\u5316\u7684\u81f4\u75c5\u8fc7\u7a0b\u6d89\u53ca\u7eb3\u7c73\u9897\u7c92\u4e0e\u80ba\u6db2\u3001\u5de8\u566c\u7ec6\u80de\u3001\u4e0a\u76ae\u7ec6\u80de\u53ca\u4e9a\u7ec6\u80de\u7ed3\u6784\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u4e9b\u591a\u91cd\u7eb3\u7c73-\u751f\u7269\u754c\u9762\u7684\u590d\u6742\u6027\u4f7f\u5f97\u6162\u6027\u6bd2\u6027\u9884\u6d4b\u6210\u4e3a\u7eb3\u7c73\u6bd2\u6027\u7814\u7a76\u7684\u4e3b\u8981\u6311\u6218\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u5e0c\u671b\u5728\u5efa\u7acb\u91d1\u5c5e\u6c27\u5316\u7269\u7eb3\u7c73\u7c92\u5b50 (MeONPs) \u8bf1\u53d1\u80ba\u7ea4\u7ef4\u5316\u7684\u9884\u6d4b\u6846\u67b6\u3002\u82cf\u5dde\u5927\u5b66\u3001\u5927\u8fde\u7406\u5de5\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u51c6\u5907\u4e86\u4e00\u4e2a\u5305\u542b 52 \u4e2a MeONPs \u7684\u6570\u636e\u5e93\uff0c\u5e76\u6536\u96c6\u4e86 MeONPs \u4e0e\u751f\u7269\u73af\u5883\uff08\u5982\u819c\u3001\u6eb6\u9176\u4f53\u3001\u7ebf\u7c92\u4f53\u548c\u5176\u4ed6\u7ec6\u80de\u8d28\u6210\u5206\uff09\u4e4b\u95f4\u591a\u4e2a\u754c\u9762\u7684\u6f5c\u5728\u9884\u6d4b\u7279\u5f81\u3002\u7814\u7a76\u4eba\u5458\u603b\u5171\u83b7\u5f97\u4e86 87 \u4e2a\u591a\u6a21\u6001\u7279\u5f81\u548c\u4e24\u4e2a\u7ea4\u7ef4\u5316\u6307\u6570\uff0c\u7136\u540e\u5bf9\u5176\u8fdb\u884c\u4e86\u673a\u5668\u5b66\u4e60\u5efa\u6a21\u3002<\/p>\n

\u4e3a\u4e86\u6784\u5efa\u9884\u6d4b\u6846\u67b6\uff0c\u8be5\u56e2\u961f\u91c7\u7528\u4e86\u516b\u79cd\u4e0d\u540c\u7684\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\uff1a\u968f\u673a\u68ee\u6797\u3001\u5c40\u90e8\u52a0\u6743\u5b66\u4e60\u3001C4.5 \u51b3\u7b56\u6811\u3001k-\u6700\u8fd1\u90bb\u3001\u652f\u6301\u5411\u91cf\u673a\u3001\u8d1d\u53f6\u65af\u7f51\u7edc\u3001\u51b3\u7b56\u8868\u548c\u903b\u8f91\u56de\u5f52\u3002<\/p>\n

\u4ed6\u4eec\u4f7f\u7528\u603b\u4f53\u9884\u6d4b\u51c6\u786e\u5ea6 (ACC)\u3001\u9a6c\u4fee\u65af\u76f8\u5173\u7cfb\u6570 (MCC)\u3001\u654f\u611f\u5ea6 (SE)\u3001\u7279\u5f02\u5ea6 (SP)\u3001\u53d7\u8bd5\u8005\u5de5\u4f5c\u7279\u5f81\u66f2\u7ebf\u4e0b\u9762\u79ef (AUC) \u548c F1 \u5206\u6570\u5f7b\u5e95\u8bc4\u4f30\u4e86\u6240\u5f00\u53d1\u7684\u9884\u6d4b\u6a21\u578b\u7684\u6027\u80fd\u3002\u968f\u673a\u68ee\u6797 (RF) \u6a21\u578b\u8868\u73b0\u6700\u4f73\uff0c\u5e76\u901a\u8fc7\u4e94\u79cd MeONP \u8fdb\u884c\u4e86\u8fdb\u4e00\u6b65\u7684\u5b9e\u9a8c\u9a8c\u8bc1\u3002<\/p>\n

<\/a><\/section>\n

\u56fe\u793a\uff1a\u80ba\u90e8\u7eb3\u7c73\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u754c\u9762\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

\u867d\u7136\u8fd9\u91cc\u4f7f\u7528\u4e86 BALF \u4e2d\u7684 TGF-\u03b21 \u548c\u7ec4\u7ec7\u5b66\u56fe\u50cf\u7684 Ashcroft \u8bc4\u5206\uff0c\u56e0\u4e3a\u7528\u4e8e\u80ba\u7ea4\u7ef4\u5316\u7684\u53ef\u9760\u7684\u975e\u52a8\u7269\u5206\u7c7b\u5668\u6709\u9650\uff0c\u4f46\u8be5\u56e2\u961f\u627f\u8ba4\u63a2\u7d22\u975e\u52a8\u7269\u5206\u7c7b\u66ff\u4ee3\u65b9\u6cd5\u7684\u91cd\u8981\u6027\uff0c\u7b26\u5408\u52a8\u7269\u8bd5\u9a8c\u7684 3R \u539f\u5219\uff08\u66ff\u4ee3\u3001\u51cf\u5c11\u3001\u6539\u8fdb\uff09\u3002<\/p>\n

