{"id":39876,"date":"2025-04-04T00:02:48","date_gmt":"2025-04-03T16:02:48","guid":{"rendered":"https:\/\/17aitech.com\/?p=39876"},"modified":"2025-04-04T00:02:48","modified_gmt":"2025-04-03T16:02:48","slug":"%e4%bb%85%e8%be%93%e5%85%a5prompt%e4%b8%8e%e5%ba%8f%e5%88%97%ef%bc%8c%e5%87%86%e7%a1%ae%e7%8e%87%e8%b6%8590%ef%bc%8cuc%e4%bc%af%e5%85%8b%e5%88%a9%e7%ad%89%e6%8f%90%e5%87%ba%e6%96%87%e6%9c%ac%e7%94%9f","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=39876","title":{"rendered":"\u4ec5\u8f93\u5165prompt\u4e0e\u5e8f\u5217\uff0c\u51c6\u786e\u7387\u8d8590%\uff0cUC\u4f2f\u514b\u5229\u7b49\u63d0\u51fa\u6587\u672c\u751f\u6210\u86cb\u767d\u8d28\u591a\u6a21\u6001\u6846\u67b6"},"content":{"rendered":"

\u6587\u7ae0\u6765\u6e90\u4e8e\u4e92\u8054\u7f51:\u4ec5\u8f93\u5165prompt\u4e0e\u5e8f\u5217\uff0c\u51c6\u786e\u7387\u8d8590%\uff0cUC\u4f2f\u514b\u5229\u7b49\u63d0\u51fa\u6587\u672c\u751f\u6210\u86cb\u767d\u8d28\u591a\u6a21\u6001\u6846\u67b6<\/a><\/p>\n

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\u7f16\u8f91\u4e28coisini<\/span><\/p>\n

\u673a\u5668\u5b66\u4e60<\/mark>\u5728\u86cb\u767d\u8d28\u53d1\u73b0\u9886\u57df\u5c55\u73b0\u51fa\u6df1\u8fdc\u7684\u6f5c\u529b\uff0c\u76f8\u5173\u5de5\u5177\u5df2\u5feb\u901f\u5e94\u7528\u4e8e\u79d1\u5b66\u6d41\u7a0b\u7684\u8f85\u52a9\u4e0e\u52a0\u901f\u3002\u5f53\u524d\uff0cAI \u8f85\u52a9\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u4e3b\u8981\u5229\u7528\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u548c\u7ed3\u6784\u4fe1\u606f\uff0c\u800c\u4e3a\u4e86\u63cf\u8ff0\u86cb\u767d\u8d28\u7684\u9ad8\u7ea7\u529f\u80fd\uff0c\u4eba\u4eec\u4ee5\u6587\u672c\u5f62\u5f0f\u6574\u7406\u4e86\u6d77\u91cf\u77e5\u8bc6\uff0c\u8fd9\u79cd\u6587\u672c\u6570\u636e\u80fd\u5426\u52a9\u529b\u86cb\u767d\u8d28\u8bbe\u8ba1\u4efb\u52a1\u5c1a\u672a\u5f97\u5230\u63a2\u7d22\u3002<\/p>\n

\u4e3a\u4e86\u586b\u8865\u8fd9\u4e00\u7a7a\u767d\uff0c\u6765\u81ea\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\uff08UC Berkeley\uff09\u3001\u52a0\u5dde\u7406\u5de5\u5b66\u9662\uff08California Institute of Technology\uff09\u7b49\u673a\u6784\u7684\u7814\u7a76\u8005\u63d0\u51fa\u4e86\u4e00\u4e2a\u5229\u7528\u6587\u672c\u63cf\u8ff0\u8fdb\u884c\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u591a\u6a21\u6001\u6846\u67b6 \u2014\u2014ProteinDT\u3002\u8be5\u6846\u67b6\u5305\u542b\u4e09\u4e2a\u8fde\u7eed\u6b65\u9aa4\uff1a\u5bf9\u9f50\u4e24\u79cd\u6a21\u6001\u8868\u5f81\u7684 ProteinCLAP\u3001\u4ece\u6587\u672c\u6a21\u6001\u751f\u6210\u86cb\u767d\u8d28\u8868\u5f81\u7684 Facilitator\uff0c\u4ee5\u53ca\u6839\u636e\u8868\u5f81\u751f\u6210\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u89e3\u7801\u5668\u3002<\/p>\n

<\/a><\/section>\n

\u8bba\u6587\u5730\u5740\uff1ahttps:\/\/www.nature.com\/articles\/s42256-025-01011-z<\/p>\n

