{"id":41060,"date":"2026-06-18T00:06:05","date_gmt":"2026-06-17T16:06:05","guid":{"rendered":"https:\/\/17aitech.com\/?p=41060"},"modified":"2026-06-18T00:06:05","modified_gmt":"2026-06-17T16:06:05","slug":"%e4%bb%8e%e8%af%ba%e5%a5%96%e9%a1%b9%e7%9b%ae%e5%88%b0%e7%94%9f%e6%88%90%e5%bc%8f%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%ef%bc%8clatent-labs-%e5%88%9b%e5%a7%8b%e4%ba%ba-simon-kohl%ef%bc%9aai-%e6%ad%a3","status":"publish","type":"post","link":"https:\/\/17aitech.com\/?p=41060","title":{"rendered":"\u4ece\u8bfa\u5956\u9879\u76ee\u5230\u751f\u6210\u5f0f\u836f\u7269\u8bbe\u8ba1\uff0cLatent Labs \u521b\u59cb\u4eba Simon Kohl\uff1aAI \u6b63\u5728\u8ba9\u751f\u7269\u5b66\u8fdb\u5165\u300c\u53ef\u7f16\u7a0b\u65f6\u4ee3\u300d | CVPR 2026"},"content":{"rendered":"

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<\/a><\/p>\n

\u4f5c\u8005\uff5c\u5434\u601d\u68a6<\/span><\/p>\n

\u7f16\u8f91\uff5c\u5c91\u5cf0<\/span><\/p>\n

\u00a0<\/p>\n

2026\u5e746\u67083\u65e5\uff0c\u8ba1\u7b97\u673a\u89c6\u89c9\u4e0e\u6a21\u5f0f\u8bc6\u522b\u9876\u7ea7\u4f1a\u8bae\uff08CVPR\uff09\u5728\u7f8e\u56fd\u4e39\u4f5b\u4e3e\u884c\u3002\u5728\u5927\u4f1a\u7279\u9080\u6f14\u8bb2\u73af\u8282\uff0c\u524d DeepMind \u86cb\u767d\u8d28\u8bbe\u8ba1\u56e2\u961f\u6838\u5fc3\u6210\u5458\u30012024\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u83b7\u5956\u9879\u76ee AlphaFold \u6838\u5fc3\u7814\u7a76\u5458\uff0cLatent Labs \u521b\u59cb\u4eba\u517c CEO Simon Kohl \u53d1\u8868\u4e86\u9898\u4e3a\u201c<\/span>Programmable Biology<\/span>\uff1a<\/span>Generative AI for Molecular Design<\/span>\u201d\u7684\u7cbe\u5f69\u6f14\u8bb2\u3002<\/span><\/p>\n

\u56f4\u7ed5\u5f53\u4eca\u836f\u7269\u53d1\u73b0\u9886\u57df\u6700\u6838\u5fc3\u7684\u75db\u70b9\uff1a\u4e00\u79cd\u65b0\u836f\u4ece\u7814\u53d1\u5230\u4e0a\u5e02\u5e73\u5747\u8017\u65f6\u8d85\u8fc710\u5e74\u3001\u82b1\u8d39\u8d8520\u4ebf\u7f8e\u5143\uff0c\u4f46\u4e5d\u6210\u5019\u9009\u836f\u7269\u6700\u7ec8\u5931\u8d25<\/span>\u3002<\/span><\/p>\n

\u800cSimon Kohl\u8ba4\u4e3a\uff0c\u8fd9\u4e00\u5207\u7684\u6839\u6e90\u5728\u4e8e\u201c\u6211\u4eec\u4ece\u9519\u8bef\u7684\u5206\u5b50\u51fa\u53d1\u201d\u3002\u4e3a\u6b64\uff0c\u4ed6\u63d0\u51fa\u4e86\u4e00\u6761\u4ece\u201c\u7ed3\u6784\u9884\u6d4b\u201d\u5230\u201c\u6761\u4ef6\u751f\u6210\u201d\u518d\u5230\u201c\u81ea\u4e3b\u667a\u80fd\u4f53\u201d\u7684\u6280\u672f\u8dc3\u8fc1\u8def\u7ebf\u3002<\/span><\/p>\n

\u6f14\u8bb2\u4ee5AlphaFold 2\u4e3a\u8d77\u70b9\uff0c\u56de\u987e\u4e86\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7a81\u7834\u5982\u4f55\u50ac\u751f\u751f\u6210\u5f0f\u836f\u7269\u8bbe\u8ba1\uff1b\u968f\u540e\u5c55\u793a\u4e86Latent Labs\u7684\u4e24\u4ee3\u57fa\u7840\u6a21\u578b\u2014\u2014<\/span>Latent\u2014X1<\/span>\uff08\u901a\u7528\u86cb\u767d\u7ed3\u5408\u7269\u8bbe\u8ba1\uff09\u4e0e<\/span>Latent\u2014X2<\/span>\uff08\u96f6\u6837\u672c\u6297\u4f53\u8bbe\u8ba1\uff09\u2014\u2014\u5982\u4f55\u5728\u6e7f\u5b9e\u9a8c\u5ba4\u4e2d\u5b9e\u73b0\u5ab2\u7f8e\u751a\u81f3\u8d85\u8d8a\u4f20\u7edf\u4e07\u4ebf\u7ea7\u7b5b\u9009\u7684\u547d\u4e2d\u7387\u548c\u4eb2\u548c\u529b\uff1b\u6700\u7ec8\u53d1\u5e03\u4e86\u5168\u7403\u9996\u4e2a\u5b9e\u9a8c\u5ba4\u9a8c\u8bc1\u7684\u6297\u4f53\u8bbe\u8ba1\u667a\u80fd\u4f53<\/span>Latent\u2014Y<\/span>\uff0c\u4ec5\u9700\u4e00\u6761\u81ea\u7136\u8bed\u8a00\u63d0\u793a\uff0c\u5373\u53ef\u81ea\u4e3b\u5b8c\u6210\u4ece\u9776\u70b9\u5206\u6790\u5230\u5206\u5b50\u8bbe\u8ba1\u7684\u5168\u6d41\u7a0b\u3002<\/span><\/p>\n

\u603b\u7ed3\u800c\u8a00\uff0c\u4eceAlphaFold 2\u89e3\u51b3\u201c\u5e8f\u5217\u5230\u7ed3\u6784\u201d\u7684\u9884\u6d4b\u95ee\u9898\uff0c\u5230\u751f\u6210\u5f0fAI\u5b9e\u73b0\u201c\u9776\u70b9\u5230\u836f\u7269\u201d\u7684\u6761\u4ef6\u8bbe\u8ba1\uff0c\u518d\u5230\u667a\u80fd\u4f53\u63a5\u7ba1\u201c\u7aef\u5230\u7aef\u201d\u7684\u81ea\u4e3b\u8bbe\u8ba1\u95ed\u73af\u2014\u2014\u8ba1\u7b97\u836f\u7269\u8bbe\u8ba1\u6b63\u4ee5\u6307\u6570\u7ea7\u901f\u5ea6\u6f14\u8fdb\uff0cSimon Kohl\u65ad\u8a00\uff1a<\/span>\u751f\u7269\u5b66\u7ec8\u5c06\u6210\u4e3a\u53ef\u7f16\u7a0b\u7684\u5de5\u7a0b\u5b66\u79d1\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u4ee5\u4e0b\u662fSimon Kohl\u5728CVPR 2026\u5927\u4f1a\u4e0a\u53d1\u8868\u7684\u6f14\u8bb2\u7cbe\u7f16\u7a3f\uff0c\u96f7\u5cf0\u7f51(\u516c\u4f17\u53f7\uff1a\u96f7\u5cf0\u7f51)<\/span>\u00b7AI\u79d1\u6280\u8bc4\u8bba\u57fa\u4e8e\u539f\u82f1\u6587\u6f14\u8bb2\u5185\u5bb9\u8fdb\u884c\u4e86\u4e0d\u6539\u539f\u610f\u7684\u7ffb\u8bd1\u7f16\u8f91\uff1a<\/span><\/p>\n

\u00a0<\/p>\n

\u300a<\/span>Programmable Biology <\/span>\uff1a<\/span> Generative AI for Molecular Design\u300b<\/span><\/p>\n

\u4e3b\u8bb2\u4eba\uff1aSimon Kohl\uff0cLatent Labs \u521b\u59cb\u4eba\u517c CEO<\/span><\/p>\n

\u00a0<\/p>\n

\u836f\u7269\u53d1\u73b0\u7684\u56f0\u5883\uff1a10\u5e74\u300120\u4ebf\u3001\u4e5d\u6210\u5931\u8d25<\/span><\/p>\n

\u5728\u8fdb\u5165\u6b63\u9898\u4e4b\u524d\uff0c\u6211\u60f3\u8ba9\u5927\u5bb6\u5148\u5bf9\u201c\u836f\u7269\u5982\u4f55\u8d77\u6548\u201d\u5efa\u7acb\u5171\u8bc6\u3002\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\uff0c\u4e00\u8a00\u4ee5\u853d\u4e4b\uff0c\u5c31\u662f\u7ed3\u5408\uff0c\u5e76\u4e14\u901a\u5e38\u662f\u963b\u65ad\u3002<\/span><\/p>\n

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\u6bd4\u5982\u53f8\u7f8e\u683c\u9c81\u80bd\uff08Semaglutide\uff09\uff0c\u5b83\u662f\u4e00\u4e2a\u5408\u6210\u80bd\u7c7b\u836f\u7269\uff0c\u901a\u8fc7\u7ed3\u5408\u5e76\u6fc0\u6d3bGLP-1\u53d7\u4f53\u6765\u6cbb\u7597\u4e8c\u578b\u7cd6\u5c3f\u75c5\u548c\u80a5\u80d6\u75c7\uff1b\u518d\u6bd4\u5982Caplacizumab\uff0c\u8fd9\u662f\u4e00\u79cd\u6e90\u81ea\u7f8a\u9a7c\u7684\u7eb3\u7c73\u6297\u4f53\uff0c\u901a\u8fc7\u963b\u65ad\u8840\u5c0f\u677f\u95f4\u76f8\u4e92\u4f5c\u7528\u6765\u6cbb\u7597\u51dd\u8840\u969c\u788d\uff1b\u8fd8\u6709\u66f2\u59a5\u73e0\u5355\u6297\uff08Trastuzumab\uff09\uff0c\u4e00\u79cd\u4eba\u6e90\u5316\u6297\u4f53\u7247\u6bb5\uff0c\u901a\u8fc7\u963b\u65adHER2\u53d7\u4f53\u6765\u6cbb\u7597\u4e73\u817a\u764c\u548c\u80c3\u764c\u3002\u5b83\u4eec\u7684\u5171\u540c\u70b9\u90fd\u662f\uff1a\u7ed3\u5408\u5e76\u963b\u65ad\u9776\u70b9\u3002<\/span><\/p>\n