\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u8ba1\u7b97\u673a\u6a21\u578b\u662f\u4f7f\u7528\u5316\u5b66\u548c\u4f53\u5916\u6570\u636e\u7684\u7ec4\u5408\u6784\u5efa\u7684\uff0c\u8fd9\u5c55\u793a\u4e86\u5411\u975e\u52a8\u7269\u9884\u6d4b\u5efa\u6a21\u65b9\u6cd5\u8fc8\u51fa\u7684\u4e00\u6b65\u3002\u968f\u7740 ENM \u7684\u6570\u91cf\u4e0d\u65ad\u589e\u52a0\uff0c\u5728\u66b4\u9732\u4e8e\u73af\u5883\u4e4b\u524d\u8bc4\u4f30\u5176\u6f5c\u5728\u7684\u4fc3\u7ea4\u7ef4\u5316\u98ce\u9669\u81f3\u5173\u91cd\u8981\u3002MFF \u5728\u8bc4\u4f30 MeONP \u7684\u7ea4\u7ef4\u5316\u98ce\u9669\u65b9\u9762\u8868\u73b0\u51fa\u5f88\u9ad8\u7684\u9884\u6d4b\u51c6\u786e\u6027\u3002<\/p>\n

\u4e3a\u4e86\u63d0\u9ad8 MFF \u6a21\u578b\u7684\u5b9e\u7528\u6027\uff0c\u8be5\u56e2\u961f\u5c06\u5176\u8f6c\u5316\u4e3a\u4e00\u6b3e\u540d\u4e3a\u300cNano-induced lung fibrosis prediction\u300d\u7684\u8f6f\u4ef6\uff08NILFP v 1.0.0\uff09\uff0c\u5e76\u7b80\u5316\u4e86\u7528\u6237\u754c\u9762\u3002<\/p>\n

GitHub\uff1ahttps:\/\/github.com\/huangyang2023\/NILFPv1.0.0<\/p>\n

<\/a><\/section>\n

\u56fe\u793a\uff1a\u8bc6\u522b\u7528\u4e8e\u673a\u5236\u89e3\u91ca\u7684\u5173\u952e\u63cf\u8ff0\u7b26\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n

NILFP \u53ef\u7528\u4e8e\u672a\u7ecf\u6d4b\u8bd5\u7684 MeONPs\u3001\u57fa\u4e8e MeONP \u7684\u7eb3\u7c73\u4ea7\u54c1\u7b49\u7684\u7ea4\u7ef4\u5316\u98ce\u9669\u8bc4\u4f30\uff0c\u4f7f\u7528\u4e09\u4e2a\u5316\u5b66\u63cf\u8ff0\u7b26\uff08\u6d41\u4f53\u52a8\u529b\u5b66\u5c3a\u5bf8\u3001zeta \u7535\u4f4d\u548c PSF \u4e2d\u7684\u6eb6\u89e3\u5ea6\uff09\u548c\u56db\u4e2a\u4f53\u5916\u63cf\u8ff0\u7b26\uff0c\u5305\u62ec\u66b4\u9732\u4e8e 12.5 \u03bcg\/mL MeONPs \u7684 THP-1 \u7ec6\u80de\u4e0a\u6e05\u6db2\u4e2d\u7684 IL-1\u03b2\u3001\u66b4\u9732\u4e8e 200 \u03bcg\/mL MeONPs \u7684 THP-1 \u7ec6\u80de\u6d3b\u529b\u4ee5\u53ca\u66b4\u9732\u4e8e 25 \u03bcg\/mL MeONPs \u7684 BEAS-2B \u7ec6\u80de\u6d3b\u529b\u548c\u5206\u6ccc\u7684 TGF-\u03b21\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u5c06\u8ba1\u7b97\u673a\u6a21\u578b\u7684\u5f3a\u5927\u9884\u6d4b\u80fd\u529b\u53ef\u4ee5\u5f52\u56e0\u4e8e\u4ee5\u4e0b\u4e09\u70b9\uff1a<\/p>\n

\uff08i\uff09\u6839\u636e MeONPs \u5728\u80ba\u90e8\u7684\u751f\u7269\u547d\u8fd0\u7cbe\u5fc3\u9009\u62e9\u5173\u952e\u7684\u7eb3\u7c73\u751f\u7269\u76f8\u4e92\u4f5c\u7528\uff1b<\/p>\n

\uff08ii\uff09\u4f7f\u7528\u76f8\u5173\u7684\u7ec6\u80de\u6a21\u578b\u6765\u7814\u7a76\u80ba\u7ea4\u7ef4\u5316\uff1b<\/p>\n

\uff08iii\uff09\u6574\u5408\u5316\u5b66\u548c\u4f53\u5916\u6570\u636e\uff0c\u5168\u9762\u8868\u793a\u80ba\u7ea4\u7ef4\u5316\u80cc\u540e\u7684\u52a8\u6001\u3002<\/p>\n

<\/a><\/section>\n

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\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41467-025-58016-w<\/p>\n

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