\u7814\u7a76\u6982\u89c8<\/p>\n

\u53d7\u57fa\u7840\u6a21\u578b\u7a81\u7834\u7684\u542f\u53d1\uff0c\u8ba1\u7b97\u5316\u5b66\u9886\u57df\u5df2\u8bc1\u660e\u7ed3\u5408\u836f\u7269\u6587\u672c\u63cf\u8ff0\u4e0e\u5316\u5b66\u7ed3\u6784\u4fe1\u606f\u7684\u591a\u6a21\u6001\u673a\u5236\u80fd\u6709\u6548\u4fc3\u8fdb\u5c0f\u5206\u5b50\u836f\u7269\u53d1\u73b0<\/mark>\uff0c\u8fd9\u4e3a\u86cb\u767d\u8d28\u9886\u57df\u5982\u4f55\u8fd0\u7528\u591a\u6a21\u6001\u673a\u5236\u63a8\u52a8\u86cb\u767d\u8d28\u5de5\u7a0b\u4e0e\u751f\u6210\u63d0\u51fa\u4e86\u65b0\u547d\u9898\u3002<\/p>\n

\u4e3a\u89e3\u7b54\u8fd9\u4e00\u95ee\u9898\uff0c\u7814\u7a76\u56e2\u961f\u5f00\u521b\u4e86\u5229\u7528\u6587\u672c\u63cf\u8ff0\u8fdb\u884c\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u65b0\u8303\u5f0f\u3002<\/p>\n

\u5177\u4f53\u800c\u8a00\uff0c\u8be5\u7814\u7a76\u81f4\u529b\u4e8e\u6316\u6398\u86cb\u767d\u8d28\u7684\u4e24\u79cd\u6a21\u6001\uff1a\u86cb\u767d\u8d28\u5e8f\u5217\u4e0e\u6587\u672c\u63cf\u8ff0\u3002\u86cb\u767d\u8d28\u5e8f\u5217\u7531 20 \u79cd\u6c28\u57fa\u9178\uff08\u53c8\u79f0\u6b8b\u57fa\uff09\u7ec4\u6210\uff0c\u51b3\u5b9a\u4e86\u86cb\u767d\u8d28\u7684\u6298\u53e0\u65b9\u5f0f\u4e0e\u529f\u80fd\u7279\u6027\uff1b\u800c\u7b2c\u4e8c\u6a21\u6001\u5219\u662f\u516c\u5f00\u6570\u636e\u6e90\uff08\u5982 UniProt\uff09\u8bb0\u5f55\u7684\u6587\u672c\u63cf\u8ff0\uff0c\u8574\u542b\u4e30\u5bcc\u7684\u86cb\u767d\u8d28\u77e5\u8bc6\uff0c\u5305\u62ec\u53c2\u4e0e\u7684\u751f\u7269\u8fc7\u7a0b\u3001\u6267\u884c\u7684\u5206\u5b50\u529f\u80fd\u4ee5\u53ca\u5b9a\u4f4d\u7684\u7ec6\u80de\u7ec4\u5206\u3002\u4e24\u79cd\u6a21\u6001\u5206\u522b\u805a\u7126\u4e8e\u8868\u8fbe\u5185\u90e8\u751f\u5316\u7ec4\u6210\u4e0e\u9886\u57df\u4e13\u5bb6\u603b\u7ed3\u7684\u9ad8\u9636\u77e5\u8bc6\uff0c\u56e0\u6b64\u63a2\u7d22\u4e24\u8005\u7684\u878d\u5408\u5bf9\u5b8c\u6210\u66f4\u5177\u6311\u6218\u6027\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u4efb\u52a1\uff08\u5982\u96f6\u6837\u672c\u6cdb\u5316\uff09\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n

\u8be5\u7814\u7a76\u63d0\u51fa\u4e86\u6587\u672c\u9a71\u52a8\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u6846\u67b6 ProteinDT\uff0c\u5176\u6838\u5fc3\u6d41\u7a0b\u5982\u4e0b\uff1a<\/p>\n

(1) \u5bf9\u6bd4\u6027\u8bed\u8a00 – \u86cb\u767d\u8d28\u9884\u8bad\u7ec3\uff08ProteinCLAP\uff09\u6b65\u9aa4\uff0c\u65e8\u5728\u5bf9\u9f50\u6587\u672c\u5e8f\u5217\u4e0e\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u8868\u5f81\u7a7a\u95f4\u3002\u8be5\u6b65\u9aa4\u901a\u8fc7\u4ece\u00a0UniProt\u00a0\u7684 Swiss-Prot \u5b50\u96c6\u63d0\u53d6\u7684 441,000 \u4e2a\u6587\u672c – \u86cb\u767d\u8d28\u5bf9\u6570\u636e\u96c6 SwissProtCLAP\uff0c\u91c7\u7528\u5bf9\u6bd4\u5b66\u4e60\u8303\u5f0f\u5b9e\u73b0\u53cc\u6a21\u6001\u8868\u5f81\u5bf9\u9f50\uff1b<\/p>\n