\u90a3\u4e48\uff0c\u4eca\u5929\u7684\u836f\u7269\u662f\u5982\u4f55\u88ab\u53d1\u73b0\u7684\u5462\uff1f\u5178\u578b\u6d41\u7a0b\u901a\u5e38\u8d85\u8fc710\u5e74\u3002<\/span><\/p>\n

\u9996\u5148\uff0c\u4f60\u5f97\u627e\u5230\u4e00\u4e2a<\/span>\u521d\u59cb\u7b5b\u9009\u6750\u6599<\/span>\uff08Starting Material\uff09<\/span>\u2014\u2014\u800c\u5728\u4eca\u5929\uff0c\u884c\u4e1a\u5185\u4e3b\u8981\u6709\u4e09\u79cd\u4e3b\u6d41\u65b9\u5f0f\u3002<\/span><\/p>\n

\u7b2c\u4e00\u79cd\u662f<\/span>\u4f53\u5185\u514d\u75ab\u6cd5\uff08In vivo immunization\uff09<\/span>\u3002\u5927\u578b\u836f\u4f01\u771f\u7684\u5728\u7ecf\u8425\u7740\u5e9e\u5927\u7684\u7f8a\u9a7c\u548c\u9ca8\u9c7c\u519c\u573a\uff0c\u8bd5\u56fe\u4ece\u8fd9\u4e9b\u52a8\u7269\u7684\u514d\u75ab\u53cd\u5e94\u4e2d\u7b5b\u9009\u51fa\u6297\u4f53\u3002\u4f46\u95ee\u9898\u662f\uff0c\u7f8a\u9a7c\u5e76\u4e0d\u662f\u4eba\u7c7b\uff1b\u8fd9\u4e9b\u5206\u5b50\u5145\u5176\u91cf\u53ea\u80fd\u7b97\u662f\u4e00\u4e2a\u8d77\u70b9\u2014\u2014\u5b83\u4eec\u4e0d\u4ec5\u4e0d\u53ef\u63a7\uff0c\u800c\u4e14\u4e0d\u591f\u7cbe\u51c6\u3002<\/span><\/p>\n

\u7b2c\u4e8c\u79cd\u662f<\/span>\u8d85\u5927\u89c4\u6a21\u5e93\u7b5b\u9009\uff08Massive library screening\uff09<\/span>\u3002\u8fd9\u79cd\u65b9\u6cd5\u8bf4\u767d\u4e86\uff0c\u5c31\u662f\u628a\u6210\u767e\u4e0a\u5343\u4ebf\u7684\u5316\u5408\u7269\u201c\u50cf\u6254\u610f\u5927\u5229\u9762\u4e00\u6837\u5f80\u5899\u4e0a\u7838\uff0c\u770b\u54ea\u4e2a\u80fd\u7c98\u4f4f\u201d\u3002\u8fd9\u79cd\u65b9\u5f0f\u867d\u7136\u4e0d\u9700\u8981\u52a8\u7269\uff0c\u4f46\u7b5b\u9009\u51fa\u6765\u7684\u5206\u5b50\u901a\u5e38\u4eb2\u548c\u529b\u5f88\u5f31\uff0c\u800c\u4e14\u6210\u672c\u6781\u9ad8\u3001\u6781\u5176\u8017\u65f6\u3002<\/span><\/p>\n

\u7b2c\u4e09\u79cd\u662f<\/span>B\u7ec6\u80de\u6316\u6398\uff08B-cell mining\uff09<\/span>\uff0c\u4e5f\u5c31\u662f\u76f4\u63a5\u4ece\u75be\u75c5\u5e78\u5b58\u8005\u7684\u8840\u6db2\u4e2d\u63d0\u53d6\u5929\u7136\u6210\u719f\u7684\u6297\u4f53\u3002\u867d\u7136\u8fd9\u4e9b\u662f\u4eba\u7c7b\u81ea\u5e26\u7684\u6297\u4f53\u3001\u4eb2\u548c\u529b\u6781\u5f3a\uff0c\u4f46\u8fd9\u79cd\u65b9\u6cd5\u9ad8\u5ea6\u4f9d\u8d56\u4f9b\u4f53\uff0c\u6839\u672c\u65e0\u6cd5\u5b9e\u73b0\u89c4\u6a21\u5316\u6269\u5c55\uff0c\u540c\u65f6\u8fd8\u9762\u4e34\u7740\u9519\u7efc\u590d\u6742\u7684\u4f26\u7406\u548c\u51c6\u5165\u95e8\u69db\u3002<\/span><\/p>\n

\u83b7\u5f97\u8d77\u70b9\u540e\uff0c\u8fd8\u8981\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u8bc1\u660e\u5b89\u5168\u6027\uff08\u7ea63\u5e74\uff09\uff0c\u518d\u7ecf\u8fc7\u4e34\u5e8aI\u671f\uff08\u5b89\u5168\u6027\uff09\u3001II\u671f\uff08\u5242\u91cf\uff09\u3001III\u671f\uff08\u5927\u89c4\u6a21\u9a8c\u8bc1\uff09\uff0c\u6700\u7ec8\u80fd\u83b7\u5f97FDA\u6279\u51c6\u7684\u836f\u7269\uff0c\u5341\u4e2d\u65e0\u4e00\u3002\u8fd9\u5c31\u662f\u5f53\u524d\u836f\u7269\u53d1\u73b0\u7684\u6f0f\u6597\u2014\u2014\u8d85\u6162\u3001\u8d85\u8d35\uff0820\u4ebf\u7f8e\u5143+\uff09\u300190%\u5931\u8d25\u3002<\/span><\/p>\n

\u800c\u6211\u8ba4\u4e3a\uff0c\u8fd9\u4e00\u5207\u7684\u6839\u6e90\u5728\u4e8e\u6211\u4eec\u4ece\u9519\u8bef\u7684\u5206\u5b50\u51fa\u53d1\u3002\u8fd9\u6b63\u662f\u6211\u4eec\u5728Latent Labs\u60f3\u8981\u6539\u53d8\u7684\u2014\u2014\u4ece\u5934\u8bbe\u8ba1\u836f\u7269\uff0c\u8ba9\u5b83\u4eec\u6709\u66f4\u9ad8\u7684\u6982\u7387\u901a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u66f4\u4fbf\u5b9c\u3001\u66f4\u5feb\u3002<\/span><\/p>\n

\u60f3\u8c61\u4e00\u4e2a\u4e16\u754c\uff1a\u9488\u5bf9\u4efb\u4f55\u75be\u75c5\u9776\u70b9\uff0c\u6211\u4eec\u53ea\u9700\u5c06\u9776\u70b9\u8f93\u5165\u751f\u6210\u5f0f\u6a21\u578b\uff0c\u6a21\u578b\u5c31\u80fd\u5373\u65f6\u4ea7\u51fa\u53ef\u7528\u7684\u836f\u7269\u5206\u5b50\u3002\u8fd9\u9700\u8981\u9ad8\u7279\u5f02\u6027\u7ed3\u5408\u3001\u53ef\u5236\u9020\u6027\u3001\u4f4e\u591a\u53cd\u5e94\u6027\u7b49\u4e00\u7cfb\u5217\u5c5e\u6027\u3002\u8fd9\u5c31\u662f\u6211\u4eec\u7684\u613f\u666f\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u8ba1\u7b97\u836f\u7269\u8bbe\u8ba1\u7684\u4e94\u5e74\u52a0\u901f\uff1a\u4eceAlphaFold 2\u5230\u667a\u80fd\u4f53<\/span><\/p>\n

\u56de\u987e\u8ba1\u7b97\u836f\u7269\u8bbe\u8ba1\u9886\u57df\u8fc7\u53bb\u4e94\u5e74\u7684\u8fdb\u5c55\uff0c\u6211\u8ba4\u4e3a\u6211\u4eec\u53d6\u5f97\u4e86\u5de8\u5927\u7684\u8fdb\u6b65\uff0c\u5728\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u582a\u6bd4\u5927\u8bed\u8a00\u6a21\u578b\u7684\u80fd\u529b\u8dc3\u5347\u3002<\/span><\/p>\n

2020\u5e74\uff0cAlphaFold 2\u6a2a\u7a7a\u51fa\u4e16\uff0c\u89e3\u51b3\u4e86\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\u2014\u2014\u8fd9\u662f\u6574\u4e2a\u9886\u57df\u7684\u201c\u79cd\u5b50\u7a81\u7834\u201d\u3002<\/span><\/p>\n

<\/a><\/p>\n

\u6b64\u540e\u51e0\u5e74\uff0cRFdiffusion\u548cProteinMPNN\u7b49\u9996\u6279\u86cb\u767d\u8d28\u8bbe\u8ba1\u751f\u6210\u6a21\u578b\u95ee\u4e16\uff0c\u76ee\u6807\u662f\u751f\u6210\u81ea\u7136\u754c\u4e0d\u5b58\u5728\u7684\u3001\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u80fd\u5de5\u4f5c\u7684\u86cb\u767d\u8d28\u30022024\u5e74\uff0cAlphaFold 3\u53d1\u5e03\uff0c\u65b0\u589e\u4e86\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u5efa\u6a21\u80fd\u529b\uff0c\u8fd9\u6070\u6070\u662f\u836f\u7269\u8bbe\u8ba1\u6240\u9700\u7684\u6838\u5fc3\u80fd\u529b\u3002\u968f\u540e\uff0cDeepMind\u53d1\u5e03\u4e86AlphaProteo\uff08\u86cb\u767d\u8d28\u7ed3\u5408\u7269\u8bbe\u8ba1\uff09\uff0cLatent Labs\u63a8\u51fa\u4e86Latent<\/span>\u2014<\/span>X1\u3002<\/span><\/p>\n

\u800c\u5728\u8fc7\u53bb12\u4e2a\u6708\u4e2d\uff0c\u6297\u4f53\u8bbe\u8ba1\u9886\u57df\u8fce\u6765\u4e86\u4e00\u7cfb\u5217\u7a81\u7834\u2014\u2014\u6297\u4f53\u8bbe\u8ba1\u88ab\u79f0\u4e3a\u8fd9\u4e00\u9886\u57df\u7684\u201c\u5723\u676f\u201d\uff0c\u6bd4\u4e00\u822c\u7ed3\u5408\u7269\u8bbe\u8ba1\u96be\u5f97\u591a\uff0c\u4e14\u76f4\u63a5\u9762\u5411\u5236\u836f\u884c\u4e1a\u6700\u6838\u5fc3\u7684\u836f\u7269\u7c7b\u522b\u3002Latent Labs\u7684Latent<\/span>\u2014<\/span> X2\u3001Chai Discovery\u7684Chai-2\u3001Nabla Bio\u7684<\/span>JAM<\/span>\u7b49\u6a21\u578b\u76f8\u7ee7\u95ee\u4e16\u3002\u6700\u8fd1\uff0cLatent Labs\u53d1\u5e03\u4e86\u5168\u7403\u9996\u4e2a\u5b9e\u9a8c\u5ba4\u9a8c\u8bc1\u7684\u6297\u4f53\u8bbe\u8ba1\u667a\u80fd\u4f53<\/span>Latent\u2014Y<\/span>\u3002<\/span><\/p>\n

\u6211\u8981\u5f3a\u8c03\u7684\u662f\uff1a\u4ec5\u4ec5\u4e94\u516d\u5e74\u95f4\uff0c\u6211\u4eec\u5c31\u4ece\u201c\u4e00\u5207\u90fd\u5728\u5b9e\u9a8c\u5ba4\u505a\u201d\u8dc3\u8fc1\u5230\u4e86\u201c\u667a\u80fd\u4f53\u5728\u8dd1\u6297\u4f53\u8bbe\u8ba1\u201d\u2014\u2014\u8fd9\u662f\u6307\u6570\u7ea7\u7684\u52a0\u901f\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u86cb\u767d\u8d28\uff1a\u6bd4\u56fe\u50cf\u66f4\u8106\u5f31\u7684\u5206\u5b50\u673a\u5668<\/span><\/p>\n

\u5728\u6df1\u5165\u6a21\u578b\u4e4b\u524d\uff0c\u8ba9\u6211\u5148\u7ed9\u4e00\u4e2a\u86cb\u767d\u8d28\u7684\u5165\u95e8\u4ecb\u7ecd\u3002\u86cb\u767d\u8d28\u662f\u751f\u547d\u5fc5\u9700\u7684\u5206\u5b50\u673a\u5668\uff0c\u7531\u6c28\u57fa\u9178\u94fe\u6298\u53e0\u6210\u4e09\u7ef4\u7ed3\u6784\u3002\u4ece\u8ba1\u7b97\u673a\u79d1\u5b66\u7684\u89d2\u5ea6\u770b\uff0c\u86cb\u767d\u8d28\u662f\u4e00\u6761\u753120\u4e2a\u5b57\u6bcd\uff08\u6c28\u57fa\u9178\uff09\u7ec4\u6210\u7684\u5b57\u7b26\u4e32\uff0c\u6bcf\u4e2a\u5b57\u6bcd\u5bf9\u5e94\u7279\u5b9a\u7684\u539f\u5b50\u96c6\u5408\u548c\u751f\u7269\u5316\u5b66\u6027\u8d28\u3002<\/span><\/p>\n

\u5173\u952e\u5728\u4e8e\uff1a\u7ed3\u6784\u51b3\u5b9a\u529f\u80fd\u3002\u800c\u4e14\u86cb\u767d\u8d28\u6709\u4e00\u4e2a\u975e\u5e38\u7279\u6b8a\u7684\u6027\u8d28\u2014\u2014\u5373\u4f7f\u53ea\u6709\u4e00\u4e2a\u6c28\u57fa\u9178\u7a81\u53d8\uff0c\u86cb\u767d\u8d28\u4e5f\u53ef\u80fd\u5b8c\u5168\u4e27\u5931\u529f\u80fd\u3002\u5bf9CVPR\u7684\u542c\u4f17\u6765\u8bf4\uff0c\u4e00\u4e2a\u7cbe\u51c6\u7684\u7c7b\u6bd4\u662f\uff1a\u5c31\u50cf\u4e00\u4e2a\u50cf\u7d20\u7684\u9519\u8bef\u5c31\u80fd\u6bc1\u6389\u4e00\u5f20\u56fe\u7247\u2014\u2014\u5f53\u7136\uff0c\u4eba\u7c7b\u89c6\u89c9\u662f\u9c81\u68d2\u7684\uff0c\u6539\u53d8\u4e00\u4e2a\u50cf\u7d20\u56fe\u7247\u4f9d\u7136\u8fde\u8d2f\uff0c\u4f46\u86cb\u767d\u8d28\u4e0d\u662f\u8fd9\u6837\u3002<\/span><\/p>\n

\u6211\u4ee5\u9e21\u86cb\u6e05\u86cb\u767d\u4e3a\u4f8b\uff1a\u5982\u679c\u5c06\u5176\u6838\u5fc3\u4f4d\u7f6e\u7684\u8d56\u6c28\u9178\u7a81\u53d8\u4e3a\u4e19\u6c28\u9178\u2014\u2014\u4ec5\u4ec5\u662f\u201c\u4e00\u4e2a\u5b57\u6bcd\u7684\u5207\u6362\u201d\u2014\u2014\u6574\u4e2a\u86cb\u767d\u5c31\u4f1a\u89e3\u4f53\uff0c\u5931\u53bb\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u53d8\u6210\u65e0\u5e8f\u86cb\u767d\u3002\u8fd9\u79cd\u7a81\u53d8\u4e5f\u662f\u764c\u75c7\u7684\u5e38\u89c1\u8bf1\u56e0\u3002\u6240\u4ee5\u4f60\u5b8c\u5168\u4e0d\u80fd\u5f04\u9519\u54ea\u6015\u4e00\u4e2a\u6c28\u57fa\u9178\u3002<\/span><\/p>\n

\u8fd9\u5c31\u5f15\u51fa\u4e86\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\uff1a1972\u5e74\uff0cAnfinsen\u5728\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u83b7\u5956\u6f14\u8bb2\u4e2d\u63d0\u51fa\u4e86\u201c\u70ed\u529b\u5b66\u5047\u8bf4\u201d\u2014\u2014\u5e8f\u5217\u5b8c\u5168\u51b3\u5b9a\u7ed3\u6784\u3002\u6b64\u540e\uff0c\u4eba\u4eec\u4e00\u76f4\u5728\u8bd5\u56fe\u8ba1\u7b97\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\u3002AlphaFold 2\u6b63\u662f\u8fd9\u4e2a50\u5e74\u96be\u9898\u7684\u89e3\u7b54\u3002<\/span><\/p>\n

\u00a0<\/p>\n

AlphaFold 2 \u5728 CASP14 \u76f2\u6d4b\u4e2d\u5c55\u73b0\u51fa\u4e86\u60ca\u4eba\u7684\u51c6\u786e\u5ea6\uff0c\u5176\u5728\u6240\u6709\u9776\u6807\u4e0a\u7684 <\/span>GDT_TS <\/span>\u4e2d\u4f4d\u6570\u8fbe\u5230\u4e86 92.4\uff0cC\u03b1 \u539f\u5b50\u7684 <\/span>RMSD<\/span> \u4e2d\u4f4d\u6570\u4ec5\u4e3a 0.96 \u00c5\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u7b2c\u4e8c\u540d\u7684\u65b9\u6cd5\u4e2d\u4f4d\u6570\u8bef\u5dee\u9ad8\u8fbe 2.8 \u00c5\uff0c\u5dee\u8ddd\u6781\u5176\u60ac\u6b8a\u3002<\/span><\/p>\n

\u5b66\u672f\u754c\u666e\u904d\u8ba4\u5b9a\u5b83\u89e3\u51b3\u4e86\u5355\u94fe\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\uff0c\u5176\u9884\u6d4b\u7cbe\u5ea6\u5df2\u4e0e\u5b9e\u9a8c\u7ed3\u679c\u4e0d\u76f8\u4e0a\u4e0b\u3002\u8fd9\u4e00\u7a81\u7834\u4e5f\u76f4\u63a5\u63a8\u52a8\u4e86 2024 \u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u6388\u4e88 Hassabis\u3001Jumper \u548c Baker\u3002<\/span><\/p>\n

\u00a0<\/p>\n

AlphaFold 2\u7684\u67b6\u6784\u7cbe\u9ad3\uff1a\u4ece\u8fdb\u5316\u4fe1\u53f7\u5230\u4e09\u7ef4\u7ed3\u6784<\/span><\/p>\n

AlphaFold 2\u6709\u4e09\u4e2a\u6838\u5fc3\u8f93\u5165\uff1a\u591a\u5e8f\u5217\u6bd4\u5bf9\uff08MSA\uff09\u3001\u914d\u5bf9\u8868\u5f81\u548c\u7ed3\u6784\u6a21\u677f\u3002\u5176\u4e2dMSA\u6700\u4e3a\u5173\u952e<\/span>\uff0c<\/span>\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u5171\u540c\u7a81\u53d8\u7684\u6b8b\u57fa\u5f80\u5f80\u5728\u4e09\u7ef4\u7a7a\u95f4\u4e2d\u63a5\u89e6\uff0c\u7531\u6b64\u53ef\u4ece\u8fdb\u5316\u4fe1\u53f7\u63a8\u65ad\u7a7a\u95f4\u5173\u7cfb\u3002\u914d\u5bf9\u8868\u5f81\u5219\u63d0\u4f9b\u4e86\u4e00\u4e2a\u201c\u8349\u7a3f\u677f\u201d\uff0c\u8ba9\u6a21\u578b\u663e\u5f0f\u5efa\u6a21\u6b8b\u57fa\u5bf9\u4e4b\u95f4\u7684\u4ea4\u4e92\u2014\u2014\u6d88\u878d\u5b9e\u9a8c\u8bc1\u660e\u8fd9\u662f\u6781\u5176\u5173\u952e\u7684\u3002\u7ed3\u6784\u6a21\u677f\u5219\u4e0d\u90a3\u4e48\u91cd\u8981\uff0c\u6a21\u578b\u5728\u65e0\u6a21\u677f\u65f6\u8868\u73b0\u51e0\u4e4e\u540c\u6837\u597d\u3002<\/span><\/p>\n