(2) ProteinFacilitator \u6a21\u578b\u4ece\u6587\u672c\u6a21\u6001\u751f\u6210\u86cb\u767d\u8d28\u5e8f\u5217\u8868\u5f81\uff0c\u91c7\u7528\u9ad8\u65af\u5206\u5e03<\/mark>\u4f30\u8ba1\u6761\u4ef6\u5206\u5e03\uff1b<\/p>\n

(3) \u7528\u4e8e\u86cb\u767d\u8d28\u751f\u6210\u7684\u89e3\u7801\u5668\u6a21\u578b\u662f\u4e00\u4e2a\u6761\u4ef6\u751f\u6210\u6a21\u578b\uff0c\u57fa\u4e8e\u4e0a\u4e00\u6b65\u4ea7\u751f\u7684\u8868\u5f81\u4fe1\u606f\u751f\u6210\u86cb\u767d\u8d28\u5e8f\u5217\u3002<\/p>\n

<\/a><\/section>\n

\u5b9e\u9a8c\u7ed3\u679c<\/p>\n

\u4e3a\u4e86\u9a8c\u8bc1 ProteinDT \u7684\u591a\u529f\u80fd\u7279\u6027\uff0c\u7814\u7a76\u56e2\u961f\u8bbe\u8ba1\u4e86\u4e09\u9879\u4e0b\u6e38\u4efb\u52a1\uff1a<\/p>\n

\u6587\u672c\u751f\u6210\u86cb\u767d\u8d28\u4efb\u52a1\uff0c\u901a\u8fc7 ProteinDT \u6d41\u7a0b\u6839\u636e\u76ee\u6807\u86cb\u767d\u8d28\u7279\u6027\u7684\u6587\u672c\u63cf\u8ff0 prompt \u751f\u6210\u86cb\u767d\u8d28\u5e8f\u5217\uff0c\u6700\u4f18\u68c0\u7d22\u51c6\u786e\u7387\u53ef\u8d85 90%\u3002<\/p>\n

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\u96f6\u6837\u672c\u6587\u672c\u5f15\u5bfc\u7684\u86cb\u767d\u8d28\u7f16\u8f91\u4efb\u52a1\uff0c\u8f93\u5165\u4e3a\u6587\u672c prompt \u548c\u86cb\u767d\u8d28\u5e8f\u5217\u3002\u7814\u7a76\u56e2\u961f\u63d0\u51fa\u4e24\u79cd\u7f16\u8f91\u65b9\u6cd5\uff1a\u6f5c\u5728\u7a7a\u95f4\u63d2\u503c\u6cd5\u5728\u5e8f\u5217\u7ea7\u8868\u5f81\u7a7a\u95f4\u8fdb\u884c\u63d2\u503c\uff1b\u6f5c\u5728\u4f18\u5316\u6cd5\u76f4\u63a5\u4f18\u5316 token \u7ea7\u8868\u5f81\u3002\u4e24\u79cd\u65b9\u6cd5\u5747\u6ce8\u5165\u6587\u672c\u6a21\u6001\u4fe1\u606f\uff0c\u5e76\u5c06\u5b66\u5f97\u7684\u8868\u5f81\u7528\u4e8e\u86cb\u767d\u8d28\u751f\u6210\u3002\u5b9e\u9a8c\u663e\u793a ProteinDT \u5728 12 \u9879\u7f16\u8f91\u4efb\u52a1\uff08\u6db5\u76d6\u7ed3\u6784\u611f\u77e5\u3001\u7a33\u5b9a\u6027\u4f18\u5316\u53ca\u80bd\u6bb5\u7ed3\u5408\u7f16\u8f91\u7b49\uff09\u4e2d\u5747\u53d6\u5f97\u6700\u4f73\u547d\u4e2d\u7387\uff0c\u5b9a\u6027\u5206\u6790\u7ed3\u679c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u5176\u6709\u6548\u6027\u3002<\/p>\n

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<\/a><\/section>\n

\u86cb\u767d\u8d28\u5c5e\u6027\u9884\u6d4b\u4efb\u52a1\uff0c\u7528\u4e8e\u8bc4\u4f30 ProteinCLAP \u5b66\u4e60\u8868\u5f81\u7684\u7a33\u5065\u6027\u4e0e\u6cdb\u5316\u80fd\u529b\u3002\u4e0e\u516d\u79cd\u524d\u6cbf\u86cb\u767d\u8d28\u5e8f\u5217\u8868\u5f81\u65b9\u6cd5\u76f8\u6bd4\uff0cProteinDT \u5728\u56db\u9879\u57fa\u51c6\u6d4b\u8bd5\u4e2d\u8868\u73b0\u6700\u4f18\u3002<\/p>\n

<\/a><\/section>\n

\u611f\u5174\u8da3\u7684\u8bfb\u8005\u53ef\u4ee5\u9605\u8bfb\u8bba\u6587\u539f\u6587\uff0c\u4e86\u89e3\u66f4\u591a\u7814\u7a76\u5185\u5bb9\u3002<\/p>\n

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