\u4ece\u8fd9\u4e9b\u8f93\u5165\u51fa\u53d1\uff0c\u6a21\u578b\u6784\u5efa\u4e24\u6761\u8868\u5f81\u8f68\u9053\uff1aMSA\u8868\u5f81\u6808\u548c\u914d\u5bf9\u8868\u5f81\u6808\uff0c\u901a\u8fc7\u6211\u4eec\u79f0\u4e4b\u4e3aEvoFormer\u7684\u521b\u65b0\u67b6\u6784\u8ba9\u4e24\u8005\u4ea4\u4e92\u3002EvoFormer\u57fa\u4e8e\u6ce8\u610f\u529b\u673a\u5236\uff0c\u4f46\u878d\u5165\u4e86\u5927\u91cf\u9886\u57df\u77e5\u8bc6\u7684\u5f52\u7eb3\u504f\u7f6e<\/span>\u3002<\/span>\u6bd4\u5982\u6211\u4eec\u5d4c\u5165\u4e86\u5c0a\u91cd\u4e09\u89d2\u4e0d\u7b49\u5f0f\u7684\u4e09\u89d2\u66f4\u65b0\uff0c\u5728\u914d\u5bf9\u8868\u5f81\u7684\u4ea4\u4e92\u4e2d\u6ce8\u5165\u51e0\u4f55\u5148\u9a8c\u3002\u6700\u540e\uff0c\u901a\u8fc7\u53e6\u4e00\u4e2a\u7f51\u7edc\u5c06\u8868\u5f81\u6620\u5c04\u5230\u4e09\u7ef4\u7a7a\u95f4<\/span>\u3002<\/span>\u5728AlphaFold 2\u4e2d\uff0c\u8fd9\u662f\u7528\u65cb\u8f6c\u548c\u5e73\u79fb\u6765\u53c2\u6570\u5316\u7684\uff0c\u8fdb\u4e00\u6b65\u6ce8\u5165\u4e86\u51e0\u4f55\u5f52\u7eb3\u504f\u7f6e<\/span>\uff08\u5c3d\u7ba1\u540e\u6765\u7684 AlphaFold 3 \u53d1\u73b0\u8fd9\u4e00\u6b65\u5e76\u975e\u5fc5\u9700\uff09<\/span>\u3002<\/span><\/p>\n

AlphaFold 2 \u7684\u6210\u529f\u8fd8\u5f97\u76ca\u4e8e\u5176\u4ed6\u521b\u65b0\u673a\u5236\uff0c\u6bd4\u5982\u5c06\u6a21\u578b\u672b\u7aef\u7684\u8868\u5f81\u91cd\u65b0\u53cd\u9988\u56de\u8d77\u70b9\u7684<\/span>\u8fed\u4ee3\u5faa\u73af\u673a\u5236\uff08Recycling\uff09<\/span>\uff0c\u4ee5\u53ca\u5bf9\u4e0b\u6e38\u5e94\u7528\u81f3\u5173\u91cd\u8981\u7684\u7f6e\u4fe1\u5ea6\u9884\u6d4b\uff08\u5305\u62ec\u9010\u6b8b\u57fa\u7684 pLDDT \u548c\u6b8b\u57fa\u5bf9\u7684 PAE \u6307\u6807\uff09\u3002\u6574\u4e2a\u67b6\u6784\u96c6\u6210\u4e86\u5927\u7ea6 10 \u5230 15 \u4e2a\u6838\u5fc3\u521b\u610f\uff0c\u5176\u4e2d\u6bcf\u4e00\u4e2a\u90fd\u8db3\u4ee5\u5355\u72ec\u652f\u6491\u4e00\u7bc7\u4f18\u79c0\u7684\u8bba\u6587\u3002<\/span><\/p>\n

AlphaFold 2 \u7684\u7a81\u7834\u8fd8\u5e26\u6765\u4e86\u4e00\u4e2a\u66f4\u6df1\u8fdc\u7684\u5f71\u54cd\u3002\u6b63\u5982\u8ba1\u7b97\u673a\u89c6\u89c9\u9886\u57df\u4e2d ImageNet \u50ac\u751f\u4e86 AlexNet\uff0c\u8fdb\u800c\u6f14\u8fdb\u51fa Inception Score \u548c FID \u6765\u52a0\u901f\u751f\u6210\u6a21\u578b\u8fed\u4ee3\u4e00\u6837\uff0c\u5728\u7ed3\u6784\u751f\u7269\u5b66\u4e2d\uff0cPDB \u6570\u636e\u96c6\u3001CASP \u8bc4\u4f30\u4ee5\u53ca\u4f5c\u4e3a\u201c\u9884\u6d4b\u5668\uff08Oracle\uff09\u201d\u7684 AlphaFold 2\uff0c\u5171\u540c\u6784\u5efa\u8d77\u4e86\u201c\u6570\u636e\u96c6 \u2192 \u8bc4\u4f30 \u2192 \u9884\u6d4b\u5668 \u2192 \u751f\u6210\u5668\u201d\u7684\u4ea7\u4e1a\u98de\u8f6e\u3002<\/span><\/p>\n

\u8fd9\u4e9b\u9884\u6d4b\u5668\u4e0d\u4ec5\u8ba9\u6211\u4eec\u80fd\u5728\u7b97\u6cd5\u4e0a\u5feb\u901f\u8fed\u4ee3\uff0c\u66f4\u80fd\u5e2e\u52a9\u6211\u4eec\u4ece\u6d77\u91cf\u8bbe\u8ba1\u4e2d\u8fdb\u884c\u7b5b\u9009\u548c\u6392\u5e8f\uff0c\u51c6\u786e\u6311\u51fa\u6700\u503c\u5f97\u8fdb\u5165\u6e7f\u5b9e\u9a8c\u5ba4\u9a8c\u8bc1\u7684\u5019\u9009\u5206\u5b50\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u4ece\u9884\u6d4b\u5230\u521b\u9020\uff1a<\/span>Latent\u2014X1<\/span>\u4e0e\u6761\u4ef6\u751f\u6210\u8303\u5f0f<\/span><\/p>\n

AlphaFold 2\u662f\u201c\u770b\u201d\u86cb\u767d\u8d28\u7684\u7ed3\u6784\uff0c\u4f46\u6211\u4eec\u8981\u201c\u9020\u201d\u86cb\u767d\u8d28\u3002\u836f\u7269\u8bbe\u8ba1\u53ef\u4ee5\u8868\u8ff0\u4e3a\u4e00\u4e2a\u6761\u4ef6\u751f\u6210\u4efb\u52a1\uff1a\u7ed9\u5b9a\u9776\u70b9\u7684\u5e8f\u5217\u548c\u7ed3\u6784\uff0c\u751f\u6210\u4e00\u4e2a\u4e0e\u4e4b\u9ad8\u7279\u5f02\u6027\u7ed3\u5408\u7684\u5206\u5b50<\/span>\u3002\u8fd9\u79cd\u7ed3\u5408\u5fc5\u987b<\/span>\u7cbe\u786e\u5230\u539f\u5b50\u5c42\u9762<\/span>\uff0c\u65e0\u8bba\u662f\u6c22\u952e\u8fd8\u662f\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u90fd\u5fc5\u987b\u6070\u5230\u597d\u5904\u3002<\/span><\/p>\n

<\/a><\/p>\n

\u5728 Latent Labs\uff0c\u6211\u4eec\u5c06\u9776\u70b9\u8868\u793a\u4e3a\u539f\u5b50\u5750\u6807\u70b9\u4e91\uff0c\u5e76\u4ee5\u6b64\u4e3a\u6761\u4ef6\uff0c\u5229\u7528\u53bb\u566a\u6269\u6563\u6a21\u578b\u4ece\u9ad8\u65af\u566a\u58f0\u4e2d\u5f00\u59cb\u751f\u6210\u7ed3\u5408\u7269\uff0c\u8fd9\u4fbf\u662f Latent\u2014X1 \u7684\u5de5\u4f5c\u539f\u7406\u3002\u5728\u53bb\u566a\u8f68\u8ff9\u4e2d\uff0c\u4f60\u53ef\u4ee5\u6e05\u6670\u5730\u89c2\u5bdf\u5230\u6a21\u578b\u5982\u4f55\u4ece\u4e00\u56e2\u6df7\u6c8c\u4e2d\u9010\u6b65\u201c\u96d5\u523b\u201d\u51fa\u7cbe\u786e\u7684\u7ed3\u5408\u7269\u7ed3\u6784\u3002<\/span><\/p>\n

\u6211\u4eec\u5b8c\u6574\u7684\u201c\u8bbe\u8ba1-\u9a8c\u8bc1\u201d\u6d41\u7a0b\u5982\u4e0b\uff1a<\/span><\/p>\n

\u7ed9\u5b9a\u9776\u70b9\u2192\u6307\u5b9a\u7ed3\u5408\u4f4d\u70b9\uff08\u6b8b\u57fa\u7ea7\u7cbe\u786e\uff09\u2192\u7528<\/span>Latent\u2014X1<\/span>\u751f\u6210\u7ed3\u5408\u7269\u2192\u7528AlphaFold 2\/3\u7c7b\u6a21\u578b\u4ea4\u53c9\u9a8c\u8bc1<\/span>\u3002<\/span><\/p>\n

\u5176\u4e2d\uff0c\u5728\u4ea4\u53c9\u9a8c\u8bc1\u73af\u8282\uff0c\u6211\u4eec\u4f1a\u91cd\u70b9\u89c2\u5bdf\u9884\u6d4b\u7ed3\u6784\u4e0e\u8bbe\u8ba1\u662f\u5426\u4e00\u81f4\uff0c\u5e76\u8bc4\u4f30\u5176\u7f6e\u4fe1\u5ea6\u3002<\/span><\/p>\n

\u6e7f\u5b9e\u9a8c\u5ba4\u9a8c\u8bc1\u73af\u8282\u81f3\u5173\u91cd\u8981\u3002<\/span>\u5728 Latent Labs \u4f4d\u4e8e\u65e7\u91d1\u5c71\u7684\u5b9e\u9a8c\u5ba4\u4e2d\uff0c\u6211\u4eec\u5728\u4eba\u7c7b\u7ec6\u80de\u7cfb\uff08\u5982\u80be\u7ec6\u80de\uff09\u4e0a\u8868\u8fbe\u8bbe\u8ba1\u51fa\u7684\u5206\u5b50\uff0c\u5e76\u7528\u7eff\u8272\u8367\u5149\u8fdb\u884c\u6807\u8bb0\uff0c\u540c\u65f6\u79fb\u5165\u5e26\u6709\u6a59\u8272\u67d3\u6599\u7684\u9776\u70b9\u3002\u4e00\u65e6\u6a59\u8272\u4fe1\u53f7\u88ab\u6210\u529f\u56fa\u5b9a\u5728\u7ec6\u80de\u4e0a\uff0c\u5373\u5ba3\u544a\u7ed3\u5408\u6210\u529f\u3002\u9274\u4e8e\u5355\u4e2a\u6c28\u57fa\u9178\u7684\u504f\u5dee\u5c31\u53ef\u80fd\u8ba9\u6240\u6709\u5fc3\u8840\u4ed8\u8bf8\u4e1c\u6d41\uff0c\u6e7f\u5b9e\u9a8c\u9a8c\u8bc1\u662f\u628a\u597d\u6700\u540e\u4e00\u5173\u7684\u94c1\u5f8b\u3002<\/span><\/p>\n

\u4f5c\u4e3a\u4e00\u6b3e\u57fa\u7840\u6a21\u578b\uff0cLatent\u2014X1 \u5e76\u672a\u9488\u5bf9\u7279\u5b9a\u7684\u751f\u7269\u836f\u6a21\u6001\u8fdb\u884c\u523b\u610f\u4f18\u5316\uff0c\u8fd9\u53cd\u800c\u8d4b\u4e88\u4e86\u5b83\u5728\u591a\u573a\u666f\u4e0b\u7684\u4f18\u5f02\u8868\u73b0\u3002\u5728\u7eb3\u7c73\u6297\u4f53\uff08Nanobody\uff09\u8bbe\u8ba1\u4e2d\uff0c\u5b83\u6210\u529f\u547d\u4e2d\u4e86\u6240\u6709\u9776\u6807\uff0c\u4eb2\u548c\u529b\u8fbe\u5230\u4e86\u7eb3\u6469\u5c14\u751a\u81f3\u76ae\u6469\u5c14\u7ea7\u522b\uff1b\u5728\u8ff7\u4f60\u7ed3\u5408\u86cb\u767d\uff08Mini-binder\uff0c\u5305\u542b 80-120 \u4e2a\u6c28\u57fa\u9178\uff09\u7684\u8bbe\u8ba1\u4e0a\uff0c\u5b83\u540c\u6837\u5168\u6570\u547d\u4e2d\u57fa\u51c6\u9776\u6807\uff0c\u4eb2\u548c\u529b\u633a\u8fdb\u76ae\u6469\u5c14\u7ea7\uff0c\u8fd9\u5df2\u6781\u5176\u63a5\u8fd1\u201c\u836f\u7269\u7ea7\u201d\u7684\u7ed3\u5408\u529b\u3002\u53d1\u5e03\u65f6\u7684\u5bf9\u6bd4\u6570\u636e\u4e5f\u8bc1\u5b9e\uff0cLatent\u2014X1 \u5728\u4eb2\u548c\u529b\u548c\u547d\u4e2d\u7387\u4e0a\u5747\u660e\u663e\u8d85\u8d8a\u4e86\u540c\u671f\u7684\u5176\u4ed6\u6a21\u578b\u3002<\/span><\/p>\n

<\/a><\/p>\n

<\/a><\/p>\n

Latent\u2014X2<\/span>\uff1a\u96f6\u6837\u672c\u8bbe\u8ba1\u836f\u7269\u7ea7\u6297\u4f53<\/span><\/p>\n

2024\u5e7412\u6708\uff0c\u6211\u4eec\u53d1\u5e03\u4e86<\/span>Latent\u2014X2\u3002\u5176<\/span>\u6838\u5fc3\u7a81\u7834\u5728\u4e8e\u96f6\u6837\u672c\u8bbe\u8ba1\u836f\u7269\u7ea7\u6297\u4f53\u3002\u6297\u4f53\u662f\u5f53\u4eca\u83b7\u6279\u836f\u7269\u4e2d\u6700\u5927\u7684\u751f\u7269\u836f\u7c7b\u522b\uff0c\u4e14\u4ecd\u5728\u6269\u5f20\u3002<\/span>\u6211\u4eec\u8bc1\u5b9e\uff0cLatent\u2014X2 \u53ef\u4ee5\u4ece\u5934\u9488\u5bf9\u4ece\u672a\u89c1\u8fc7\u7684\u9776\u70b9\u8bbe\u8ba1\u6297\u4f53\uff0c\u5e76\u4e14\u5728\u7eb3\u7c73\u6297\u4f53\u3001\u5355\u57df\u6297\u4f53\u7b49\u591a\u79cd\u6297\u4f53\u683c\u5f0f\u4e0a\u5747\u80fd\u4fdd\u6301\u9ad8\u4eb2\u548c\u529b\u3002<\/span><\/p>\n

\u5728\u836f\u7269\u76f8\u4f3c\u6027\uff08Drug-likeness\uff09\u65b9\u9762\uff0c<\/span>Latent\u2014X2<\/span>\u540c\u6837\u4ee4\u4eba\u632f\u594b\u3002\u597d\u7684\u836f\u7269\u5206\u5b50\u9700\u8981\u70ed\u7a33\u5b9a\u6027\u9ad8\uff08\u7194\u70b9\u9ad8\uff09\u3001\u5355\u4f53\u6027\u597d\uff08\u4e0d\u81ea\u805a\u96c6\uff0c\u4fbf\u4e8e\u9ad8\u5bc6\u5ea6\u50a8\u5b58\u548c\u8fd0\u8f93\uff09\u3001\u4ea7\u91cf\u9ad8\uff08\u5236\u9020\u6210\u672c\u4f4e\uff09\u3001\u591a\u53cd\u5e94\u6027\u4f4e\uff08\u65e0\u8131\u9776\u6548\u5e94\uff09\u3001\u758f\u6c34\u6027\u4f4e\uff08\u4e0d\u6613\u805a\u96c6\uff09\u3002\u4f20\u7edf\u4e0a\uff0c\u8fd9\u4e9b\u5c5e\u6027\u7684\u4f18\u5316\u662f\u4e00\u4e2a\u201c\u6253\u5730\u9f20\u201d\u6e38\u620f<\/span>\uff1a\u5f53\u4f60\u6309\u4e0b\u5176\u4e2d\u4e00\u4e2a\u6307\u6807\u65f6\uff0c\u53e6\u4e00\u4e2a\u6307\u6807\u5c31\u4f1a\u968f\u4e4b\u6076\u5316\u3002<\/span><\/p>\n

\u7136\u800c\uff0c\u7531 Latent\u2014X2 \u8bbe\u8ba1\u7684\u5206\u5b50\u4e2d\uff0c\u6709 47% \u7684\u5019\u9009\u7269\u65e0\u9700\u7ecf\u5386\u4efb\u4f55\u8fed\u4ee3\u4f18\u5316\uff0c\u5c31\u80fd\u540c\u65f6\u8de8\u8fc7\u6240\u6709\u5173\u952e\u6307\u6807\u7684\u9608\u503c\uff0c\u5176\u6574\u4f53\u6c34\u51c6\u5df2\u975e\u5e38\u63a5\u8fd1\u5e02\u9762\u4e0a\u73b0\u6709\u7684\u6cbb\u7597\u6027\u6297\u4f53\u3002<\/span><\/p>\n

<\/a><\/p>\n

\u66f4\u4ee4\u4eba\u9707\u64bc\u7684\u662f\u73af\u80bd\u8bbe\u8ba1\u7684\u5bf9\u6bd4\u5b9e\u9a8c\u3002\u6211\u4eec\u5728PHD2\u548cKRAS\u4e24\u4e2a\u9776\u70b9\u4e0a\uff0c\u5c06<\/span>Latent\u2014X2<\/span>\u4ec510\u4e2a\u8bbe\u8ba1\u4e0e\u4e07\u4ebf\u7ea7\u968f\u673a\u7b5b\u9009\u5e93\u7684\u7ed3\u679c\u5bf9\u6bd4<\/span>\uff1a<\/span>\u5728PHD2\u4e0a\uff0c10\u4e2a\u8bbe\u8ba1\u7684\u7ed3\u5408\u529b\u6bd4\u4e07\u4ebf\u7ea7\u7b5b\u9009\u7684\u6700\u4f18\u7ed3\u679c\u5f3a\u4e24\u4e2a\u6570\u91cf\u7ea7<\/span>\u3002<\/span><\/p>\n

\u800c\u5728\u5386\u53f2\u4e0a\u88ab\u516c\u8ba4\u4e3a\u201c\u4e0d\u53ef\u6210\u836f\u201d\u7684 KRAS \u9776\u6807\u4e0a\uff0c\u8fd9 10 \u4e2a\u8bbe\u8ba1\u540c\u6837\u62ff\u5230\u4e86\u4e0e\u4e07\u4ebf\u7ea7\u7b5b\u9009\u5206\u5ead\u6297\u793c\u7684\u7ed3\u5408\u7269\u3002\u5728\u6548\u7387\u4e0a\uff0cAI \u8ba1\u7b97\u4ec5\u8017\u65f6 1 \u5929\uff0c\u540e\u7eed\u5b9e\u9a8c\u5ba4\u9a8c\u8bc1\u82b1\u8d39 4 \u5468\uff1b\u800c\u4f20\u7edf\u7b5b\u9009\u5219\u9700\u8981\u8017\u8d39 3 \u5230 6 \u4e2a\u6708\u7684\u65f6\u95f4\uff0c\u5e76\u541e\u566c\u5927\u91cf\u7684\u4eba\u529b\u548c\u8bd5\u5242\u6210\u672c\u3002<\/span><\/p>\n

\u6211\u4eec\u8fd8\u5728\u4e0e\u5916\u90e8\u5408\u4f5c\u4f19\u4f34\u8fdb\u884c\u79bb\u5b50\u901a\u9053\u6291\u5236\u9879\u76ee\u3002\u79bb\u5b50\u901a\u9053\u662f\u4ecb\u5bfc\u795e\u7ecf\u5143\u79bb\u5b50\u6d41\u7684\u819c\u86cb\u767d\u5b54\u9053\uff0c\u5bf9\u9547\u75db\u836f\u7269\u5177\u6709\u91cd\u8981\u610f\u4e49\uff0c\u4e00\u76f4\u88ab\u8ba4\u4e3a\u662f\u6781\u5177\u6311\u6218\u6027\u7684\u9776\u6807\u3002<\/span>\u5982\u4eca\uff0cLatent\u2014X2 \u8bbe\u8ba1\u7684\u73af\u80bd\u5df2\u6210\u529f\u963b\u65ad\u4e86\u4eba\u7c7b NAV1.7 \u94a0\u79bb\u5b50\u901a\u9053\uff0c\u6210\u4e3a\u4e86\u201c\u7528 AI \u8ba1\u7b97\u7cbe\u5ea6\u66ff\u4ee3\u4f20\u7edf\u86ee\u529b\u7b5b\u9009\u201d\u7684\u7ecf\u5178\u8303\u4f8b\u3002<\/span><\/p>\n

Latent\u2014Y<\/span>\uff1a\u5168\u7403\u9996\u4e2a\u5b9e\u9a8c\u5ba4\u9a8c\u8bc1\u7684\u6297\u4f53\u8bbe\u8ba1\u667a\u80fd\u4f53<\/span><\/p>\n

\u5728Latent X\u7cfb\u5217\u6a21\u578b\u7684\u57fa\u7840\u4e0a\uff0c\u6211\u4eec\u66f4\u8fdb\u4e86\u4e00\u6b65<\/span>\uff0c<\/span>\u521b\u5efa\u4e86\u667a\u80fd\u4f53\u7cfb\u7edf<\/span>Latent\u2014Y<\/span>\uff0c\u8fd9\u662f\u5168\u7403\u9996\u4e2a\u5b9e\u9a8c\u5ba4\u9a8c\u8bc1\u7684\u6297\u4f53\u8bbe\u8ba1\u667a\u80fd\u4f53\uff0c\u4e5f\u662f\u836f\u7269\u8bbe\u8ba1\u56e2\u961f\u7684\u201c\u529b\u91cf\u500d\u589e\u5668\u201d\u3002<\/span><\/p>\n

<\/a><\/p>\n

\u5728\u6b64\u6211\u4e3a\u5927\u5bb6\u6f14\u793a\u5b83\u7684\u5177\u4f53\u5de5\u4f5c\u6d41\u3002\u6211\u4eec\u5728\u63d0\u793a\u6846\u4e2d\u8f93\u5165\u4e00\u53e5\u7b80\u5355\u7684\u6307\u4ee4\uff1a\u201c\u751f\u6210\u963b\u65ad\u4eba IL-6 \u7684\u7eb3\u7c73\u6297\u4f53\u3002\u201d\u63a5\u4e0b\u6765\uff0c\u667a\u80fd\u4f53\u4fbf\u5f00\u59cb\u72ec\u7acb\u63a5\u7ba1\u540e\u7eed\u6d41\u7a0b\uff1a<\/span><\/p>\n

\u00a0<\/p>\n

\u6574\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u667a\u80fd\u4f53\u53ef\u4ee5\u5e76\u884c\u6267\u884c\u591a\u4e2a\u6b65\u9aa4<\/span>\uff0c\u771f\u6b63\u5b9e\u73b0\u4e86\u7814\u53d1\u6548\u80fd\u7684\u6210\u500d\u653e\u5927\u3002<\/span><\/p>\n

\u5b9e\u9a8c\u5ba4\u9a8c\u8bc1\u7ed3\u679c\u4ee4\u4eba\u4fe1\u670d\u3002\u4ec5\u51ed\u7c7b\u4f3c\u201c\u7528\u7eb3\u7c73\u6297\u4f53\u963b\u65adPRLR\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u201d\u7684\u63d0\u793a\uff0c\u65e0\u9700\u4efb\u4f55\u8fed\u4ee3\uff0c\u5c31\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u83b7\u5f97\u4e86\u975e\u5e38\u7d27\u5bc6\u7684\u7ed3\u5408\u3002<\/span><\/p>\n

\u6211\u4eec\u8fd8\u5bf9\u5176\u8fdb\u884c\u4e86\u66f4\u6709\u6311\u6218\u6027\u7684\u538b\u529b\u6d4b\u8bd5\uff1a\u76f4\u63a5\u5c06\u4e00\u7bc7\u53d1\u8868\u5728 \u300aScience\u300b \u6216 \u300aNature\u300b \u4e0a\u7684\u8bba\u6587 PDF \u5582\u7ed9\u667a\u80fd\u4f53\uff0c\u8ba9\u5b83\u81ea\u4e3b\u8bc6\u522b\u6587\u4e2d\u63cf\u8ff0\u7684\u751f\u7269\u5b66\u529f\u80fd\u5e76\u8bbe\u8ba1\u5bf9\u5e94\u7684\u7eb3\u7c73\u6297\u4f53\u3002\u5728\u9488\u5bf9 20 \u7bc7\u8bba\u6587\u7684\u6d4b\u8bd5\u4e2d\uff0c\u9762\u5bf9\u4eba Transferrin \u53d7\u4f53 1\uff08\u4e00\u79cd\u8840\u8111\u5c4f\u969c\u9776\u6807\uff09\u7684\u8bbe\u8ba1\u4efb\u52a1\uff0c\u667a\u80fd\u4f53\u4ea7\u51fa\u7684 40 \u4e2a\u5019\u9009\u7269\u4e2d\u6709 11 \u4e2a\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u6210\u529f\u5b9e\u73b0\u4e86\u7ed3\u5408\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u5f00\u653e\u95ee\u9898\u4e0e\u672a\u6765\u5c55\u671b<\/span><\/p>\n

\u4e0d\u53ef\u5426\u8ba4\uff0c\u8be5\u9886\u57df\u76ee\u524d\u4f9d\u7136\u5b58\u5728\u8bf8\u591a\u6709\u5f85\u653b\u514b\u7684\u5f00\u653e\u6027\u95ee\u9898\u3002<\/span><\/p>\n

<\/a><\/p>\n

\u9996\u5f53\u5176\u51b2\u662f\u86cb\u767d\u8d28\u52a8\u529b\u5b66<\/span>\u3002<\/span>\u76ee\u524d\u6211\u4eec\u7684\u6a21\u578b\u672c\u8d28\u4e0a\u662f\u9759\u6001\u5efa\u6a21\uff0c\u4f46\u86cb\u767d\u8d28\u5728\u81ea\u7136\u754c\u4e2d\u662f\u52a8\u6001\u7684\u67d4\u6027\u7269\u4f53\uff0c\u8fd9\u5bf9\u9176\u50ac\u5316\u7b49\u529f\u80fd\u81f3\u5173\u91cd\u8981\u3002\u5206\u5b50\u52a8\u529b\u5b66\uff08MD\uff09\u9886\u57df\u957f\u671f\u5b58\u5728\uff0c\u4f46\u4f20\u7edf\u529b\u573a\u6cdb\u5316\u6027\u5dee\uff0c\u673a\u5668\u5b66\u4e60\u529b\u573a\u6b63\u5728\u5e26\u6765\u5e0c\u671b\u3002\u95ee\u9898\u4e00\u65b9\u9762\u662f\u529b\u573a\u7cbe\u5ea6\uff0c\u53e6\u4e00\u65b9\u9762\u662f\u8ba1\u7b97\u91cf<\/span>\u3002<\/span>\u4e5f\u8bb8Jensen\u548cNVIDIA\u4f1a\u5e2e\u6211\u4eec\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\u3002<\/span><\/p>\n

\u7b2c\u4e8c\u662f\u65e0\u6cd5\u53ef\u9760\u9884\u6d4b\u4eba\u4f53\u836f\u7269\u54cd\u5e94\u3002\u76ee\u524d\u8fd8\u4e0d\u6e05\u695a\u9700\u8981\u4ec0\u4e48\u624d\u80fd\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898<\/span>\uff0c<\/span>\u81f3\u5c11\u9700\u8981\u6536\u96c6\u66f4\u591a\u6570\u636e\u3002\u7b2c\u4e09\u662f\u7cfb\u7edf\u6027\u6bd2\u6027\u9884\u6d4b\uff0c\u540c\u6837\u662f\u6570\u636e\u74f6\u9888<\/span>\uff1a<\/span>\u4eba\u4f53\u4ea4\u4e92\u7f51\u7edc\u5982\u6b64\u5e9e\u5927\uff0c\u76ee\u524d\u8fdc\u672a\u88ab\u5145\u5206\u7406\u89e3\uff0c\u7eaf\u7406\u8bba\u63a8\u5bfc\u4e0d\u53ef\u80fd\uff0c\u5fc5\u987b\u5148\u6536\u96c6\u8db3\u591f\u7684\u673a\u5668\u5b66\u4e60\u5c31\u7eea\u6570\u636e\u3002<\/span><\/p>\n

\u5c55\u671b\u672a\u6765 5 \u5230 10 \u5e74\uff0c\u6211\u76f8\u4fe1\u4ee5\u4e0b\u8d8b\u52bf\u5c06\u81ea\u7136\u53d1\u751f\uff1a<\/span><\/p>\n

\u6700\u7ec8\uff0c\u5f53\u6240\u6709\u8fd9\u4e9b\u6280\u672f\u8fdb\u6b65\u6c47\u805a\u5728\u4e00\u8d77\u65f6\uff0c\u4eba\u7c7b\u5c06\u62e5\u6709\u653b\u514b\u6240\u6709\u75be\u75c5\u7684\u6b66\u5668\u3002\u8fd9\u542c\u8d77\u6765\u662f\u4e00\u4e2a\u6781\u5176\u4e50\u89c2\u7684\u8bba\u65ad\uff0c\u4f46\u6211\u575a\u4fe1\u8fd9\u53ea\u662f\u65f6\u95f4\u95ee\u9898\uff0c\u800c\u4e0d\u662f\u201c\u80fd\u5426\u5b9e\u73b0\u201d\u7684\u95ee\u9898\u3002<\/span><\/p>\n

\u6211\u4eec\u6b63\u7ad9\u5728\u5386\u53f2\u7684\u62d0\u70b9\u4e0a\uff1a<\/span>\u751f\u7269\u5b66\u7ec8\u5c06\u6210\u4e3a\u4e00\u95e8\u53ef\u7f16\u7a0b\u7684\u5de5\u7a0b\u5b66\u79d1\u3002<\/span><\/p>\n

\u00a0<\/p>\n

Q&A \u95ee\u7b54\u73af\u8282<\/span><\/p>\n

\u00a0<\/p>\n

\u542c\u4f17A\uff1a \u65e2\u7136\u8f93\u5165\u662f\u9700\u8981\u7ed3\u5408\u7684\u9776\u70b9\uff0c\u90a3\u9776\u70b9\u672c\u8eab\u7684\u53d1\u73b0\u5462\uff1f\u8fd9\u4f1a\u4e0d\u4f1a\u6210\u4e3a\u65b0\u7684\u74f6\u9888\uff1f<\/span><\/p>\n

Simon Kohl<\/span>\uff1a\u975e\u5e38\u597d\u7684\u95ee\u9898\u3002\u9776\u70b9\u8bc6\u522b\uff08Target ID\uff09\u672c\u8eab\u51e0\u4e4e\u5c31\u662f\u4e00\u4e2a\u72ec\u7acb\u7684\u7814\u7a76\u9886\u57df\u3002\u8001\u5b9e\u8bf4\uff0c\u6211\u4eec\u5e76\u4e0d\u7f3a\u9776\u70b9\u3002\u4f46\u786e\u5b9e\u5f88\u591a\u75be\u75c5\u4f1a\u4ece\u66f4\u597d\u7684\u9776\u70b9\u4e2d\u53d7\u76ca\u3002\u6211\u8ba4\u4e3a\u50cf\u6211\u4eec\u8fd9\u6837\u7684\u6a21\u578b\u4e5f\u80fd\u5728\u8fd9\u65b9\u9762\u63d0\u4f9b\u5e2e\u52a9\u2014\u2014\u6bd4\u5982\u6211\u4e4b\u524d\u63d0\u5230\u7684\u201c\u7814\u7a76\u8bd5\u5242\u201d\u65b9\u5411\uff0c\u5c31\u662f\u5e2e\u52a9\u66f4\u597d\u5730\u7406\u89e3\u9776\u70b9\u751f\u7269\u5b66\uff0c\u786e\u5b9a\u75be\u75c5\u901a\u8def\u4e2d\u8be5\u963b\u65ad\u54ea\u4e9b\u4ea4\u4e92\u3002\u8fd9\u867d\u7136\u662f\u6211\u4eca\u5929\u63cf\u8ff0\u5185\u5bb9\u7684\u4e0b\u6e38\uff0c\u4f46\u540c\u6837\u4ee4\u4eba\u5174\u594b\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u00a0<\/p>\n

\u542c\u4f17B\uff1a \u5728\u6e7f\u5b9e\u9a8c\u5ba4\u5de5\u4f5c\u4e2d\uff0c\u4f60\u4eec\u662f\u5426\u5728\u6784\u5efa\u7ec6\u80de\u6210\u50cf\u6570\u636e\u96c6\uff0c\u8bd5\u56fe\u8df3\u8fc7\u67d0\u4e9b\u5c42\u7ea7\u76f4\u63a5\u57fa\u4e8e\u9776\u70b9\u5efa\u6a21\u7ec6\u80de\u7ed3\u6784\uff1f<\/span><\/p>\n

Simon Kohl\uff1a<\/span>\u8fd9\u975e\u5e38\u6709\u8da3\u3002\u76ee\u524d\u8fd9\u4e2a\u9886\u57df\u6574\u4f53\u662f\u6570\u636e\u74f6\u9888\u2014\u2014\u6211\u4eec\u4ecePDB\u7b49\u6570\u636e\u96c6\u4e2d\u5df2\u7ecf\u201c\u69a8\u5e72\u201d\u4e86\u5f88\u591a\u3002\u6211\u8ba4\u4e3a\u5f53\u524d\u5230\u4e34\u5e8a\u7684\u5dee\u8ddd\uff0c\u6070\u6070\u9700\u8981\u66f4\u591a\u7c7b\u4f3c\u4f60\u63cf\u8ff0\u7684\u6570\u636e\u96c6\u3002\u95ee\u9898\u662f\u5982\u4f55\u4ee5\u9ad8\u5ea6\u53ef\u6269\u5c55\u7684\u65b9\u5f0f\u505a\u5230\u8fd9\u4e00\u70b9\uff0c\u4ea7\u51fa<\/span>\u5bf9<\/span>\u673a\u5668\u5b66\u4e60<\/span>\u53cb\u597d\u7684\u6807\u51c6\u5316<\/span>\u7684\u6570\u636e\u3002\u8fd9\u4e2a\u9886\u57df\u5e76\u4e0d\u7f3a\u6570\u636e\uff0c\u4f46\u6570\u636e\u662f\u5f02\u6784\u7684\u3001\u5206\u6563\u7684\u3001\u592a\u5c0f\u7684\u3001\u672a\u540c\u8d28\u5316\u7684\u3002\u8fd9\u7c7b\u52aa\u529b\u6211\u4eec\u975e\u5e38\u671f\u5f85\u770b\u5230\u8fdb\u5c55\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u542c\u4f17C\uff1a <\/span>Latent\u2014Y<\/span>\u667a\u80fd\u4f53\u76ee\u524d\u505c\u5728\u6e7f\u5b9e\u9a8c\u73af\u8282\uff0c\u4f60\u4eec\u662f\u5426\u5728\u63a8\u8fdb\u81ea\u52a8\u5316\u9a8c\u8bc1\u95ed\u73af\uff1f<\/span><\/p>\n

Simon Kohl\uff1a<\/span>\u662f\u7684\uff0c\u8fd9\u6b63\u662f\u4e00\u4e2a\u81ea\u6539\u8fdb\u7684\u601d\u8def\u3002\u76ee\u524d\u5df2\u6709\u5b9e\u9a8c\u670d\u52a1\u5546\u63d0\u4f9bAPI\u63a5\u53e3\u5230\u4ed6\u4eec\u7684\u5b9e\u9a8c\u5ba4\uff0c\u5c06\u8fd9\u4e2aAPI\u7ed9\u667a\u80fd\u4f53\uff0c\u6211\u8ba4\u4e3a\u975e\u5e38\u4ee4\u4eba\u5174\u594b\u3002\u5f53\u7136\u6709\u5f88\u591a\u590d\u6742\u6027\u2014\u2014\u6ca1\u6709\u4e00\u4e2a\u5b9e\u9a8c\u5ba4\u80fd\u8986\u76d6\u6240\u6709\u7a7a\u95f4\uff0c\u5b9e\u9a8c\u5ba4\u4e5f\u4e0d\u50cf\u7406\u60f3\u4e2d\u90a3\u6837\u6a21\u5757\u5316\u3002\u4f46\u5bf9\u66f4\u5e38\u89c1\u7684\u5de5\u4f5c\u6d41\uff0c\u8fd9\u662f\u975e\u5e38\u53ef\u884c\u7684\uff0c\u6211\u4eec\u5df2\u7ecf\u5728\u63a2\u7d22\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u542c\u4f17D\uff1a \u4f60\u5c55\u793a\u4e86\u8ff7\u4f60\u7ed3\u5408\u86cb\u767d\u548c\u80bd\u6bb5\u7684\u8bbe\u8ba1\u3002\u4f60\u8ba4\u4e3a\u8fd9\u4e9b\u66f4\u7b80\u5355\u7684\u5206\u5b50\u80fd\u5426\u66ff\u4ee3\u6297\u4f53\u836f\u7269\uff1f<\/span><\/p>\n

Simon Kohl\uff1a<\/span>\u6211\u8ba4\u4e3a\u6709\u53ef\u80fd\u3002\u6297\u4f53\u901a\u5e38\u9700\u8981\u9759\u8109\u6ce8\u5c04\u2014\u2014\u5b83\u4eec\u65e0\u6cd5\u901a\u8fc7\u6211\u4eec\u7684\u6d88\u5316\u9053\u751f\u5316\u73af\u5883\uff0c\u4f1a\u88ab\u5207\u788e\u3002\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48\u5c0f\u5206\u5b50\u4ecd\u6709\u5438\u5f15\u529b\u2014\u2014\u53ef\u4ee5\u53e3\u670d\u8fdb\u5165\u8840\u6d41\u3002\u73af\u80bd\u56e0\u6b64\u7279\u522b\u503c\u5f97\u5173\u6ce8\u3002\u4e00\u65e6\u6211\u4eec\u80fd\u5efa\u6a21\u4eba\u4f53\u836f\u7269\u54cd\u5e94\uff0c\u6211\u8ba4\u4e3a\u6ca1\u6709\u7406\u7531\u4e0d\u80fd\u8bbe\u8ba1\u51fa\u975e\u514d\u75ab\u539f\u6027\u3001\u65e0\u6bd2\u6027\u7684\u8ff7\u4f60\u7ed3\u5408\u86cb\u767d\u6216\u80bd\u6bb5\u3002\u4f46\u76ee\u524d\uff0c\u4eba\u7c7b\u86cb\u767d\u652f\u67b6\u63d0\u4f9b\u4e86\u66f4\u597d\u7684\u8d77\u70b9\uff0c\u8fd9\u662f\u6297\u4f53\u5982\u6b64\u6d41\u884c\u7684\u6839\u672c\u539f\u56e0\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u542c\u4f17E\uff1a \u751f\u6210\u5f0fAI\u80fd\u5426\u5e2e\u52a9\u9884\u6d4b\u4f53\u5916\u6bd2\u6027\uff1f<\/span><\/p>\n

Simon Kohl\uff1a<\/span>\u8fd9\u8fd8\u662f\u4e00\u4e2a\u6570\u636e\u95ee\u9898\u3002\u4eba\u4f53\u4ea4\u4e92\u7f51\u7edc\u592a\u5e9e\u5927\u4e86\uff0c\u8fdc\u672a\u88ab\u5145\u5206\u7406\u89e3\uff0c\u7eaf\u7406\u8bba\u63a8\u5bfc\u4eca\u5929\u4e0d\u53ef\u80fd\u3002\u5982\u679c\u6211\u4eec\u6709\u8db3\u591f\u7684\u6570\u636e\u6765\u6784\u5efa\u9884\u6d4b\u5668\uff0c\u90a3\u5c31\u53ef\u4ee5\u3002\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u8fd9\u662f\u201c\u65e0\u804a\u7684\u56de\u7b54\u201d\uff0c\u4f46\u786e\u5b9e\u9700\u8981\u5148\u66f4\u591a\u5730\u63a2\u6d4b\u7cfb\u7edf\uff0c\u7136\u540e\u624d\u80fd\u6784\u5efa\u53ef\u6cdb\u5316\u7684\u9884\u6d4b\u5668\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u542c\u4f17F\uff1a \u86cb\u767d\u8d28\u52a8\u529b\u5b66\u662f\u4e00\u4e2a\u5f00\u653e\u6311\u6218\uff0c\u4f60\u521d\u6b65\u7684\u60f3\u6cd5\u662f\u4ec0\u4e48\uff1f<\/span><\/p>\n

Simon Kohl\uff1a<\/span>\u5206\u5b50\u52a8\u529b\u5b66\uff08MD\uff09\u662f\u957f\u671f\u5b58\u5728\u7684\u9886\u57df\uff0c\u4f46\u7ecf\u5178\u529b\u573a\u6cdb\u5316\u6027\u5dee\u3002\u4eba\u4eec\u73b0\u5728\u5728\u6784\u5efa\u673a\u5668\u5b66\u4e60\u529b\u573a\u6765\u6539\u5584\u8fd9\u4e00\u70b9\uff0c\u5df2\u7ecf\u5c55\u73b0\u51fa\u5f88\u5927\u524d\u666f\u2014\u2014\u90e8\u5206\u539f\u56e0\u6b63\u662f\u7ecf\u5178\u529b\u573a\u7684\u8106\u5f31\u6027\u3002\u4f46\u95ee\u9898\u6709\u4e24\u65b9\u9762\uff1a\u4e00\u662f\u529b\u573a\u7cbe\u5ea6\uff0c\u4e8c\u662f\u8ba1\u7b97\u91cf\u3002\u76ee\u524d\u8981\u5728\u8db3\u591f\u7684\u65f6\u95f4\u5c3a\u5ea6\u6216\u539f\u5b50\u5c3a\u5ea6\u4e0a\u5efa\u6a21\u51e0\u4e4e\u4e0d\u53ef\u80fd\uff0c\u4f46\u8fd9\u5e76\u4e0d\u610f\u5473\u7740\u4e0d\u4f1a\u88ab\u89e3\u51b3\u2014\u2014\u53ea\u662f\u4eca\u5929\u4ecd\u7136\u56f0\u96be\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u542c\u4f17G\uff1a \u4ece\u7845\u5230\u6e7f\u5b9e\u9a8c\u5ba4\u7684\u8fc7\u6e21\u4e2d\uff0c\u4f60\u4eec\u5982\u4f55\u4ece\u6570\u767e\u4e07\u8bbe\u8ba1\u4e2d\u9009\u62e9\u6700\u597d\u7684\uff1f<\/span><\/p>\n

Simon Kohl\uff1a<\/span>\u4e24\u65b9\u9762\u3002\u9996\u5148\uff0c\u751f\u6210\u6a21\u578b\u672c\u8eab\u5fc5\u987b\u8db3\u591f\u597d\u2014\u2014\u5982\u679c\u672a\u8fc7\u6ee4\u7684\u6210\u529f\u7387\u592a\u4f4e\uff0c\u4efb\u4f55\u7b5b\u9009\u5668\u90fd\u6551\u4e0d\u4e86\u3002\u5176\u6b21\uff0c\u6211\u4eec\u4f7f\u7528\u7ed3\u6784\u9884\u6d4b\u6a21\u578b\u8fdb\u884c\u4ea4\u53c9\u9a8c\u8bc1\u2014\u2014\u5c06\u8bbe\u8ba1\u6298\u53e0\u540e\u770b\u7ed3\u6784\u662f\u5426\u4e0e\u8bbe\u8ba1\u4e00\u81f4\uff0c\u7ed3\u5408\u7f6e\u4fe1\u5ea6\u6307\u6807\u548c\u7279\u5b9a\u9608\u503c\u3002\u8fd9\u4f7f\u5f97\u6211\u4eec\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u6bcf\u4e2a\u9776\u6807\u6700\u591a\u53ea\u9700\u6d4b\u8bd5\u4e0d\u5230100\u4e2a\u8bbe\u8ba1\u3002\u8fd9\u53ea\u6709\u5f53\u751f\u6210\u5668\u548c\u8bc4\u5206\u5668\u90fd\u5f88\u5f3a\u65f6\u624d\u53ef\u80fd\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u542c\u4f17H\uff1a \u8be5\u9886\u57df\u7684\u6570\u636e\u7a00\u7f3a\u662f\u5426\u610f\u5473\u7740\u9700\u8981\u957f\u671f\u4f9d\u8d56\u4e13\u4e1a\u5316\u67b6\u6784\uff1f\u8fd8\u662f\u8bf4\u4f1a\u8fbe\u5230\u4e00\u4e2a\u62d0\u70b9\uff0c\u901a\u7528\u6570\u636e\u53ef\u4ee5\u8ba9\u57fa\u7840\u6a21\u578b\u7ed5\u8fc7\u4e13\u4e1a\u5316\u8bbe\u8ba1\uff1f<\/span><\/p>\n

Simon Kohl\uff1a<\/span>\u9886\u57df\u5185\u786e\u5b9e\u5728\u5411\u66f4\u5927\u6570\u636e\u96c6\u548c\u5408\u6210\u6570\u636e\u65b9\u5411\u63a8\u8fdb\u3002\u4e5f\u8bb8\u4e0d\u592a\u4e3a\u4eba\u6240\u77e5\u7684\u662f\uff0c\u5373\u4f7f\u5728AlphaFold 2\u4e2d\uff0c\u5408\u6210\u6570\u636e\uff08\u5373\u81ea\u84b8\u998f\u81ea\u9884\u6d4b\u6570\u636e\uff09\u4e0e\u5b9e\u9a8c\u5ba4\u6570\u636e\u7684\u6bd4\u4f8b\u4e5f\u662f3:1\u2014\u2014\u6211\u4eec\u7528\u4e86\u66f4\u591a\u7684\u81ea\u6211\u9884\u6d4b\u84b8\u998f\u6570\u636e\u6765\u8c03\u4f18\u6a21\u578b\u3002\u5173\u4e8e\u4e13\u4e1a\u5316\u67b6\u6784\uff0c\u786e\u5b9e\u5728\u6d88\u51cf\u2014\u2014\u5373\u4f7f\u5728\u6211\u4eec\u7684\u5de5\u4f5c\u4e2d\uff0c\u4eca\u5929\u4f7f\u7528\u7684\u5f52\u7eb3\u504f\u7f6e\u4e5f\u5c11\u5f97\u591a\u3002\u968f\u7740\u6570\u636e\u589e\u52a0\uff0c\u7b49\u53d8\u6027\u7b49\u7ea6\u675f\u53ef\u4ee5\u88ab\u66f4\u901a\u7528\u7684\u7cfb\u7edf\u66ff\u4ee3\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u542c\u4f17I\uff1a \u5bf9\u4e8e\u5206\u5e03\u5916\u91c7\u6837\u95ee\u9898\uff0c\u4f60\u8ba4\u4e3a\u5e94\u8be5\u5982\u4f55\u5e94\u5bf9\uff1f\u662f\u5426\u5b58\u5728\u6839\u672c\u6027\u9650\u5236\uff1f<\/span><\/p>\n

Simon Kohl\uff1a<\/span>\u8001\u5b9e\u8bf4\uff0c\u8fd9\u6ca1\u6709\u6211\u6700\u521d\u62c5\u5fc3\u7684\u90a3\u4e48\u4e25\u91cd\u3002\u76ee\u524d\u4e00\u4e9b\u6a21\u578b\u5df2\u7ecf\u5728\u76f8\u5f53\u5206\u5e03\u5916\u7684\u60c5\u51b5\u4e0b\u5de5\u4f5c\u5f97\u4e0d\u9519\u2014\u2014\u6bd4\u5982\u6709\u4e9b\u6a21\u578b\u4f1a\u4ea7\u751f\u81ea\u7136\u754c\u4e2d\u4e0d\u5b58\u5728\u7684\u3001\u8868\u9762\u9ad8\u5ea6\u5e26\u7535\u7684\u86cb\u767d\u8d28\uff0c\u4f46\u5b83\u4eec\u7adf\u7136\u8868\u8fbe\u5f97\u8fd8\u4e0d\u9519\u3002\u5f53\u7136\u5b83\u4eec\u7684\u836f\u7269\u8bbe\u8ba1\u5c5e\u6027\u53ef\u80fd\u4e0d\u597d\u3002\u6211\u8ba4\u4e3a\u6709\u5e2e\u52a9\u7684\u662f\uff1a\u751f\u6210\u6a21\u578b\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5f88\u597d\u7684\u5148\u9a8c\uff0c\u800c\u8bc4\u5206\u5668\u8fdb\u4e00\u6b65\u88c1\u526a\u5c3e\u90e8\u3002\u8fd9\u662f\u6211\u7684\u76f4\u89c9\u2014\u2014\u5206\u5e03\u5916\u4e0d\u662f\u5de8\u5927\u7684\u95ee\u9898\u3002<\/span><\/p>\n


<\/span><\/p>\n

>> \u70b9\u51fb\u5173\u6ce8CVPR\u4e13\u9898\u4e13\u533a\uff0c\u83b7\u53d6\u5e74\u5ea6\u7efc\u8ff0\u3001\u6df1\u5ea6\u8bba\u6587\u89e3\u8bfb\u4e0e\u884c\u4e1a\u8d8b\u52bf\u5168\u76d8\u70b9 <<\u00a0<\/p>\n

\u96f7\u5cf0\u7f51\u539f\u521b\u6587\u7ae0\uff0c\u672a\u7ecf\u6388\u6743\u7981\u6b62\u8f6c\u8f7d\u3002\u8be6\u60c5\u89c1\u8f6c\u8f7d\u987b\u77e5<\/a>\u3002<\/p>\n

\n
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\n <\/a>\n <\/p>\n

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\u4f5c\u8005\uff5c\u5434\u601d\u68a6 \u7f16\u8f91\uff5c\u5c91\u5cf0 \u00a0 2026\u5e74 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[27],"tags":[55,66],"class_list":["post-41060","post","type-post","status-publish","format-standard","hentry","category-news","tag-55","tag-66"],"yoast_head":"\n\u4ece\u8bfa\u5956\u9879\u76ee\u5230\u751f\u6210\u5f0f\u836f\u7269\u8bbe\u8ba1\uff0cLatent Labs \u521b\u59cb\u4eba Simon Kohl\uff1aAI \u6b63\u5728\u8ba9\u751f\u7269\u5b66\u8fdb\u5165\u300c\u53ef\u7f16\u7a0b\u65f6\u4ee3\u300d | CVPR 2026 - 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